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CFTR [endoplasmic reticulum membrane]
Stable Identifier
R-BTA-8868730
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
endoplasmic reticulum membrane
Synonyms
misfolded CFTR, F1MN01
Locations in the PathwayBrowser
Expand all
Autophagy (Bos taurus)
Macroautophagy (Bos taurus)
Selective autophagy (Bos taurus)
Aggrephagy (Bos taurus)
Aggresome dissociates from dynein and microtubule (Bos taurus)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins [cytosol] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
CFTR [endoplasmic reticulum membrane] (Bos taurus)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins [cytosol] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
CFTR [endoplasmic reticulum membrane] (Bos taurus)
Parkin transfers Ub to misfolded proteins (Bos taurus)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Bos taurus)
Ub-Misfolded Proteins [cytosol] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
CFTR [endoplasmic reticulum membrane] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins [cytosol] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
CFTR [endoplasmic reticulum membrane] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins [cytosol] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
CFTR [endoplasmic reticulum membrane] (Bos taurus)
PolyUb-Misfolded proteins bind vimentin to form aggresome (Bos taurus)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins [cytosol] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
CFTR [endoplasmic reticulum membrane] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins [cytosol] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
CFTR [endoplasmic reticulum membrane] (Bos taurus)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Bos taurus)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins [cytosol] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
CFTR [endoplasmic reticulum membrane] (Bos taurus)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Bos taurus)
Ub-Misfolded Proteins [cytosol] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
CFTR [endoplasmic reticulum membrane] (Bos taurus)
Transport of small molecules (Bos taurus)
ABC-family proteins mediated transport (Bos taurus)
CFTR binds components of the ERAD machinery for ubiquitination and degradation (Bos taurus)
CFTR [endoplasmic reticulum membrane] (Bos taurus)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
CFTR [endoplasmic reticulum membrane] (Bos taurus)
CFTR transits to the plasma membrane (Bos taurus)
CFTR [endoplasmic reticulum membrane] (Bos taurus)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Bos taurus)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
CFTR [endoplasmic reticulum membrane] (Bos taurus)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
CFTR [endoplasmic reticulum membrane] (Bos taurus)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
CFTR [endoplasmic reticulum membrane] (Bos taurus)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
CFTR [endoplasmic reticulum membrane] (Bos taurus)
misfolded CFTR is degraded by the 26S proteasome (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
CFTR [endoplasmic reticulum membrane] (Bos taurus)
External Reference Information
External Reference
UniProt:F1MN01
Gene Names
CFTR
Reference Genes
ENSEMBL:ENSBTAG00000006589.6
Other Identifiers
281067
GO:0000166
GO:0003824
GO:0005215
GO:0005254
GO:0005260
GO:0005524
GO:0005768
GO:0005783
GO:0005789
GO:0005829
GO:0005886
GO:0006811
GO:0006821
GO:0010008
GO:0015701
GO:0016020
GO:0016324
GO:0016787
GO:0016853
GO:0016887
GO:0031410
GO:0031901
GO:0034220
GO:0034707
GO:0042626
GO:0043226
GO:0055038
GO:0055085
GO:0140359
GO:0140657
GO:1902476
Participates
as an input of
CFTR binds components of the ERAD machinery for ubiquitination and degradation (Bos taurus)
CFTR transits to the plasma membrane (Bos taurus)
as a component of
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
Other forms of this molecule
CFTR [clathrin-coated endocytic vesicle membrane]
CFTR [plasma membrane]
CFTR [lysosomal membrane]
CFTR [Golgi-associated vesicle membrane]
CFTR [plasma membrane]
Inferred From
CFTR [endoplasmic reticulum membrane]
(Homo sapiens)
misfolded CFTR [endoplasmic reticulum membrane]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000001626
Ensembl
ENSBTAG00000006589
,
ENSBTAT00000053450
,
ENSBTAP00000049907
VGNC
50053
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