Reactome | MDM4 [nucleoplasm]

MDM4 [nucleoplasm]

Stable Identifier

R-CFA-349430

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

MDM4, A0A8I3PE84

Locations in the PathwayBrowser

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Cellular responses to stimuli (Canis familiaris)

- Cellular responses to stress (Canis familiaris)
  - Cellular Senescence (Canis familiaris)
    - Oncogene Induced Senescence (Canis familiaris)
      - MDM2 ubiquitinates TP53 (Canis familiaris)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Canis familiaris)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Canis familiaris)
        
        p-S166,S188-MDM2:MDM4 [nucleoplasm] (Canis familiaris)
        
        MDM4 [nucleoplasm] (Canis familiaris)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Canis familiaris)
        
        p-S166,S188-MDM2:MDM4 [nucleoplasm] (Canis familiaris)
        
        MDM4 [nucleoplasm] (Canis familiaris)
    - Oxidative Stress Induced Senescence (Canis familiaris)
      - MDM2 ubiquitinates TP53 (Canis familiaris)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Canis familiaris)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Canis familiaris)
        
        p-S166,S188-MDM2:MDM4 [nucleoplasm] (Canis familiaris)
        
        MDM4 [nucleoplasm] (Canis familiaris)
        
        p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Canis familiaris)
        
        p-S166,S188-MDM2:MDM4 [nucleoplasm] (Canis familiaris)
        
        MDM4 [nucleoplasm] (Canis familiaris)

Metabolism of proteins (Canis familiaris)

- Post-translational protein modification (Canis familiaris)
  - Deubiquitination (Canis familiaris)
    - Ub-specific processing proteases (Canis familiaris)
      - USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Canis familiaris)
        
        USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Canis familiaris)
        
        TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Canis familiaris)
        
        MDM4 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PE84

Gene Names

MDM4

Reference Genes

BioGPS Gene:478939 MDM4

ENSEMBL:ENSCAFG00845023369.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845023369.1 MDM4

Monarch:478939 MDM4

NCBI Gene:478939 MDM4

Reference Transcript

RefSeq:XM_536098.5 MDM4

Other Identifiers

478939

CfaAffx.15196.1.S1_at

GO:0000122

GO:0005634

GO:0005654

GO:0006351

GO:0006355

GO:0012501

GO:0017053

GO:0019899

GO:0023052

GO:0030163

GO:0030330

GO:0042177

GO:0043066

GO:0043226

GO:0045892

GO:0050821

GO:0051726

GO:0065003

GO:0071456

Participates

as a member of

as a component of

p-S166,S188-MDM2:MDM4 [nucleoplasm] (Canis familiaris)

Other forms of this molecule

MDM4 [nucleoplasm]

phospho-MDM4 [nucleoplasm]

Inferred From

MDM4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_536098.3

OpenTargets

ENSG00000198625

Ensembl

ENSCAFG00845023369, ENSCAFT00845041289, ENSCAFP00845032370

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