Reactome | SH2D2A [cytosol]

SH2D2A [cytosol]

Stable Identifier

R-BTA-4420125

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

SH2D2A, A7Z041

Locations in the PathwayBrowser

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Signal Transduction (Bos taurus)

- Signaling by Receptor Tyrosine Kinases (Bos taurus)
  - Signaling by VEGF (Bos taurus)
    - VEGFA-VEGFR2 Pathway (Bos taurus)
      - AXL autophosphorylates on Y779 and Y821 (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Bos taurus)
        
        SH2D2A [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Bos taurus)
        
        SH2D2A [cytosol] (Bos taurus)
      - AXL binds SRC-1 (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Bos taurus)
        
        SH2D2A [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Bos taurus)
        
        SH2D2A [cytosol] (Bos taurus)
      - Phosphorylation of SRC-1 (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Bos taurus)
        
        SH2D2A [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Bos taurus)
        
        SH2D2A [cytosol] (Bos taurus)
      - SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Bos taurus)
        
        SH2D2A [cytosol] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Bos taurus)
        
        SH2D2A [cytosol] (Bos taurus)
      - VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Bos taurus)
        
        SH2D2A [cytosol] (Bos taurus)
      - p-6Y-VEGFR2 binds SH2D2A (Bos taurus)
        
        SH2D2A [cytosol] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Bos taurus)
        
        SH2D2A [cytosol] (Bos taurus)
      - p-AXL binds PI3K (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Bos taurus)
        
        SH2D2A [cytosol] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Bos taurus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Bos taurus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Bos taurus)
        
        SH2D2A [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:A7Z041

Gene Names

SH2D2A

Reference Genes

BioGPS Gene:530059 SH2D2A

ENSEMBL:ENSBTAG00000024470.4

KEGG Gene (Bos taurus):530059 SH2D2A

Monarch:530059 SH2D2A

NCBI Gene:530059 SH2D2A

Reference Transcript

RefSeq:NM_001105401.2 SH2D2A

Other Identifiers

530059

GO:0002376

GO:0005737

GO:0042098

Participates

as an input of

p-6Y-VEGFR2 binds SH2D2A (Bos taurus)

as a component of

VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Bos taurus)

Inferred From

SH2D2A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001098871.1

OpenTargets

ENSG00000027869

Ensembl

ENSBTAT00000046702, ENSBTAG00000024470, ENSBTAP00000043972

VGNC

34557