Reactome | VWF [extracellular region]

VWF [extracellular region]

Stable Identifier

R-BTA-67271

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

extracellular region

Synonyms

VWF(23-763), F1N0R5

Locations in the PathwayBrowser

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Hemostasis (Bos taurus)

- Platelet activation, signaling and aggregation (Bos taurus)
  - GP1b-IX-V activation signalling (Bos taurus)
    - GP1b signaling involves c-Src (Bos taurus)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
        
        Collagen type I fibril:vWF [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
    - GP1b-IX-V binds 14-3-3-zeta (Bos taurus)
      - GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Bos taurus)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
        
        Collagen type I fibril:vWF [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
        
        Collagen type I fibril:vWF [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
    - GP1b-IX-V binds filamin (Bos taurus)
      - GPIb-IX-V:vWF:filamin-A [plasma membrane] (Bos taurus)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
        
        Collagen type I fibril:vWF [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
        
        Collagen type I fibril:vWF [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
    - GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Bos taurus)
      - GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Bos taurus)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
        
        Collagen type I fibril:vWF [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
      - GPIb-IX-V:vWF:14-3-3-zeta:p85 [plasma membrane] (Bos taurus)
        
        GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Bos taurus)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
        
        Collagen type I fibril:vWF [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
    - GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Bos taurus)
      - GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Bos taurus)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
        
        Collagen type I fibril:vWF [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
        
        Collagen type I fibril:vWF [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
    - GPIb-IX-V binds to vWF:Collagen complex (Bos taurus)
      - Collagen type I fibril:vWF [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
        
        Collagen type I fibril:vWF [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
    - vWF binds to collagen (Bos taurus)
      - Collagen type I fibril:vWF [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
      - VWF [extracellular region] (Bos taurus)
  - Platelet Aggregation (Plug Formation) (Bos taurus)
    - Integrin signaling (Bos taurus)
      - Autophosphorylation of PTK2 at Y397 (Bos taurus)
        
        Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
      - Autophosphorylation of SRC (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
      - Clustering of Integrin alphaIIb beta3 complexes (Bos taurus)
        
        Focal complex [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
      - Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
      - GRB2:SOS provides linkage to MAPK signaling for Integrins (Bos taurus)
        
        Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Bos taurus)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        Recruitment of GRB2 to p-PTK2 (Bos taurus)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
      - Interaction of integrin alphaIIb beta3 with Fibrinogen (Bos taurus)
        
        Focal complex [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
      - Phosphorylation of pPTK2 by SRC (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
      - Release of CSK from SRC (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
      - SYK activation by SRC (Bos taurus)
        
        Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
      - SYK binds to integrin alphaIIb beta3 (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
      - Translocation of PTK2 to Focal complexes (Bos taurus)
        
        Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
      - p130Cas linkage to MAPK signaling for integrins (Bos taurus)
        
        Crk binding to p130cas (Bos taurus)
        
        CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        Phosphorylation of BCAR1 by SRC-PTK2 complex (Bos taurus)
        
        BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        Recruitment of BCAR1 to PTK2 complex (Bos taurus)
        
        BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
    - Thrombin binding to GP1b:IX:V (Bos taurus)
      - GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Bos taurus)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
        
        Collagen type I fibril:vWF [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
        
        Collagen type I fibril:vWF [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
  - Response to elevated platelet cytosolic Ca2+ (Bos taurus)
    - Platelet degranulation (Bos taurus)
      - Exocytosis of platelet alpha granule contents (Bos taurus)
        
        Platelet alpha granule contents [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)

Signal Transduction (Bos taurus)

- Integrin signaling (Bos taurus)
  - Autophosphorylation of PTK2 at Y397 (Bos taurus)
    - Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
    - Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
  - Autophosphorylation of SRC (Bos taurus)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
    - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
  - Clustering of Integrin alphaIIb beta3 complexes (Bos taurus)
    - Focal complex [plasma membrane] (Bos taurus)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
  - Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
  - GRB2:SOS provides linkage to MAPK signaling for Integrins (Bos taurus)
    - Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)
      - GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
      - GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Bos taurus)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
    - Recruitment of GRB2 to p-PTK2 (Bos taurus)
      - GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
      - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
  - Interaction of integrin alphaIIb beta3 with Fibrinogen (Bos taurus)
    - Focal complex [plasma membrane] (Bos taurus)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
    - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
      - VWF [extracellular region] (Bos taurus)
  - Phosphorylation of pPTK2 by SRC (Bos taurus)
    - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
    - Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
  - Release of CSK from SRC (Bos taurus)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
  - SYK activation by SRC (Bos taurus)
    - Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
    - Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Bos taurus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
  - SYK binds to integrin alphaIIb beta3 (Bos taurus)
    - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
    - Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
  - Translocation of PTK2 to Focal complexes (Bos taurus)
    - Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
    - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
  - p130Cas linkage to MAPK signaling for integrins (Bos taurus)
    - Crk binding to p130cas (Bos taurus)
      - CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
      - p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
    - Phosphorylation of BCAR1 by SRC-PTK2 complex (Bos taurus)
      - BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
      - p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
    - Recruitment of BCAR1 to PTK2 complex (Bos taurus)
      - BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
      - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
- MAPK family signaling cascades (Bos taurus)
  - MAPK1/MAPK3 signaling (Bos taurus)
    - RAF/MAP kinase cascade (Bos taurus)
      - MAP2K and MAPK activation (Bos taurus)
        
        Dissociation of RAS:RAF complex (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
        
        Focal complex [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
        
        Focal complex [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Bos taurus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
        
        Focal complex [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
        
        Focal complex [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
        
        Focal complex [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
        
        Focal complex [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
        
        Focal complex [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
        
        Focal complex [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        MAP2Ks phosphorylate MAPKs (Bos taurus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
        
        Focal complex [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
        
        Focal complex [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
        
        Focal complex [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
        
        Focal complex [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
        
        Focal complex [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        RAF phosphorylates MAP2K dimer (Bos taurus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
        
        Focal complex [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
        
        Focal complex [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
        
        Focal complex [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
        
        Focal complex [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
        
        Focal complex [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
        
        Focal complex [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
        
        Focal complex [plasma membrane] (Bos taurus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
        
        VWF [extracellular region] (Bos taurus)

External Reference Information

External Reference

UniProt:F1N0R5

Gene Names

VWF

Reference Genes

ENSEMBL:ENSBTAG00000012265.6

Other Identifiers

280958

GO:0005515

GO:0005518

GO:0005576

GO:0005615

GO:0007155

GO:0007596

GO:0007599

GO:0030168

GO:0030312

GO:0031012

GO:0031410

GO:0031589

GO:0033093

GO:0042060

GO:0042802

GO:0043226

GO:0062023

Participates

as a member of

as an input of

vWF binds to collagen (Bos taurus)

as a component of

Collagen type I fibril:vWF [extracellular region] (Bos taurus)

Other forms of this molecule

VWF [platelet alpha granule lumen]

VWF [extracellular region]

Inferred From

VWF(23-763) [extracellular region] (Homo sapiens)

Cross References

OpenTargets

ENSG00000110799

Ensembl

ENSBTAT00000016273, ENSBTAP00000016273, ENSBTAG00000012265

VGNC

36860

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