Reactome | JUN [nucleoplasm]

JUN [nucleoplasm]

Stable Identifier

R-CFA-450250

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

JUN, A0A8I3RTD9

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Signaling by Interleukins (Canis familiaris)
    - Interleukin-17 signaling (Canis familiaris)
      - MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        Activation of the AP-1 family of transcription factors (Canis familiaris)
        
        Activated JNKs phosphorylate c-JUN (Canis familiaris)
        
        JUN [nucleoplasm] (Canis familiaris)
- Innate Immune System (Canis familiaris)
  - Fc epsilon receptor (FCERI) signaling (Canis familiaris)
    - FCERI mediated MAPK activation (Canis familiaris)
      - Activated JNKs phosphorylate c-JUN (Canis familiaris)
        
        JUN [nucleoplasm] (Canis familiaris)
  - Toll-like Receptor Cascades (Canis familiaris)
    - Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        Activation of the AP-1 family of transcription factors (Canis familiaris)
        
        Activated JNKs phosphorylate c-JUN (Canis familiaris)
        
        JUN [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
      - Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        Activation of the AP-1 family of transcription factors (Canis familiaris)
        
        Activated JNKs phosphorylate c-JUN (Canis familiaris)
        
        JUN [nucleoplasm] (Canis familiaris)
      - Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        Activation of the AP-1 family of transcription factors (Canis familiaris)
        
        Activated JNKs phosphorylate c-JUN (Canis familiaris)
        
        JUN [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
      - MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        Activation of the AP-1 family of transcription factors (Canis familiaris)
        
        Activated JNKs phosphorylate c-JUN (Canis familiaris)
        
        JUN [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
      - MyD88-independent TLR4 cascade (Canis familiaris)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        Activation of the AP-1 family of transcription factors (Canis familiaris)
        
        Activated JNKs phosphorylate c-JUN (Canis familiaris)
        
        JUN [nucleoplasm] (Canis familiaris)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        Activation of the AP-1 family of transcription factors (Canis familiaris)
        
        Activated JNKs phosphorylate c-JUN (Canis familiaris)
        
        JUN [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        Activation of the AP-1 family of transcription factors (Canis familiaris)
        
        Activated JNKs phosphorylate c-JUN (Canis familiaris)
        
        JUN [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        Activation of the AP-1 family of transcription factors (Canis familiaris)
        
        Activated JNKs phosphorylate c-JUN (Canis familiaris)
        
        JUN [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        Activation of the AP-1 family of transcription factors (Canis familiaris)
        
        Activated JNKs phosphorylate c-JUN (Canis familiaris)
        
        JUN [nucleoplasm] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by Nuclear Receptors (Canis familiaris)
  - ESR-mediated signaling (Canis familiaris)
    - Estrogen-dependent gene expression (Canis familiaris)
      - Binding of AP1 transcriptional activator complexes to CCND1 promoter (Canis familiaris)
        
        CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Canis familiaris)
        
        ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Canis familiaris)
        
        FOS:JUN [nucleoplasm] (Canis familiaris)
        
        JUN [nucleoplasm] (Canis familiaris)
        
        ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Canis familiaris)
        
        FOS:JUN [nucleoplasm] (Canis familiaris)
        
        JUN [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3RTD9

Gene Names

JUN

Reference Genes

ENSEMBL:ENSCAFG00845006541.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845006541.1 JUN

Other Identifiers

609429

CfaAffx.28854.1.S1_s_at

GO:0000122

GO:0000785

GO:0000791

GO:0000976

GO:0000978

GO:0000981

GO:0001227

GO:0001228

GO:0003677

GO:0003700

GO:0005096

GO:0005634

GO:0005654

GO:0005694

GO:0006351

GO:0006355

GO:0006357

GO:0007179

GO:0012501

GO:0019046

GO:0019899

GO:0023052

GO:0031625

GO:0034614

GO:0035497

GO:0035976

GO:0042802

GO:0043065

GO:0043226

GO:0043922

GO:0043923

GO:0044389

GO:0045892

GO:0045893

GO:0045944

GO:0060395

GO:0061629

GO:0070412

GO:0071276

GO:0090575

GO:0098772

GO:0140110

GO:0140296

GO:1902895

GO:1904707

GO:1990441

GO:1990837

GO:2000144

Participates

as an input of

Activated JNKs phosphorylate c-JUN (Canis familiaris)

as a component of

FOS:JUN [nucleoplasm] (Canis familiaris)

Other forms of this molecule

phospho-JUN [nucleoplasm]

Inferred From

JUN [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000177606

Ensembl

ENSCAFG00845006541, ENSCAFP00845009067, ENSCAFT00845011604

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