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MAP3K14 [cytosol]
Stable Identifier
R-CFA-168189
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
A0A8I3MWN3
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Costimulation by the CD28 family (Canis familiaris)
CD28 co-stimulation (Canis familiaris)
CD28 dependent PI3K/Akt signaling (Canis familiaris)
p-S400-Cot phosphorylates NIK (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
TNFR2 non-canonical NF-kB pathway (Canis familiaris)
K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Canis familiaris)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Canis familiaris)
K48polyUb-TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
NIK-->noncanonical NF-kB signaling (Canis familiaris)
Activation of NIK (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK phosphorylates IKKA dimer (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
NIK autophosphorylates on T559 (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Canis familiaris)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Canis familiaris)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
p100:RELB binds active NIK:p-IKKA dimer (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Protesomal degradation of K48polyUb-TRAF3 (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Canis familiaris)
K48polyUb-TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Canis familiaris)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Canis familiaris)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Canis familiaris)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
TRAF2:cIAP1/2 complex binds FN14:TWEAK (Canis familiaris)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
TRAF3 binds BAFFR:BAFF (Canis familiaris)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
TRAFs bind RANK:RANKL (Canis familiaris)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Canis familiaris)
Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Canis familiaris)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
TRAF3:NIK binds TRAF2:cIAP1/2 (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Canis familiaris)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Canis familiaris)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
Dectin-1 mediated noncanonical NF-kB signaling (Canis familiaris)
Activation of NIK (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK phosphorylates IKKA dimer (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Canis familiaris)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Canis familiaris)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
p100:RELB binds active NIK:p-IKKA dimer (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3MWN3
Reference Genes
ENSEMBL:ENSCAFG00845005731.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845005731.1
Other Identifiers
490926
CfaAffx.21280.1.S1_at
GO:0000166
GO:0001650
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004704
GO:0005524
GO:0005634
GO:0005654
GO:0005730
GO:0005829
GO:0006468
GO:0006955
GO:0007249
GO:0016740
GO:0023052
GO:0036211
GO:0038061
GO:0043226
GO:0043231
GO:0051607
GO:0071260
GO:0098542
GO:0098772
GO:0140096
Participates
as an input of
NIK autophosphorylates on T559 (Canis familiaris)
p-S400-Cot phosphorylates NIK (Canis familiaris)
Activation of NIK (Canis familiaris)
Active NIK phosphorylates IKKA dimer (Canis familiaris)
as an output of
Activation of NIK (Canis familiaris)
Protesomal degradation of K48polyUb-TRAF3 (Canis familiaris)
as a component of
TRAF3:NIK [cytosol] (Canis familiaris)
K48polyUb-TRAF3:NIK [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
Other forms of this molecule
phospho-p-T559-MAP3K14 [cytosol]
K48polyUb-NIK [cytosol]
phospho-p-MAP3K14 [cytosol]
Inferred From
MAP3K14 [cytosol]
(Homo sapiens)
Active NIK [cytosol]
(Homo sapiens)
Cross References
Ensembl
ENSCAFT00845010168
,
ENSCAFP00845007923
,
ENSCAFG00845005731
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