NLRP3 elicitor small molecules [cytosol]

Stable Identifier
R-ALL-877245
Type
Set [DefinedSet]
Compartment
cytosol
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General
Several intact viruses, fungi and bacteria can induce NLRP3 activation, as can human proteins such as beta-amyloid (Schroder & Tschopp 2010).
Literature References
PubMed ID Title Journal Year
18604209 The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

Fitzgerald, KA, Stewart, CR, Petzold, GC, Moore, KJ, Latz, E, Reinheckel, T, Hornung, V, Golenbock, DT, Monks, BG, Halle, A

Nat Immunol 2008
19258328 NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury

Coyle, AJ, Grant, EP, Hoffman, HM, Yamasaki, K, Taylor, KR, Gallo, RL, Bertin, J, Audish, D, Misaghi, A, Muto, J, Cogen, AL

J Biol Chem 2009
18577586 The Nalp3 inflammasome is essential for the development of silicosis

Tephly, LA, Eisenbarth, SC, Carter, AB, Iyer, SS, Rothman, PB, Cassel, SL, Sadler, JJ, Sutterwala, FS, Flavell, RA, Colegio, OR

Proc Natl Acad Sci U S A 2008
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