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Fe2+ [cytosol]
Stable Identifier
R-ALL-71067
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
iron (ferrous), iron atom, Fe(II), Fe++, Iron, Fe3+, Fe(III)
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
Cytoprotection by HMOX1 (Bos taurus)
HMOX1 dimer, HMOX2 cleave heme (Bos taurus)
Fe2+ [cytosol]
Cellular response to hypoxia (Bos taurus)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Bos taurus)
FIH1:AscH-:Fe2+ dimer [cytosol] (Bos taurus)
FIH1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Bos taurus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Bos taurus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Proteasome proteolyzes ub-HIF-alpha (Bos taurus)
VBC complex (with or without LIMD1) [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Antimicrobial peptides (Bos taurus)
Ion influx/efflux at host-pathogen interface (Bos taurus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
ROS and RNS production in phagocytes (Bos taurus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
Metabolism (Bos taurus)
Inositol phosphate metabolism (Bos taurus)
Synthesis of IP2, IP, and Ins in the cytosol (Bos taurus)
MIOX oxidises Ins to GlcA (Bos taurus)
MIOX:2xFe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Metabolism of amino acids and derivatives (Bos taurus)
Carnitine synthesis (Bos taurus)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Bos taurus)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Bos taurus)
BBOX1:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Metabolism of amine-derived hormones (Bos taurus)
Catecholamine biosynthesis (Bos taurus)
Tyrosine is hydroxylated to dopa (Bos taurus)
TH:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Serotonin and melatonin biosynthesis (Bos taurus)
Tryptophan is hydroxylated (Bos taurus)
TPH:Fe++ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Phenylalanine and tyrosine metabolism (Bos taurus)
Phenylalanine metabolism (Bos taurus)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Bos taurus)
PAH:Fe2+ tetramer [cytosol] (Bos taurus)
Fe2+ [cytosol]
Tyrosine catabolism (Bos taurus)
HGD dioxygenates homogentisate (Bos taurus)
HGD hexamer [cytosol] (Bos taurus)
Fe2+ [cytosol]
HPD dioxygenates HPP (Bos taurus)
HPD:AscH-:Fe2+ dimer [cytosol] (Bos taurus)
HPD:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
nitisinone:HPD dimer [cytosol] (Bos taurus)
HPD:AscH-:Fe2+ dimer [cytosol] (Bos taurus)
HPD:AscH-:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Sulfur amino acid metabolism (Bos taurus)
Degradation of cysteine and homocysteine (Bos taurus)
ADO oxidises 2AET to HTAU (Bos taurus)
ADO:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Bos taurus)
CDO1:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Methionine salvage pathway (Bos taurus)
Acireductone is oxidized to MOB (Bos taurus)
ARD:Fe++ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Tryptophan catabolism (Bos taurus)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Bos taurus)
HAAO [cytosol] (Bos taurus)
Fe2+ [cytosol]
Metabolism of carbohydrates (Bos taurus)
Pentose phosphate pathway (Bos taurus)
RPE dimers isomerise RU5P to XY5P (Bos taurus)
RPE:Fe2+ dimers [cytosol] (Bos taurus)
RPE:Fe2+ dimer [cytosol] (Bos taurus)
RPE:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Bos taurus)
RPEL1:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
xylulose 5-phosphate <=> D-ribulose 5-phosphate (Bos taurus)
RPE:Fe2+ dimers [cytosol] (Bos taurus)
RPE:Fe2+ dimer [cytosol] (Bos taurus)
RPE:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Bos taurus)
RPEL1:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Metabolism of lipids (Bos taurus)
Biosynthesis of specialized proresolving mediators (SPMs) (Bos taurus)
Biosynthesis of DHA-derived SPMs (Bos taurus)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Bos taurus)
ALOX12:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Bos taurus)
ALOX12:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Biosynthesis of DPA-derived SPMs (Bos taurus)
Biosynthesis of DPAn-3 SPMs (Bos taurus)
Biosynthesis of DPAn-3-derived maresins (Bos taurus)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Bos taurus)
ALOX12:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Bos taurus)
ALOX12:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Biosynthesis of DPAn-6 SPMs (Bos taurus)
ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Bos taurus)
ALOX12:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Synthesis of Lipoxins (LX) (Bos taurus)
ALOX12 oxidises LTA4 to LXA4/B4 (Bos taurus)
ALOX12:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Fatty acid metabolism (Bos taurus)
Arachidonic acid metabolism (Bos taurus)
Synthesis of 12-eicosatetraenoic acid derivatives (Bos taurus)
Arachidonic acid is converted to 12-oxoETE by ALOX12 (Bos taurus)
ALOX12:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Bos taurus)
ALOX12B:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Bos taurus)
ALOX12/15 [cytosol] (Bos taurus)
ALOX12:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
ALOX15:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Bos taurus)
Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Bos taurus)
ALOX15/15B [cytosol] (Bos taurus)
ALOX15:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
ALOX15B:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (Bos taurus)
Arachidonic acid is converted to HXA3/B3 by ALOX12 (Bos taurus)
ALOX12:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Bos taurus)
ALOX5 is phosphorylated by MAPKAP2 (Bos taurus)
ALOX5:Ca2+:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
p-S272-ALOX5:Ca2+:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
LTA4 is converted to EXA4 by ALOX15 (Bos taurus)
ALOX15:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Metabolism of nucleotides (Bos taurus)
Nucleotide biosynthesis (Bos taurus)
Purine ribonucleoside monophosphate biosynthesis (Bos taurus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Bos taurus)
PPAT dimer [cytosol] (Bos taurus)
Fe2+ [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Bos taurus)
PPAT dimer [cytosol] (Bos taurus)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Bos taurus)
PPAT dimer [cytosol] (Bos taurus)
Fe2+ [cytosol]
Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Bos taurus)
PPAT dimer [cytosol] (Bos taurus)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Bos taurus)
PPAT dimer [cytosol] (Bos taurus)
Fe2+ [cytosol]
Metabolism of porphyrins (Bos taurus)
Heme degradation (Bos taurus)
HMOX1 dimer, HMOX2 cleave heme (Bos taurus)
Fe2+ [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of fat-soluble vitamins (Bos taurus)
Retinoid metabolism and transport (Bos taurus)
BCMO1:Fe2+ cleaves betaC to atRAL (Bos taurus)
BCMO1:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Bos taurus)
Hypusine synthesis from eIF5A-lysine (Bos taurus)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Bos taurus)
DOHH:Fe++ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Protein hydroxylation (Bos taurus)
JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Bos taurus)
JMJD4:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
JMJD7 dimer hydroxlates a lysine residue of DRG1 (Bos taurus)
JMJD7 dimer [cytosol] (Bos taurus)
JMJD7:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
JMJD7 dimer hydroxlates a lysine residue of DRG2 (Bos taurus)
JMJD7 dimer [cytosol] (Bos taurus)
JMJD7:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Bos taurus)
KDM8:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Bos taurus)
KDM8:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Sensory Perception (Bos taurus)
Visual phototransduction (Bos taurus)
Retinoid metabolism and transport (Bos taurus)
BCMO1:Fe2+ cleaves betaC to atRAL (Bos taurus)
BCMO1:Fe2+ [cytosol] (Bos taurus)
Fe2+ [cytosol]
Signal Transduction (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
Opioid Signalling (Bos taurus)
DARPP-32 events (Bos taurus)
DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Bos taurus)
Phosphorylated (T34) DARPP-32:PP1A [cytosol] (Bos taurus)
PP1A(Fe and Mn cofactors) [cytosol] (Bos taurus)
Fe2+ [cytosol]
Transport of small molecules (Bos taurus)
Iron uptake and transport (Bos taurus)
ACO1 binds 4Fe-4S (Bos taurus)
Fe2+ [cytosol]
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Bos taurus)
Fe2+ [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Bos taurus)
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Bos taurus)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)
Fe2+ [cytosol]
Transferrin endocytosis and recycling (Bos taurus)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Bos taurus)
Fe2+ [cytosol]
SLC-mediated transmembrane transport (Bos taurus)
Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
Metal ion SLC transporters (Bos taurus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Bos taurus)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)
Fe2+ [cytosol]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to hypoxia (Caenorhabditis elegans)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Caenorhabditis elegans)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Caenorhabditis elegans)
PHD2,3 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
PHD2,3 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Caenorhabditis elegans)
PHD2,3 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
PHD2,3 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
PHD2,3 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
PHD2,3 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
PHD2,3 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
PHD2,3 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Proteasome proteolyzes ub-HIF-alpha (Caenorhabditis elegans)
VBC complex (with or without LIMD1) [cytosol] (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
PHD2,3 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
PHD2,3 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Immune System (Caenorhabditis elegans)
Innate Immune System (Caenorhabditis elegans)
Antimicrobial peptides (Caenorhabditis elegans)
Ion influx/efflux at host-pathogen interface (Caenorhabditis elegans)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
ROS and RNS production in phagocytes (Caenorhabditis elegans)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
Metabolism (Caenorhabditis elegans)
Inositol phosphate metabolism (Caenorhabditis elegans)
Synthesis of IP2, IP, and Ins in the cytosol (Caenorhabditis elegans)
MIOX oxidises Ins to GlcA (Caenorhabditis elegans)
MIOX:2xFe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Carnitine synthesis (Caenorhabditis elegans)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Caenorhabditis elegans)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Caenorhabditis elegans)
BBOX1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Metabolism of amine-derived hormones (Caenorhabditis elegans)
Catecholamine biosynthesis (Caenorhabditis elegans)
Tyrosine is hydroxylated to dopa (Caenorhabditis elegans)
TH:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Serotonin and melatonin biosynthesis (Caenorhabditis elegans)
Tryptophan is hydroxylated (Caenorhabditis elegans)
TPH:Fe++ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Phenylalanine and tyrosine metabolism (Caenorhabditis elegans)
Phenylalanine metabolism (Caenorhabditis elegans)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Caenorhabditis elegans)
PAH:Fe2+ tetramer [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Tyrosine catabolism (Caenorhabditis elegans)
HGD dioxygenates homogentisate (Caenorhabditis elegans)
HGD hexamer [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
HPD dioxygenates HPP (Caenorhabditis elegans)
HPD:AscH-:Fe2+ dimer [cytosol] (Caenorhabditis elegans)
HPD:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
nitisinone:HPD dimer [cytosol] (Caenorhabditis elegans)
HPD:AscH-:Fe2+ dimer [cytosol] (Caenorhabditis elegans)
HPD:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Sulfur amino acid metabolism (Caenorhabditis elegans)
Degradation of cysteine and homocysteine (Caenorhabditis elegans)
ADO oxidises 2AET to HTAU (Caenorhabditis elegans)
ADO:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Caenorhabditis elegans)
CDO1:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Methionine salvage pathway (Caenorhabditis elegans)
Acireductone is oxidized to MOB (Caenorhabditis elegans)
ARD:Fe++ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Tryptophan catabolism (Caenorhabditis elegans)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Caenorhabditis elegans)
HAAO [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Metabolism of carbohydrates (Caenorhabditis elegans)
Pentose phosphate pathway (Caenorhabditis elegans)
RPE dimers isomerise RU5P to XY5P (Caenorhabditis elegans)
RPE:Fe2+ dimers [cytosol] (Caenorhabditis elegans)
RPE:Fe2+ dimer [cytosol] (Caenorhabditis elegans)
RPE:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Caenorhabditis elegans)
RPEL1:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
xylulose 5-phosphate <=> D-ribulose 5-phosphate (Caenorhabditis elegans)
RPE:Fe2+ dimers [cytosol] (Caenorhabditis elegans)
RPE:Fe2+ dimer [cytosol] (Caenorhabditis elegans)
RPE:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Caenorhabditis elegans)
RPEL1:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Metabolism of lipids (Caenorhabditis elegans)
Metabolism of steroids (Caenorhabditis elegans)
Bile acid and bile salt metabolism (Caenorhabditis elegans)
Synthesis of bile acids and bile salts (Caenorhabditis elegans)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Caenorhabditis elegans)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Caenorhabditis elegans)
Fe2+ [cytosol]
Metabolism of nucleotides (Caenorhabditis elegans)
Nucleotide biosynthesis (Caenorhabditis elegans)
Purine ribonucleoside monophosphate biosynthesis (Caenorhabditis elegans)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Caenorhabditis elegans)
PPAT dimer [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Caenorhabditis elegans)
PPAT dimer [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Caenorhabditis elegans)
PPAT dimer [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Caenorhabditis elegans)
PPAT dimer [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Caenorhabditis elegans)
PPAT dimer [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of fat-soluble vitamins (Caenorhabditis elegans)
Retinoid metabolism and transport (Caenorhabditis elegans)
