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NGF [extracellular region]
Stable Identifier
R-CFA-167034
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
extracellular region
Synonyms
NGF, A0A8I3PYI3
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
p75 NTR receptor-mediated signalling (Canis familiaris)
Cell death signalling via NRAGE, NRIF and NADE (Canis familiaris)
NADE modulates death signalling (Canis familiaris)
14-3-3epsilon attentuates NADE-related apoptosis (Canis familiaris)
NGF ligand:p75NTR:NADE:14-3-3epsilon [plasma membrane] (Canis familiaris)
NGF:p75NTR:NADE [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
NGF:p75NTR:NADE [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
p75NTR binds to NADE (Canis familiaris)
NGF:p75NTR:NADE [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
p75NTR:NADE promotes caspase2/3 activation (Canis familiaris)
NGF:p75NTR:NADE [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
NRIF signals cell death from the nucleus (Canis familiaris)
TRAF6 binds to p75NTR:NRIF (Canis familiaris)
NGF ligand:p75NTR:NRIF [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:NRIF [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Canis familiaris)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:NRIF [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
NFG and proNGF binds to p75NTR (Canis familiaris)
NGF homodimer binds to p75NTR (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
p75NTR regulates axonogenesis (Canis familiaris)
Axonal growth stimulation (Canis familiaris)
NGF binding to p75NTR inactivates RHOA (Canis familiaris)
RHOA:GDP:ARHGDIA:NGFR:NGF [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
p75NTR signals via NF-kB (Canis familiaris)
NF-kB is activated and signals survival (Canis familiaris)
IKKbeta is activated (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
p75NTR recruits signalling complexes (Canis familiaris)
IKK-beta is recruited (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
IRAK interacts with TRAF6 (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
MYD88 dissociates (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
TRAF6 is auto-ubiquitinated (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
p62 is recruited and forms a complex with TRAF6 (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
p62 recruits an atypical PKC (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
p75NTR interacts with RIP2 (Canis familiaris)
NGF:p75NTR:RIP2 [plasma membrane] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by NTRKs (Canis familiaris)
Expression and Processing of Neurotrophins (Canis familiaris)
NGF processing (Canis familiaris)
Pro-beta-NGF and mature beta-NGF are secreted (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
Signaling by NTRK1 (TRKA) (Canis familiaris)
Activation of TRKA receptors (Canis familiaris)
TRKA activation by NGF (Canis familiaris)
Activated TrkA receptor internalizes to endosomes (Canis familiaris)
Activated TrkA receptor complex [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
The bound receptor dimerizes (Canis familiaris)
beta-NGF dimer:TrkA receptor [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
beta-NGF dimer:TrkA receptor dimer [plasma membrane] (Canis familiaris)
beta-NGF dimer:TrkA receptor [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
beta-NGF dimer binds to TrkA receptor (Canis familiaris)
beta-NGF dimer:TrkA receptor [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
PI3K/AKT activation (Canis familiaris)
Active IRS recruits PI3K to the plasma membrane and activates it (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
Retrograde neurotrophin signalling (Canis familiaris)
Axonal transport of NGF:Trk complexes (Canis familiaris)
Activated TrkA receptor complex:Clathrin-coated vesicle:Endophilin [plasma membrane] (Canis familiaris)
Activated TrkA receptor complex [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
Signalling to ERKs (Canis familiaris)
Prolonged ERK activation events (Canis familiaris)
ARMS-mediated activation (Canis familiaris)
ARMS is phosphorylated by active TrkA receptor (Canis familiaris)
Active TrkA receptor:ARMS:Crk complex [plasma membrane] (Canis familiaris)
Activated TrkA receptor complex [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Canis familiaris)
Activated TrkA receptor complex [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
C3G stimulates nucleotide exchange on Rap1 (Canis familiaris)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Canis familiaris)
Activated TrkA receptor complex [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
Crk's SH3 domain engages C3G (Canis familiaris)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Canis familiaris)
Activated TrkA receptor complex [plasma membrane] (Canis familiaris)
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
NGF [extracellular region] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3PYI3
Gene Names
NGF
Reference Genes
BioGPS Gene:403402 NGF
ENSEMBL:ENSCAFG00845027859.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845027859.1 NGF
KEGG Gene (Canis lupus familiaris):403402 NGF
Monarch:403402 NGF
NCBI Gene:403402 NGF
Reference Transcript
RefSeq:NM_001194950.1 NGF
Other Identifiers
403402
Cfa.3899.1.S1_s_at
CfaAffx.15276.1.S1_at
GO:0005102
GO:0005163
GO:0005576
GO:0008191
GO:0008625
GO:0010628
GO:0012501
GO:0023052
GO:0030154
GO:0048812
GO:0048856
GO:0098772
Participates
as a component of
mature beta-NGF homodimer [extracellular region] (Canis familiaris)
Other forms of this molecule
NGF [extracellular region]
NGF [Golgi lumen]
NGF [cytosol]
NGF [Golgi lumen]
Inferred From
NGF [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_001181879.1
OpenTargets
ENSG00000134259
Ensembl
ENSCAFG00845027859
,
ENSCAFP00845038559
,
ENSCAFT00845049144
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