Reactome | CNKSR1 [cytosol]

CNKSR1 [cytosol]

Stable Identifier

R-CFA-5672629

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

E2RDN9

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - FLT3 Signaling (Canis familiaris)
    - RAF/MAP kinase cascade (Canis familiaris)
      - MAP2K and MAPK activation (Canis familiaris)
        
        Dissociation of RAS:RAF complex (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)
        
        MAP2Ks phosphorylate MAPKs (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)
        
        RAF phosphorylates MAP2K dimer (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)

Signal Transduction (Canis familiaris)

- MAPK family signaling cascades (Canis familiaris)
  - MAPK1/MAPK3 signaling (Canis familiaris)
    - RAF/MAP kinase cascade (Canis familiaris)
      - MAP2K and MAPK activation (Canis familiaris)
        
        Dissociation of RAS:RAF complex (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)
        
        MAP2Ks phosphorylate MAPKs (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)
        
        RAF phosphorylates MAP2K dimer (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        CNKSR1 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:E2RDN9

Reference Genes

ENSEMBL:ENSCAFG00000012630

Other Identifiers

100855977

CfaAffx.19586.1.S1_at

CNKSR1

CNKSR1-203

ENSCAFG00000012630

ENSCAFP00000018607

ENSCAFT00000020063

EntrezGene:100855977

EntrezGene:CNKSR1

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005938

GO:0007165

GO:0007265

GO:0007266

GO:0008150

GO:0030674

IPR001478

IPR001660

IPR001849

IPR011993

IPR013761

IPR017874

IPR036034

PF00169

PF10534

SM00233

SM00454

UPI0003ADAB16

VGNC:39403

XM_003638922

XP_003638970

Participant Of

hasCandidate

RAF/MAPK scaffolds [cytosol]

Inferred From

CNKSR1 [cytosol] (Homo sapiens)