BCMO1:Fe2+ cleaves betaC to atRAL (Caenorhabditis elegans)
BCMO1:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Caenorhabditis elegans)
Hypusine synthesis from eIF5A-lysine (Caenorhabditis elegans)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Caenorhabditis elegans)
DOHH:Fe++ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Protein hydroxylation (Caenorhabditis elegans)
JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Caenorhabditis elegans)
JMJD4:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Caenorhabditis elegans)
KDM8:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Caenorhabditis elegans)
KDM8:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Sensory Perception (Caenorhabditis elegans)
Visual phototransduction (Caenorhabditis elegans)
Retinoid metabolism and transport (Caenorhabditis elegans)
BCMO1:Fe2+ cleaves betaC to atRAL (Caenorhabditis elegans)
BCMO1:Fe2+ [cytosol] (Caenorhabditis elegans)
Fe2+ [cytosol]
Transport of small molecules (Caenorhabditis elegans)
Iron uptake and transport (Caenorhabditis elegans)
ACO1 binds 4Fe-4S (Caenorhabditis elegans)
Fe2+ [cytosol]
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Caenorhabditis elegans)
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Caenorhabditis elegans)
Fe2+ [cytosol]
Transferrin endocytosis and recycling (Caenorhabditis elegans)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Caenorhabditis elegans)
Fe2+ [cytosol]
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of bile salts and organic acids, metal ions and amine compounds (Caenorhabditis elegans)
Metal ion SLC transporters (Caenorhabditis elegans)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Caenorhabditis elegans)
Fe2+ [cytosol]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
Cytoprotection by HMOX1 (Canis familiaris)
HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)
Fe2+ [cytosol]
Cellular response to hypoxia (Canis familiaris)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Canis familiaris)
FIH1:AscH-:Fe2+ dimer [cytosol] (Canis familiaris)
FIH1:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Canis familiaris)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Canis familiaris)
PHD2,3 [cytosol] (Canis familiaris)
EGLN1:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
PHD2,3 [cytosol] (Canis familiaris)
EGLN1:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Canis familiaris)
PHD2,3 [cytosol] (Canis familiaris)
EGLN1:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
PHD2,3 [cytosol] (Canis familiaris)
EGLN1:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Canis familiaris)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
PHD2,3 [cytosol] (Canis familiaris)
EGLN1:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
PHD2,3 [cytosol] (Canis familiaris)
EGLN1:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
PHD2,3 [cytosol] (Canis familiaris)
EGLN1:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
PHD2,3 [cytosol] (Canis familiaris)
EGLN1:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Proteasome proteolyzes ub-HIF-alpha (Canis familiaris)
VBC complex (with or without LIMD1) [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
PHD2,3 [cytosol] (Canis familiaris)
EGLN1:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
PHD2,3 [cytosol] (Canis familiaris)
EGLN1:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Antimicrobial peptides (Canis familiaris)
Ion influx/efflux at host-pathogen interface (Canis familiaris)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Canis familiaris)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
ROS and RNS production in phagocytes (Canis familiaris)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Canis familiaris)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
Metabolism (Canis familiaris)
Inositol phosphate metabolism (Canis familiaris)
Synthesis of IP2, IP, and Ins in the cytosol (Canis familiaris)
MIOX oxidises Ins to GlcA (Canis familiaris)
MIOX:2xFe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Metabolism of amino acids and derivatives (Canis familiaris)
Carnitine synthesis (Canis familiaris)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Canis familiaris)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Canis familiaris)
BBOX1:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Metabolism of amine-derived hormones (Canis familiaris)
Catecholamine biosynthesis (Canis familiaris)
Tyrosine is hydroxylated to dopa (Canis familiaris)
TH:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Serotonin and melatonin biosynthesis (Canis familiaris)
Tryptophan is hydroxylated (Canis familiaris)
TPH:Fe++ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Phenylalanine and tyrosine metabolism (Canis familiaris)
Phenylalanine metabolism (Canis familiaris)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Canis familiaris)
PAH:Fe2+ tetramer [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Tyrosine catabolism (Canis familiaris)
HGD dioxygenates homogentisate (Canis familiaris)
HGD hexamer [cytosol] (Canis familiaris)
Fe2+ [cytosol]
HPD dioxygenates HPP (Canis familiaris)
HPD:AscH-:Fe2+ dimer [cytosol] (Canis familiaris)
HPD:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
nitisinone:HPD dimer [cytosol] (Canis familiaris)
HPD:AscH-:Fe2+ dimer [cytosol] (Canis familiaris)
HPD:AscH-:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Sulfur amino acid metabolism (Canis familiaris)
Degradation of cysteine and homocysteine (Canis familiaris)
ADO oxidises 2AET to HTAU (Canis familiaris)
ADO:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Canis familiaris)
CDO1:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Methionine salvage pathway (Canis familiaris)
Acireductone is oxidized to MOB (Canis familiaris)
ARD:Fe++ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Tryptophan catabolism (Canis familiaris)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Canis familiaris)
HAAO [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Metabolism of carbohydrates (Canis familiaris)
Pentose phosphate pathway (Canis familiaris)
RPE dimers isomerise RU5P to XY5P (Canis familiaris)
RPE:Fe2+ dimers [cytosol] (Canis familiaris)
RPE:Fe2+ dimer [cytosol] (Canis familiaris)
RPE:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Canis familiaris)
RPEL1:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
xylulose 5-phosphate <=> D-ribulose 5-phosphate (Canis familiaris)
RPE:Fe2+ dimers [cytosol] (Canis familiaris)
RPE:Fe2+ dimer [cytosol] (Canis familiaris)
RPE:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Canis familiaris)
RPEL1:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Metabolism of lipids (Canis familiaris)
Biosynthesis of specialized proresolving mediators (SPMs) (Canis familiaris)
Biosynthesis of DHA-derived SPMs (Canis familiaris)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Canis familiaris)
ALOX12:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Canis familiaris)
ALOX12:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Biosynthesis of DPA-derived SPMs (Canis familiaris)
Biosynthesis of DPAn-3 SPMs (Canis familiaris)
Biosynthesis of DPAn-3-derived maresins (Canis familiaris)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Canis familiaris)
ALOX12:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Canis familiaris)
ALOX12:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Biosynthesis of DPAn-6 SPMs (Canis familiaris)
ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Canis familiaris)
ALOX12:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Synthesis of Lipoxins (LX) (Canis familiaris)
ALOX12 oxidises LTA4 to LXA4/B4 (Canis familiaris)
ALOX12:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Fatty acid metabolism (Canis familiaris)
Arachidonic acid metabolism (Canis familiaris)
Synthesis of 12-eicosatetraenoic acid derivatives (Canis familiaris)
Arachidonic acid is converted to 12-oxoETE by ALOX12 (Canis familiaris)
ALOX12:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Canis familiaris)
ALOX12B:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Canis familiaris)
ALOX12/15 [cytosol] (Canis familiaris)
ALOX12:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
ALOX15:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Canis familiaris)
Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Canis familiaris)
ALOX15/15B [cytosol] (Canis familiaris)
ALOX15:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
ALOX15B:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (Canis familiaris)
Arachidonic acid is converted to HXA3/B3 by ALOX12 (Canis familiaris)
ALOX12:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Canis familiaris)
LTA4 is converted to EXA4 by ALOX15 (Canis familiaris)
ALOX15:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Metabolism of nucleotides (Canis familiaris)
Nucleotide biosynthesis (Canis familiaris)
Purine ribonucleoside monophosphate biosynthesis (Canis familiaris)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Canis familiaris)
PPAT dimer [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Canis familiaris)
PPAT dimer [cytosol] (Canis familiaris)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Canis familiaris)
PPAT dimer [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Canis familiaris)
PPAT dimer [cytosol] (Canis familiaris)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Canis familiaris)
PPAT dimer [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Metabolism of porphyrins (Canis familiaris)
Heme degradation (Canis familiaris)
HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)
Fe2+ [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of fat-soluble vitamins (Canis familiaris)
Retinoid metabolism and transport (Canis familiaris)
BCMO1:Fe2+ cleaves betaC to atRAL (Canis familiaris)
BCMO1:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Canis familiaris)
Hypusine synthesis from eIF5A-lysine (Canis familiaris)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Canis familiaris)
DOHH:Fe++ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Protein hydroxylation (Canis familiaris)
JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Canis familiaris)
JMJD4:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
JMJD7 dimer hydroxlates a lysine residue of DRG1 (Canis familiaris)
JMJD7 dimer [cytosol] (Canis familiaris)
JMJD7:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
JMJD7 dimer hydroxlates a lysine residue of DRG2 (Canis familiaris)
JMJD7 dimer [cytosol] (Canis familiaris)
JMJD7:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Canis familiaris)
KDM8:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Canis familiaris)
KDM8:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Sensory Perception (Canis familiaris)
Visual phototransduction (Canis familiaris)
Retinoid metabolism and transport (Canis familiaris)
BCMO1:Fe2+ cleaves betaC to atRAL (Canis familiaris)
BCMO1:Fe2+ [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Signal Transduction (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (i) signalling events (Canis familiaris)
Opioid Signalling (Canis familiaris)
DARPP-32 events (Canis familiaris)
DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Canis familiaris)
Phosphorylated (T34) DARPP-32:PP1A [cytosol] (Canis familiaris)
PP1A(Fe and Mn cofactors) [cytosol] (Canis familiaris)
Fe2+ [cytosol]
Transport of small molecules (Canis familiaris)
Iron uptake and transport (Canis familiaris)
ACO1 binds 4Fe-4S (Canis familiaris)
Fe2+ [cytosol]
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Canis familiaris)
Fe2+ [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Canis familiaris)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)
Fe2+ [cytosol]
Transferrin endocytosis and recycling (Canis familiaris)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Canis familiaris)
Fe2+ [cytosol]
SLC-mediated transmembrane transport (Canis familiaris)
Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
Metal ion SLC transporters (Canis familiaris)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Canis familiaris)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Canis familiaris)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)
Fe2+ [cytosol]
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular response to chemical stress (Danio rerio)
Cytoprotection by HMOX1 (Danio rerio)
HMOX1 dimer, HMOX2 cleave heme (Danio rerio)
Fe2+ [cytosol]
Cellular response to hypoxia (Danio rerio)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Danio rerio)
FIH1:AscH-:Fe2+ dimer [cytosol] (Danio rerio)
FIH1:AscH-:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Immune System (Danio rerio)
Innate Immune System (Danio rerio)
Antimicrobial peptides (Danio rerio)
Ion influx/efflux at host-pathogen interface (Danio rerio)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Danio rerio)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
ROS and RNS production in phagocytes (Danio rerio)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Danio rerio)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
Metabolism (Danio rerio)
Inositol phosphate metabolism (Danio rerio)
Synthesis of IP2, IP, and Ins in the cytosol (Danio rerio)
MIOX oxidises Ins to GlcA (Danio rerio)
MIOX:2xFe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Metabolism of amino acids and derivatives (Danio rerio)
Carnitine synthesis (Danio rerio)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Danio rerio)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Danio rerio)
BBOX1:AscH-:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Metabolism of amine-derived hormones (Danio rerio)
Catecholamine biosynthesis (Danio rerio)
Tyrosine is hydroxylated to dopa (Danio rerio)
TH:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Serotonin and melatonin biosynthesis (Danio rerio)
Tryptophan is hydroxylated (Danio rerio)
TPH:Fe++ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Phenylalanine and tyrosine metabolism (Danio rerio)
Phenylalanine metabolism (Danio rerio)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Danio rerio)
PAH:Fe2+ tetramer [cytosol] (Danio rerio)
Fe2+ [cytosol]
Tyrosine catabolism (Danio rerio)
HGD dioxygenates homogentisate (Danio rerio)
HGD hexamer [cytosol] (Danio rerio)
Fe2+ [cytosol]
HPD dioxygenates HPP (Danio rerio)
HPD:AscH-:Fe2+ dimer [cytosol] (Danio rerio)
HPD:AscH-:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
nitisinone:HPD dimer [cytosol] (Danio rerio)
HPD:AscH-:Fe2+ dimer [cytosol] (Danio rerio)
