Reactome | toca-1 [cytosol]

toca-1 [cytosol]

Stable Identifier

R-CEL-8862261

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

FNBP1, Q19253

Locations in the PathwayBrowser

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Signal Transduction (Caenorhabditis elegans)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Caenorhabditis elegans)
  - Signaling by Rho GTPases (Caenorhabditis elegans)
    - RHO GTPase cycle (Caenorhabditis elegans)
      - RHOQ GTPase cycle (Caenorhabditis elegans)
        
        RHOQ binds effectors at the plasma membrane (Caenorhabditis elegans)
        
        RHOQ effectors [cytosol] (Caenorhabditis elegans)
        
        FNBP1 dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of FNBP1 [cytosol] (Caenorhabditis elegans)
        
        toca-1 [cytosol] (Caenorhabditis elegans)
        
        RHOQ:GTP:RHOQ effectors [plasma membrane] (Caenorhabditis elegans)
        
        RHOQ effectors [cytosol] (Caenorhabditis elegans)
        
        FNBP1 dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of FNBP1 [cytosol] (Caenorhabditis elegans)
        
        toca-1 [cytosol] (Caenorhabditis elegans)

Vesicle-mediated transport (Caenorhabditis elegans)

- Membrane Trafficking (Caenorhabditis elegans)
  - Clathrin-mediated endocytosis (Caenorhabditis elegans)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        FNBP1 dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of FNBP1 [cytosol] (Caenorhabditis elegans)
        
        toca-1 [cytosol] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        FNBP1 dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of FNBP1 [cytosol] (Caenorhabditis elegans)
        
        toca-1 [cytosol] (Caenorhabditis elegans)
    - BAR domain proteins recruit dynamin (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        FNBP1 dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of FNBP1 [cytosol] (Caenorhabditis elegans)
        
        toca-1 [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        FNBP1 dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of FNBP1 [cytosol] (Caenorhabditis elegans)
        
        toca-1 [cytosol] (Caenorhabditis elegans)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        FNBP1 dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of FNBP1 [cytosol] (Caenorhabditis elegans)
        
        toca-1 [cytosol] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        FNBP1 dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of FNBP1 [cytosol] (Caenorhabditis elegans)
        
        toca-1 [cytosol] (Caenorhabditis elegans)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        FNBP1 dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of FNBP1 [cytosol] (Caenorhabditis elegans)
        
        toca-1 [cytosol] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        FNBP1 dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of FNBP1 [cytosol] (Caenorhabditis elegans)
        
        toca-1 [cytosol] (Caenorhabditis elegans)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        FNBP1 dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of FNBP1 [cytosol] (Caenorhabditis elegans)
        
        toca-1 [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        FNBP1 dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of FNBP1 [cytosol] (Caenorhabditis elegans)
        
        toca-1 [cytosol] (Caenorhabditis elegans)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        FNBP1 dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of FNBP1 [cytosol] (Caenorhabditis elegans)
        
        toca-1 [cytosol] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        FNBP1 dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of FNBP1 [cytosol] (Caenorhabditis elegans)
        
        toca-1 [cytosol] (Caenorhabditis elegans)
    - RAB5 and GAPVD1 bind AP-2 (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        FNBP1 dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of FNBP1 [cytosol] (Caenorhabditis elegans)
        
        toca-1 [cytosol] (Caenorhabditis elegans)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        FNBP1 dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of FNBP1 [cytosol] (Caenorhabditis elegans)
        
        toca-1 [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        FNBP1 dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of FNBP1 [cytosol] (Caenorhabditis elegans)
        
        toca-1 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q19253

Gene Names

toca-1

Reference Genes

BioGPS Gene:180492 toca-1

ENSEMBL:WBGene00017298

Monarch:180492 toca-1

NCBI Gene:180492 toca-1

UCSC:Q19253 toca-1

Wormbase:WBGene00017298

Reference Transcript

Other Identifiers

180492

18623184

186372_at

A_12_P119111

CE30940

CE_WBGene00017298_A

CGZ0015123

CGZ0015124

F09E10.8

F09E10.8a

F09E10.8a_1015-1074_0.893_6_C

F09E10.8a_611-670_0.879_11_B

F09E10.8a_957-1016_0.895_4_A

F09E10.8b

F09E10_8aP00740

F09E10_8aP00813

F09E10_8aP00874

F09E10_8bP00348

F09E10_8bP00952

F09E10_8bP01531

GO:0005515

GO:0007165

GO:0023052

WBGene00017298

cea2.d.02065

cea2.d.19391

Participates

as a member of

Homologues of FNBP1 [cytosol] (Caenorhabditis elegans)

Other forms of this molecule

toca-1 [cytosol]

Inferred From

FNBP1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_741723.1, NP_741722.1

PRO

Q19253

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