Reactome | WASL [cytosol]

WASL [cytosol]

Stable Identifier

R-BTA-201873

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

N-WASP, Q95107

Locations in the PathwayBrowser

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Developmental Biology (Bos taurus)

- Nervous system development (Bos taurus)
  - Axon guidance (Bos taurus)
    - EPH-Ephrin signaling (Bos taurus)
      - EPHB-mediated forward signaling (Bos taurus)
        
        CDC42 and PIP2 bind WASL, activating it (Bos taurus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Bos taurus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Bos taurus)
        
        ITSN1:N-WASP [cytosol] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Bos taurus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Bos taurus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Bos taurus)
        
        ITSN1:N-WASP [cytosol] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)
        
        N-WASP binds ARP2/3 and G-actin (Bos taurus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Bos taurus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Bos taurus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Bos taurus)
        
        ITSN1:N-WASP [cytosol] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Bos taurus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Bos taurus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Bos taurus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Bos taurus)
        
        ITSN1:N-WASP [cytosol] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)
    - Netrin-1 signaling (Bos taurus)
      - DCC mediated attractive signaling (Bos taurus)
        
        Recruitment and activation of N-WASP by Cdc42 (Bos taurus)
        
        WASL [cytosol] (Bos taurus)

Immune System (Bos taurus)

- Innate Immune System (Bos taurus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
    - Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
      - Src phosphorylate WASP,N-WASP (Bos taurus)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)

Signal Transduction (Bos taurus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
  - Signaling by Rho GTPases (Bos taurus)
    - RHO GTPase Effectors (Bos taurus)
      - RHO GTPases Activate WASPs and WAVEs (Bos taurus)
        
        Src phosphorylate WASP,N-WASP (Bos taurus)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)

Vesicle-mediated transport (Bos taurus)

- Membrane Trafficking (Bos taurus)
  - Clathrin-mediated endocytosis (Bos taurus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)
    - BAR domain proteins recruit dynamin (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)
    - RAB5 and GAPVD1 bind AP-2 (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)
    - SNX9 recruits components of the actin polymerizing machinery (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)
      - WASL [cytosol] (Bos taurus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        WASL [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:Q95107

Gene Names

WASL

Reference Genes

BioGPS Gene:281577 WASL

ENSEMBL:ENSBTAG00000004643

ENSEMBL:ENSBTAG00000004643.5 WASL

KEGG Gene (Bos taurus):281577 WASL

Monarch:281577 WASL

NCBI Gene:281577 WASL

Reference Transcript

RefSeq:NM_174219.2 WASL

Other Identifiers

281577

GO:0003779

GO:0007010

GO:0007015

GO:0008092

Participates

as a component of

as an input of

Other forms of this molecule

WASL [endocytic vesicle membrane]

WASL [plasma membrane]

phospho-WASL [cytosol]

Inferred From

WASL,CTTN [cytosol] (Homo sapiens)

WASP/N-WASP [cytosol] (Homo sapiens)

N-WASP [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_776644.1

OpenTargets

ENSG00000106299

Ensembl

ENSBTAG00000004643, ENSBTAT00000006094, ENSBTAP00000006094

VGNC

56336

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:A7MB62 ACTR2	4	ACTR2 [azurophil granule lumen] (R-BTA-6798740) ACTR2 [extracellular region] (R-BTA-6806232) ACTR2 [ficolin-1-rich granule lumen] (R-BTA-6800937) ARP2 [cytosol] (R-BTA-419956)	0.564	2
UniProt:Q95107	4	WASL [endocytic vesicle membrane] (R-BTA-535012) WASL [plasma membrane] (R-BTA-203010) phospho-WASL [cytosol] (R-BTA-2197672) WASL [cytosol] (R-BTA-201873)	0.499	3

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