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CBL [cytosol]
Stable Identifier
R-CFA-112199
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
CBL, A0A8I3MBU4
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
FLT3 Signaling (Canis familiaris)
Negative regulation of FLT3 (Canis familiaris)
Active FLT3 binds to CBL (Canis familiaris)
CBL [cytosol] (Canis familiaris)
active FLT3:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
FLT3 phosphorylates CBL (Canis familiaris)
active FLT3:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)
Regulation of signaling by CBL (Canis familiaris)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Canis familiaris)
CBL [cytosol] (Canis familiaris)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Interleukin-6 family signaling (Canis familiaris)
Interleukin-6 signaling (Canis familiaris)
PTPN11 binds CBL (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by EGFR (Canis familiaris)
EGFR downregulation (Canis familiaris)
Binding of CBL to EGFR (Canis familiaris)
CBL [cytosol] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
CBL binds and ubiquitinates phosphorylated Sprouty (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
CBL binds to GRB2 (Canis familiaris)
CBL [cytosol] (Canis familiaris)
CBL:GRB2 [cytosol] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Canis familiaris)
CBL:GRB2 [cytosol] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
CBL ubiquitinates Sprouty (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
CBL-mediated ubiquitination of CIN85 (Canis familiaris)
CBL [cytosol] (Canis familiaris)
CDC42:GTP binds CBL:Beta-Pix (Canis familiaris)
CBL [cytosol] (Canis familiaris)
CBL:Beta-Pix:CDC42:GTP [cytosol] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Localization of CBL:GRB2 to the membrane (Canis familiaris)
CBL:GRB2 [cytosol] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Canis familiaris)
CBL:GRB2 [cytosol] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Phosphorylation of CBL (EGFR:CBL) (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Canis familiaris)
CBL:GRB2 [cytosol] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Sprouty lures CBL away from EGFR (Canis familiaris)
CBL [cytosol] (Canis familiaris)
CBL:SPRY1/2 [cytosol] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Signaling by FGFR (Canis familiaris)
Signaling by FGFR1 (Canis familiaris)
Negative regulation of FGFR1 signaling (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
CBL dissociates from ubiquitinated p-SPRY2 (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Phosphorylated SPRY2 is ubiquitinated by CBL (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
SPRY2 binds CBL (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Signaling by FGFR2 (Canis familiaris)
Negative regulation of FGFR2 signaling (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
CBL dissociates from ubiquitinated p-SPRY2 (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Phosphorylated SPRY2 is ubiquitinated by CBL (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
SPRY2 binds CBL (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Signaling by FGFR3 (Canis familiaris)
Negative regulation of FGFR3 signaling (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
CBL dissociates from ubiquitinated p-SPRY2 (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Phosphorylated SPRY2 is ubiquitinated by CBL (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
SPRY2 binds CBL (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Signaling by FGFR4 (Canis familiaris)
Negative regulation of FGFR4 signaling (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
CBL dissociates from ubiquitinated p-SPRY2 (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Phosphorylated SPRY2 is ubiquitinated by CBL (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
SPRY2 binds CBL (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Signaling by MET (Canis familiaris)
Negative regulation of MET activity (Canis familiaris)
CBL binds MET (Canis familiaris)
CBL:GRB2,CBL [cytosol] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
CBL:GRB2 [cytosol] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Canis familiaris)
CBL:GRB2 [cytosol] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
MET phosphorylates CBL (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Canis familiaris)
CBL:GRB2 [cytosol] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Signaling by SCF-KIT (Canis familiaris)
Regulation of KIT signaling (Canis familiaris)
Recruitment of CBL to KIT (Canis familiaris)
CBL [cytosol] (Canis familiaris)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
Signaling by TGFB family members (Canis familiaris)
Signaling by TGF-beta Receptor Complex (Canis familiaris)
TGF-beta receptor signaling activates SMADs (Canis familiaris)
CBL binds TGFBR2 (Canis familiaris)
CBL [cytosol] (Canis familiaris)
TGFBR2:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
CBL neddylates TGFBR2 (Canis familiaris)
CBL [cytosol] (Canis familiaris)
TGFBR2:CBL [plasma membrane] (Canis familiaris)
CBL [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3MBU4
Gene Names
CBL
Reference Genes
ENSEMBL:ENSCAFG00845000222.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845000222.1 CBL
Other Identifiers
489369
CfaAffx.18803.1.S1_at
GO:0001784
GO:0003824
GO:0004842
GO:0005509
GO:0005515
GO:0005794
GO:0005829
GO:0005886
GO:0005929
GO:0006508
GO:0006511
GO:0007166
GO:0012501
GO:0016192
GO:0016567
GO:0016600
GO:0016740
GO:0017124
GO:0023051
GO:0023052
GO:0030163
GO:0032487
GO:0036211
GO:0042059
GO:0043066
GO:0043226
GO:0046872
GO:0046875
GO:0048260
GO:0051897
GO:0061630
GO:0070086
GO:0140096
GO:2000583
Participates
as an input of
Active FLT3 binds to CBL (Canis familiaris)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Canis familiaris)
PTPN11 binds CBL (Canis familiaris)
Recruitment of CBL to KIT (Canis familiaris)
SPRY2 binds CBL (Canis familiaris)
CDC42:GTP binds CBL:Beta-Pix (Canis familiaris)
Sprouty lures CBL away from EGFR (Canis familiaris)
CBL binds to GRB2 (Canis familiaris)
Binding of CBL to EGFR (Canis familiaris)
CBL binds TGFBR2 (Canis familiaris)
as a component of
active FLT3:CBL [plasma membrane] (Canis familiaris)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Canis familiaris)
HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Canis familiaris)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Canis familiaris)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
CBL:Beta-Pix:CDC42:GTP [cytosol] (Canis familiaris)
CBL:SPRY1/2 [cytosol] (Canis familiaris)
CBL:GRB2 [cytosol] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Canis familiaris)
TGFBR2:CBL [plasma membrane] (Canis familiaris)
as a candidate of
CBL:GRB2,CBL [cytosol] (Canis familiaris)
as an output of
CBL dissociates from ubiquitinated p-SPRY2 (Canis familiaris)
CBL neddylates TGFBR2 (Canis familiaris)
Other forms of this molecule
phospho-CBL [cytosol]
phospho-CBL [cytosol]
phospho-CBL [plasma membrane]
phospho-CBL [cytosol]
phospho-CBL [cytosol]
Inferred From
CBL [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000110395
Ensembl
ENSCAFP00845000244
,
ENSCAFG00845000222
,
ENSCAFT00845000345
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