Reactome | GRAP2 [cytosol]

GRAP2 [cytosol]

Stable Identifier

R-BTA-202367

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

GRAP2, E1BKA6

Locations in the PathwayBrowser

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Immune System (Bos taurus)

- Adaptive Immune System (Bos taurus)
  - Costimulation by the CD28 family (Bos taurus)
    - CD28 co-stimulation (Bos taurus)
      - Gads binds CD28 (Bos taurus)
        
        CD28:GRAP2 [plasma membrane] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
  - TCR signaling (Bos taurus)
    - Generation of second messenger molecules (Bos taurus)
      - Disassociation of PLC-gamma1 from SLP-76 (Bos taurus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
        
        GADS:p-5Y-LAT [plasma membrane] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane] (Bos taurus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
        
        GADS:p-5Y-LAT [plasma membrane] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
      - Phosphorylation of PLC-gamma1 (Bos taurus)
        
        PLC-gamma1 bound to LAT or SLP-76 [plasma membrane] (Bos taurus)
        
        PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Bos taurus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
        
        GADS:p-5Y-LAT [plasma membrane] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        Phosphorylated PLC-gamma1 bound to LAT or SLP-76 [plasma membrane] (Bos taurus)
        
        phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane] (Bos taurus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
        
        GADS:p-5Y-LAT [plasma membrane] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Bos taurus)
        
        ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
        
        GADS:p-5Y-LAT [plasma membrane] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
      - Phosphorylation of SLP-76 (Bos taurus)
        
        SLP-76 bound to Gads:LAT [plasma membrane] (Bos taurus)
        
        GADS:p-5Y-LAT [plasma membrane] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
        
        GADS:p-5Y-LAT [plasma membrane] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
      - Recruitment of Gads to LAT (Bos taurus)
        
        GADS:p-5Y-LAT [plasma membrane] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
      - Recruitment of ITK to SLP-76 (Bos taurus)
        
        ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
        
        GADS:p-5Y-LAT [plasma membrane] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
        
        GADS:p-5Y-LAT [plasma membrane] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
      - Recruitment of PLC-gamma1 to SLP-76 (Bos taurus)
        
        PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Bos taurus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
        
        GADS:p-5Y-LAT [plasma membrane] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
        
        GADS:p-5Y-LAT [plasma membrane] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
      - Recruitment of SLP-76 to Gads (Bos taurus)
        
        GADS:p-5Y-LAT [plasma membrane] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        SLP-76 bound to Gads:LAT [plasma membrane] (Bos taurus)
        
        GADS:p-5Y-LAT [plasma membrane] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
- Cytokine Signaling in Immune system (Bos taurus)
  - FLT3 Signaling (Bos taurus)
    - Active FLT3 binds to GRAP2 (Bos taurus)
      - GRAP2 [cytosol] (Bos taurus)
      - active FLT3:GRAP2 [plasma membrane] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
- Innate Immune System (Bos taurus)
  - DAP12 interactions (Bos taurus)
    - DAP12 signaling (Bos taurus)
      - Activation of RAC1 by VAV2/3 (Bos taurus)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Bos taurus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Bos taurus)
        
        GADS:SLP76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
        
        GADS:SLP76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
        
        GADS:SLP76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
        
        GADS:SLP76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
      - Recruitment of VAV and BTK to p-SLP-76 (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
      - Release of p-PLCG1 (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Bos taurus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Bos taurus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
  - Fc epsilon receptor (FCERI) signaling (Bos taurus)
    - FCERI mediated Ca+2 mobilization (Bos taurus)
      - Autophosphorylation of BTK/ITK (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
      - Hydrolysis of PIP2 by PLCG (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Bos taurus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
      - Phosphorylation of TEC kinases by p-SYK (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
    - FCERI mediated MAPK activation (Bos taurus)
      - Activation of RAC1 by VAV (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
      - Autophosphorylation of PAK (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
      - Phosphorylation and activation of VAV (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
      - Phosphorylation of SLP-76 by p-SYK (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
        
        GADS:SLP76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Bos taurus)
        
        GADS:SLP76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
        
        GADS:SLP76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
      - Recruitment of PAK to the membrane by binding active RAC1 (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
        
        GADS:SLP76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
        
        GADS:SLP76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
      - Recruitment of VAV to p-SLP-76 (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Bos taurus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
        
        GRAP2 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:E1BKA6

Gene Names

GRAP2

Reference Genes

BioGPS Gene:522346 GRAP2

ENSEMBL:ENSBTAG00000015157.6

KEGG Gene (Bos taurus):522346 GRAP2

Monarch:522346 GRAP2

NCBI Gene:522346 GRAP2

Reference Transcript

Other Identifiers

522346

GO:0001784

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005829

GO:0005886

GO:0007165

GO:0023052

GO:0031410

GO:0043226

GO:0043408

Participates

as an input of

as a component of

as a member of

Adapter proteins [cytosol] (Bos taurus)

Inferred From

GRAP2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001179489.1, XP_005207450.1, XP_005207451.1

OpenTargets

ENSG00000100351

Ensembl

ENSBTAT00000020161, ENSBTAG00000015157, ENSBTAP00000020161

VGNC

29627

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