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p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane]
Stable Identifier
R-BTA-975164
Type
Complex
Species
Bos taurus
Compartment
endosome membrane
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Bos taurus)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Bos taurus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Bos taurus)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Bos taurus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Bos taurus)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Bos taurus)
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Bos taurus)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Bos taurus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Bos taurus)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
phospho-p-IRAK2 [endosome membrane]
(Bos taurus)
x 3
TRAF6 [endosome membrane]
(Bos taurus)
Participates
as a component of
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Bos taurus)
as an input of
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
as an output of
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Bos taurus)
as a member of
K63-linked polyUb TRAF6 complexes [endosome membrane] (Bos taurus)
Inferred From
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane]
(Homo sapiens)
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