Reactome | BLM [nucleoplasm]

BLM [nucleoplasm]

Stable Identifier

R-CEL-174881

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

O18017

Locations in the PathwayBrowser

Expand all

DNA Repair (Caenorhabditis elegans)

- DNA Double-Strand Break Repair (Caenorhabditis elegans)
  - Homology Directed Repair (Caenorhabditis elegans)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Caenorhabditis elegans)
      - Processing of DNA double-strand break ends (Caenorhabditis elegans)
        
        ATR phosphorylates RPA2 (Caenorhabditis elegans)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Caenorhabditis elegans)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Caenorhabditis elegans)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Caenorhabditis elegans)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Caenorhabditis elegans)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Caenorhabditis elegans)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Caenorhabditis elegans)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Caenorhabditis elegans)
        
        BLM [nucleoplasm] (Caenorhabditis elegans)
        
        EXO1:BLM,WRN [nucleoplasm] (Caenorhabditis elegans)
        
        BLM,WRN [nucleoplasm] (Caenorhabditis elegans)
        
        BLM [nucleoplasm] (Caenorhabditis elegans)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Caenorhabditis elegans)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Caenorhabditis elegans)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Caenorhabditis elegans)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Caenorhabditis elegans)
        
        BLM [nucleoplasm] (Caenorhabditis elegans)
        
        EXO1:BLM,WRN [nucleoplasm] (Caenorhabditis elegans)
        
        BLM,WRN [nucleoplasm] (Caenorhabditis elegans)
        
        BLM [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:O18017

Reference Genes

BioGPS Gene:178201

CTD Gene:178201

ENSEMBL:WBGene00001865

Monarch:178201

NCBI Gene:178201

UCSC:O18017

Wormbase:WBGene00001865

Reference Transcript

RefSeq:NM_069989.5

Other Identifiers

178201

18541631

189916_at

A_12_P108686

CE31724

CE_WBGene00001865_A

CE_WBGene00001865_B

CE_WBGene00001865_C

CGZ0033011

GO:0000166

GO:0003676

GO:0003824

GO:0004386

GO:0005524

GO:0006260

GO:0006281

GO:0006310

GO:0043138

GO:0044237

GO:0140097

GO:0140657

T04A11.6

T04A11.6_1304-1363_0.824_85_C

T04A11.6_1565-1624_0.844_53_B

T04A11.6_1647-1706_0.858_36_A

T04A11_6P01467

T04A11_6P02326

T04A11_6P02873

WBGene00001865

cea2.c.30778

Participates

as a candidate of

BLM,WRN [nucleoplasm] (Caenorhabditis elegans)

as a component of

BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Caenorhabditis elegans)

Inferred From

BLM [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_502390.2

IntEnz

3.6.4.12

PRO

O18017

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