Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
RBCK1 [cytosol]
Stable Identifier
R-BTA-976018
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
RBCK1, Q1JPC8
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
Polyubiquitination of substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
Release of E3 from polyubiquitinated substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
TNF signaling (Bos taurus)
Regulation of TNFR1 signaling (Bos taurus)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Bos taurus)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
LUBAC ubiquitinates RIPK1 at K627 (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
OPTN recruits CYLD to the TNFR1 complex (Bos taurus)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNFR1-induced NF-kappa-B signaling pathway (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
TNFR1-induced proapoptotic signaling (Bos taurus)
TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Bos taurus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
CYLD:SPATA2:LUBAC [cytosol] (Bos taurus)
LUBAC [cytosol] (Bos taurus)
RBCK1 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q1JPC8
Gene Names
RBCK1
Reference Genes
BioGPS Gene:504400 RBCK1
ENSEMBL:ENSBTAG00000017002.6
KEGG Gene (Bos taurus):504400 RBCK1
Monarch:504400 RBCK1
NCBI Gene:504400 RBCK1
Reference Transcript
RefSeq:NM_001075161.1 RBCK1
Other Identifiers
504400
GO:0003824
GO:0004842
GO:0005515
GO:0016567
GO:0016740
GO:0023052
GO:0030163
GO:0036211
GO:0043123
GO:0043130
GO:0043161
GO:0046872
GO:0071797
GO:0097039
GO:0140096
Participates
as a component of
LUBAC [cytosol] (Bos taurus)
as a member of
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
Inferred From
RBCK1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001068629.1
OpenTargets
ENSG00000125826
Ensembl
ENSBTAP00000022612
,
ENSBTAT00000022612
,
ENSBTAG00000017002
VGNC
33776
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text