Reactome | FCHO1 [cytosol]

FCHO1 [cytosol]

Stable Identifier

R-BTA-8862257

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

FCHO1, F1MZ25

Locations in the PathwayBrowser

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Vesicle-mediated transport (Bos taurus)

- Membrane Trafficking (Bos taurus)
  - Clathrin-mediated endocytosis (Bos taurus)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Bos taurus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Bos taurus)
        
        FCHO1,2 dimer [cytosol] (Bos taurus)
        
        FCHO1 dimer [cytosol] (Bos taurus)
        
        FCHO1 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
        
        FCHO1,2 dimer [cytosol] (Bos taurus)
        
        FCHO1 dimer [cytosol] (Bos taurus)
        
        FCHO1 [cytosol] (Bos taurus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
        
        FCHO1,2 dimer [cytosol] (Bos taurus)
        
        FCHO1 dimer [cytosol] (Bos taurus)
        
        FCHO1 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
        
        FCHO1,2 dimer [cytosol] (Bos taurus)
        
        FCHO1 dimer [cytosol] (Bos taurus)
        
        FCHO1 [cytosol] (Bos taurus)
    - Cargo recognition for clathrin-mediated endocytosis (Bos taurus)
      - ARBB recruits GPCRs into clathrin-coated pits (Bos taurus)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
        
        FCHO1,2 dimer [cytosol] (Bos taurus)
        
        FCHO1 dimer [cytosol] (Bos taurus)
        
        FCHO1 [cytosol] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
        
        FCHO1,2 dimer [cytosol] (Bos taurus)
        
        FCHO1 dimer [cytosol] (Bos taurus)
        
        FCHO1 [cytosol] (Bos taurus)
    - Clathrin recruits PIK3C2A (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
        
        FCHO1,2 dimer [cytosol] (Bos taurus)
        
        FCHO1 dimer [cytosol] (Bos taurus)
        
        FCHO1 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
        
        FCHO1,2 dimer [cytosol] (Bos taurus)
        
        FCHO1 dimer [cytosol] (Bos taurus)
        
        FCHO1 [cytosol] (Bos taurus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
        
        FCHO1,2 dimer [cytosol] (Bos taurus)
        
        FCHO1 dimer [cytosol] (Bos taurus)
        
        FCHO1 [cytosol] (Bos taurus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Bos taurus)
      - FCHO1,2 dimer [cytosol] (Bos taurus)
        
        FCHO1 dimer [cytosol] (Bos taurus)
        
        FCHO1 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
        
        FCHO1,2 dimer [cytosol] (Bos taurus)
        
        FCHO1 dimer [cytosol] (Bos taurus)
        
        FCHO1 [cytosol] (Bos taurus)
    - Recruitment of AP-2 complex and clathrin (Bos taurus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Bos taurus)
        
        FCHO1,2 dimer [cytosol] (Bos taurus)
        
        FCHO1 dimer [cytosol] (Bos taurus)
        
        FCHO1 [cytosol] (Bos taurus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Bos taurus)
        
        FCHO1,2 dimer [cytosol] (Bos taurus)
        
        FCHO1 dimer [cytosol] (Bos taurus)
        
        FCHO1 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:F1MZ25

Gene Names

FCHO1

Reference Genes

BioGPS Gene:505672 FCHO1

ENSEMBL:ENSBTAG00000002136.6

KEGG Gene (Bos taurus):505672 FCHO1

Monarch:505672 FCHO1

NCBI Gene:505672 FCHO1

Reference Transcript

Other Identifiers

505672

GO:0005737

GO:0005886

GO:0005905

GO:0016192

GO:0030136

GO:0031410

GO:0043226

GO:0048268

GO:0065003

GO:0072583

Participates

as a component of

FCHO1 dimer [cytosol] (Bos taurus)

Inferred From

FCHO1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_002688586.1, XP_581997.4

OpenTargets

ENSG00000130475

Ensembl

ENSBTAT00000077431, ENSBTAP00000047176, ENSBTAT00000050484, ENSBTAP00000071623, ENSBTAG00000002136

VGNC

28935

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