Reactome | SH2D2A [cytosol]

SH2D2A [cytosol]

Stable Identifier

R-CEL-4420125

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

G5EE62

Locations in the PathwayBrowser

Expand all

Signal Transduction (Caenorhabditis elegans)

- Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
  - Signaling by VEGF (Caenorhabditis elegans)
    - VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
      - AXL autophosphorylates on Y779 and Y821 (Caenorhabditis elegans)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of SH2D2A [cytosol] (Caenorhabditis elegans)
        
        SH2D2A [cytosol] (Caenorhabditis elegans)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of SH2D2A [cytosol] (Caenorhabditis elegans)
        
        SH2D2A [cytosol] (Caenorhabditis elegans)
      - AXL binds SRC-1 (Caenorhabditis elegans)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of SH2D2A [cytosol] (Caenorhabditis elegans)
        
        SH2D2A [cytosol] (Caenorhabditis elegans)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of SH2D2A [cytosol] (Caenorhabditis elegans)
        
        SH2D2A [cytosol] (Caenorhabditis elegans)
      - Phosphorylation of SRC-1 (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of SH2D2A [cytosol] (Caenorhabditis elegans)
        
        SH2D2A [cytosol] (Caenorhabditis elegans)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of SH2D2A [cytosol] (Caenorhabditis elegans)
        
        SH2D2A [cytosol] (Caenorhabditis elegans)
      - VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of SH2D2A [cytosol] (Caenorhabditis elegans)
        
        SH2D2A [cytosol] (Caenorhabditis elegans)
      - p-AXL binds PI3K (Caenorhabditis elegans)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of SH2D2A [cytosol] (Caenorhabditis elegans)
        
        SH2D2A [cytosol] (Caenorhabditis elegans)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of SH2D2A [cytosol] (Caenorhabditis elegans)
        
        SH2D2A [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:G5EE62

Reference Genes

BioGPS Gene:178081

CTD Gene:178081

ENSEMBL:WBGene00008720

Monarch:178081

NCBI Gene:178081

Wormbase:WBGene00008720

Reference Transcript

RefSeq:NM_069781.6

Other Identifiers

178081

178205_s_at

18536592

A_12_P113134

CE05589

CE_WBGene00008720_A

CE_WBGene00008720_B

CE_WBGene00008720_C

CGZ0015755

F12F6.1

F12F6.1_1813-1872_0.918_10_C

F12F6.1_2332-2391_0.932_4_B

F12F6.1_2498-2557_0.936_3_A

F12F6_1P01392

F12F6_1P01793

F12F6_1P02503

GO:0005737

WBGene00008720

cea2.p.90306

Participates

as a member of

Homologues of SH2D2A [cytosol] (Caenorhabditis elegans)

Inferred From

SH2D2A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_502182.2

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