Reactome | tam-1 [nucleoplasm]

tam-1 [nucleoplasm]

Stable Identifier

R-CEL-1031706

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

PML, G5ED20

Locations in the PathwayBrowser

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Gene expression (Transcription) (Caenorhabditis elegans)

- RNA Polymerase II Transcription (Caenorhabditis elegans)
  - Generic Transcription Pathway (Caenorhabditis elegans)
    - Transcriptional Regulation by TP53 (Caenorhabditis elegans)
      - Regulation of TP53 Activity (Caenorhabditis elegans)
        
        Regulation of TP53 Activity through Acetylation (Caenorhabditis elegans)
        
        KAT6A acetylates TP53 (Caenorhabditis elegans)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of PML [nucleoplasm] (Caenorhabditis elegans)
        
        tam-1 [nucleoplasm] (Caenorhabditis elegans)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:p-S15,S20-TP53 [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of PML [nucleoplasm] (Caenorhabditis elegans)
        
        tam-1 [nucleoplasm] (Caenorhabditis elegans)
        
        MTA2-NuRD complex deacetylates TP53 (Caenorhabditis elegans)
        
        BRD7:Ac-K382,p-S15,S20-TP53:EP300, KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (Caenorhabditis elegans)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of PML [nucleoplasm] (Caenorhabditis elegans)
        
        tam-1 [nucleoplasm] (Caenorhabditis elegans)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,p-S15,S20-TP53, BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] (Caenorhabditis elegans)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,p-S15,S20-TP53 Tetramer [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of PML [nucleoplasm] (Caenorhabditis elegans)
        
        tam-1 [nucleoplasm] (Caenorhabditis elegans)
    - Transcriptional regulation by RUNX1 (Caenorhabditis elegans)
      - Regulation of RUNX1 Expression and Activity (Caenorhabditis elegans)
        
        PML binds RUNX1 (Caenorhabditis elegans)
        
        Homologues of PML [nucleoplasm] (Caenorhabditis elegans)
        
        tam-1 [nucleoplasm] (Caenorhabditis elegans)
        
        RUNX1:PML [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of PML [nucleoplasm] (Caenorhabditis elegans)
        
        tam-1 [nucleoplasm] (Caenorhabditis elegans)

Metabolism of proteins (Caenorhabditis elegans)

- Post-translational protein modification (Caenorhabditis elegans)
  - SUMOylation (Caenorhabditis elegans)
    - SUMO E3 ligases SUMOylate target proteins (Caenorhabditis elegans)
      - SUMOylation of DNA damage response and repair proteins (Caenorhabditis elegans)
        
        UBE2I, HDAC7 SUMOylate PML with SUMO1 (Caenorhabditis elegans)
        
        Homologues of PML [nucleoplasm] (Caenorhabditis elegans)
        
        tam-1 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:G5ED20

Gene Names

tam-1

Reference Genes

BioGPS Gene:178887 tam-1

CTD Gene:178887 tam-1

ENSEMBL:WBGene00006523

Monarch:178887 tam-1

NCBI Gene:178887 tam-1

Wormbase:WBGene00006523

Reference Transcript

RefSeq:NM_071934.4 tam-1

Other Identifiers

173460_s_at

178887

18588615

188038_s_at

A_12_P114826

A_12_P149600

CE09704

CE_WBGene00006523_A

CGZ0018442

F26G5.9

F26G5.9_429-488_0.775_175_C

F26G5.9_640-699_0.801_135_A

F26G5.9_71-130_0.792_153_B

F26G5_9P01335

F26G5_9P01741

F26G5_9P02335

WBGene00006523

cea2.c.35754

Participates

as a member of

Homologues of PML [nucleoplasm] (Caenorhabditis elegans)

Other forms of this molecule

tam-1 [nucleoplasm]

Inferred From

PML [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_504335.1