Reactome | PRKAG3 [cytosol]

PRKAG3 [cytosol]

Stable Identifier

R-BTA-381839

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

Q2LL38

Locations in the PathwayBrowser

Expand all

Autophagy (Bos taurus)

- Macroautophagy (Bos taurus)
  - AMPK (complex) phosphorylates ULK1 (complex) (Bos taurus)
    - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
      - p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK gamma [cytosol] (Bos taurus)
        
        PRKAG3 [cytosol] (Bos taurus)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Bos taurus)
      - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK gamma [cytosol] (Bos taurus)
        
        PRKAG3 [cytosol] (Bos taurus)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Bos taurus)
      - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK gamma [cytosol] (Bos taurus)
        
        PRKAG3 [cytosol] (Bos taurus)
  - Thr-180 of ULK1 is phosphorylated (Bos taurus)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Bos taurus)
      - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK gamma [cytosol] (Bos taurus)
        
        PRKAG3 [cytosol] (Bos taurus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Bos taurus)
      - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK gamma [cytosol] (Bos taurus)
        
        PRKAG3 [cytosol] (Bos taurus)
  - ULK complex translocates to the ER (Bos taurus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Bos taurus)
      - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK gamma [cytosol] (Bos taurus)
        
        PRKAG3 [cytosol] (Bos taurus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Bos taurus)
      - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK gamma [cytosol] (Bos taurus)
        
        PRKAG3 [cytosol] (Bos taurus)
  - ULK1 phosphorylates AMBRA1:BECN1 complex (Bos taurus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Bos taurus)
      - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK gamma [cytosol] (Bos taurus)
        
        PRKAG3 [cytosol] (Bos taurus)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Bos taurus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Bos taurus)
      - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK gamma [cytosol] (Bos taurus)
        
        PRKAG3 [cytosol] (Bos taurus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Bos taurus)
      - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK gamma [cytosol] (Bos taurus)
        
        PRKAG3 [cytosol] (Bos taurus)
  - ULK1 phosphorylates Beclin-1 (Bos taurus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Bos taurus)
      - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK gamma [cytosol] (Bos taurus)
        
        PRKAG3 [cytosol] (Bos taurus)
  - p-AMPK:AMP binds the ULK complex (Bos taurus)
    - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
      - p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK gamma [cytosol] (Bos taurus)
        
        PRKAG3 [cytosol] (Bos taurus)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Bos taurus)
      - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK gamma [cytosol] (Bos taurus)
        
        PRKAG3 [cytosol] (Bos taurus)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Bos taurus)
    - p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
      - p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK gamma [cytosol] (Bos taurus)
        
        PRKAG3 [cytosol] (Bos taurus)

Gene expression (Transcription) (Bos taurus)

- RNA Polymerase II Transcription (Bos taurus)
  - Generic Transcription Pathway (Bos taurus)
    - Transcriptional Regulation by TP53 (Bos taurus)
      - TP53 Regulates Metabolic Genes (Bos taurus)
        
        SESN1,2,3 bind AMPK (Bos taurus)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK gamma [cytosol] (Bos taurus)
        
        PRKAG3 [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK gamma [cytosol] (Bos taurus)
        
        PRKAG3 [cytosol] (Bos taurus)
        
        p-AMPK phosphorylates TSC1:TSC2 (Bos taurus)
        
        p-AMPK heterotrimer:AMP [cytosol] (Bos taurus)
        
        p-AMPK heterotrimer [cytosol] (Bos taurus)
        
        AMPK gamma [cytosol] (Bos taurus)
        
        PRKAG3 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:Q2LL38

Reference Genes

BioGPS Gene:511961

ENSEMBL:ENSBTAG00000013492

ENSEMBL:ENSBTAG00000013492.6

KEGG Gene (Bos taurus):511961

Monarch:511961

NCBI Gene:511961

Reference Transcript

Other Identifiers

511961

GO:0000166

GO:0005524

GO:0005634

GO:0005737

GO:0006629

GO:0006631

GO:0006633

GO:0016208

GO:0019887

GO:0019901

GO:0031588

GO:0043226

GO:0098772

Participates

as a member of

AMPK gamma [cytosol] (Bos taurus)

Other forms of this molecule

PRKAG3 [nucleoplasm]

Inferred From

PRKAG3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001155891.1, NP_001025473.2, NP_001155893.1, NP_001155892.1

Ensembl

ENSBTAG00000013492, ENSBTAT00000017940, ENSBTAP00000017940

VGNC

33323

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