Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
MFN2 [mitochondrial outer membrane]
Stable Identifier
R-CFA-5205668
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
mitochondrial outer membrane
Synonyms
K48polyUb-MFN2, E2R3M9
Locations in the PathwayBrowser
Expand all
Autophagy (Canis familiaris)
Macroautophagy (Canis familiaris)
Selective autophagy (Canis familiaris)
Mitophagy (Canis familiaris)
PINK1-PRKN Mediated Mitophagy (Canis familiaris)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Canis familiaris)
ATG5:ATG12:LC3:K48polyUB Mitophagy Substrates:SQSTM1 [phagocytic vesicle] (Canis familiaris)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Canis familiaris)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Canis familiaris)
MFN2 [mitochondrial outer membrane] (Canis familiaris)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Canis familiaris)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Canis familiaris)
MFN2 [mitochondrial outer membrane] (Canis familiaris)
Parkin promotes the ubiquitination of mitochondrial substrates (Canis familiaris)
MFN2 [mitochondrial outer membrane] (Canis familiaris)
p62 binds ubiquitinated mitochondrial substrates (Canis familiaris)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Canis familiaris)
MFN2 [mitochondrial outer membrane] (Canis familiaris)
MFN2 [mitochondrial outer membrane] (Canis familiaris)
p62 links damaged mitochondria to LC3 (Canis familiaris)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Canis familiaris)
MFN2 [mitochondrial outer membrane] (Canis familiaris)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Canis familiaris)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Canis familiaris)
MFN2 [mitochondrial outer membrane] (Canis familiaris)
External Reference Information
External Reference
UniProt:E2R3M9
Gene Names
MFN2
Reference Genes
BioGPS Gene:487439 MFN2
ENSEMBL:ENSCAFG00845001739.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845001739.1 MFN2
KEGG Gene (Canis lupus familiaris):487439 MFN2
Monarch:487439 MFN2
NCBI Gene:487439 MFN2
Reference Transcript
RefSeq:XM_014111151.1 MFN2
RefSeq:XM_860305.4 MFN2
RefSeq:NM_001284441.1 MFN2
RefSeq:XM_014111147.1 MFN2
RefSeq:XM_014111148.1 MFN2
RefSeq:XM_014111143.1 MFN2
RefSeq:XM_014111145.1 MFN2
RefSeq:XM_005617986.2 MFN2
RefSeq:XM_005617987.2 MFN2
Other Identifiers
487439
Cfa.18057.1.S1_at
Cfa.18158.2.S1_a_at
Cfa.18158.2.S1_s_at
CfaAffx.25249.1.S1_s_at
GO:0000166
GO:0003824
GO:0003924
GO:0005525
GO:0005739
GO:0005741
GO:0006626
GO:0006886
GO:0006914
GO:0007005
GO:0007006
GO:0008053
GO:0012501
GO:0016020
GO:0016787
GO:0023052
GO:0031625
GO:0034497
GO:0043226
GO:0046580
GO:0051646
GO:0061024
GO:1904707
GO:1905461
Participates
as an input of
p62 binds ubiquitinated mitochondrial substrates (Canis familiaris)
as an output of
Parkin promotes the ubiquitination of mitochondrial substrates (Canis familiaris)
as a component of
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Canis familiaris)
Other forms of this molecule
MFN2 [mitochondrial outer membrane]
Inferred From
K48polyUb-MFN2 [mitochondrial outer membrane]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K48-linked polyubiquitin chain [cytosol]) at unknown position
Modification
K48-linked polyubiquitin chain [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_005618044.1
,
NP_001271370.1
,
XP_865398.1
,
XP_013966626.1
,
XP_013966618.1
,
XP_005618043.1
,
XP_013966622.1
,
XP_013966620.1
,
XP_013966623.1
OpenTargets
ENSG00000116688
Ensembl
ENSCAFG00845001739
,
ENSCAFT00845003081
,
ENSCAFP00845002462
VGNC
43193
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text