Reactome | KLHL2 [cytosol]

KLHL2 [cytosol]

Stable Identifier

R-BTA-8863217

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

KLHL2, A0A3Q1LWA6

Locations in the PathwayBrowser

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Immune System (Bos taurus)

- Adaptive Immune System (Bos taurus)
  - Class I MHC mediated antigen processing & presentation (Bos taurus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
      - Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL2 [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL2 [cytosol] (Bos taurus)
      - Polyubiquitination of substrate (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL2 [cytosol] (Bos taurus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL2 [cytosol] (Bos taurus)
        
        E3:Ub:substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL2 [cytosol] (Bos taurus)
      - Release of E3 from polyubiquitinated substrate (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL2 [cytosol] (Bos taurus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL2 [cytosol] (Bos taurus)
      - Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL2 [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL2 [cytosol] (Bos taurus)
        
        E3:Ub:substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL2 [cytosol] (Bos taurus)

Metabolism of proteins (Bos taurus)

- Post-translational protein modification (Bos taurus)
  - Neddylation (Bos taurus)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Bos taurus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Bos taurus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL2 [cytosol] (Bos taurus)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL2 [cytosol] (Bos taurus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Bos taurus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
        
        CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL2 [cytosol] (Bos taurus)
      - CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL2 [cytosol] (Bos taurus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
        
        CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL2 [cytosol] (Bos taurus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL2 [cytosol] (Bos taurus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL2 [cytosol] (Bos taurus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL2 [cytosol] (Bos taurus)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Bos taurus)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL2 [cytosol] (Bos taurus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Bos taurus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL2 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:A0A3Q1LWA6

Gene Names

KLHL2

Reference Genes

BioGPS Gene:533936 KLHL2

ENSEMBL:ENSBTAG00000005263.6

Monarch:533936 KLHL2

NCBI Gene:533936 KLHL2

Reference Transcript

RefSeq:XM_005217427.2 KLHL2

Other Identifiers

533936

GO:0003779

GO:0005515

GO:0005856

GO:0008092

GO:0015629

GO:0042802

GO:0043226

GO:0060090

GO:1990756

Participates

as a member of

BTB proteins [cytosol] (Bos taurus)

Inferred From

KLHL2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005217484.1

OpenTargets

ENSG00000109466

Ensembl

ENSBTAT00000080421, ENSBTAP00000061700, ENSBTAG00000005263

VGNC

30648

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