Reactome | SH2D2A [cytosol]

SH2D2A [cytosol]

Stable Identifier

R-CFA-4420125

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

SH2D2A, A0A8I3N7R1

Locations in the PathwayBrowser

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Signal Transduction (Canis familiaris)

- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by VEGF (Canis familiaris)
    - VEGFA-VEGFR2 Pathway (Canis familiaris)
      - AXL autophosphorylates on Y779 and Y821 (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Canis familiaris)
        
        SH2D2A [cytosol] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Canis familiaris)
        
        SH2D2A [cytosol] (Canis familiaris)
      - AXL binds SRC-1 (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Canis familiaris)
        
        SH2D2A [cytosol] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Canis familiaris)
        
        SH2D2A [cytosol] (Canis familiaris)
      - Phosphorylation of SRC-1 (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Canis familiaris)
        
        SH2D2A [cytosol] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Canis familiaris)
        
        SH2D2A [cytosol] (Canis familiaris)
      - SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Canis familiaris)
        
        SH2D2A [cytosol] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Canis familiaris)
        
        SH2D2A [cytosol] (Canis familiaris)
      - VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Canis familiaris)
        
        SH2D2A [cytosol] (Canis familiaris)
      - p-6Y-VEGFR2 binds SH2D2A (Canis familiaris)
        
        SH2D2A [cytosol] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Canis familiaris)
        
        SH2D2A [cytosol] (Canis familiaris)
      - p-AXL binds PI3K (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Canis familiaris)
        
        SH2D2A [cytosol] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Canis familiaris)
        
        SH2D2A [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3N7R1

Gene Names

SH2D2A

Reference Genes

BioGPS Gene:100687395 SH2D2A

ENSEMBL:ENSCAFG00845008042.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845008042.1 SH2D2A

KEGG Gene (Canis lupus familiaris):100687395 SH2D2A

Monarch:100687395 SH2D2A

NCBI Gene:100687395 SH2D2A

Reference Transcript

RefSeq:XM_014115040.1 SH2D2A

Other Identifiers

100687395

GO:0002376

GO:0042098

Participates

as an input of

p-6Y-VEGFR2 binds SH2D2A (Canis familiaris)

as a component of

VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Canis familiaris)

Inferred From

SH2D2A [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_013970515.1

OpenTargets

ENSG00000027869

Ensembl

ENSCAFT00845014174, ENSCAFP00845010989, ENSCAFG00845008042