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SOS1 [cytosol]
Stable Identifier
R-BTA-64847
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
SOS1, F1N7C3
Locations in the PathwayBrowser
Expand all
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
NCAM signaling for neurite out-growth (Bos taurus)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Bos taurus)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Bos taurus)
pFAK:Grb2:Sos [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS binds Grb2 bound to pFAK:NCAM1 (Bos taurus)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Bos taurus)
pFAK:Grb2:Sos [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
RET signaling (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Hemostasis (Bos taurus)
Cell surface interactions at the vascular wall (Bos taurus)
Tie2 Signaling (Bos taurus)
Interaction of SOS-1 to Tie2 bound Grb2 (Bos taurus)
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Bos taurus)
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
Platelet Aggregation (Plug Formation) (Bos taurus)
Integrin signaling (Bos taurus)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Bos taurus)
Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Bos taurus)
p-6Y-SYK phosphorylates BLNK (SLP65) (Bos taurus)
BLNK:GRB2:SOS1:CIN85 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
FLT3 Signaling (Bos taurus)
Active FLT3:GRB2 binds SOS1 (Bos taurus)
Active FLT3:GRB2:SOS1 [plasma membrane] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Bos taurus)
Active FLT3:GRB2:SOS1 [plasma membrane] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-2 family signaling (Bos taurus)
Interleukin receptor SHC signaling (Bos taurus)
Phosphorylated SHC recruits GRB2:SOS1 (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Interleukin-15 signaling (Bos taurus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Bos taurus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Bos taurus)
SOS1, SOS2 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS1, SOS2 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
Interleukin receptor SHC signaling (Bos taurus)
Phosphorylated SHC recruits GRB2:SOS1 (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
DAP12 interactions (Bos taurus)
DAP12 signaling (Bos taurus)
Activation of RAC1 by VAV2/3 (Bos taurus)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Recruitment of GADS:SLP-76 to p-5Y-LAT (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Recruitment of GRB2:SOS to p-5Y-LAT (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Recruitment of VAV and BTK to p-SLP-76 (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Release of p-PLCG1 (Bos taurus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS mediated nucleotide exchange of RAS (SHC) (Bos taurus)
SOS1 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated Ca+2 mobilization (Bos taurus)
Autophosphorylation of BTK/ITK (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Hydrolysis of PIP2 by PLCG (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Phosphorylation of TEC kinases by p-SYK (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
FCERI mediated MAPK activation (Bos taurus)
Activation of RAC1 by VAV (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Autophosphorylation of PAK (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Interaction of GRB2:SOS complex with p-SHC1 (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Phosphorylation and activation of VAV (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Phosphorylation of SLP-76 by p-SYK (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Recruitment of GADS:SLP-76 to p-5Y-LAT (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Recruitment of GRB2:SOS to p-5Y-LAT (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Recruitment of PAK to the membrane by binding active RAC1 (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Recruitment of VAV to p-SLP-76 (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS mediated nucleotide exchange of RAS (SHC) (Bos taurus)
SOS1 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Role of LAT2/NTAL/LAB on calcium mobilization (Bos taurus)
PI3K associates with phosphorylated GAB2 (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Recruitment of GRB2:SOS to p-10Y-NTAL (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
p75 NTR receptor-mediated signalling (Bos taurus)
Cell death signalling via NRAGE, NRIF and NADE (Bos taurus)
NRAGE signals death through JNK (Bos taurus)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Bos taurus)
GEFs [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Integrin signaling (Bos taurus)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Bos taurus)
Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
RAS GEFs promote RAS nucleotide exchange (Bos taurus)
RAS GEFs [plasma membrane] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Active FLT3:GRB2:SOS1 [plasma membrane] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2-1:SOS1:p-Y-SHC [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2:SOS1:p-KIT complex [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Bos taurus)
pFAK:Grb2:Sos [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-SHC1:GRB2:SOS [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (12/13) signalling events (Bos taurus)
GEFs activate RhoA,B,C (Bos taurus)
GEFs [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
G alpha (q) signalling events (Bos taurus)
Gastrin-CREB signalling pathway via PKC and MAPK (Bos taurus)
EGFR Transactivation by Gastrin (Bos taurus)
GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Bos taurus)
GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by EGFR (Bos taurus)
GRB2 events in EGFR signaling (Bos taurus)
GRB2-1 binds SOS1 (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2:SOS1 complex binds to EGF:EGFR complex (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SHC1 events in EGFR signaling (Bos taurus)
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Signaling by ERBB2 (Bos taurus)
GRB2 events in ERBB2 signaling (Bos taurus)
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Bos taurus)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Signaling by ERBB4 (Bos taurus)
