Reactome | RIF1 [nucleoplasm]

RIF1 [nucleoplasm]

Stable Identifier

R-BTA-480742

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

RIF1, E1BCK1

Locations in the PathwayBrowser

Expand all

DNA Repair (Bos taurus)

- DNA Double-Strand Break Repair (Bos taurus)
  - Nonhomologous End-Joining (NHEJ) (Bos taurus)
    - Activated ATM phosphorylates DCLRE1C (Bos taurus)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C [nucleoplasm] (Bos taurus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Bos taurus)
        
        RIF1 [nucleoplasm] (Bos taurus)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Bos taurus)
        
        RIF1 [nucleoplasm] (Bos taurus)
    - Association of Ku heterodimer with ends of DNA double-strand break (Bos taurus)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Bos taurus)
        
        RIF1 [nucleoplasm] (Bos taurus)
      - RIF1 [nucleoplasm] (Bos taurus)
    - RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Bos taurus)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Bos taurus)
        
        RIF1 [nucleoplasm] (Bos taurus)
      - RIF1 [nucleoplasm] (Bos taurus)
    - TP53BP1 recruits DCLRE1C to ATM (Bos taurus)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C [nucleoplasm] (Bos taurus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Bos taurus)
        
        RIF1 [nucleoplasm] (Bos taurus)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Bos taurus)
        
        RIF1 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:E1BCK1

Gene Names

RIF1

Reference Genes

ENSEMBL:ENSBTAG00000021020.6

Other Identifiers

541247

GO:0000122

GO:0000723

GO:0000781

GO:0000785

GO:0000793

GO:0001939

GO:0001940

GO:0002376

GO:0005634

GO:0005635

GO:0005654

GO:0005694

GO:0005856

GO:0005886

GO:0006281

GO:0006310

GO:0006325

GO:0006351

GO:0006355

GO:0006974

GO:0007049

GO:0031509

GO:0031965

GO:0032200

GO:0035019

GO:0035861

GO:0043226

GO:0043247

GO:0045814

GO:0045830

GO:0048856

GO:0051233

GO:0140445

GO:1990830

GO:2000042

GO:2001034

Participates

as an output of

Association of Ku heterodimer with ends of DNA double-strand break (Bos taurus)

as an input of

RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Bos taurus)

as a component of

DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Bos taurus)

Inferred From

RIF1 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000080345

Ensembl

ENSBTAT00000027997, ENSBTAG00000021020, ENSBTAP00000027997

VGNC

33965