HPD:AscH-:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Sulfur amino acid metabolism (Danio rerio)
Degradation of cysteine and homocysteine (Danio rerio)
ADO oxidises 2AET to HTAU (Danio rerio)
ADO:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Danio rerio)
CDO1:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Methionine salvage pathway (Danio rerio)
Acireductone is oxidized to MOB (Danio rerio)
ARD:Fe++ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Tryptophan catabolism (Danio rerio)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Danio rerio)
HAAO [cytosol] (Danio rerio)
Fe2+ [cytosol]
Metabolism of carbohydrates (Danio rerio)
Pentose phosphate pathway (Danio rerio)
RPE dimers isomerise RU5P to XY5P (Danio rerio)
RPE:Fe2+ dimers [cytosol] (Danio rerio)
RPE:Fe2+ dimer [cytosol] (Danio rerio)
RPE:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Danio rerio)
RPEL1:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
xylulose 5-phosphate <=> D-ribulose 5-phosphate (Danio rerio)
RPE:Fe2+ dimers [cytosol] (Danio rerio)
RPE:Fe2+ dimer [cytosol] (Danio rerio)
RPE:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Danio rerio)
RPEL1:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Metabolism of lipids (Danio rerio)
Biosynthesis of specialized proresolving mediators (SPMs) (Danio rerio)
Biosynthesis of DHA-derived SPMs (Danio rerio)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Danio rerio)
ALOX12:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Danio rerio)
ALOX12:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Biosynthesis of DPA-derived SPMs (Danio rerio)
Biosynthesis of DPAn-3 SPMs (Danio rerio)
Biosynthesis of DPAn-3-derived maresins (Danio rerio)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Danio rerio)
ALOX12:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Danio rerio)
ALOX12:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Biosynthesis of DPAn-6 SPMs (Danio rerio)
ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Danio rerio)
ALOX12:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Synthesis of Lipoxins (LX) (Danio rerio)
ALOX12 oxidises LTA4 to LXA4/B4 (Danio rerio)
ALOX12:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Fatty acid metabolism (Danio rerio)
Arachidonic acid metabolism (Danio rerio)
Synthesis of 12-eicosatetraenoic acid derivatives (Danio rerio)
Arachidonic acid is converted to 12-oxoETE by ALOX12 (Danio rerio)
ALOX12:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Danio rerio)
ALOX12B:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Danio rerio)
ALOX12/15 [cytosol] (Danio rerio)
ALOX12:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
ALOX15:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Danio rerio)
Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Danio rerio)
ALOX15/15B [cytosol] (Danio rerio)
ALOX15:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
ALOX15B:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (Danio rerio)
Arachidonic acid is converted to HXA3/B3 by ALOX12 (Danio rerio)
ALOX12:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Danio rerio)
ALOX5 is phosphorylated by MAPKAP2 (Danio rerio)
ALOX5:Ca2+:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
p-S272-ALOX5:Ca2+:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
LTA4 is converted to EXA4 by ALOX15 (Danio rerio)
ALOX15:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Metabolism of steroids (Danio rerio)
Bile acid and bile salt metabolism (Danio rerio)
Synthesis of bile acids and bile salts (Danio rerio)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Danio rerio)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Danio rerio)
Fe2+ [cytosol]
Metabolism of nucleotides (Danio rerio)
Nucleotide biosynthesis (Danio rerio)
Purine ribonucleoside monophosphate biosynthesis (Danio rerio)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Danio rerio)
PPAT dimer [cytosol] (Danio rerio)
Fe2+ [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Danio rerio)
PPAT dimer [cytosol] (Danio rerio)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Danio rerio)
PPAT dimer [cytosol] (Danio rerio)
Fe2+ [cytosol]
Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Danio rerio)
PPAT dimer [cytosol] (Danio rerio)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Danio rerio)
PPAT dimer [cytosol] (Danio rerio)
Fe2+ [cytosol]
Metabolism of porphyrins (Danio rerio)
Heme degradation (Danio rerio)
HMOX1 dimer, HMOX2 cleave heme (Danio rerio)
Fe2+ [cytosol]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of fat-soluble vitamins (Danio rerio)
Retinoid metabolism and transport (Danio rerio)
BCMO1:Fe2+ cleaves betaC to atRAL (Danio rerio)
BCMO1:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Danio rerio)
Hypusine synthesis from eIF5A-lysine (Danio rerio)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Danio rerio)
DOHH:Fe++ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Protein hydroxylation (Danio rerio)
JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Danio rerio)
JMJD4:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
JMJD7 dimer hydroxlates a lysine residue of DRG1 (Danio rerio)
JMJD7 dimer [cytosol] (Danio rerio)
JMJD7:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Danio rerio)
KDM8:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Sensory Perception (Danio rerio)
Visual phototransduction (Danio rerio)
Retinoid metabolism and transport (Danio rerio)
BCMO1:Fe2+ cleaves betaC to atRAL (Danio rerio)
BCMO1:Fe2+ [cytosol] (Danio rerio)
Fe2+ [cytosol]
Transport of small molecules (Danio rerio)
Iron uptake and transport (Danio rerio)
ACO1 binds 4Fe-4S (Danio rerio)
Fe2+ [cytosol]
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Danio rerio)
Fe2+ [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Danio rerio)
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Danio rerio)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Danio rerio)
Fe2+ [cytosol]
Transferrin endocytosis and recycling (Danio rerio)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Danio rerio)
Fe2+ [cytosol]
SLC-mediated transmembrane transport (Danio rerio)
Transport of bile salts and organic acids, metal ions and amine compounds (Danio rerio)
Metal ion SLC transporters (Danio rerio)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Danio rerio)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Danio rerio)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Danio rerio)
Fe2+ [cytosol]
Immune System (Dictyostelium discoideum)
Innate Immune System (Dictyostelium discoideum)
Antimicrobial peptides (Dictyostelium discoideum)
Ion influx/efflux at host-pathogen interface (Dictyostelium discoideum)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Dictyostelium discoideum)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
ROS and RNS production in phagocytes (Dictyostelium discoideum)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Dictyostelium discoideum)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
Metabolism (Dictyostelium discoideum)
Inositol phosphate metabolism (Dictyostelium discoideum)
Synthesis of IP2, IP, and Ins in the cytosol (Dictyostelium discoideum)
MIOX oxidises Ins to GlcA (Dictyostelium discoideum)
MIOX:2xFe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Metabolism of amine-derived hormones (Dictyostelium discoideum)
Catecholamine biosynthesis (Dictyostelium discoideum)
Tyrosine is hydroxylated to dopa (Dictyostelium discoideum)
TH:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Serotonin and melatonin biosynthesis (Dictyostelium discoideum)
Tryptophan is hydroxylated (Dictyostelium discoideum)
TPH:Fe++ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Phenylalanine and tyrosine metabolism (Dictyostelium discoideum)
Phenylalanine metabolism (Dictyostelium discoideum)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Dictyostelium discoideum)
PAH:Fe2+ tetramer [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Tyrosine catabolism (Dictyostelium discoideum)
HGD dioxygenates homogentisate (Dictyostelium discoideum)
HGD hexamer [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
HPD dioxygenates HPP (Dictyostelium discoideum)
HPD:AscH-:Fe2+ dimer [cytosol] (Dictyostelium discoideum)
HPD:AscH-:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
nitisinone:HPD dimer [cytosol] (Dictyostelium discoideum)
HPD:AscH-:Fe2+ dimer [cytosol] (Dictyostelium discoideum)
HPD:AscH-:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Sulfur amino acid metabolism (Dictyostelium discoideum)
Degradation of cysteine and homocysteine (Dictyostelium discoideum)
ADO oxidises 2AET to HTAU (Dictyostelium discoideum)
ADO:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Dictyostelium discoideum)
CDO1:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Methionine salvage pathway (Dictyostelium discoideum)
Acireductone is oxidized to MOB (Dictyostelium discoideum)
ARD:Fe++ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Tryptophan catabolism (Dictyostelium discoideum)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Dictyostelium discoideum)
HAAO [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Metabolism of carbohydrates (Dictyostelium discoideum)
Pentose phosphate pathway (Dictyostelium discoideum)
RPE dimers isomerise RU5P to XY5P (Dictyostelium discoideum)
RPE:Fe2+ dimers [cytosol] (Dictyostelium discoideum)
RPE:Fe2+ dimer [cytosol] (Dictyostelium discoideum)
RPE:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Dictyostelium discoideum)
RPEL1:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
xylulose 5-phosphate <=> D-ribulose 5-phosphate (Dictyostelium discoideum)
RPE:Fe2+ dimers [cytosol] (Dictyostelium discoideum)
RPE:Fe2+ dimer [cytosol] (Dictyostelium discoideum)
RPE:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Dictyostelium discoideum)
RPEL1:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Metabolism of lipids (Dictyostelium discoideum)
Biosynthesis of specialized proresolving mediators (SPMs) (Dictyostelium discoideum)
Biosynthesis of DHA-derived SPMs (Dictyostelium discoideum)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Dictyostelium discoideum)
ALOX12:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Dictyostelium discoideum)
ALOX12:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Biosynthesis of DPA-derived SPMs (Dictyostelium discoideum)
Biosynthesis of DPAn-3 SPMs (Dictyostelium discoideum)
Biosynthesis of DPAn-3-derived maresins (Dictyostelium discoideum)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Dictyostelium discoideum)
ALOX12:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Dictyostelium discoideum)
ALOX12:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Biosynthesis of DPAn-6 SPMs (Dictyostelium discoideum)
ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Dictyostelium discoideum)
ALOX12:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Synthesis of Lipoxins (LX) (Dictyostelium discoideum)
ALOX12 oxidises LTA4 to LXA4/B4 (Dictyostelium discoideum)
ALOX12:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Fatty acid metabolism (Dictyostelium discoideum)
Arachidonic acid metabolism (Dictyostelium discoideum)
Synthesis of 12-eicosatetraenoic acid derivatives (Dictyostelium discoideum)
Arachidonic acid is converted to 12-oxoETE by ALOX12 (Dictyostelium discoideum)
ALOX12:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Dictyostelium discoideum)
ALOX12B:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Dictyostelium discoideum)
ALOX12/15 [cytosol] (Dictyostelium discoideum)
ALOX12:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
ALOX15:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Dictyostelium discoideum)
Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Dictyostelium discoideum)
ALOX15/15B [cytosol] (Dictyostelium discoideum)
ALOX15:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
ALOX15B:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (Dictyostelium discoideum)
Arachidonic acid is converted to HXA3/B3 by ALOX12 (Dictyostelium discoideum)
ALOX12:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Dictyostelium discoideum)
LTA4 is converted to EXA4 by ALOX15 (Dictyostelium discoideum)
ALOX15:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Metabolism of steroids (Dictyostelium discoideum)
Bile acid and bile salt metabolism (Dictyostelium discoideum)
Synthesis of bile acids and bile salts (Dictyostelium discoideum)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Dictyostelium discoideum)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Dictyostelium discoideum)
Fe2+ [cytosol]
Metabolism of proteins (Dictyostelium discoideum)
Post-translational protein modification (Dictyostelium discoideum)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Dictyostelium discoideum)
Hypusine synthesis from eIF5A-lysine (Dictyostelium discoideum)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Dictyostelium discoideum)
DOHH:Fe++ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Protein hydroxylation (Dictyostelium discoideum)
JMJD7 dimer hydroxlates a lysine residue of DRG1 (Dictyostelium discoideum)
JMJD7 dimer [cytosol] (Dictyostelium discoideum)
JMJD7:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
JMJD7 dimer hydroxlates a lysine residue of DRG2 (Dictyostelium discoideum)
JMJD7 dimer [cytosol] (Dictyostelium discoideum)
JMJD7:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Dictyostelium discoideum)
KDM8:Fe2+ [cytosol] (Dictyostelium discoideum)
Fe2+ [cytosol]
Transport of small molecules (Dictyostelium discoideum)
Iron uptake and transport (Dictyostelium discoideum)
ACO1 binds 4Fe-4S (Dictyostelium discoideum)
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Dictyostelium discoideum)
Fe2+ [cytosol]
Transferrin endocytosis and recycling (Dictyostelium discoideum)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Dictyostelium discoideum)
Fe2+ [cytosol]
SLC-mediated transmembrane transport (Dictyostelium discoideum)
Transport of bile salts and organic acids, metal ions and amine compounds (Dictyostelium discoideum)
Metal ion SLC transporters (Dictyostelium discoideum)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Dictyostelium discoideum)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Dictyostelium discoideum)
Fe2+ [cytosol]
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to chemical stress (Drosophila melanogaster)
Cytoprotection by HMOX1 (Drosophila melanogaster)
HMOX1 dimer, HMOX2 cleave heme (Drosophila melanogaster)
Fe2+ [cytosol]
Cellular response to hypoxia (Drosophila melanogaster)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Drosophila melanogaster)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Drosophila melanogaster)
