Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
TOLLIP [cytosol]
Stable Identifier
R-BTA-446885
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
TOLLIP, Q2LGB5
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-1 signaling (Bos taurus)
Hyperphosphorylated IRAK1 associates with TRAF6 (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
TOLLIP [cytosol] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
TOLLIP [cytosol] (Bos taurus)
IRAK1 binds to MYD88 within the IL1R complex (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
TOLLIP [cytosol] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
TOLLIP [cytosol] (Bos taurus)
IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
TOLLIP [cytosol] (Bos taurus)
IRAK4 is activated by autophosphorylation (Bos taurus)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
TOLLIP [cytosol] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
TOLLIP [cytosol] (Bos taurus)
IRAK4 phosphorylates IRAK1 (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
TOLLIP [cytosol] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
TOLLIP [cytosol] (Bos taurus)
IRAK4-activated IRAK1 autophosphorylates (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
TOLLIP [cytosol] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
TOLLIP [cytosol] (Bos taurus)
TRAF6 binding leads to IRAK1:TRAF6 release (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
TOLLIP [cytosol] (Bos taurus)
TOLLIP [cytosol] (Bos taurus)
The Interleukin 1 receptor complex binds Tollip (Bos taurus)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
TOLLIP [cytosol] (Bos taurus)
TOLLIP [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q2LGB5
Gene Names
TOLLIP
Reference Genes
BioGPS Gene:539480 TOLLIP
ENSEMBL:ENSBTAG00000008237
ENSEMBL:ENSBTAG00000008237.6 TOLLIP
KEGG Gene (Bos taurus):539480 TOLLIP
Monarch:539480 TOLLIP
NCBI Gene:539480 TOLLIP
Reference Transcript
RefSeq:NM_001039961.1 TOLLIP
Other Identifiers
539480
GO:0002376
GO:0005737
GO:0005768
GO:0005769
GO:0006511
GO:0006914
GO:0006954
GO:0016310
GO:0030163
GO:0031410
GO:0031624
GO:0043130
GO:0043226
GO:0045087
GO:0098542
Participates
as an output of
TRAF6 binding leads to IRAK1:TRAF6 release (Bos taurus)
as a component of
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
as an input of
The Interleukin 1 receptor complex binds Tollip (Bos taurus)
Other forms of this molecule
TOLLIP [azurophil granule lumen]
TOLLIP [extracellular region]
TOLLIP [specific granule lumen]
Inferred From
TOLLIP [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001035050.1
OpenTargets
ENSG00000078902
Ensembl
ENSBTAP00000010835
,
ENSBTAG00000008237
,
ENSBTAT00000010835
VGNC
36216
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text