Reactome | NDUFS2 [mitochondrial matrix]

NDUFS2 [mitochondrial matrix]

Stable Identifier

R-BTA-6788520

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

mitochondrial matrix

Synonyms

P17694

Locations in the PathwayBrowser

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Metabolism (Bos taurus)

- Aerobic respiration and respiratory electron transport (Bos taurus)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Bos taurus)
    - Respiratory electron transport (Bos taurus)
      - Complex I biogenesis (Bos taurus)
        
        IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2 [mitochondrial matrix] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2 [mitochondrial matrix] (Bos taurus)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2 [mitochondrial matrix] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2 [mitochondrial matrix] (Bos taurus)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2 [mitochondrial matrix] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2 [mitochondrial matrix] (Bos taurus)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2 [mitochondrial matrix] (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2 [mitochondrial matrix] (Bos taurus)
        
        NDUF subunits bind to form the IP subcomplex (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2 [mitochondrial matrix] (Bos taurus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2 [mitochondrial matrix] (Bos taurus)
        
        NUBPL transfers 4Fe-4S to Complex I subunits (Bos taurus)
        
        NDUF subunits [mitochondrial matrix] (Bos taurus)
        
        NDUFS2 [mitochondrial matrix] (Bos taurus)
        
        NDUF:4Fe-4S subunits [mitochondrial matrix] (Bos taurus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2 [mitochondrial matrix] (Bos taurus)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2 [mitochondrial matrix] (Bos taurus)
        
        980kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2 [mitochondrial matrix] (Bos taurus)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2 [mitochondrial matrix] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2 [mitochondrial matrix] (Bos taurus)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Bos taurus)
        
        980kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2 [mitochondrial matrix] (Bos taurus)
        
        Complex I [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2 [mitochondrial matrix] (Bos taurus)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Bos taurus)
        
        Complex I [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Bos taurus)
        
        NDUFS2 [mitochondrial matrix] (Bos taurus)

External Reference Information

External Reference

UniProt:P17694

Reference Genes

BioGPS Gene:327697

ENSEMBL:ENSBTAG00000002203

ENSEMBL:ENSBTAG00000002203.6

KEGG Gene (Bos taurus):327697

Monarch:327697

NCBI Gene:327697

Reference Transcript

RefSeq:NM_001075137.1

Other Identifiers

327697

GO:0003824

GO:0003954

GO:0005215

GO:0005634

GO:0005654

GO:0005739

GO:0005743

GO:0005747

GO:0006091

GO:0006120

GO:0006979

GO:0007005

GO:0008137

GO:0016020

GO:0016491

GO:0016651

GO:0019826

GO:0022008

GO:0030154

GO:0031625

GO:0032981

GO:0042063

GO:0042775

GO:0043226

GO:0046872

GO:0048038

GO:0048856

GO:0051287

GO:0051536

GO:0051539

GO:0061351

GO:0065003

GO:0070469

GO:0071453

GO:0140299

Participates

as a member of

NDUF subunits [mitochondrial matrix] (Bos taurus)

as a component of

NDUFS2:4Fe-4S [mitochondrial matrix] (Bos taurus)

Inferred From

NDUFS2 [mitochondrial matrix] (Homo sapiens)

Cross References

RefSeq

NP_001068605.1

Ensembl

ENSBTAP00000002852, ENSBTAT00000002852, ENSBTAG00000002203

VGNC

31969

PDB

7DGS, 7R47, 7QSK, 7R46, 5LDX, 7R4G, 7R41, 5LC5, 5O31, 7QSL, 7R48, 7QSN, 7R4D, 7R43, 7DGQ, 7DGZ, 7R4C, 7DH0, 7R42, 7DKF, 7QSM, 7R45, 7QSO, 7DGR, 7R44, 5LDW, 7R4F, 7QSD

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