PHD2,3 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
PHD2,3 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Drosophila melanogaster)
PHD2,3 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
PHD2,3 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Drosophila melanogaster)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
PHD2,3 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
PHD2,3 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
PHD2,3 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
PHD2,3 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Proteasome proteolyzes ub-HIF-alpha (Drosophila melanogaster)
VBC complex (with or without LIMD1) [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
PHD2,3 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
PHD2,3 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Immune System (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
Antimicrobial peptides (Drosophila melanogaster)
Ion influx/efflux at host-pathogen interface (Drosophila melanogaster)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Drosophila melanogaster)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
ROS and RNS production in phagocytes (Drosophila melanogaster)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Drosophila melanogaster)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
Metabolism (Drosophila melanogaster)
Inositol phosphate metabolism (Drosophila melanogaster)
Synthesis of IP2, IP, and Ins in the cytosol (Drosophila melanogaster)
MIOX oxidises Ins to GlcA (Drosophila melanogaster)
MIOX:2xFe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Carnitine synthesis (Drosophila melanogaster)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Drosophila melanogaster)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Drosophila melanogaster)
BBOX1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Metabolism of amine-derived hormones (Drosophila melanogaster)
Catecholamine biosynthesis (Drosophila melanogaster)
Tyrosine is hydroxylated to dopa (Drosophila melanogaster)
TH:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Serotonin and melatonin biosynthesis (Drosophila melanogaster)
Tryptophan is hydroxylated (Drosophila melanogaster)
TPH:Fe++ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Phenylalanine and tyrosine metabolism (Drosophila melanogaster)
Phenylalanine metabolism (Drosophila melanogaster)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Drosophila melanogaster)
PAH:Fe2+ tetramer [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Tyrosine catabolism (Drosophila melanogaster)
HGD dioxygenates homogentisate (Drosophila melanogaster)
HGD hexamer [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
HPD dioxygenates HPP (Drosophila melanogaster)
HPD:AscH-:Fe2+ dimer [cytosol] (Drosophila melanogaster)
HPD:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
nitisinone:HPD dimer [cytosol] (Drosophila melanogaster)
HPD:AscH-:Fe2+ dimer [cytosol] (Drosophila melanogaster)
HPD:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Sulfur amino acid metabolism (Drosophila melanogaster)
Degradation of cysteine and homocysteine (Drosophila melanogaster)
ADO oxidises 2AET to HTAU (Drosophila melanogaster)
ADO:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Drosophila melanogaster)
CDO1:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Methionine salvage pathway (Drosophila melanogaster)
Acireductone is oxidized to MOB (Drosophila melanogaster)
ARD:Fe++ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Metabolism of carbohydrates (Drosophila melanogaster)
Pentose phosphate pathway (Drosophila melanogaster)
RPE dimers isomerise RU5P to XY5P (Drosophila melanogaster)
RPE:Fe2+ dimers [cytosol] (Drosophila melanogaster)
RPE:Fe2+ dimer [cytosol] (Drosophila melanogaster)
RPE:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Drosophila melanogaster)
RPEL1:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
xylulose 5-phosphate <=> D-ribulose 5-phosphate (Drosophila melanogaster)
RPE:Fe2+ dimers [cytosol] (Drosophila melanogaster)
RPE:Fe2+ dimer [cytosol] (Drosophila melanogaster)
RPE:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Drosophila melanogaster)
RPEL1:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Metabolism of nucleotides (Drosophila melanogaster)
Nucleotide biosynthesis (Drosophila melanogaster)
Purine ribonucleoside monophosphate biosynthesis (Drosophila melanogaster)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Drosophila melanogaster)
PPAT dimer [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Drosophila melanogaster)
PPAT dimer [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Drosophila melanogaster)
PPAT dimer [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Drosophila melanogaster)
PPAT dimer [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Drosophila melanogaster)
PPAT dimer [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Metabolism of porphyrins (Drosophila melanogaster)
Heme degradation (Drosophila melanogaster)
HMOX1 dimer, HMOX2 cleave heme (Drosophila melanogaster)
Fe2+ [cytosol]
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of fat-soluble vitamins (Drosophila melanogaster)
Retinoid metabolism and transport (Drosophila melanogaster)
BCMO1:Fe2+ cleaves betaC to atRAL (Drosophila melanogaster)
BCMO1:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Drosophila melanogaster)
Hypusine synthesis from eIF5A-lysine (Drosophila melanogaster)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Drosophila melanogaster)
DOHH:Fe++ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Protein hydroxylation (Drosophila melanogaster)
JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Drosophila melanogaster)
JMJD4:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
JMJD7 dimer hydroxlates a lysine residue of DRG1 (Drosophila melanogaster)
JMJD7 dimer [cytosol] (Drosophila melanogaster)
JMJD7:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
JMJD7 dimer hydroxlates a lysine residue of DRG2 (Drosophila melanogaster)
JMJD7 dimer [cytosol] (Drosophila melanogaster)
JMJD7:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Drosophila melanogaster)
KDM8:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Drosophila melanogaster)
KDM8:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Sensory Perception (Drosophila melanogaster)
Visual phototransduction (Drosophila melanogaster)
Retinoid metabolism and transport (Drosophila melanogaster)
BCMO1:Fe2+ cleaves betaC to atRAL (Drosophila melanogaster)
BCMO1:Fe2+ [cytosol] (Drosophila melanogaster)
Fe2+ [cytosol]
Transport of small molecules (Drosophila melanogaster)
Iron uptake and transport (Drosophila melanogaster)
ACO1 binds 4Fe-4S (Drosophila melanogaster)
Fe2+ [cytosol]
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Drosophila melanogaster)
Fe2+ [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Drosophila melanogaster)
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Drosophila melanogaster)
Fe2+ [cytosol]
Transferrin endocytosis and recycling (Drosophila melanogaster)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Drosophila melanogaster)
Fe2+ [cytosol]
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of bile salts and organic acids, metal ions and amine compounds (Drosophila melanogaster)
Metal ion SLC transporters (Drosophila melanogaster)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Drosophila melanogaster)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Drosophila melanogaster)
Fe2+ [cytosol]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to chemical stress (Gallus gallus)
Cytoprotection by HMOX1 (Gallus gallus)
HMOX1 dimer, HMOX2 cleave heme (Gallus gallus)
Fe2+ [cytosol]
Cellular response to hypoxia (Gallus gallus)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Gallus gallus)
FIH1:AscH-:Fe2+ dimer [cytosol] (Gallus gallus)
FIH1:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Gallus gallus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Gallus gallus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Immune System (Gallus gallus)
Innate Immune System (Gallus gallus)
Antimicrobial peptides (Gallus gallus)
Ion influx/efflux at host-pathogen interface (Gallus gallus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Gallus gallus)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
ROS and RNS production in phagocytes (Gallus gallus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Gallus gallus)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
Metabolism (Gallus gallus)
Inositol phosphate metabolism (Gallus gallus)
Synthesis of IP2, IP, and Ins in the cytosol (Gallus gallus)
MIOX oxidises Ins to GlcA (Gallus gallus)
MIOX:2xFe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Metabolism of amino acids and derivatives (Gallus gallus)
Carnitine synthesis (Gallus gallus)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Gallus gallus)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Gallus gallus)
BBOX1:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Metabolism of amine-derived hormones (Gallus gallus)
Catecholamine biosynthesis (Gallus gallus)
Tyrosine is hydroxylated to dopa (Gallus gallus)
TH:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Serotonin and melatonin biosynthesis (Gallus gallus)
Tryptophan is hydroxylated (Gallus gallus)
TPH:Fe++ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Phenylalanine and tyrosine metabolism (Gallus gallus)
Phenylalanine metabolism (Gallus gallus)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Gallus gallus)
PAH:Fe2+ tetramer [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Tyrosine catabolism (Gallus gallus)
HGD dioxygenates homogentisate (Gallus gallus)
HGD hexamer [cytosol] (Gallus gallus)
Fe2+ [cytosol]
HPD dioxygenates HPP (Gallus gallus)
HPD:AscH-:Fe2+ dimer [cytosol] (Gallus gallus)
HPD:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
nitisinone:HPD dimer [cytosol] (Gallus gallus)
HPD:AscH-:Fe2+ dimer [cytosol] (Gallus gallus)
HPD:AscH-:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Sulfur amino acid metabolism (Gallus gallus)
Degradation of cysteine and homocysteine (Gallus gallus)
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Gallus gallus)
CDO1:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Methionine salvage pathway (Gallus gallus)
Acireductone is oxidized to MOB (Gallus gallus)
ARD:Fe++ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Tryptophan catabolism (Gallus gallus)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Gallus gallus)
HAAO [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Metabolism of carbohydrates (Gallus gallus)
Pentose phosphate pathway (Gallus gallus)
RPE dimers isomerise RU5P to XY5P (Gallus gallus)
RPE:Fe2+ dimers [cytosol] (Gallus gallus)
RPE:Fe2+ dimer [cytosol] (Gallus gallus)
RPE:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Gallus gallus)
RPEL1:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
xylulose 5-phosphate <=> D-ribulose 5-phosphate (Gallus gallus)
RPE:Fe2+ dimers [cytosol] (Gallus gallus)
RPE:Fe2+ dimer [cytosol] (Gallus gallus)
RPE:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Gallus gallus)
RPEL1:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Metabolism of lipids (Gallus gallus)
Fatty acid metabolism (Gallus gallus)
Arachidonic acid metabolism (Gallus gallus)
Synthesis of 12-eicosatetraenoic acid derivatives (Gallus gallus)
Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Gallus gallus)
ALOX12B:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Gallus gallus)
Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Gallus gallus)
ALOX15B:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Gallus gallus)
ALOX5 is phosphorylated by MAPKAP2 (Gallus gallus)
ALOX5:Ca2+:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
p-S272-ALOX5:Ca2+:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Metabolism of steroids (Gallus gallus)
Bile acid and bile salt metabolism (Gallus gallus)
Synthesis of bile acids and bile salts (Gallus gallus)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Gallus gallus)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Gallus gallus)
Fe2+ [cytosol]
Metabolism of nucleotides (Gallus gallus)
Nucleotide biosynthesis (Gallus gallus)
Purine ribonucleoside monophosphate biosynthesis (Gallus gallus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Gallus gallus)
PPAT dimer [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Gallus gallus)
PPAT dimer [cytosol] (Gallus gallus)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Gallus gallus)
PPAT dimer [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Gallus gallus)
PPAT dimer [cytosol] (Gallus gallus)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Gallus gallus)
PPAT dimer [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Metabolism of porphyrins (Gallus gallus)
Heme degradation (Gallus gallus)
HMOX1 dimer, HMOX2 cleave heme (Gallus gallus)
Fe2+ [cytosol]
Metabolism of vitamins and cofactors (Gallus gallus)
Metabolism of fat-soluble vitamins (Gallus gallus)
Retinoid metabolism and transport (Gallus gallus)
BCMO1:Fe2+ cleaves betaC to atRAL (Gallus gallus)
BCMO1:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Gallus gallus)
Hypusine synthesis from eIF5A-lysine (Gallus gallus)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Gallus gallus)
DOHH:Fe++ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Protein hydroxylation (Gallus gallus)
JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Gallus gallus)
JMJD4:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
JMJD7 dimer hydroxlates a lysine residue of DRG1 (Gallus gallus)
JMJD7 dimer [cytosol] (Gallus gallus)
JMJD7:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
JMJD7 dimer hydroxlates a lysine residue of DRG2 (Gallus gallus)
JMJD7 dimer [cytosol] (Gallus gallus)
JMJD7:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Gallus gallus)
KDM8:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Sensory Perception (Gallus gallus)
Visual phototransduction (Gallus gallus)
Retinoid metabolism and transport (Gallus gallus)
BCMO1:Fe2+ cleaves betaC to atRAL (Gallus gallus)
BCMO1:Fe2+ [cytosol] (Gallus gallus)
Fe2+ [cytosol]
Transport of small molecules (Gallus gallus)
Iron uptake and transport (Gallus gallus)
ACO1 binds 4Fe-4S (Gallus gallus)
Fe2+ [cytosol]
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Gallus gallus)
Fe2+ [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Gallus gallus)