SHC1 events in ERBB4 signaling (Bos taurus)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Bos taurus)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Downstream signaling of activated FGFR1 (Bos taurus)
FRS-mediated FGFR1 signaling (Bos taurus)
Activated FGFR1:p-FRS binds GRB2:SOS1 (Bos taurus)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SHC-mediated cascade:FGFR1 (Bos taurus)
Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Bos taurus)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Signaling by FGFR2 (Bos taurus)
Downstream signaling of activated FGFR2 (Bos taurus)
FRS-mediated FGFR2 signaling (Bos taurus)
Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Activated FGFR2:pFRS binds GRB2:SOS1 (Bos taurus)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SHC-mediated cascade:FGFR2 (Bos taurus)
Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Bos taurus)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Signaling by FGFR3 (Bos taurus)
Downstream signaling of activated FGFR3 (Bos taurus)
FRS-mediated FGFR3 signaling (Bos taurus)
Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Activated FGFR3:pFRS binds GRB2:SOS1 (Bos taurus)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SHC-mediated cascade:FGFR3 (Bos taurus)
Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Bos taurus)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Signaling by FGFR4 (Bos taurus)
Downstream signaling of activated FGFR4 (Bos taurus)
FRS-mediated FGFR4 signaling (Bos taurus)
Activated FGFR4:p-FRS binds GRB2:SOS1 (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SHC-mediated cascade:FGFR4 (Bos taurus)
Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Bos taurus)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Signaling by Insulin receptor (Bos taurus)
Insulin receptor signalling cascade (Bos taurus)
GRB2-1 binds SOS1 (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2-1:SOS1 binds p-Y427-SHC1 (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
IRS-mediated signalling (Bos taurus)
SOS-mediated signalling (Bos taurus)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Signal attenuation (Bos taurus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Bos taurus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Bos taurus)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Signaling by MET (Bos taurus)
MET activates RAS signaling (Bos taurus)
Activated MET binds RANBP9 and SOS1 (Bos taurus)
HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Activated MET recruits GRB2-1:SOS1 (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Bos taurus)
HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Bos taurus)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SHC1-2 bound to MET recruits GRB2:SOS1 (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
Signalling to ERKs (Bos taurus)
Signalling to RAS (Bos taurus)
GRB2-1:SOS1 binds p-Y-SHC (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2-1:SOS1:p-Y-SHC [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Signaling by NTRK2 (TRKB) (Bos taurus)
Activated NTRK2 signals through FRS2 and FRS3 (Bos taurus)
NTRK2-phosphorylated FRS2 binds GRB2 (Bos taurus)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2:GRB2-1:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Signaling by PDGF (Bos taurus)
Downstream signal transduction (Bos taurus)
GRB2:SOS1 complex binds to the active receptor (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Signaling by SCF-KIT (Bos taurus)
Activation of RAS by p-KIT bound SOS1 (Bos taurus)
GRB2:SOS1:p-KIT complex [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2:SOS interacts with p-KIT (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2:SOS1:p-KIT complex [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Regulation of KIT signaling (Bos taurus)
Recruitment of CBL to KIT (Bos taurus)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Bos taurus)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Bos taurus)
GRB2:SOS1:p-KIT complex [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Bos taurus)
GRB2:SOS1:p-KIT complex [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Bos taurus)
IGF1R signaling cascade (Bos taurus)
IRS-related events triggered by IGF1R (Bos taurus)
IRS-mediated signalling (Bos taurus)
SOS-mediated signalling (Bos taurus)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
SHC-related events triggered by IGF1R (Bos taurus)
GRB2-1:SOS1 binds p-3Y-SHC1 (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
GRB2-1:SOS1:p-3Y-SHC1 [cytosol] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase cycle (Bos taurus)
RAC1 GTPase cycle (Bos taurus)
RAC1 GEFs activate RAC1 (Bos taurus)
RAC1 GEFs [cytosol] (Bos taurus)
SOS1 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:F1N7C3
Gene Names
SOS1
Reference Genes
BioGPS Gene:537682 SOS1
ENSEMBL:ENSBTAG00000011643.5
KEGG Gene (Bos taurus):537682 SOS1
Monarch:537682 SOS1
NCBI Gene:537682 SOS1
Reference Transcript
RefSeq:XM_617859.8 SOS1
RefSeq:XM_002691241.5 SOS1
Other Identifiers
537682
GO:0005085
GO:0005886
GO:0007264
GO:0007265
GO:0023052
GO:0046982
GO:0098772
Participates
as a candidate of
RAC1 GEFs [cytosol] (Bos taurus)
SOS1, SOS2 [cytosol] (Bos taurus)
as an input of
Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)
Active FLT3:GRB2 binds SOS1 (Bos taurus)
SOS binds Grb2 bound to pFAK:NCAM1 (Bos taurus)
Activated MET binds RANBP9 and SOS1 (Bos taurus)
Interaction of SOS-1 to Tie2 bound Grb2 (Bos taurus)
GRB2-1 binds SOS1 (Bos taurus)
as a component of
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Bos taurus)
BLNK:GRB2:SOS1:CIN85 [cytosol] (Bos taurus)
pFAK:Grb2:Sos [cytosol] (Bos taurus)
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Bos taurus)
Active FLT3:GRB2:SOS1 [plasma membrane] (Bos taurus)
HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Bos taurus)
GRB2-1:SOS1 [cytosol] (Bos taurus)
as a member of
GEFs [cytosol] (Bos taurus)
Other forms of this molecule
phospho-SOS1 [cytosol]
SOS1 [plasma membrane]
Inferred From
SOS1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_617859.5
,
XP_002691287.2
OpenTargets
ENSG00000115904
Ensembl
ENSBTAT00000015471
,
ENSBTAG00000011643
,
ENSBTAP00000015471
VGNC
35134
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