Reactome | pole-2 [nucleoplasm]

pole-2 [nucleoplasm]

Stable Identifier

R-CEL-68482

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

POLE2, Q19196

Locations in the PathwayBrowser

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DNA Repair (Caenorhabditis elegans)

- Base Excision Repair (Caenorhabditis elegans)
  - Resolution of Abasic Sites (AP sites) (Caenorhabditis elegans)
    - Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Caenorhabditis elegans)
      - PCNA-Dependent Long Patch Base Excision Repair (Caenorhabditis elegans)
        
        LIG1 binds APEX1 and PCNA at SSB (Caenorhabditis elegans)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
        
        LIG1 bound to APEX1 and PCNA ligates SSB (Caenorhabditis elegans)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE-mediated DNA strand displacement synthesis (Caenorhabditis elegans)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
- DNA Damage Bypass (Caenorhabditis elegans)
  - Recognition of DNA damage by PCNA-containing replication complex (Caenorhabditis elegans)
    - RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Caenorhabditis elegans)
      - POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
    - RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Caenorhabditis elegans)
      - PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
  - Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Caenorhabditis elegans)
    - Termination of translesion DNA synthesis (Caenorhabditis elegans)
      - POLD,POLE binds deISGylated PCNA after TLS (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
- Nucleotide Excision Repair (Caenorhabditis elegans)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Caenorhabditis elegans)
    - Dual Incision in GG-NER (Caenorhabditis elegans)
      - DNA polymerases delta, epsilon or kappa bind the GG-NER site (Caenorhabditis elegans)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE,POLK [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
    - Gap-filling DNA repair synthesis and ligation in GG-NER (Caenorhabditis elegans)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Caenorhabditis elegans)
    - Dual incision in TC-NER (Caenorhabditis elegans)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Caenorhabditis elegans)
        
        POLD,POLE,POLK [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Caenorhabditis elegans)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-2 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q19196

Gene Names

pole-2

Reference Genes

BioGPS Gene:177673 pole-2

ENSEMBL:WBGene00017237

Monarch:177673 pole-2

NCBI Gene:177673 pole-2

UCSC:Q19196 pole-2

Wormbase:WBGene00017237

Reference Transcript

RefSeq:NM_069088.5 pole-2

Other Identifiers

175203_s_at

177673

18550920

187194_at

A_12_P171917

CE29749

CE_WBGene00017237_A

CGZ0012569

F08B4.5

F08B4.5_1149-1208_0.919_6_B

F08B4.5_822-881_0.848_26_A

F08B4.5_976-1035_0.911_7_C

F08B4_5P00500

F08B4_5P00778

F08B4_5P01481

GO:0000228

GO:0003677

GO:0005634

GO:0005694

GO:0006260

GO:0006261

GO:0008622

GO:0043226

WBGene00017237

cea2.p.89922

Participates

as a component of

DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)

Inferred From

POLE2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_501489.3

PRO

Q19196

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