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Gallus gallus)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)
Fe2+ [cytosol]
Transferrin endocytosis and recycling (Gallus gallus)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Gallus gallus)
Fe2+ [cytosol]
SLC-mediated transmembrane transport (Gallus gallus)
Transport of bile salts and organic acids, metal ions and amine compounds (Gallus gallus)
Metal ion SLC transporters (Gallus gallus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Gallus gallus)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Gallus gallus)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)
Fe2+ [cytosol]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Cytoprotection by HMOX1 (Homo sapiens)
HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)
Fe2+ [cytosol]
Cellular response to hypoxia (Homo sapiens)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Homo sapiens)
FIH1:AscH-:Fe2+ dimer [cytosol] (Homo sapiens)
FIH1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Proteasome proteolyzes ub-HIF-alpha (Homo sapiens)
VBC complex (with or without LIMD1) [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Phenylketonuria (Homo sapiens)
Defective PAH does not hydroxylate L-Phe to L-Tyr (Homo sapiens)
PAH S40L:Fe2+ tetramer [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Disorders of transmembrane transporters (Homo sapiens)
SLC transporter disorders (Homo sapiens)
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) (Homo sapiens)
Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region (Homo sapiens)
Fe2+ [cytosol]
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Infection with Mycobacterium tuberculosis (Homo sapiens)
Latent infection - Other responses of Mtb to phagocytosis (Homo sapiens)
Mtb iron assimilation by chelation (Homo sapiens)
BfrA stores iron (Homo sapiens)
Fe2+ [cytosol]
BfrB stores iron (Homo sapiens)
Fe2+ [cytosol]
Iron is reduced and separates from mycobactin (Homo sapiens)
Fe2+ [cytosol]
Tolerance of reactive oxygen produced by macrophages (Homo sapiens)
SodB reduces superoxide to H2O2 (Homo sapiens)
SodB tetramer [cytosol] (Mycobacterium tuberculosis)
Fe2+ [cytosol]
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Antimicrobial peptides (Homo sapiens)
Ion influx/efflux at host-pathogen interface (Homo sapiens)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Homo sapiens)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
ROS and RNS production in phagocytes (Homo sapiens)
Hydrogen peroxide and Fe2+ react to hydroxyl, hydroxide and Fe3+ (Homo sapiens)
Fe2+ [cytosol]
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Homo sapiens)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
Superoxide anion reacts with Fe-S cluster (Homo sapiens)
Fe2+ [cytosol]
Metabolism (Homo sapiens)
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IP2, IP, and Ins in the cytosol (Homo sapiens)
MIOX oxidises Ins to GlcA (Homo sapiens)
MIOX:2xFe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Metabolism of amino acids and derivatives (Homo sapiens)
Carnitine synthesis (Homo sapiens)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Homo sapiens)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Homo sapiens)
BBOX1:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Metabolism of amine-derived hormones (Homo sapiens)
Catecholamine biosynthesis (Homo sapiens)
Tyrosine is hydroxylated to dopa (Homo sapiens)
TH:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Serotonin and melatonin biosynthesis (Homo sapiens)
Tryptophan is hydroxylated (Homo sapiens)
TPH:Fe++ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Phenylalanine and tyrosine metabolism (Homo sapiens)
Phenylalanine metabolism (Homo sapiens)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Homo sapiens)
PAH:Fe2+ tetramer [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Tyrosine catabolism (Homo sapiens)
HGD dioxygenates homogentisate (Homo sapiens)
HGD hexamer [cytosol] (Homo sapiens)
Fe2+ [cytosol]
HPD dioxygenates HPP (Homo sapiens)
HPD:AscH-:Fe2+ dimer [cytosol] (Homo sapiens)
HPD:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
nitisinone:HPD dimer [cytosol] (Homo sapiens)
HPD:AscH-:Fe2+ dimer [cytosol] (Homo sapiens)
HPD:AscH-:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Sulfur amino acid metabolism (Homo sapiens)
Degradation of cysteine and homocysteine (Homo sapiens)
ADO oxidises 2AET to HTAU (Homo sapiens)
ADO:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Homo sapiens)
CDO1:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Methionine salvage pathway (Homo sapiens)
Acireductone is oxidized to MOB (Homo sapiens)
ARD:Fe++ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Tryptophan catabolism (Homo sapiens)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Homo sapiens)
HAAO [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Metabolism of carbohydrates (Homo sapiens)
Pentose phosphate pathway (Homo sapiens)
RPE dimers isomerise RU5P to XY5P (Homo sapiens)
RPE:Fe2+ dimers [cytosol] (Homo sapiens)
RPE:Fe2+ dimer [cytosol] (Homo sapiens)
RPE:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Homo sapiens)
RPEL1:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
xylulose 5-phosphate <=> D-ribulose 5-phosphate (Homo sapiens)
RPE:Fe2+ dimers [cytosol] (Homo sapiens)
RPE:Fe2+ dimer [cytosol] (Homo sapiens)
RPE:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Homo sapiens)
RPEL1:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Metabolism of lipids (Homo sapiens)
Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
Biosynthesis of DHA-derived SPMs (Homo sapiens)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Biosynthesis of DPA-derived SPMs (Homo sapiens)
Biosynthesis of DPAn-3 SPMs (Homo sapiens)
Biosynthesis of DPAn-3-derived maresins (Homo sapiens)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Biosynthesis of DPAn-6 SPMs (Homo sapiens)
ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Synthesis of Lipoxins (LX) (Homo sapiens)
ALOX12 oxidises LTA4 to LXA4/B4 (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Fatty acid metabolism (Homo sapiens)
Arachidonic acid metabolism (Homo sapiens)
Synthesis of 12-eicosatetraenoic acid derivatives (Homo sapiens)
Arachidonic acid is converted to 12-oxoETE by ALOX12 (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Homo sapiens)
ALOX12B:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Homo sapiens)
ALOX12/15 [cytosol] (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
ALOX15:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Homo sapiens)
Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Homo sapiens)
ALOX15/15B [cytosol] (Homo sapiens)
ALOX15:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
ALOX15B:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (Homo sapiens)
Arachidonic acid is converted to HXA3/B3 by ALOX12 (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Homo sapiens)
ALOX5 is phosphorylated by MAPKAP2 (Homo sapiens)
ALOX5:Ca2+:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
p-S272-ALOX5:Ca2+:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
LTA4 is converted to EXA4 by ALOX15 (Homo sapiens)
ALOX15:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Synthesis of bile acids and bile salts (Homo sapiens)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Homo sapiens)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Homo sapiens)
Fe2+ [cytosol]
Metabolism of nucleotides (Homo sapiens)
Nucleotide biosynthesis (Homo sapiens)
Purine ribonucleoside monophosphate biosynthesis (Homo sapiens)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Homo sapiens)
PPAT dimer [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Homo sapiens)
PPAT dimer [cytosol] (Homo sapiens)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Homo sapiens)
PPAT dimer [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Homo sapiens)
PPAT dimer [cytosol] (Homo sapiens)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Homo sapiens)
PPAT dimer [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Metabolism of porphyrins (Homo sapiens)
Heme degradation (Homo sapiens)
HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)
Fe2+ [cytosol]
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of cofactors (Homo sapiens)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Homo sapiens)
Ferrous iron reduces the BH3 radical back to BH4 (Homo sapiens)
Fe2+ [cytosol]
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
BCMO1:Fe2+ cleaves betaC to atRAL (Homo sapiens)
BCMO1:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Metabolism of RNA (Homo sapiens)
tRNA processing (Homo sapiens)
tRNA modification in the nucleus and cytosol (Homo sapiens)
ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34 (Homo sapiens)
ALKBH8:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Homo sapiens)
Hypusine synthesis from eIF5A-lysine (Homo sapiens)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Homo sapiens)
DOHH:Fe++ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Protein hydroxylation (Homo sapiens)
JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Homo sapiens)
JMJD4:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
JMJD7 dimer hydroxlates a lysine residue of DRG1 (Homo sapiens)
JMJD7 dimer [cytosol] (Homo sapiens)
JMJD7:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
JMJD7 dimer hydroxlates a lysine residue of DRG2 (Homo sapiens)
JMJD7 dimer [cytosol] (Homo sapiens)
JMJD7:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Homo sapiens)
KDM8:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Homo sapiens)
KDM8:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
BCMO1:Fe2+ cleaves betaC to atRAL (Homo sapiens)
BCMO1:Fe2+ [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
DARPP-32 events (Homo sapiens)
DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Homo sapiens)
Phosphorylated (T34) DARPP-32:PP1A [cytosol] (Homo sapiens)
PP1A(Fe and Mn cofactors) [cytosol] (Homo sapiens)
Fe2+ [cytosol]
Transport of small molecules (Homo sapiens)
Iron uptake and transport (Homo sapiens)
ACO1 binds 4Fe-4S (Homo sapiens)
Fe2+ [cytosol]
ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs (Homo sapiens)
Fe2+ [cytosol]
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Homo sapiens)
Fe2+ [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Homo sapiens)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)
Fe2+ [cytosol]
Transferrin endocytosis and recycling (Homo sapiens)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Homo sapiens)
Fe2+ [cytosol]
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Metal ion SLC transporters (Homo sapiens)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Homo sapiens)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Homo sapiens)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)
Fe2+ [cytosol]
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to chemical stress (Mus musculus)
Cytoprotection by HMOX1 (Mus musculus)
HMOX1 dimer, HMOX2 cleave heme (Mus musculus)
Fe2+ [cytosol]
Cellular response to hypoxia (Mus musculus)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Mus musculus)
FIH1:AscH-:Fe2+ dimer [cytosol] (Mus musculus)
FIH1:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Mus musculus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Mus musculus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Proteasome proteolyzes ub-HIF-alpha (Mus musculus)
VBC complex (with or without LIMD1) [cytosol] (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Mus musculus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
Antimicrobial peptides (Mus musculus)
Ion influx/efflux at host-pathogen interface (Mus musculus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Mus musculus)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
ROS and RNS production in phagocytes (Mus musculus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Mus musculus)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
Metabolism (Mus musculus)
Inositol phosphate metabolism (Mus musculus)
Synthesis of IP2, IP, and Ins in the cytosol (Mus musculus)
MIOX oxidises Ins to GlcA (Mus musculus)
MIOX:2xFe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Metabolism of amino acids and derivatives (Mus musculus)
Carnitine synthesis (Mus musculus)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Mus musculus)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Mus musculus)
BBOX1:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Metabolism of amine-derived hormones (Mus musculus)
Catecholamine biosynthesis (Mus musculus)
Tyrosine is hydroxylated to dopa (Mus musculus)
TH:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Serotonin and melatonin biosynthesis (Mus musculus)
Tryptophan is hydroxylated (Mus musculus)
TPH:Fe++ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Phenylalanine and tyrosine metabolism (Mus musculus)
Phenylalanine metabolism (Mus musculus)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Mus musculus)
PAH:Fe2+ tetramer [cytosol] (Mus musculus)
Fe2+ [cytosol]
Tyrosine catabolism (Mus musculus)
HGD dioxygenates homogentisate (Mus musculus)
HGD hexamer [cytosol] (Mus musculus)
Fe2+ [cytosol]
HPD dioxygenates HPP (Mus musculus)
HPD:AscH-:Fe2+ dimer [cytosol] (Mus musculus)
HPD:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
nitisinone:HPD dimer [cytosol] (Mus musculus)
HPD:AscH-:Fe2+ dimer [cytosol] (Mus musculus)
HPD:AscH-:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Sulfur amino acid metabolism (Mus musculus)
Degradation of cysteine and homocysteine (Mus musculus)
ADO oxidises 2AET to HTAU (Mus musculus)
ADO:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Mus musculus)
CDO1:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Methionine salvage pathway (Mus musculus)
Acireductone is oxidized to MOB (Mus musculus)
ARD:Fe++ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Tryptophan catabolism (Mus musculus)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Mus musculus)
HAAO [cytosol] (Mus musculus)
Fe2+ [cytosol]
Metabolism of carbohydrates (Mus musculus)
Pentose phosphate pathway (Mus musculus)
RPE dimers isomerise RU5P to XY5P (Mus musculus)
RPE:Fe2+ dimers [cytosol] (Mus musculus)
RPE:Fe2+ dimer [cytosol] (Mus musculus)
RPE:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Mus musculus)
RPEL1:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
xylulose 5-phosphate <=> D-ribulose 5-phosphate (Mus musculus)
RPE:Fe2+ dimers [cytosol] (Mus musculus)
RPE:Fe2+ dimer [cytosol] (Mus musculus)
RPE:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Mus musculus)
