Reactome | RPL27A [cytosol]

RPL27A [cytosol]

Stable Identifier

R-CEL-72442

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

Q9BKU5

Locations in the PathwayBrowser

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Metabolism of RNA (Caenorhabditis elegans)

- Nonsense-Mediated Decay (NMD) (Caenorhabditis elegans)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Caenorhabditis elegans)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Caenorhabditis elegans)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        RPL27A [cytosol] (Caenorhabditis elegans)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        RPL27A [cytosol] (Caenorhabditis elegans)
    - SMG6 hydrolyzes mRNA with premature termination codon (Caenorhabditis elegans)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        RPL27A [cytosol] (Caenorhabditis elegans)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Caenorhabditis elegans)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        RPL27A [cytosol] (Caenorhabditis elegans)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        RPL27A [cytosol] (Caenorhabditis elegans)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Caenorhabditis elegans)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Caenorhabditis elegans)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        RPL27A [cytosol] (Caenorhabditis elegans)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        RPL27A [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9BKU5

Reference Genes

BioGPS Gene:171767

ENSEMBL:WBGene00021350

Monarch:171767

NCBI Gene:171767

UCSC:Q9BKU5

Wormbase:WBGene00021350

Reference Transcript

RefSeq:NM_058526.6

Other Identifiers

171767

173315_at

18475413

A_12_P100693

A_12_P117718

A_12_P153160

A_12_P153161

A_12_P153162

A_12_P153163

A_12_P153164

A_12_P154710

CE26774

CE_WBGene00021350_A

CGZ0044444

CGZ0044446

GO:0003735

GO:0005198

GO:0005829

GO:0005840

GO:0006412

GO:0015934

GO:0022625

GO:0043226

GO:1990904

WBGene00021350

Y37E3.8

Y37E3.8a

Y37E3.8a_17-76_0.803_13_C

Y37E3.8a_173-232_0.860_7_B

Y37E3.8a_355-414_0.964_1_A

Y37E3_8aP00026

Y37E3_8aP00063

Y37E3_8aP00072

Y37E3_8bP00071

Y37E3_8bP00077

Y37E3_8bP00168

cea2.d.43366

Participates

as a component of

Other forms of this molecule

3OHH39-RPL27A [nucleoplasm]

RPL27A [nucleoplasm]

Inferred From

RPL27A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_490927.1

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