Reactome | ELMO2 [cytosol]

ELMO2 [cytosol]

Stable Identifier

R-CFA-372642

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

ELMO2, A0A8I3P8D4

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Innate Immune System (Canis familiaris)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
    - Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
      - Activation of RAC1 by CRKII:DOCK180:ELMO (Canis familiaris)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        ELMO2 [cytosol] (Canis familiaris)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Canis familiaris)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        ELMO2 [cytosol] (Canis familiaris)
      - Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Canis familiaris)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        ELMO2 [cytosol] (Canis familiaris)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Canis familiaris)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        ELMO2 [cytosol] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by Non-Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by PTK6 (Canis familiaris)
    - PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Canis familiaris)
      - Activation of RAC1 by the PXN:CRK complex (Canis familiaris)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        ELMO2 [cytosol] (Canis familiaris)
      - Phosphorylated PXN recruits the CRK complex (Canis familiaris)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        ELMO2 [cytosol] (Canis familiaris)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        ELMO2 [cytosol] (Canis familiaris)
- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by VEGF (Canis familiaris)
    - VEGFA-VEGFR2 Pathway (Canis familiaris)
      - DOCK180:ELMO binds CRK (Canis familiaris)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Canis familiaris)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        ELMO2 [cytosol] (Canis familiaris)
        
        DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        ELMO2 [cytosol] (Canis familiaris)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Canis familiaris)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        ELMO2 [cytosol] (Canis familiaris)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Canis familiaris)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        ELMO1,ELMO2 [cytosol] (Canis familiaris)
        
        ELMO2 [cytosol] (Canis familiaris)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
  - Signaling by Rho GTPases (Canis familiaris)
    - RHO GTPase cycle (Canis familiaris)
      - RHOG GTPase cycle (Canis familiaris)
        
        RHOG binds effectors at the plasma membrane (Canis familiaris)
        
        RHOG plasma membrane effectors [cytosol] (Canis familiaris)
        
        ELMO2 [cytosol] (Canis familiaris)
        
        RHOG:GTP:RHOG plasma membrane effectors [plasma membrane] (Canis familiaris)
        
        RHOG plasma membrane effectors [cytosol] (Canis familiaris)
        
        ELMO2 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3P8D4

Gene Names

ELMO2

Reference Genes

ENSEMBL:ENSCAFG00845018858.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845018858.1 ELMO2

Reference Transcript

RefSeq:XM_005635132.2 ELMO2

Other Identifiers

119865677

Cfa.19514.2.S1_at

Cfa.5124.1.S1_at

CfaAffx.16203.1.S1_s_at

GO:0005737

GO:0005829

GO:0006909

GO:0006915

GO:0012501

GO:0016020

GO:0016192

GO:0017124

GO:0030971

GO:0048870

GO:0060326

Participates

as a candidate of

RHOG plasma membrane effectors [cytosol] (Canis familiaris)

as a member of

ELMO1,ELMO2 [cytosol] (Canis familiaris)

Inferred From

ELMO2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005635189.1

OpenTargets

ENSG00000062598

Ensembl

ENSCAFP00845026316, ENSCAFG00845018858, ENSCAFT00845033614