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MRN [nucleoplasm]
Stable Identifier
R-BTA-75164
Type
Complex
Species
Bos taurus
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular Senescence (Bos taurus)
DNA Damage/Telomere Stress Induced Senescence (Bos taurus)
KAT5 acetylates ATM at DNA DSBs (Bos taurus)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
KAT5 acetylates ATM at shortened telomeres (Bos taurus)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
Shortened telomere:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
Shortened telomere:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
MRN activates ATM (Bos taurus)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
MRN bound to shortened telomeres activates ATM (Bos taurus)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
Shortened telomere:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
Shortened telomere:MRN:KAT5:p-S1981,Ac-K3016-ATM [nucleoplasm] (Bos taurus)
Shortened telomere:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
MRN complex binds DNA double strand breaks (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
MRN complex binds shortened telomeres (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
Shortened telomere:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
MRN complex bound to DNA ends recruits ATM (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
MRN complex bound to shortened telomeres recruits ATM (Bos taurus)
Shortened telomere:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
Shortened telomere:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
DNA Repair (Bos taurus)
DNA Double-Strand Break Repair (Bos taurus)
DNA Double Strand Break Response (Bos taurus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Bos taurus)
ATM phosphorylates NBN (Bos taurus)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
Sensing of DNA Double Strand Breaks (Bos taurus)
Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
KAT5 acetylates ATM at DNA DSBs (Bos taurus)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
MRN activates ATM (Bos taurus)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
MRN complex binds DNA double strand breaks (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
MRN complex bound to DNA ends recruits ATM (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
Homology Directed Repair (Bos taurus)
HDR through MMEJ (alt-NHEJ) (Bos taurus)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
LIG3 ligates remaining SSBs in MMEJ (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
MRN and RBBP8 resect DNA DSBs in MMEJ (Bos taurus)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
MRN complex binds RBBP8 (Bos taurus)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
MRN recruits LIG3:XRCC1 to MMEJ sites (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Bos taurus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Bos taurus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Bos taurus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Bos taurus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
MRE11 [nucleoplasm]
(Bos taurus)
NBN [nucleoplasm]
(Bos taurus)
RAD50 [nucleoplasm]
(Bos taurus)
Participates
as an output of
LIG3 ligates remaining SSBs in MMEJ (Bos taurus)
Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Bos taurus)
as a component of
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Bos taurus)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Bos taurus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Bos taurus)
Shortened telomere:MRN [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
as an input of
MRN complex binds shortened telomeres (Bos taurus)
MRN complex binds DNA double strand breaks (Bos taurus)
Inferred From
MRN [nucleoplasm]
(Homo sapiens)
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