RPEL1:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Metabolism of lipids (Mus musculus)
Biosynthesis of specialized proresolving mediators (SPMs) (Mus musculus)
Biosynthesis of DHA-derived SPMs (Mus musculus)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Mus musculus)
ALOX12:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Mus musculus)
ALOX12:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Biosynthesis of DPA-derived SPMs (Mus musculus)
Biosynthesis of DPAn-3 SPMs (Mus musculus)
Biosynthesis of DPAn-3-derived maresins (Mus musculus)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Mus musculus)
ALOX12:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Mus musculus)
ALOX12:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Biosynthesis of DPAn-6 SPMs (Mus musculus)
ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Mus musculus)
ALOX12:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Synthesis of Lipoxins (LX) (Mus musculus)
ALOX12 oxidises LTA4 to LXA4/B4 (Mus musculus)
ALOX12:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Fatty acid metabolism (Mus musculus)
Arachidonic acid metabolism (Mus musculus)
Synthesis of 12-eicosatetraenoic acid derivatives (Mus musculus)
Arachidonic acid is converted to 12-oxoETE by ALOX12 (Mus musculus)
ALOX12:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Mus musculus)
ALOX12B:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Mus musculus)
ALOX12/15 [cytosol] (Mus musculus)
ALOX12:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
ALOX15:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Mus musculus)
Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Mus musculus)
ALOX15/15B [cytosol] (Mus musculus)
ALOX15:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
ALOX15B:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (Mus musculus)
Arachidonic acid is converted to HXA3/B3 by ALOX12 (Mus musculus)
ALOX12:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Mus musculus)
ALOX5 is phosphorylated by MAPKAP2 (Mus musculus)
ALOX5:Ca2+:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
p-S272-ALOX5:Ca2+:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
LTA4 is converted to EXA4 by ALOX15 (Mus musculus)
ALOX15:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Metabolism of steroids (Mus musculus)
Bile acid and bile salt metabolism (Mus musculus)
Synthesis of bile acids and bile salts (Mus musculus)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Mus musculus)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Mus musculus)
Fe2+ [cytosol]
Metabolism of nucleotides (Mus musculus)
Nucleotide biosynthesis (Mus musculus)
Purine ribonucleoside monophosphate biosynthesis (Mus musculus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Mus musculus)
PPAT dimer [cytosol] (Mus musculus)
Fe2+ [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Mus musculus)
PPAT dimer [cytosol] (Mus musculus)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Mus musculus)
PPAT dimer [cytosol] (Mus musculus)
Fe2+ [cytosol]
Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Mus musculus)
PPAT dimer [cytosol] (Mus musculus)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Mus musculus)
PPAT dimer [cytosol] (Mus musculus)
Fe2+ [cytosol]
Metabolism of porphyrins (Mus musculus)
Heme degradation (Mus musculus)
HMOX1 dimer, HMOX2 cleave heme (Mus musculus)
Fe2+ [cytosol]
Metabolism of vitamins and cofactors (Mus musculus)
Metabolism of fat-soluble vitamins (Mus musculus)
Retinoid metabolism and transport (Mus musculus)
BCMO1:Fe2+ cleaves betaC to atRAL (Mus musculus)
BCMO1:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Mus musculus)
Hypusine synthesis from eIF5A-lysine (Mus musculus)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Mus musculus)
DOHH:Fe++ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Protein hydroxylation (Mus musculus)
JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Mus musculus)
JMJD4:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
JMJD7 dimer hydroxlates a lysine residue of DRG1 (Mus musculus)
JMJD7 dimer [cytosol] (Mus musculus)
JMJD7:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
JMJD7 dimer hydroxlates a lysine residue of DRG2 (Mus musculus)
JMJD7 dimer [cytosol] (Mus musculus)
JMJD7:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Mus musculus)
KDM8:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Mus musculus)
KDM8:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Sensory Perception (Mus musculus)
Visual phototransduction (Mus musculus)
Retinoid metabolism and transport (Mus musculus)
BCMO1:Fe2+ cleaves betaC to atRAL (Mus musculus)
BCMO1:Fe2+ [cytosol] (Mus musculus)
Fe2+ [cytosol]
Signal Transduction (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (i) signalling events (Mus musculus)
Opioid Signalling (Mus musculus)
DARPP-32 events (Mus musculus)
DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Mus musculus)
Phosphorylated (T34) DARPP-32:PP1A [cytosol] (Mus musculus)
PP1A(Fe and Mn cofactors) [cytosol] (Mus musculus)
Fe2+ [cytosol]
Transport of small molecules (Mus musculus)
Iron uptake and transport (Mus musculus)
ACO1 binds 4Fe-4S (Mus musculus)
Fe2+ [cytosol]
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Mus musculus)
Fe2+ [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Mus musculus)
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Mus musculus)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Mus musculus)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Mus musculus)
Fe2+ [cytosol]
Transferrin endocytosis and recycling (Mus musculus)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Mus musculus)
Fe2+ [cytosol]
SLC-mediated transmembrane transport (Mus musculus)
Transport of bile salts and organic acids, metal ions and amine compounds (Mus musculus)
Metal ion SLC transporters (Mus musculus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Mus musculus)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Mus musculus)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Mus musculus)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Mus musculus)
Fe2+ [cytosol]
Immune System (Plasmodium falciparum)
Innate Immune System (Plasmodium falciparum)
Antimicrobial peptides (Plasmodium falciparum)
Ion influx/efflux at host-pathogen interface (Plasmodium falciparum)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Plasmodium falciparum)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
ROS and RNS production in phagocytes (Plasmodium falciparum)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Plasmodium falciparum)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
Metabolism (Plasmodium falciparum)
Metabolism of carbohydrates (Plasmodium falciparum)
Pentose phosphate pathway (Plasmodium falciparum)
RPE dimers isomerise RU5P to XY5P (Plasmodium falciparum)
RPE:Fe2+ dimers [cytosol] (Plasmodium falciparum)
RPE:Fe2+ dimer [cytosol] (Plasmodium falciparum)
RPE:Fe2+ [cytosol] (Plasmodium falciparum)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Plasmodium falciparum)
RPEL1:Fe2+ [cytosol] (Plasmodium falciparum)
Fe2+ [cytosol]
xylulose 5-phosphate <=> D-ribulose 5-phosphate (Plasmodium falciparum)
RPE:Fe2+ dimers [cytosol] (Plasmodium falciparum)
RPE:Fe2+ dimer [cytosol] (Plasmodium falciparum)
RPE:Fe2+ [cytosol] (Plasmodium falciparum)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Plasmodium falciparum)
RPEL1:Fe2+ [cytosol] (Plasmodium falciparum)
Fe2+ [cytosol]
Metabolism of proteins (Plasmodium falciparum)
Post-translational protein modification (Plasmodium falciparum)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Plasmodium falciparum)
Hypusine synthesis from eIF5A-lysine (Plasmodium falciparum)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Plasmodium falciparum)
DOHH:Fe++ [cytosol] (Plasmodium falciparum)
Fe2+ [cytosol]
Transport of small molecules (Plasmodium falciparum)
Iron uptake and transport (Plasmodium falciparum)
ACO1 binds 4Fe-4S (Plasmodium falciparum)
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Plasmodium falciparum)
Fe2+ [cytosol]
SLC-mediated transmembrane transport (Plasmodium falciparum)
Transport of bile salts and organic acids, metal ions and amine compounds (Plasmodium falciparum)
Metal ion SLC transporters (Plasmodium falciparum)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Plasmodium falciparum)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Plasmodium falciparum)
Fe2+ [cytosol]
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to chemical stress (Rattus norvegicus)
Cytoprotection by HMOX1 (Rattus norvegicus)
HMOX1 dimer, HMOX2 cleave heme (Rattus norvegicus)
Fe2+ [cytosol]
Cellular response to hypoxia (Rattus norvegicus)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Rattus norvegicus)
FIH1:AscH-:Fe2+ dimer [cytosol] (Rattus norvegicus)
FIH1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Rattus norvegicus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Rattus norvegicus)
PHD2,3 [cytosol] (Rattus norvegicus)
EGLN1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
PHD2,3 [cytosol] (Rattus norvegicus)
EGLN1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Rattus norvegicus)
PHD2,3 [cytosol] (Rattus norvegicus)
EGLN1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
PHD2,3 [cytosol] (Rattus norvegicus)
EGLN1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Rattus norvegicus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
PHD2,3 [cytosol] (Rattus norvegicus)
EGLN1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
PHD2,3 [cytosol] (Rattus norvegicus)
EGLN1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
PHD2,3 [cytosol] (Rattus norvegicus)
EGLN1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
PHD2,3 [cytosol] (Rattus norvegicus)
EGLN1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Proteasome proteolyzes ub-HIF-alpha (Rattus norvegicus)
VBC complex (with or without LIMD1) [cytosol] (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
PHD2,3 [cytosol] (Rattus norvegicus)
EGLN1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
PHD2,3 [cytosol] (Rattus norvegicus)
EGLN1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Immune System (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Antimicrobial peptides (Rattus norvegicus)
Ion influx/efflux at host-pathogen interface (Rattus norvegicus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Rattus norvegicus)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
ROS and RNS production in phagocytes (Rattus norvegicus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Rattus norvegicus)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
Metabolism (Rattus norvegicus)
Inositol phosphate metabolism (Rattus norvegicus)
Synthesis of IP2, IP, and Ins in the cytosol (Rattus norvegicus)
MIOX oxidises Ins to GlcA (Rattus norvegicus)
MIOX:2xFe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Metabolism of amino acids and derivatives (Rattus norvegicus)
Carnitine synthesis (Rattus norvegicus)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Rattus norvegicus)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Rattus norvegicus)
BBOX1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Metabolism of amine-derived hormones (Rattus norvegicus)
Catecholamine biosynthesis (Rattus norvegicus)
Tyrosine is hydroxylated to dopa (Rattus norvegicus)
TH:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Serotonin and melatonin biosynthesis (Rattus norvegicus)
Tryptophan is hydroxylated (Rattus norvegicus)
TPH:Fe++ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Phenylalanine and tyrosine metabolism (Rattus norvegicus)
Phenylalanine metabolism (Rattus norvegicus)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Rattus norvegicus)
PAH:Fe2+ tetramer [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Tyrosine catabolism (Rattus norvegicus)
HGD dioxygenates homogentisate (Rattus norvegicus)
HGD hexamer [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
HPD dioxygenates HPP (Rattus norvegicus)
HPD:AscH-:Fe2+ dimer [cytosol] (Rattus norvegicus)
HPD:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
nitisinone:HPD dimer [cytosol] (Rattus norvegicus)
HPD:AscH-:Fe2+ dimer [cytosol] (Rattus norvegicus)
HPD:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Sulfur amino acid metabolism (Rattus norvegicus)
Degradation of cysteine and homocysteine (Rattus norvegicus)
ADO oxidises 2AET to HTAU (Rattus norvegicus)
ADO:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Rattus norvegicus)
CDO1:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Methionine salvage pathway (Rattus norvegicus)
Acireductone is oxidized to MOB (Rattus norvegicus)
ARD:Fe++ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Tryptophan catabolism (Rattus norvegicus)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Rattus norvegicus)
HAAO [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Metabolism of carbohydrates (Rattus norvegicus)
Pentose phosphate pathway (Rattus norvegicus)
RPE dimers isomerise RU5P to XY5P (Rattus norvegicus)
RPE:Fe2+ dimers [cytosol] (Rattus norvegicus)
RPE:Fe2+ dimer [cytosol] (Rattus norvegicus)
RPE:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Rattus norvegicus)
RPEL1:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
xylulose 5-phosphate <=> D-ribulose 5-phosphate (Rattus norvegicus)
RPE:Fe2+ dimers [cytosol] (Rattus norvegicus)
RPE:Fe2+ dimer [cytosol] (Rattus norvegicus)
RPE:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Rattus norvegicus)
RPEL1:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Metabolism of lipids (Rattus norvegicus)
Biosynthesis of specialized proresolving mediators (SPMs) (Rattus norvegicus)
Biosynthesis of DHA-derived SPMs (Rattus norvegicus)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Rattus norvegicus)
ALOX12:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Rattus norvegicus)
ALOX12:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Biosynthesis of DPA-derived SPMs (Rattus norvegicus)
Biosynthesis of DPAn-3 SPMs (Rattus norvegicus)
Biosynthesis of DPAn-3-derived maresins (Rattus norvegicus)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Rattus norvegicus)
ALOX12:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Rattus norvegicus)
ALOX12:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Biosynthesis of DPAn-6 SPMs (Rattus norvegicus)
ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Rattus norvegicus)
ALOX12:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Synthesis of Lipoxins (LX) (Rattus norvegicus)
ALOX12 oxidises LTA4 to LXA4/B4 (Rattus norvegicus)
