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phospho-p-S172-TBK1 [cytosol]
Stable Identifier
R-BTA-168379
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
E1BKP4
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Cytosolic sensors of pathogen-associated DNA (Bos taurus)
STING mediated induction of host immune responses (Bos taurus)
IRF3-mediated induction of type I IFN (Bos taurus)
IRF3 is phosphorylated by TBK1 (Bos taurus)
NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Bos taurus)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Bos taurus)
phospho-p-S172-TBK1 [cytosol] (Bos taurus)
STING:p-S172-TBK1 [cytoplasmic vesicle membrane] (Bos taurus)
phospho-p-S172-TBK1 [cytosol] (Bos taurus)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Bos taurus)
phospho-p-S172-TBK1 [cytosol] (Bos taurus)
phospho-p-S172-TBK1 [cytosol] (Bos taurus)
TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Bos taurus)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Bos taurus)
phospho-p-S172-TBK1 [cytosol] (Bos taurus)
STAT6-mediated induction of chemokines (Bos taurus)
TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Bos taurus)
STING:p-S172-TBK1:STAT6 [cytoplasmic vesicle membrane] (Bos taurus)
phospho-p-S172-TBK1 [cytosol] (Bos taurus)
TBK1 phosphorylates STAT6 at Ser407 (Bos taurus)
STING:p-S172-TBK1 [cytoplasmic vesicle membrane] (Bos taurus)
phospho-p-S172-TBK1 [cytosol] (Bos taurus)
STING:p-S172-TBK1:STAT6 [cytoplasmic vesicle membrane] (Bos taurus)
phospho-p-S172-TBK1 [cytosol] (Bos taurus)
phospho-p-S172-TBK1 [cytosol] (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Bos taurus)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Bos taurus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Bos taurus)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Bos taurus)
phospho-p-S172-TBK1 [cytosol] (Bos taurus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Bos taurus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Bos taurus)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Bos taurus)
phospho-p-S172-TBK1 [cytosol] (Bos taurus)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Bos taurus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Bos taurus)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Bos taurus)
phospho-p-S172-TBK1 [cytosol] (Bos taurus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Bos taurus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Bos taurus)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Bos taurus)
phospho-p-S172-TBK1 [cytosol] (Bos taurus)
TBK1 is phosphorylated within the activated TLR4 complex (Bos taurus)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Bos taurus)
phospho-p-S172-TBK1 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
TNF signaling (Bos taurus)
Regulation of TNFR1 signaling (Bos taurus)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Bos taurus)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Bos taurus)
phospho-p-S172-TBK1 [cytosol] (Bos taurus)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Bos taurus)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Bos taurus)
phospho-p-S172-TBK1 [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Bos taurus)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Bos taurus)
phospho-p-S172-TBK1 [cytosol] (Bos taurus)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Bos taurus)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Bos taurus)
phospho-p-S172-TBK1 [cytosol] (Bos taurus)
TNFR1-induced proapoptotic signaling (Bos taurus)
TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Bos taurus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Bos taurus)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Bos taurus)
phospho-p-S172-TBK1 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:E1BKP4
Reference Genes
BioGPS Gene:533141
ENSEMBL:ENSBTAG00000017401.6
KEGG Gene (Bos taurus):533141
Monarch:533141
NCBI Gene:533141
Reference Transcript
RefSeq:XM_005206636.3
RefSeq:NM_001192755.1
Other Identifiers
533141
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005737
GO:0006468
GO:0016740
GO:0036211
GO:0140096
Participates
as a component of
STING:p-S172-TBK1:STAT6 [cytoplasmic vesicle membrane] (Bos taurus)
STING:p-S172-TBK1 [cytoplasmic vesicle membrane] (Bos taurus)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Bos taurus)
p-S172-TBK1:p-S172-TBK1 [cytosol] (Bos taurus)
Other forms of this molecule
phospho-E1BKP4 [cytosol]
K63polyUb-K30,K401-TBK1 [cytosol]
TBK1 [cytosol]
Inferred From
p-S172-TBK1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 172 (in Homo sapiens)
Coordinate
172
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_005206693.1
,
NP_001179684.1
Ensembl
ENSBTAG00000017401
,
ENSBTAP00000023134
,
ENSBTAT00000023134
VGNC
35656
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