Reactome | MAPK9 [cytosol]

MAPK9 [cytosol]

Stable Identifier

R-CEL-450355-3

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

Q8WQG9

Locations in the PathwayBrowser

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Immune System (Caenorhabditis elegans)

- Cytokine Signaling in Immune system (Caenorhabditis elegans)
  - Signaling by Interleukins (Caenorhabditis elegans)
    - Interleukin-17 signaling (Caenorhabditis elegans)
      - MAP kinase activation (Caenorhabditis elegans)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
        
        MAPK8,9,10 [cytosol] (Caenorhabditis elegans)
        
        Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)
        
        MAPK9 [cytosol] (Caenorhabditis elegans)
- Innate Immune System (Caenorhabditis elegans)
  - Fc epsilon receptor (FCERI) signaling (Caenorhabditis elegans)
    - FCERI mediated MAPK activation (Caenorhabditis elegans)
      - Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
        
        MAPK8,9,10 [cytosol] (Caenorhabditis elegans)
        
        Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)
        
        MAPK9 [cytosol] (Caenorhabditis elegans)
  - Toll-like Receptor Cascades (Caenorhabditis elegans)
    - Toll Like Receptor 10 (TLR10) Cascade (Caenorhabditis elegans)
      - MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
        
        MAPK8,9,10 [cytosol] (Caenorhabditis elegans)
        
        Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)
        
        MAPK9 [cytosol] (Caenorhabditis elegans)
    - Toll Like Receptor 2 (TLR2) Cascade (Caenorhabditis elegans)
      - Toll Like Receptor TLR1:TLR2 Cascade (Caenorhabditis elegans)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
        
        MAPK8,9,10 [cytosol] (Caenorhabditis elegans)
        
        Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)
        
        MAPK9 [cytosol] (Caenorhabditis elegans)
      - Toll Like Receptor TLR6:TLR2 Cascade (Caenorhabditis elegans)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
        
        MAPK8,9,10 [cytosol] (Caenorhabditis elegans)
        
        Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)
        
        MAPK9 [cytosol] (Caenorhabditis elegans)
    - Toll Like Receptor 3 (TLR3) Cascade (Caenorhabditis elegans)
      - MAP kinase activation (Caenorhabditis elegans)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
        
        MAPK8,9,10 [cytosol] (Caenorhabditis elegans)
        
        Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)
        
        MAPK9 [cytosol] (Caenorhabditis elegans)
    - Toll Like Receptor 4 (TLR4) Cascade (Caenorhabditis elegans)
      - MyD88-independent TLR4 cascade (Caenorhabditis elegans)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
        
        MAPK8,9,10 [cytosol] (Caenorhabditis elegans)
        
        Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)
        
        MAPK9 [cytosol] (Caenorhabditis elegans)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
        
        MAPK8,9,10 [cytosol] (Caenorhabditis elegans)
        
        Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)
        
        MAPK9 [cytosol] (Caenorhabditis elegans)
    - Toll Like Receptor 5 (TLR5) Cascade (Caenorhabditis elegans)
      - MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
        
        MAPK8,9,10 [cytosol] (Caenorhabditis elegans)
        
        Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)
        
        MAPK9 [cytosol] (Caenorhabditis elegans)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Caenorhabditis elegans)
      - MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
        
        MAPK8,9,10 [cytosol] (Caenorhabditis elegans)
        
        Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)
        
        MAPK9 [cytosol] (Caenorhabditis elegans)
    - Toll Like Receptor 9 (TLR9) Cascade (Caenorhabditis elegans)
      - MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
        
        MAPK8,9,10 [cytosol] (Caenorhabditis elegans)
        
        Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)
        
        MAPK9 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q8WQG9

Reference Genes

BioGPS Gene:177460

CTD Gene:177460

ENSEMBL:WBGene00002178

Monarch:177460

NCBI Gene:177460

UCSC:Q8WQG9

Wormbase:WBGene00002178

Reference Transcript

Other Identifiers

175640_at

177460

18532534

190415_s_at

A_12_P102374

A_12_P106773

B0478.1

B0478.1a

B0478.1a_1101-1160_0.937_3_B

B0478.1a_1181-1240_0.926_8_C

B0478.1a_1361-1420_0.960_1_A

B0478.1a_833

B0478.1b

B0478_1aP00012

B0478_1aP00182

B0478_1aP00204

B0478_1bP00092

B0478_1bP00659

B0478_1bP00834

CE27574

CE30123

CE_WBGene00002178_A

CE_WBGene00002178_B

CGZ0001202

GO:0003824

GO:0004672

GO:0004707

GO:0005524

GO:0006468

GO:0016740

GO:0023052

GO:0036211

GO:0140096

WBGene00002178

cea2.d.00191

cea2.d.09640

Participates

as a member of

Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)

Other forms of this molecule

MAPK8 [cytosol]

MAPK10 [cytosol]

phospho-p-T183,Y185-MAPK9 [cytosol]

phospho-p-T,Y-MAPK8 [cytosol]

phospho-p-T221,Y223-MAPK10 [cytosol]

phospho-p-T,Y-MAPK8 [nucleoplasm]

phospho-p-T183,Y185-MAPK9 [nucleoplasm]

phospho-p-T221,Y223-MAPK10 [nucleoplasm]

Inferred From

MAPK9 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_741434.2, NP_001021270.1

PRO

Q8WQG9

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.623	3

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