Reactome | SOCS3 [cytosol]

SOCS3 [cytosol]

Stable Identifier

R-BTA-873794

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

SOCS3, Q9BEG9

Locations in the PathwayBrowser

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Immune System (Bos taurus)

- Adaptive Immune System (Bos taurus)
  - Class I MHC mediated antigen processing & presentation (Bos taurus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
      - Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
      - Polyubiquitination of substrate (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
        
        E3:Ub:substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
      - Release of E3 from polyubiquitinated substrate (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
      - Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
        
        E3:Ub:substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
- Cytokine Signaling in Immune system (Bos taurus)
  - Interferon Signaling (Bos taurus)
    - Interferon alpha/beta signaling (Bos taurus)
      - Activation of JAK kinases (Bos taurus)
        
        p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Bos taurus)
        
        p-IFNAR1:p-TYK2:SOCS-1/SOCS-3 [plasma membrane] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
    - Interferon gamma signaling (Bos taurus)
      - Regulation of IFNG signaling (Bos taurus)
        
        SOCS-1 and SOCS-3 binds to p-JAK2 (Bos taurus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
      - Transphosphorylation of JAK1 (Bos taurus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
  - Signaling by CSF3 (G-CSF) (Bos taurus)
    - Inactivation of CSF3 (G-CSF) signaling (Bos taurus)
      - SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
        
        SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Bos taurus)
        
        SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
  - Signaling by Interleukins (Bos taurus)
    - Interleukin-6 family signaling (Bos taurus)
      - Interleukin-6 signaling (Bos taurus)
        
        SOCS3 binds IL6ST (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
        
        Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Bos taurus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)

Metabolism of proteins (Bos taurus)

- Post-translational protein modification (Bos taurus)
  - Neddylation (Bos taurus)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Bos taurus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Bos taurus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
        
        CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
      - CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
        
        CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Bos taurus)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        SOCS3 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:Q9BEG9

Gene Names

SOCS3

Reference Genes

BioGPS Gene:282081 SOCS3

ENSEMBL:ENSBTAG00000008441

ENSEMBL:ENSBTAG00000008441.3 SOCS3

KEGG Gene (Bos taurus):282081 SOCS3

Monarch:282081 SOCS3

NCBI Gene:282081 SOCS3

Reference Transcript

Other Identifiers

282081

GO:0023052

GO:0035556

Participates

as a member of

as an input of

as a component of

Inferred From

SOCS3 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005221196.1, NP_776891.1

OpenTargets

ENSG00000184557

Ensembl

ENSBTAG00000008441, ENSBTAP00000011106, ENSBTAT00000011106

VGNC

35121

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