Reactome | CCL4 [extracellular region]

CCL4 [extracellular region]

Stable Identifier

R-CFA-443976

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

extracellular region

Synonyms

CCL4(24-92), Q68AZ0

Locations in the PathwayBrowser

Expand all

Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (i) signalling events (Canis familiaris)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Canis familiaris)
        
        CCL4 [extracellular region] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Canis familiaris)
        
        CCL4 [extracellular region] (Canis familiaris)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Canis familiaris)
        
        CCL4 [extracellular region] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Canis familiaris)
        
        CCL4 [extracellular region] (Canis familiaris)
      - The Ligand:GPCR:Gi complex dissociates (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Canis familiaris)
        
        CCL4 [extracellular region] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Canis familiaris)
        
        CCL4 [extracellular region] (Canis familiaris)

External Reference Information

External Reference

UniProt:Q68AZ0

Gene Names

CCL4

Reference Genes

BioGPS Gene:448786 CCL4

ENSEMBL:ENSCAFG00030020896

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000018164.5 CCL4

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00030020896.1 CCL4

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00040004450.1 CCL4

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00805028767 CCL4

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845008857.1 CCL4

KEGG Gene (Canis lupus familiaris):448786 CCL4

Monarch:448786 CCL4

NCBI Gene:448786 CCL4

Reference Transcript

RefSeq:NM_001005250.1 CCL4

Other Identifiers

448786

480600

Cfa.15795.1.A1_s_at

CfaAffx.27804.1.S1_s_at

GO:0002376

GO:0005576

GO:0006955

GO:0008009

GO:0048018

GO:0048870

GO:0098772

Participates

as a component of

CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Canis familiaris)

Inferred From

CCL4, (CCL4L1) [extracellular region] (Homo sapiens)

CCL4(24-92) [extracellular region] (Homo sapiens)

CCL4L1 [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_001005250.1

OpenTargets

ENSG00000275302

Ensembl

ENSCAFT00845015652, ENSCAFG00845008857, ENSCAFP00845012169