ALOX12:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Fatty acid metabolism (Rattus norvegicus)
Arachidonic acid metabolism (Rattus norvegicus)
Synthesis of 12-eicosatetraenoic acid derivatives (Rattus norvegicus)
Arachidonic acid is converted to 12-oxoETE by ALOX12 (Rattus norvegicus)
ALOX12:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Rattus norvegicus)
ALOX12B:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Rattus norvegicus)
ALOX12/15 [cytosol] (Rattus norvegicus)
ALOX12:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
ALOX15:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Rattus norvegicus)
Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Rattus norvegicus)
ALOX15/15B [cytosol] (Rattus norvegicus)
ALOX15:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
ALOX15B:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (Rattus norvegicus)
Arachidonic acid is converted to HXA3/B3 by ALOX12 (Rattus norvegicus)
ALOX12:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Rattus norvegicus)
ALOX5 is phosphorylated by MAPKAP2 (Rattus norvegicus)
ALOX5:Ca2+:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
p-S272-ALOX5:Ca2+:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
LTA4 is converted to EXA4 by ALOX15 (Rattus norvegicus)
ALOX15:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Metabolism of steroids (Rattus norvegicus)
Bile acid and bile salt metabolism (Rattus norvegicus)
Synthesis of bile acids and bile salts (Rattus norvegicus)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Rattus norvegicus)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Rattus norvegicus)
Fe2+ [cytosol]
Metabolism of nucleotides (Rattus norvegicus)
Nucleotide biosynthesis (Rattus norvegicus)
Purine ribonucleoside monophosphate biosynthesis (Rattus norvegicus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Rattus norvegicus)
PPAT dimer [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Rattus norvegicus)
PPAT dimer [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Rattus norvegicus)
PPAT dimer [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Rattus norvegicus)
PPAT dimer [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Rattus norvegicus)
PPAT dimer [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Metabolism of porphyrins (Rattus norvegicus)
Heme degradation (Rattus norvegicus)
HMOX1 dimer, HMOX2 cleave heme (Rattus norvegicus)
Fe2+ [cytosol]
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of fat-soluble vitamins (Rattus norvegicus)
Retinoid metabolism and transport (Rattus norvegicus)
BCMO1:Fe2+ cleaves betaC to atRAL (Rattus norvegicus)
BCMO1:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Rattus norvegicus)
Hypusine synthesis from eIF5A-lysine (Rattus norvegicus)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Rattus norvegicus)
DOHH:Fe++ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Protein hydroxylation (Rattus norvegicus)
JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Rattus norvegicus)
JMJD4:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
JMJD7 dimer hydroxlates a lysine residue of DRG1 (Rattus norvegicus)
JMJD7 dimer [cytosol] (Rattus norvegicus)
JMJD7:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
JMJD7 dimer hydroxlates a lysine residue of DRG2 (Rattus norvegicus)
JMJD7 dimer [cytosol] (Rattus norvegicus)
JMJD7:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Rattus norvegicus)
KDM8:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Rattus norvegicus)
KDM8:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Sensory Perception (Rattus norvegicus)
Visual phototransduction (Rattus norvegicus)
Retinoid metabolism and transport (Rattus norvegicus)
BCMO1:Fe2+ cleaves betaC to atRAL (Rattus norvegicus)
BCMO1:Fe2+ [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Signal Transduction (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G alpha (i) signalling events (Rattus norvegicus)
Opioid Signalling (Rattus norvegicus)
DARPP-32 events (Rattus norvegicus)
DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Rattus norvegicus)
Phosphorylated (T34) DARPP-32:PP1A [cytosol] (Rattus norvegicus)
PP1A(Fe and Mn cofactors) [cytosol] (Rattus norvegicus)
Fe2+ [cytosol]
Transport of small molecules (Rattus norvegicus)
Iron uptake and transport (Rattus norvegicus)
ACO1 binds 4Fe-4S (Rattus norvegicus)
Fe2+ [cytosol]
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Rattus norvegicus)
Fe2+ [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Rattus norvegicus)
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Rattus norvegicus)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)
Fe2+ [cytosol]
Transferrin endocytosis and recycling (Rattus norvegicus)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Rattus norvegicus)
Fe2+ [cytosol]
SLC-mediated transmembrane transport (Rattus norvegicus)
Transport of bile salts and organic acids, metal ions and amine compounds (Rattus norvegicus)
Metal ion SLC transporters (Rattus norvegicus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Rattus norvegicus)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Rattus norvegicus)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)
Fe2+ [cytosol]
Metabolism (Saccharomyces cerevisiae)
Metabolism of amino acids and derivatives (Saccharomyces cerevisiae)
Carnitine synthesis (Saccharomyces cerevisiae)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Saccharomyces cerevisiae)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Saccharomyces cerevisiae)
BBOX1:AscH-:Fe2+ [cytosol] (Saccharomyces cerevisiae)
Fe2+ [cytosol]
Sulfur amino acid metabolism (Saccharomyces cerevisiae)
Methionine salvage pathway (Saccharomyces cerevisiae)
Acireductone is oxidized to MOB (Saccharomyces cerevisiae)
ARD:Fe++ [cytosol] (Saccharomyces cerevisiae)
Fe2+ [cytosol]
Tryptophan catabolism (Saccharomyces cerevisiae)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Saccharomyces cerevisiae)
HAAO [cytosol] (Saccharomyces cerevisiae)
Fe2+ [cytosol]
Metabolism of carbohydrates (Saccharomyces cerevisiae)
Pentose phosphate pathway (Saccharomyces cerevisiae)
RPE dimers isomerise RU5P to XY5P (Saccharomyces cerevisiae)
RPE:Fe2+ dimers [cytosol] (Saccharomyces cerevisiae)
RPE:Fe2+ dimer [cytosol] (Saccharomyces cerevisiae)
RPE:Fe2+ [cytosol] (Saccharomyces cerevisiae)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Saccharomyces cerevisiae)
RPEL1:Fe2+ [cytosol] (Saccharomyces cerevisiae)
Fe2+ [cytosol]
xylulose 5-phosphate <=> D-ribulose 5-phosphate (Saccharomyces cerevisiae)
RPE:Fe2+ dimers [cytosol] (Saccharomyces cerevisiae)
RPE:Fe2+ dimer [cytosol] (Saccharomyces cerevisiae)
RPE:Fe2+ [cytosol] (Saccharomyces cerevisiae)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Saccharomyces cerevisiae)
RPEL1:Fe2+ [cytosol] (Saccharomyces cerevisiae)
Fe2+ [cytosol]
Metabolism of lipids (Saccharomyces cerevisiae)
Metabolism of steroids (Saccharomyces cerevisiae)
Bile acid and bile salt metabolism (Saccharomyces cerevisiae)
Synthesis of bile acids and bile salts (Saccharomyces cerevisiae)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Saccharomyces cerevisiae)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)
Fe2+ [cytosol]
Metabolism of proteins (Saccharomyces cerevisiae)
Post-translational protein modification (Saccharomyces cerevisiae)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Saccharomyces cerevisiae)
Hypusine synthesis from eIF5A-lysine (Saccharomyces cerevisiae)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Saccharomyces cerevisiae)
DOHH:Fe++ [cytosol] (Saccharomyces cerevisiae)
Fe2+ [cytosol]
Metabolism (Schizosaccharomyces pombe)
Metabolism of amino acids and derivatives (Schizosaccharomyces pombe)
Sulfur amino acid metabolism (Schizosaccharomyces pombe)
Methionine salvage pathway (Schizosaccharomyces pombe)
Acireductone is oxidized to MOB (Schizosaccharomyces pombe)
ARD:Fe++ [cytosol] (Schizosaccharomyces pombe)
Fe2+ [cytosol]
Metabolism of carbohydrates (Schizosaccharomyces pombe)
Pentose phosphate pathway (Schizosaccharomyces pombe)
RPE dimers isomerise RU5P to XY5P (Schizosaccharomyces pombe)
RPE:Fe2+ dimers [cytosol] (Schizosaccharomyces pombe)
RPE:Fe2+ dimer [cytosol] (Schizosaccharomyces pombe)
RPE:Fe2+ [cytosol] (Schizosaccharomyces pombe)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Schizosaccharomyces pombe)
RPEL1:Fe2+ [cytosol] (Schizosaccharomyces pombe)
Fe2+ [cytosol]
xylulose 5-phosphate <=> D-ribulose 5-phosphate (Schizosaccharomyces pombe)
RPE:Fe2+ dimers [cytosol] (Schizosaccharomyces pombe)
RPE:Fe2+ dimer [cytosol] (Schizosaccharomyces pombe)
RPE:Fe2+ [cytosol] (Schizosaccharomyces pombe)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Schizosaccharomyces pombe)
RPEL1:Fe2+ [cytosol] (Schizosaccharomyces pombe)
Fe2+ [cytosol]
Metabolism of lipids (Schizosaccharomyces pombe)
Metabolism of steroids (Schizosaccharomyces pombe)
Bile acid and bile salt metabolism (Schizosaccharomyces pombe)
Synthesis of bile acids and bile salts (Schizosaccharomyces pombe)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Schizosaccharomyces pombe)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)
Fe2+ [cytosol]
Metabolism of proteins (Schizosaccharomyces pombe)
Post-translational protein modification (Schizosaccharomyces pombe)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Schizosaccharomyces pombe)
Hypusine synthesis from eIF5A-lysine (Schizosaccharomyces pombe)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Schizosaccharomyces pombe)
DOHH:Fe++ [cytosol] (Schizosaccharomyces pombe)
Fe2+ [cytosol]
Protein hydroxylation (Schizosaccharomyces pombe)
JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Schizosaccharomyces pombe)
JMJD4:Fe2+ [cytosol] (Schizosaccharomyces pombe)
Fe2+ [cytosol]
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Cellular response to chemical stress (Sus scrofa)
Cytoprotection by HMOX1 (Sus scrofa)
HMOX1 dimer, HMOX2 cleave heme (Sus scrofa)
Fe2+ [cytosol]
Cellular response to hypoxia (Sus scrofa)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Sus scrofa)
FIH1:AscH-:Fe2+ dimer [cytosol] (Sus scrofa)
FIH1:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Sus scrofa)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Sus scrofa)
PHD2,3 [cytosol] (Sus scrofa)
EGLN1:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
PHD2,3 [cytosol] (Sus scrofa)
EGLN1:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Sus scrofa)
PHD2,3 [cytosol] (Sus scrofa)
EGLN1:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
PHD2,3 [cytosol] (Sus scrofa)
EGLN1:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Sus scrofa)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
PHD2,3 [cytosol] (Sus scrofa)
EGLN1:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
PHD2,3 [cytosol] (Sus scrofa)
EGLN1:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
PHD2,3 [cytosol] (Sus scrofa)
EGLN1:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
PHD2,3 [cytosol] (Sus scrofa)
EGLN1:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Proteasome proteolyzes ub-HIF-alpha (Sus scrofa)
VBC complex (with or without LIMD1) [cytosol] (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
PHD2,3 [cytosol] (Sus scrofa)
EGLN1:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
PHD2,3 [cytosol] (Sus scrofa)
EGLN1:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Immune System (Sus scrofa)
Innate Immune System (Sus scrofa)
Antimicrobial peptides (Sus scrofa)
Ion influx/efflux at host-pathogen interface (Sus scrofa)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Sus scrofa)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
ROS and RNS production in phagocytes (Sus scrofa)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Sus scrofa)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
Metabolism (Sus scrofa)
Inositol phosphate metabolism (Sus scrofa)
Synthesis of IP2, IP, and Ins in the cytosol (Sus scrofa)
MIOX oxidises Ins to GlcA (Sus scrofa)
MIOX:2xFe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Metabolism of amino acids and derivatives (Sus scrofa)
Carnitine synthesis (Sus scrofa)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Sus scrofa)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Sus scrofa)
BBOX1:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Metabolism of amine-derived hormones (Sus scrofa)
Catecholamine biosynthesis (Sus scrofa)
Tyrosine is hydroxylated to dopa (Sus scrofa)
TH:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Serotonin and melatonin biosynthesis (Sus scrofa)
Tryptophan is hydroxylated (Sus scrofa)
TPH:Fe++ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Phenylalanine and tyrosine metabolism (Sus scrofa)
Phenylalanine metabolism (Sus scrofa)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Sus scrofa)
PAH:Fe2+ tetramer [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Tyrosine catabolism (Sus scrofa)
HGD dioxygenates homogentisate (Sus scrofa)
HGD hexamer [cytosol] (Sus scrofa)
Fe2+ [cytosol]
HPD dioxygenates HPP (Sus scrofa)
HPD:AscH-:Fe2+ dimer [cytosol] (Sus scrofa)
HPD:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
nitisinone:HPD dimer [cytosol] (Sus scrofa)
HPD:AscH-:Fe2+ dimer [cytosol] (Sus scrofa)
HPD:AscH-:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Sulfur amino acid metabolism (Sus scrofa)
Degradation of cysteine and homocysteine (Sus scrofa)
ADO oxidises 2AET to HTAU (Sus scrofa)
ADO:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Sus scrofa)
CDO1:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Methionine salvage pathway (Sus scrofa)
Acireductone is oxidized to MOB (Sus scrofa)
ARD:Fe++ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Tryptophan catabolism (Sus scrofa)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Sus scrofa)
HAAO [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Metabolism of carbohydrates (Sus scrofa)
Pentose phosphate pathway (Sus scrofa)
RPE dimers isomerise RU5P to XY5P (Sus scrofa)
RPE:Fe2+ dimers [cytosol] (Sus scrofa)
RPE:Fe2+ dimer [cytosol] (Sus scrofa)
RPE:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Sus scrofa)
RPEL1:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
xylulose 5-phosphate <=> D-ribulose 5-phosphate (Sus scrofa)
RPE:Fe2+ dimers [cytosol] (Sus scrofa)
RPE:Fe2+ dimer [cytosol] (Sus scrofa)
RPE:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Sus scrofa)
RPEL1:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Metabolism of lipids (Sus scrofa)
Biosynthesis of specialized proresolving mediators (SPMs) (Sus scrofa)
Biosynthesis of DHA-derived SPMs (Sus scrofa)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Sus scrofa)
