Reactome | par-5 [cytosol]

par-5 [cytosol]

Stable Identifier

R-CEL-1445116

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

YWHAQ, P41932

Locations in the PathwayBrowser

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Cell Cycle (Caenorhabditis elegans)

- Cell Cycle Checkpoints (Caenorhabditis elegans)
  - G2/M Checkpoints (Caenorhabditis elegans)
    - G2/M DNA damage checkpoint (Caenorhabditis elegans)
      - Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Caenorhabditis elegans)
        
        Association of p-S216-CDC25C with 14-3-3 proteins (Caenorhabditis elegans)
        
        14-3-3 dimer [cytosol] (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        par-5 [cytosol] (Caenorhabditis elegans)
        
        p-S216-CDC25C:14-3-3 protein complex [cytosol] (Caenorhabditis elegans)
        
        14-3-3 dimer [cytosol] (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        par-5 [cytosol] (Caenorhabditis elegans)

Gene expression (Transcription) (Caenorhabditis elegans)

- RNA Polymerase II Transcription (Caenorhabditis elegans)
  - Generic Transcription Pathway (Caenorhabditis elegans)
    - FOXO-mediated transcription (Caenorhabditis elegans)
      - Regulation of localization of FOXO transcription factors (Caenorhabditis elegans)
        
        14-3-3 proteins bind AKT-phosphorylated FOXO1 (Caenorhabditis elegans)
        
        YWHAZ dimer,YWHAQ dimer,YWHAG dimer,YWHAB dimer [cytosol] (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        par-5 [cytosol] (Caenorhabditis elegans)
        
        p-T24,S256,S319-FOXO1:YWHAZ,YWHAQ,YWHAG,YWHAB [cytosol] (Caenorhabditis elegans)
        
        YWHAZ dimer,YWHAQ dimer,YWHAG dimer,YWHAB dimer [cytosol] (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        par-5 [cytosol] (Caenorhabditis elegans)
        
        14-3-3 proteins bind AKT-phosphorylated FOXO3 (Caenorhabditis elegans)
        
        YWHAZ dimer,YWHAQ dimer,SFN dimer [cytosol] (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        par-5 [cytosol] (Caenorhabditis elegans)
        
        p-T32,S253,S315-FOXO3:YWHAZ,YWHAQ,SFN [cytosol] (Caenorhabditis elegans)
        
        YWHAZ dimer,YWHAQ dimer,SFN dimer [cytosol] (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        par-5 [cytosol] (Caenorhabditis elegans)
        
        14-3-3 proteins bind AKT-phosphorylated FOXO4 (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        par-5 [cytosol] (Caenorhabditis elegans)
        
        p-T32,S197,S262-FOXO4:YWHAZ dimer [cytosol] (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        par-5 [cytosol] (Caenorhabditis elegans)

Hemostasis (Caenorhabditis elegans)

- Platelet activation, signaling and aggregation (Caenorhabditis elegans)
  - GP1b-IX-V activation signalling (Caenorhabditis elegans)
    - 14-3-3-zeta binds Raf1 (Caenorhabditis elegans)
      - 14-3-3-zeta:Raf1 [cytosol] (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        par-5 [cytosol] (Caenorhabditis elegans)
      - YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        par-5 [cytosol] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by NOTCH (Caenorhabditis elegans)
  - Signaling by NOTCH4 (Caenorhabditis elegans)
    - NOTCH4 Activation and Transmission of Signal to the Nucleus (Caenorhabditis elegans)
      - NICD4 traffics to the nucleus (Caenorhabditis elegans)
        
        p-4S-NICD4:YWHAZ dimer [cytosol] (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        par-5 [cytosol] (Caenorhabditis elegans)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Caenorhabditis elegans)
  - Signaling by Rho GTPases (Caenorhabditis elegans)
    - RHO GTPase Effectors (Caenorhabditis elegans)
      - RHO GTPases activate PKNs (Caenorhabditis elegans)
        
        Association of p-S216-CDC25C with 14-3-3 proteins (Caenorhabditis elegans)
        
        14-3-3 dimer [cytosol] (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        par-5 [cytosol] (Caenorhabditis elegans)
        
        p-S216-CDC25C:14-3-3 protein complex [cytosol] (Caenorhabditis elegans)
        
        14-3-3 dimer [cytosol] (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        par-5 [cytosol] (Caenorhabditis elegans)
- Signaling by WNT (Caenorhabditis elegans)
  - TCF dependent signaling in response to WNT (Caenorhabditis elegans)
    - Deactivation of the beta-catenin transactivating complex (Caenorhabditis elegans)
      - YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Caenorhabditis elegans)
        
        XPO1:YWHAZ:p-S20-CBY1:CTNNB1 [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        par-5 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:P41932

Gene Names

par-5

Reference Genes

ENSEMBL:WBGene00003920

UCSC:P41932 par-5

Wormbase:WBGene00003920

Reference Transcript

RefSeq:NM_069834.5 par-5

Other Identifiers

173137_s_at

174903_at

178113

18554799

189382_s_at

A_12_P105563

A_12_P140860

A_12_P140861

A_12_P140862

CE06200

CE_WBGene00003920_A

CE_WBGene00003920_C

CGZ0030121

M117.2

M117.2_192-251_0.916_5_B

M117.2_337-396_0.916_4_C

M117.2_696-755_0.970_1_A

M117_2P00034

M117_2P00371

M117_2P00538

WBGene00003920

cea2.c.30520

Participates

as a member of

Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)

Other forms of this molecule

par-5 [nucleoplasm]

par-5 [cytosol]

Inferred From

YWHAZ [cytosol] (Homo sapiens)

YWHAQ [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_502235.1

PRO

P41932

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q21921	1	SIRT1 [nucleoplasm] (R-CEL-427531)	0.656	3
UniProt:Q11184	2	let-756 [extracellular region] (R-CEL-189898) let-756 [extracellular region] (R-CEL-189856)	0.543	3
UniProt:Q10666	6	phospho-pop-1 [nucleoplasm] (R-CEL-4411389) phospho-pop-1 [nucleoplasm] (R-CEL-4411392) pop-1 [nucleoplasm] (R-CEL-3299543) pop-1 [nucleoplasm] (R-CEL-5228649) pop-1 [nucleoplasm] (R-CEL-3214972) pop-1 [nucleoplasm] (R-CEL-201923)	0.524	2
UniProt:G5EC23	2	hcf-1 [nucleoplasm] (R-CEL-9821232) hcf-1 [nucleoplasm] (R-CEL-1592209)	0.499	2

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