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phospho-MAPK8 [nucleoplasm]
Stable Identifier
R-CFA-216349
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
nucleoplasm
Synonyms
p-T,Y-MAPK8, A0A8I3NY64
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular Senescence (Canis familiaris)
Oxidative Stress Induced Senescence (Canis familiaris)
Activated JNKs phosphorylate c-JUN (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
Activated human JNKs migrate to nucleoplasm (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
DNA Repair (Canis familiaris)
DNA Double-Strand Break Repair (Canis familiaris)
DNA Double Strand Break Response (Canis familiaris)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Canis familiaris)
APBB1 and MAPK8 bind diphosphorylated H2AFX (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-17 signaling (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated human JNKs migrate to nucleoplasm (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
Activation of the AP-1 family of transcription factors (Canis familiaris)
Activated JNKs phosphorylate c-JUN (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
Phosphorylated MAPKs phosphorylate ATF-2 (Canis familiaris)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
Innate Immune System (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated MAPK activation (Canis familiaris)
Activated JNKs phosphorylate c-JUN (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
Activated human JNKs migrate to nucleoplasm (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated human JNKs migrate to nucleoplasm (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
Activation of the AP-1 family of transcription factors (Canis familiaris)
Activated JNKs phosphorylate c-JUN (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
Phosphorylated MAPKs phosphorylate ATF-2 (Canis familiaris)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated human JNKs migrate to nucleoplasm (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
Activation of the AP-1 family of transcription factors (Canis familiaris)
Activated JNKs phosphorylate c-JUN (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
Phosphorylated MAPKs phosphorylate ATF-2 (Canis familiaris)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated human JNKs migrate to nucleoplasm (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
Activation of the AP-1 family of transcription factors (Canis familiaris)
Activated JNKs phosphorylate c-JUN (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
Phosphorylated MAPKs phosphorylate ATF-2 (Canis familiaris)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated human JNKs migrate to nucleoplasm (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
Activation of the AP-1 family of transcription factors (Canis familiaris)
Activated JNKs phosphorylate c-JUN (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
Phosphorylated MAPKs phosphorylate ATF-2 (Canis familiaris)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated human JNKs migrate to nucleoplasm (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
Activation of the AP-1 family of transcription factors (Canis familiaris)
Activated JNKs phosphorylate c-JUN (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
Phosphorylated MAPKs phosphorylate ATF-2 (Canis familiaris)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated human JNKs migrate to nucleoplasm (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
Activation of the AP-1 family of transcription factors (Canis familiaris)
Activated JNKs phosphorylate c-JUN (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
Phosphorylated MAPKs phosphorylate ATF-2 (Canis familiaris)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated human JNKs migrate to nucleoplasm (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
Activation of the AP-1 family of transcription factors (Canis familiaris)
Activated JNKs phosphorylate c-JUN (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
Phosphorylated MAPKs phosphorylate ATF-2 (Canis familiaris)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated human JNKs migrate to nucleoplasm (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
Activation of the AP-1 family of transcription factors (Canis familiaris)
Activated JNKs phosphorylate c-JUN (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
Phosphorylated MAPKs phosphorylate ATF-2 (Canis familiaris)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated human JNKs migrate to nucleoplasm (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
Activation of the AP-1 family of transcription factors (Canis familiaris)
Activated JNKs phosphorylate c-JUN (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
Phosphorylated MAPKs phosphorylate ATF-2 (Canis familiaris)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Canis familiaris)
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
p75 NTR receptor-mediated signalling (Canis familiaris)
Cell death signalling via NRAGE, NRIF and NADE (Canis familiaris)
NRAGE signals death through JNK (Canis familiaris)
Active JNK moves to the nucleus and phosphorylates different transcription factors (Canis familiaris)
phospho-MAPK8 [nucleoplasm] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NY64
Gene Names
MAPK8
Reference Genes
ENSEMBL:ENSCAFG00845019380.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845019380.1 MAPK8
Other Identifiers
477746
Cfa.18609.1.S1_s_at
GO:0000165
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0004705
GO:0004707
GO:0005524
GO:0005634
GO:0005737
GO:0006468
GO:0006979
GO:0007254
GO:0009411
GO:0010628
GO:0012501
GO:0016301
GO:0016310
GO:0016740
GO:0019899
GO:0019903
GO:0023052
GO:0032880
GO:0034198
GO:0034599
GO:0034614
GO:0035033
GO:0036211
GO:0042826
GO:0043066
GO:0043226
GO:0048511
GO:0051247
GO:0051403
GO:0065003
GO:0071222
GO:0071260
GO:0071276
GO:0098772
GO:0106310
GO:0120283
GO:0140096
GO:1900227
Participates
as an input of
APBB1 and MAPK8 bind diphosphorylated H2AFX (Canis familiaris)
as a component of
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm] (Canis familiaris)
as an output of
Active JNK moves to the nucleus and phosphorylates different transcription factors (Canis familiaris)
as a member of
p-MAPK8,9,10 [nucleoplasm] (Canis familiaris)
Other forms of this molecule
MAPK8 [cytosol]
phospho-MAPK8 [cytosol]
Inferred From
p-T,Y-MAPK8 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at unknown position
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
OpenTargets
ENSG00000107643
Ensembl
ENSCAFG00845019380
,
ENSCAFP00845026784
,
ENSCAFT00845034214
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