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phospho-p-S176,S180-CHUK [cytosol]
Stable Identifier
R-BTA-177667
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
Q95KV1
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
TNFR2 non-canonical NF-kB pathway (Bos taurus)
NIK-->noncanonical NF-kB signaling (Bos taurus)
Active NIK phosphorylates IKKA dimer (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
p-S176,S180-IKKA dimer [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
p-S176,S180-IKKA dimer [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
p-S176,S180-IKKA dimer [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
p-S176,S180-IKKA dimer [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Bos taurus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
p-S176,S180-IKKA dimer [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
p-S176,S180-IKKA dimer [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Bos taurus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
p-S176,S180-IKKA dimer [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
p-S176,S180-IKKA dimer [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
p100:RELB binds active NIK:p-IKKA dimer (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
p-S176,S180-IKKA dimer [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
p-S176,S180-IKKA dimer [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
Dectin-1 mediated noncanonical NF-kB signaling (Bos taurus)
Active NIK phosphorylates IKKA dimer (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
p-S176,S180-IKKA dimer [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
p-S176,S180-IKKA dimer [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
p-S176,S180-IKKA dimer [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
p-S176,S180-IKKA dimer [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Bos taurus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
p-S176,S180-IKKA dimer [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
p-S176,S180-IKKA dimer [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Bos taurus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
p-S176,S180-IKKA dimer [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
p-S176,S180-IKKA dimer [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
p100:RELB binds active NIK:p-IKKA dimer (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
p-S176,S180-IKKA dimer [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
p-S176,S180-IKKA dimer [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
Cytosolic sensors of pathogen-associated DNA (Bos taurus)
ZBP1(DAI) mediated induction of type I IFNs (Bos taurus)
RIP-mediated NFkB activation via ZBP1 (Bos taurus)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Bos taurus)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Bos taurus)
TRAF6 mediated NF-kB activation (Bos taurus)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Bos taurus)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
TNF signaling (Bos taurus)
Regulation of TNFR1 signaling (Bos taurus)
CHUK, IKBKB phosphorylate CYLD at S418 (Bos taurus)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Bos taurus)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Bos taurus)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Bos taurus)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Bos taurus)
phospho-p-S176,S180-CHUK [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q95KV1
Reference Genes
BioGPS Gene:281073
ENSEMBL:ENSBTAG00000007591
ENSEMBL:ENSBTAG00000007591.6
KEGG Gene (Bos taurus):281073
Monarch:281073
NCBI Gene:281073
Reference Transcript
RefSeq:NM_174021.2
Other Identifiers
281073
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006468
GO:0008384
GO:0008385
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0033209
GO:0036211
GO:0042803
GO:0043226
GO:0045944
GO:0046982
GO:0050896
GO:0071356
GO:0140096
Participates
as a component of
p-S176,S180-IKKA dimer [cytosol] (Bos taurus)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Bos taurus)
Other forms of this molecule
phospho-p-T23-CHUK [cytosol]
CHUK [cytosol]
Inferred From
p-S176,S180-CHUK [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 176 (in Homo sapiens)
Coordinate
176
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 180 (in Homo sapiens)
Coordinate
180
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_776446.1
IntEnz
2.7.11.10
Ensembl
ENSBTAG00000007591
,
ENSBTAP00000009985
,
ENSBTAT00000009985
VGNC
27354
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