Reactome | RPL17 [cytosol]

RPL17 [cytosol]

Stable Identifier

R-BTA-72418

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

E1B871

Locations in the PathwayBrowser

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Metabolism of RNA (Bos taurus)

- Nonsense-Mediated Decay (NMD) (Bos taurus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Bos taurus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Bos taurus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        Homologues of RPL17 [cytosol] (Bos taurus)
        
        RPL17 [cytosol] (Bos taurus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        Homologues of RPL17 [cytosol] (Bos taurus)
        
        RPL17 [cytosol] (Bos taurus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Bos taurus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        Homologues of RPL17 [cytosol] (Bos taurus)
        
        RPL17 [cytosol] (Bos taurus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Bos taurus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        Homologues of RPL17 [cytosol] (Bos taurus)
        
        RPL17 [cytosol] (Bos taurus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        Homologues of RPL17 [cytosol] (Bos taurus)
        
        RPL17 [cytosol] (Bos taurus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Bos taurus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        Homologues of RPL17 [cytosol] (Bos taurus)
        
        RPL17 [cytosol] (Bos taurus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        Homologues of RPL17 [cytosol] (Bos taurus)
        
        RPL17 [cytosol] (Bos taurus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Bos taurus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Bos taurus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        Homologues of RPL17 [cytosol] (Bos taurus)
        
        RPL17 [cytosol] (Bos taurus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        Homologues of RPL17 [cytosol] (Bos taurus)
        
        RPL17 [cytosol] (Bos taurus)
- rRNA processing (Bos taurus)
  - rRNA processing in the nucleus and cytosol (Bos taurus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Bos taurus)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        Homologues of RPL17 [cytosol] (Bos taurus)
        
        RPL17 [cytosol] (Bos taurus)

Metabolism of proteins (Bos taurus)

- Translation (Bos taurus)
  - Eukaryotic Translation Initiation (Bos taurus)
    - Cap-dependent Translation Initiation (Bos taurus)
      - Formation of a pool of free 40S subunits (Bos taurus)
        
        Release of 40S and 60S subunits from the 80S ribosome (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        Homologues of RPL17 [cytosol] (Bos taurus)
        
        RPL17 [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        Homologues of RPL17 [cytosol] (Bos taurus)
        
        RPL17 [cytosol] (Bos taurus)
      - GTP hydrolysis and joining of the 60S ribosomal subunit (Bos taurus)
        
        The 60S subunit joins the translation initiation complex (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        Homologues of RPL17 [cytosol] (Bos taurus)
        
        RPL17 [cytosol] (Bos taurus)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        Homologues of RPL17 [cytosol] (Bos taurus)
        
        RPL17 [cytosol] (Bos taurus)
        
        eIF5B:GTP is hydrolyzed and released (Bos taurus)
        
        80S:Met-tRNAi:mRNA [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        Homologues of RPL17 [cytosol] (Bos taurus)
        
        RPL17 [cytosol] (Bos taurus)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        Homologues of RPL17 [cytosol] (Bos taurus)
        
        RPL17 [cytosol] (Bos taurus)
    - L13a-mediated translational silencing of Ceruloplasmin expression (Bos taurus)
      - Dissociation of L13a from the 60s ribosomal subunit (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        Homologues of RPL17 [cytosol] (Bos taurus)
        
        RPL17 [cytosol] (Bos taurus)
        
        60s ribosomal complex lacking L13a subunit [cytosol] (Bos taurus)
        
        Homologues of RPL17 [cytosol] (Bos taurus)
        
        RPL17 [cytosol] (Bos taurus)
  - SRP-dependent cotranslational protein targeting to membrane (Bos taurus)
    - Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Bos taurus)
      - SRP:polypeptide+signal:ribosome [cytosol] (Bos taurus)
        
        ribosome:mRNA:polypeptide+signal [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        Homologues of RPL17 [cytosol] (Bos taurus)
        
        RPL17 [cytosol] (Bos taurus)
      - ribosome:mRNA:polypeptide+signal [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        Homologues of RPL17 [cytosol] (Bos taurus)
        
        RPL17 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:E1B871

Reference Genes

ENSEMBL:ENSBTAG00000030199.3

Participates

as a member of

Homologues of RPL17 [cytosol] (Bos taurus)

Inferred From

RPL17 [cytosol] (Homo sapiens)

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