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phospho-TBK1 [cytosol]
Stable Identifier
R-CFA-168379
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
p-S172-TBK1, A0A8I3NK16
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Canis familiaris)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Canis familiaris)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Canis familiaris)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Canis familiaris)
phospho-TBK1 [cytosol] (Canis familiaris)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Canis familiaris)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Canis familiaris)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Canis familiaris)
phospho-TBK1 [cytosol] (Canis familiaris)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Canis familiaris)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Canis familiaris)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Canis familiaris)
phospho-TBK1 [cytosol] (Canis familiaris)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Canis familiaris)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Canis familiaris)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Canis familiaris)
phospho-TBK1 [cytosol] (Canis familiaris)
TBK1 is phosphorylated within the activated TLR4 complex (Canis familiaris)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Canis familiaris)
phospho-TBK1 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
TNF signaling (Canis familiaris)
Regulation of TNFR1 signaling (Canis familiaris)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Canis familiaris)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Canis familiaris)
phospho-TBK1 [cytosol] (Canis familiaris)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Canis familiaris)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Canis familiaris)
phospho-TBK1 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Canis familiaris)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Canis familiaris)
phospho-TBK1 [cytosol] (Canis familiaris)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Canis familiaris)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Canis familiaris)
phospho-TBK1 [cytosol] (Canis familiaris)
TNFR1-induced proapoptotic signaling (Canis familiaris)
TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Canis familiaris)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Canis familiaris)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Canis familiaris)
phospho-TBK1 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NK16
Gene Names
TBK1
Reference Genes
ENSEMBL:ENSCAFG00845011038.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845011038.1 TBK1
Reference Transcript
RefSeq:XM_538266.5 TBK1
Other Identifiers
481145
CfaAffx.1484.1.S1_at
GO:0000166
GO:0002218
GO:0002376
GO:0002753
GO:0003676
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006468
GO:0006914
GO:0010468
GO:0010508
GO:0010629
GO:0016239
GO:0016740
GO:0019903
GO:0023052
GO:0032479
GO:0032481
GO:0032727
GO:0032728
GO:0036211
GO:0042802
GO:0043123
GO:0043226
GO:0043231
GO:0044565
GO:0045087
GO:0045944
GO:0050830
GO:0051219
GO:0060340
GO:0098542
GO:0140096
GO:0140374
GO:1904262
GO:1904263
GO:1904417
Participates
as a component of
p-S172-TBK1:p-S172-TBK1 [cytosol] (Canis familiaris)
Other forms of this molecule
phospho-TBK1 [cytosol]
TBK1 [cytosol]
TBK1 [cytosol]
Inferred From
p-S172-TBK1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 172 (in Homo sapiens)
Coordinate
172
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_538266.3
OpenTargets
ENSG00000183735
Ensembl
ENSCAFP00845015571
,
ENSCAFG00845011038
,
ENSCAFT00845019880
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