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CRKL [cytosol]
Stable Identifier
R-CFA-354384
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
CRKL, A0A8I3PN08
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)
Regulation of signaling by CBL (Canis familiaris)
CBL binds CRK (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRKL [cytosol] (Canis familiaris)
p(Y700,731,774)-CBL:CRK [cytosol] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRKL [cytosol] (Canis familiaris)
CBL:CRKL binds RAPGEF1 (Canis familiaris)
p(Y700,731,774)-CBL:CRK [cytosol] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRKL [cytosol] (Canis familiaris)
p(Y700,731,774)-CBL:CRK:RAPGEF1 [cytosol] (Canis familiaris)
p(Y700,731,774)-CBL:CRK [cytosol] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRKL [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by MET (Canis familiaris)
MET promotes cell motility (Canis familiaris)
MET activates RAP1 and RAC1 (Canis familiaris)
CRK,CRKL recruits RAC1 GEF to activated MET (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRKL [cytosol] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRKL [cytosol] (Canis familiaris)
DOCK7 activates RAC1 (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRKL [cytosol] (Canis familiaris)
GAB1 recruits CRK,CRKL to MET (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRKL [cytosol] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRKL [cytosol] (Canis familiaris)
RAPGEF1 activates RAP1 (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRKL [cytosol] (Canis familiaris)
RAPGEF1 binds CRK,CRKL (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRKL [cytosol] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRKL [cytosol] (Canis familiaris)
MET receptor recycling (Canis familiaris)
GGA3 associates with activated MET receptor (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRKL [cytosol] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRKL [cytosol] (Canis familiaris)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRKL [cytosol] (Canis familiaris)
Signaling by NTRKs (Canis familiaris)
Signaling by NTRK1 (TRKA) (Canis familiaris)
Signalling to ERKs (Canis familiaris)
Prolonged ERK activation events (Canis familiaris)
Frs2-mediated activation (Canis familiaris)
p-FRS2:CRKL binds C3G (Canis familiaris)
Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Canis familiaris)
CRKL [cytosol] (Canis familiaris)
Active TrkA receptor:p-FRS2:CRKL:RAPGEF1 [endosome membrane] (Canis familiaris)
Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Canis familiaris)
CRKL [cytosol] (Canis familiaris)
Signaling by PDGF (Canis familiaris)
Downstream signal transduction (Canis familiaris)
Crk binds to the active PDGF receptor (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRKL [cytosol] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRKL [cytosol] (Canis familiaris)
p130Cas and C3G bind PDGFR bound Crk (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRKL [cytosol] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRKL [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3PN08
Gene Names
CRKL
Reference Genes
BioGPS Gene:608125 CRKL
ENSEMBL:ENSCAFG00845024825.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845024825.1 CRKL
Monarch:608125 CRKL
NCBI Gene:608125 CRKL
Reference Transcript
RefSeq:XM_844856.4 CRKL
Other Identifiers
608125
CfaAffx.23374.1.S1_at
CfaAffx.23379.1.S1_s_at
GO:0001558
GO:0001568
GO:0001655
GO:0001764
GO:0001783
GO:0001784
GO:0001933
GO:0001934
GO:0002376
GO:0002685
GO:0003151
GO:0005515
GO:0005634
GO:0005654
GO:0005829
GO:0005886
GO:0006629
GO:0007155
GO:0007163
GO:0007167
GO:0007283
GO:0007338
GO:0007389
GO:0007507
GO:0008284
GO:0008543
GO:0008584
GO:0009887
GO:0009952
GO:0010468
GO:0010629
GO:0012501
GO:0016358
GO:0021766
GO:0021987
GO:0022414
GO:0023052
GO:0030010
GO:0030154
GO:0031594
GO:0032991
GO:0033628
GO:0034330
GO:0035022
GO:0035591
GO:0035685
GO:0036211
GO:0038026
GO:0042802
GO:0043226
GO:0043410
GO:0045202
GO:0048384
GO:0048538
GO:0048856
GO:0048870
GO:0050773
GO:0050852
GO:0060017
GO:0060090
GO:0060326
GO:0060465
GO:0061024
GO:0061629
GO:0070374
GO:0071466
GO:0071560
GO:0071774
GO:0086100
GO:0095500
GO:0098698
GO:0098749
GO:0098761
GO:0098890
GO:1900026
GO:1903977
GO:1904393
GO:1904395
GO:1904888
GO:2000404
Participates
as a member of
CRK, CRKL [cytosol] (Canis familiaris)
as a component of
Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Canis familiaris)
Other forms of this molecule
phospho-CRKL [cytosol]
Inferred From
CRKL [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_849949.1
OpenTargets
ENSG00000099942
Ensembl
ENSCAFG00845024825
,
ENSCAFP00845034351
,
ENSCAFT00845043835
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