Reactome | NDUFS3 [mitochondrial matrix]

NDUFS3 [mitochondrial matrix]

Stable Identifier

R-BTA-163927

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

mitochondrial matrix

Synonyms

NDUFS3, F1MS25

Locations in the PathwayBrowser

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Metabolism (Bos taurus)

- Aerobic respiration and respiratory electron transport (Bos taurus)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Bos taurus)
    - Respiratory electron transport (Bos taurus)
      - Complex I biogenesis (Bos taurus)
        
        IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFS3 [mitochondrial matrix] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFS3 [mitochondrial matrix] (Bos taurus)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFS3 [mitochondrial matrix] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFS3 [mitochondrial matrix] (Bos taurus)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFS3 [mitochondrial matrix] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFS3 [mitochondrial matrix] (Bos taurus)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFS3 [mitochondrial matrix] (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFS3 [mitochondrial matrix] (Bos taurus)
        
        NDUF subunits bind to form the IP subcomplex (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFS3 [mitochondrial matrix] (Bos taurus)
        
        NDUFS3 [mitochondrial matrix] (Bos taurus)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFS3 [mitochondrial matrix] (Bos taurus)
        
        980kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFS3 [mitochondrial matrix] (Bos taurus)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFS3 [mitochondrial matrix] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFS3 [mitochondrial matrix] (Bos taurus)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Bos taurus)
        
        980kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 [mitochondrial inner membrane] (Bos taurus)
        
        IP subcomplex [mitochondrial matrix] (Bos taurus)
        
        NDUFS3 [mitochondrial matrix] (Bos taurus)
        
        Complex I [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        NDUFS3 [mitochondrial matrix] (Bos taurus)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Bos taurus)
        
        Complex I [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        NDUFS3 [mitochondrial matrix] (Bos taurus)

External Reference Information

External Reference

UniProt:F1MS25

Gene Names

NDUFS3

Reference Genes

ENSEMBL:ENSBTAG00000018483.5

Other Identifiers

287327

GO:0003824

GO:0003954

GO:0005215

GO:0005634

GO:0005654

GO:0005739

GO:0005743

GO:0005747

GO:0006091

GO:0006120

GO:0007005

GO:0008137

GO:0012501

GO:0016491

GO:0016604

GO:0016651

GO:0023052

GO:0030308

GO:0031966

GO:0032981

GO:0043226

GO:0065003

GO:0072593

GO:2001243

Participates

as a member of

Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Bos taurus)

as an input of

NDUF subunits bind to form the IP subcomplex (Bos taurus)

as a component of

Other forms of this molecule

NDUFS3 [cytosol]

Inferred From

NDUFS3 [mitochondrial matrix] (Homo sapiens)

Cross References

OpenTargets

ENSG00000213619

Ensembl

ENSBTAP00000024600, ENSBTAT00000024600, ENSBTAG00000018483

VGNC

50228

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