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TRAF6 [cytosol]
Stable Identifier
R-BTA-2685681
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
K63polyUb-TRAF6, Q3ZCC3
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
Activation of IKK complex (Bos taurus)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Bos taurus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Activation of TAK1-TAB2 complex (Bos taurus)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Bos taurus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-1 signaling (Bos taurus)
Polyubiquitinated TRAF6 binds the TAK1 complex (Bos taurus)
hp-IRAK1:3xK63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K6-poly-Ub oligo-TRAF6:TAK1 complex [cytosol] (Bos taurus)
hp-IRAK1:3xK63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TAK1 is activated within the TAK1 complex (Bos taurus)
hp-IRAK1:K6-poly-Ub oligo-TRAF6:TAK1 complex [cytosol] (Bos taurus)
hp-IRAK1:3xK63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Bos taurus)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 is K63 poly-ubiquitinated (Bos taurus)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Interleukin-17 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Bos taurus)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Bos taurus)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
Alpha-protein kinase 1 signaling pathway (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
K63polyUb-TAK1 autophosphorylates (Bos taurus)
p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-TAK1 [plasma membrane] (Bos taurus)
p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Bos taurus)
K63polyUb-TRAF6 oligomer [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-p3Y,1S-TAK1 [plasma membrane] (Bos taurus)
p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Bos taurus)
K63polyUb-TRAF6 oligomer [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Bos taurus)
p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-p3Y,1S-TAK1 [plasma membrane] (Bos taurus)
p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Bos taurus)
K63polyUb-TRAF6 oligomer [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRIKA2 binds K63polyUb-TRAF6 oligomer (Bos taurus)
p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Bos taurus)
K63polyUb-TRAF6 oligomer [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2 [plasma membrane] (Bos taurus)
p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Bos taurus)
K63polyUb-TRAF6 oligomer [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated NF-kB activation (Bos taurus)
Activation of TAK1 complex bound to pUb-TRAF6 (Bos taurus)
DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane] (Bos taurus)
DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Bos taurus)
CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Phosphorylation of IKK-beta by TAK1 (Bos taurus)
DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane] (Bos taurus)
DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Bos taurus)
CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Bos taurus)
DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Bos taurus)
CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane] (Bos taurus)
DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Bos taurus)
CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Bos taurus)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Bos taurus)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Bos taurus)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Bos taurus)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Bos taurus)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Bos taurus)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Bos taurus)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Bos taurus)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Bos taurus)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Bos taurus)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Bos taurus)
Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Bos taurus)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Bos taurus)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Bos taurus)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Bos taurus)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Activation of TAK1 complex bound to activated TLR4 complex (Bos taurus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Bos taurus)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Bos taurus)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Bos taurus)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Phosphorylated TAK1 leaves activated TLR receptor complex (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Bos taurus)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Bos taurus)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Bos taurus)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Bos taurus)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Bos taurus)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Bos taurus)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Bos taurus)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Bos taurus)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Bos taurus)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Bos taurus)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Bos taurus)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Bos taurus)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Bos taurus)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Deubiquitination (Bos taurus)
Ovarian tumor domain proteases (Bos taurus)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Bos taurus)
OTUD7B,TNFAIP3,ZRANB1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Ub-specific processing proteases (Bos taurus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Bos taurus)
CYLD:K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Bos taurus)
K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
p75 NTR receptor-mediated signalling (Bos taurus)
p75NTR signals via NF-kB (Bos taurus)
p75NTR recruits signalling complexes (Bos taurus)
TRAF6 is auto-ubiquitinated (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Bos taurus)
TRAF6 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q3ZCC3
Gene Names
TRAF6
Reference Genes
BioGPS Gene:539124 TRAF6
ENSEMBL:ENSBTAG00000036009
ENSEMBL:ENSBTAG00000036009.3 TRAF6
KEGG Gene (Bos taurus):539124 TRAF6
Monarch:539124 TRAF6
NCBI Gene:539124 TRAF6
Reference Transcript
RefSeq:NM_001034661.2 TRAF6
RefSeq:XM_005216385.3 TRAF6
RefSeq:XM_005216384.3 TRAF6
Other Identifiers
539124
GO:0003824
GO:0004842
GO:0005164
GO:0005515
GO:0007165
GO:0008270
GO:0012501
GO:0016567
GO:0016740
GO:0023052
GO:0036211
GO:0042981
GO:0043122
GO:0140096
Participates
as a component of
OTUD7B,TNFAIP3,ZRANB1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Bos taurus)
hp-IRAK1:3xK63polyUb-TRAF6 [cytosol] (Bos taurus)
CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Bos taurus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Bos taurus)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Bos taurus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Bos taurus)
as a member of
K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Bos taurus)
as a repeated unit of
K63polyUb-TRAF6 oligomer [cytosol] (Bos taurus)
Other forms of this molecule
TRAF6 [cytosol]
TRAF6 [cytosol]
TRAF6 [endosome membrane]
TRAF6 [endosome membrane]
TRAF6 [plasma membrane]
TRAF6 [plasma membrane]
TRAF6 [cytosol]
Inferred From
K63polyUb-TRAF6 [cytosol]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 124 (in Homo sapiens)
Coordinate
124
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_005216442.1
,
NP_001029833.1
,
XP_005216441.1
OpenTargets
ENSG00000175104
IntEnz
2.3.2.27
Ensembl
ENSBTAT00000021630
,
ENSBTAP00000021630
,
ENSBTAG00000036009
VGNC
36278
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