Reactome | YWHAZ [cytosol]

YWHAZ [cytosol]

Stable Identifier

R-BTA-206099

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

P63103

Locations in the PathwayBrowser

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Cell Cycle (Bos taurus)

- Cell Cycle Checkpoints (Bos taurus)
  - G2/M Checkpoints (Bos taurus)
    - G2/M DNA damage checkpoint (Bos taurus)
      - Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Bos taurus)
        
        Association of p-S216-CDC25C with 14-3-3 proteins (Bos taurus)
        
        14-3-3 dimer [cytosol] (Bos taurus)
        
        YWHAZ dimer [cytosol] (Bos taurus)
        
        YWHAZ [cytosol] (Bos taurus)
        
        p-S216-CDC25C:14-3-3 protein complex [cytosol] (Bos taurus)
        
        14-3-3 dimer [cytosol] (Bos taurus)
        
        YWHAZ dimer [cytosol] (Bos taurus)
        
        YWHAZ [cytosol] (Bos taurus)

Programmed Cell Death (Bos taurus)

- Apoptosis (Bos taurus)
  - Intrinsic Pathway for Apoptosis (Bos taurus)
    - Activation of BH3-only proteins (Bos taurus)
      - Activation of BAD and translocation to mitochondria (Bos taurus)
        
        Activation of BAD by calcineurin (Bos taurus)
        
        14-3-3 dimer [cytosol] (Bos taurus)
        
        YWHAZ dimer [cytosol] (Bos taurus)
        
        YWHAZ [cytosol] (Bos taurus)
        
        14-3-3 proteins:p-S99-BAD complex [cytosol] (Bos taurus)
        
        14-3-3 dimer [cytosol] (Bos taurus)
        
        YWHAZ dimer [cytosol] (Bos taurus)
        
        YWHAZ [cytosol] (Bos taurus)
        
        Sequestration of BAD protein by 14-3-3 (Bos taurus)
        
        14-3-3 dimer [cytosol] (Bos taurus)
        
        YWHAZ dimer [cytosol] (Bos taurus)
        
        YWHAZ [cytosol] (Bos taurus)
        
        14-3-3 proteins:p-S99-BAD complex [cytosol] (Bos taurus)
        
        14-3-3 dimer [cytosol] (Bos taurus)
        
        YWHAZ dimer [cytosol] (Bos taurus)
        
        YWHAZ [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:P63103

Reference Genes

BioGPS Gene:287022

ENSEMBL:ENSBTAG00000000236

KEGG Gene (Bos taurus):287022

Monarch:287022

NCBI Gene:287022

Reference Transcript

RefSeq:NM_174814.2

Other Identifiers

1A37

1A38

1A4O

287022

2V7D

AAA30514

AAI02383

BC102382

Bt.2891.1.S1_at

ENSBTAG00000000236

ENSBTAP00000000289

ENSBTAT00000000289

EntrezGene:287022

EntrezGene:YWHAZ

GO:0003674

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0019904

GO:0031410

GO:0042470

GO:0043226

IPR000308

IPR023409

IPR023410

IPR036815

L07955

NM_174814

NP_777239

PF00244

PR00305

SM00101

UPI000003300D

VGNC:53885

XM_025001429

XM_025001430

XP_024857197

XP_024857198

YWHAZ

YWHAZ-201

Participant Of

hasMember

14-3-3 beta, zeta [cytosol]

input

p-S585-IL3RB binds 14-3-3 proteins

hasComponent

Other forms of this molecule

YWHAZ [nucleoplasm]

Inferred From

YWHAZ [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_777239.1

PRO

P63103

PDB

1A38, 1A4O, 1A37, 2V7D

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08069 IGF1R	3	IGF1R(31-736) [plasma membrane] (R-HSA-2404169) IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.593	3