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VHL [cytosol]
Stable Identifier
R-CFA-391423
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
VHL, D3G8A7
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to hypoxia (Canis familiaris)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Canis familiaris)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Canis familiaris)
VHL [cytosol] (Canis familiaris)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
Proteasome proteolyzes ub-HIF-alpha (Canis familiaris)
VBC complex (with or without LIMD1) [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Class I MHC mediated antigen processing & presentation (Canis familiaris)
Antigen processing: Ubiquitination & Proteasome degradation (Canis familiaris)
Interaction of E3 with substrate and E2-Ub complex (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
Polyubiquitination of substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
Release of E3 from polyubiquitinated substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Neddylation (Canis familiaris)
26S proteasome degrades HIFalpha (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Canis familiaris)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL2-box protein [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
NEDD8-CRL2 E3 ligase complex [cytosol] (Canis familiaris)
CUL2-box protein [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Canis familiaris)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL2-box protein [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL2-box protein [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL2-box protein [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL2-box protein [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL2-box protein [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
NEDD8-CRL2 E3 ligase complex [cytosol] (Canis familiaris)
CUL2-box protein [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Canis familiaris)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL2-box protein [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL2-box protein [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
VBC complex [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
RHOBTB3 ATPase cycle (Canis familiaris)
RHOBTB3 binds interacting proteins at trans-Golgi network (Canis familiaris)
RHOBTB3 interacting proteins [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
RHOBTB3:ATP:RHOBTB3 interacting proteins [trans-Golgi network membrane] (Canis familiaris)
RHOBTB3 interacting proteins [cytosol] (Canis familiaris)
VHL [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:D3G8A7
Gene Names
VHL
Reference Genes
ENSEMBL:ENSCAFG00845008162.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845008162.1 VHL
Other Identifiers
494000
Cfa.15389.1.A1_s_at
Cfa.16229.1.S1_at
Cfa.2164.1.A1_at
CfaAffx.8667.1.S1_s_at
Participates
as a member of
RHOBTB3 interacting proteins [cytosol] (Canis familiaris)
CUL2-box protein [cytosol] (Canis familiaris)
as a component of
VBC complex [cytosol] (Canis familiaris)
Other forms of this molecule
VHL [nucleoplasm]
Inferred From
VHL [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000134086
Ensembl
ENSCAFT00845014355
,
ENSCAFP00845011119
,
ENSCAFG00845008162
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