ALOX12:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Sus scrofa)
ALOX12:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Biosynthesis of DPA-derived SPMs (Sus scrofa)
Biosynthesis of DPAn-3 SPMs (Sus scrofa)
Biosynthesis of DPAn-3-derived maresins (Sus scrofa)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Sus scrofa)
ALOX12:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Sus scrofa)
ALOX12:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Biosynthesis of DPAn-6 SPMs (Sus scrofa)
ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Sus scrofa)
ALOX12:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Synthesis of Lipoxins (LX) (Sus scrofa)
ALOX12 oxidises LTA4 to LXA4/B4 (Sus scrofa)
ALOX12:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Fatty acid metabolism (Sus scrofa)
Arachidonic acid metabolism (Sus scrofa)
Synthesis of 12-eicosatetraenoic acid derivatives (Sus scrofa)
Arachidonic acid is converted to 12-oxoETE by ALOX12 (Sus scrofa)
ALOX12:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Sus scrofa)
ALOX12B:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Sus scrofa)
ALOX12/15 [cytosol] (Sus scrofa)
ALOX12:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
ALOX15:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Sus scrofa)
Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Sus scrofa)
ALOX15/15B [cytosol] (Sus scrofa)
ALOX15:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
ALOX15B:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (Sus scrofa)
Arachidonic acid is converted to HXA3/B3 by ALOX12 (Sus scrofa)
ALOX12:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Sus scrofa)
ALOX5 is phosphorylated by MAPKAP2 (Sus scrofa)
ALOX5:Ca2+:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
p-S272-ALOX5:Ca2+:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
LTA4 is converted to EXA4 by ALOX15 (Sus scrofa)
ALOX15:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Metabolism of steroids (Sus scrofa)
Bile acid and bile salt metabolism (Sus scrofa)
Synthesis of bile acids and bile salts (Sus scrofa)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Sus scrofa)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Sus scrofa)
Fe2+ [cytosol]
Metabolism of nucleotides (Sus scrofa)
Nucleotide biosynthesis (Sus scrofa)
Purine ribonucleoside monophosphate biosynthesis (Sus scrofa)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Sus scrofa)
PPAT dimer [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Sus scrofa)
PPAT dimer [cytosol] (Sus scrofa)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Sus scrofa)
PPAT dimer [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Sus scrofa)
PPAT dimer [cytosol] (Sus scrofa)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Sus scrofa)
PPAT dimer [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Metabolism of porphyrins (Sus scrofa)
Heme degradation (Sus scrofa)
HMOX1 dimer, HMOX2 cleave heme (Sus scrofa)
Fe2+ [cytosol]
Metabolism of vitamins and cofactors (Sus scrofa)
Metabolism of fat-soluble vitamins (Sus scrofa)
Retinoid metabolism and transport (Sus scrofa)
BCMO1:Fe2+ cleaves betaC to atRAL (Sus scrofa)
BCMO1:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Metabolism of proteins (Sus scrofa)
Post-translational protein modification (Sus scrofa)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Sus scrofa)
Hypusine synthesis from eIF5A-lysine (Sus scrofa)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Sus scrofa)
DOHH:Fe++ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Protein hydroxylation (Sus scrofa)
JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Sus scrofa)
JMJD4:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
JMJD7 dimer hydroxlates a lysine residue of DRG1 (Sus scrofa)
JMJD7 dimer [cytosol] (Sus scrofa)
JMJD7:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
JMJD7 dimer hydroxlates a lysine residue of DRG2 (Sus scrofa)
JMJD7 dimer [cytosol] (Sus scrofa)
JMJD7:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Sus scrofa)
KDM8:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Sus scrofa)
KDM8:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Sensory Perception (Sus scrofa)
Visual phototransduction (Sus scrofa)
Retinoid metabolism and transport (Sus scrofa)
BCMO1:Fe2+ cleaves betaC to atRAL (Sus scrofa)
BCMO1:Fe2+ [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Signal Transduction (Sus scrofa)
Signaling by GPCR (Sus scrofa)
GPCR downstream signalling (Sus scrofa)
G alpha (i) signalling events (Sus scrofa)
Opioid Signalling (Sus scrofa)
DARPP-32 events (Sus scrofa)
DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Sus scrofa)
Phosphorylated (T34) DARPP-32:PP1A [cytosol] (Sus scrofa)
PP1A(Fe and Mn cofactors) [cytosol] (Sus scrofa)
Fe2+ [cytosol]
Transport of small molecules (Sus scrofa)
Iron uptake and transport (Sus scrofa)
ACO1 binds 4Fe-4S (Sus scrofa)
Fe2+ [cytosol]
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Sus scrofa)
Fe2+ [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Sus scrofa)
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Sus scrofa)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)
Fe2+ [cytosol]
Transferrin endocytosis and recycling (Sus scrofa)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Sus scrofa)
Fe2+ [cytosol]
SLC-mediated transmembrane transport (Sus scrofa)
Transport of bile salts and organic acids, metal ions and amine compounds (Sus scrofa)
Metal ion SLC transporters (Sus scrofa)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Sus scrofa)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Sus scrofa)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)
Fe2+ [cytosol]
Cellular responses to stimuli (Xenopus tropicalis)
Cellular responses to stress (Xenopus tropicalis)
Cellular response to chemical stress (Xenopus tropicalis)
Cytoprotection by HMOX1 (Xenopus tropicalis)
HMOX1 dimer, HMOX2 cleave heme (Xenopus tropicalis)
Fe2+ [cytosol]
Cellular response to hypoxia (Xenopus tropicalis)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Xenopus tropicalis)
FIH1:AscH-:Fe2+ dimer [cytosol] (Xenopus tropicalis)
FIH1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Xenopus tropicalis)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Xenopus tropicalis)
PHD2,3 [cytosol] (Xenopus tropicalis)
EGLN1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Xenopus tropicalis)
PHD2,3 [cytosol] (Xenopus tropicalis)
EGLN1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Xenopus tropicalis)
PHD2,3 [cytosol] (Xenopus tropicalis)
EGLN1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Xenopus tropicalis)
PHD2,3 [cytosol] (Xenopus tropicalis)
EGLN1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Xenopus tropicalis)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Xenopus tropicalis)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Xenopus tropicalis)
PHD2,3 [cytosol] (Xenopus tropicalis)
EGLN1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Xenopus tropicalis)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Xenopus tropicalis)
PHD2,3 [cytosol] (Xenopus tropicalis)
EGLN1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Xenopus tropicalis)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Xenopus tropicalis)
PHD2,3 [cytosol] (Xenopus tropicalis)
EGLN1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Xenopus tropicalis)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Xenopus tropicalis)
PHD2,3 [cytosol] (Xenopus tropicalis)
EGLN1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
Immune System (Xenopus tropicalis)
Innate Immune System (Xenopus tropicalis)
Antimicrobial peptides (Xenopus tropicalis)
Ion influx/efflux at host-pathogen interface (Xenopus tropicalis)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Xenopus tropicalis)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
ROS and RNS production in phagocytes (Xenopus tropicalis)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Xenopus tropicalis)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
Metabolism (Xenopus tropicalis)
Metabolism of amino acids and derivatives (Xenopus tropicalis)
Carnitine synthesis (Xenopus tropicalis)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Xenopus tropicalis)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Xenopus tropicalis)
BBOX1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
Metabolism of amine-derived hormones (Xenopus tropicalis)
Catecholamine biosynthesis (Xenopus tropicalis)
Tyrosine is hydroxylated to dopa (Xenopus tropicalis)
TH:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
Phenylalanine and tyrosine metabolism (Xenopus tropicalis)
Phenylalanine metabolism (Xenopus tropicalis)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Xenopus tropicalis)
PAH:Fe2+ tetramer [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
Tyrosine catabolism (Xenopus tropicalis)
HPD dioxygenates HPP (Xenopus tropicalis)
HPD:AscH-:Fe2+ dimer [cytosol] (Xenopus tropicalis)
HPD:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
nitisinone:HPD dimer [cytosol] (Xenopus tropicalis)
HPD:AscH-:Fe2+ dimer [cytosol] (Xenopus tropicalis)
HPD:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
Sulfur amino acid metabolism (Xenopus tropicalis)
Degradation of cysteine and homocysteine (Xenopus tropicalis)
ADO oxidises 2AET to HTAU (Xenopus tropicalis)
ADO:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Xenopus tropicalis)
CDO1:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
Methionine salvage pathway (Xenopus tropicalis)
Acireductone is oxidized to MOB (Xenopus tropicalis)
ARD:Fe++ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
Tryptophan catabolism (Xenopus tropicalis)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Xenopus tropicalis)
HAAO [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
Metabolism of carbohydrates (Xenopus tropicalis)
Pentose phosphate pathway (Xenopus tropicalis)
RPE dimers isomerise RU5P to XY5P (Xenopus tropicalis)
RPE:Fe2+ dimers [cytosol] (Xenopus tropicalis)
RPE:Fe2+ dimer [cytosol] (Xenopus tropicalis)
RPE:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Xenopus tropicalis)
RPEL1:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
xylulose 5-phosphate <=> D-ribulose 5-phosphate (Xenopus tropicalis)
RPE:Fe2+ dimers [cytosol] (Xenopus tropicalis)
RPE:Fe2+ dimer [cytosol] (Xenopus tropicalis)
RPE:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
RPEL1:Fe2+ dimer [cytosol] (Xenopus tropicalis)
RPEL1:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
Metabolism of lipids (Xenopus tropicalis)
Fatty acid metabolism (Xenopus tropicalis)
Arachidonic acid metabolism (Xenopus tropicalis)
Synthesis of 12-eicosatetraenoic acid derivatives (Xenopus tropicalis)
Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Xenopus tropicalis)
ALOX12B:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Xenopus tropicalis)
Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Xenopus tropicalis)
ALOX15B:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
Metabolism of steroids (Xenopus tropicalis)
Bile acid and bile salt metabolism (Xenopus tropicalis)
Synthesis of bile acids and bile salts (Xenopus tropicalis)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Xenopus tropicalis)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Xenopus tropicalis)
Fe2+ [cytosol]
Metabolism of nucleotides (Xenopus tropicalis)
Nucleotide biosynthesis (Xenopus tropicalis)
Purine ribonucleoside monophosphate biosynthesis (Xenopus tropicalis)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Xenopus tropicalis)
PPAT dimer [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Xenopus tropicalis)
PPAT dimer [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Xenopus tropicalis)
PPAT dimer [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Xenopus tropicalis)
PPAT dimer [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
PPAT tetramer [cytosol] (Xenopus tropicalis)
PPAT dimer [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
Metabolism of porphyrins (Xenopus tropicalis)
Heme degradation (Xenopus tropicalis)
HMOX1 dimer, HMOX2 cleave heme (Xenopus tropicalis)
Fe2+ [cytosol]
Metabolism of vitamins and cofactors (Xenopus tropicalis)
Metabolism of fat-soluble vitamins (Xenopus tropicalis)
Retinoid metabolism and transport (Xenopus tropicalis)
BCMO1:Fe2+ cleaves betaC to atRAL (Xenopus tropicalis)
BCMO1:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
Metabolism of proteins (Xenopus tropicalis)
Post-translational protein modification (Xenopus tropicalis)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Xenopus tropicalis)
Hypusine synthesis from eIF5A-lysine (Xenopus tropicalis)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Xenopus tropicalis)
DOHH:Fe++ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
Protein hydroxylation (Xenopus tropicalis)
JMJD7 dimer hydroxlates a lysine residue of DRG1 (Xenopus tropicalis)
JMJD7 dimer [cytosol] (Xenopus tropicalis)
JMJD7:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
JMJD7 dimer hydroxlates a lysine residue of DRG2 (Xenopus tropicalis)
JMJD7 dimer [cytosol] (Xenopus tropicalis)
JMJD7:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Xenopus tropicalis)
KDM8:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Xenopus tropicalis)
KDM8:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
Sensory Perception (Xenopus tropicalis)
Visual phototransduction (Xenopus tropicalis)
Retinoid metabolism and transport (Xenopus tropicalis)
BCMO1:Fe2+ cleaves betaC to atRAL (Xenopus tropicalis)
BCMO1:Fe2+ [cytosol] (Xenopus tropicalis)
Fe2+ [cytosol]
Transport of small molecules (Xenopus tropicalis)
Iron uptake and transport (Xenopus tropicalis)
ACO1 binds 4Fe-4S (Xenopus tropicalis)
Fe2+ [cytosol]
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Xenopus tropicalis)
Fe2+ [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Xenopus tropicalis)
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Xenopus tropicalis)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Xenopus tropicalis)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Xenopus tropicalis)
Fe2+ [cytosol]
Transferrin endocytosis and recycling (Xenopus tropicalis)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Xenopus tropicalis)
Fe2+ [cytosol]
SLC-mediated transmembrane transport (Xenopus tropicalis)
Transport of bile salts and organic acids, metal ions and amine compounds (Xenopus tropicalis)
Metal ion SLC transporters (Xenopus tropicalis)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Xenopus tropicalis)
Divalent metals transported by NRAMP1 [cytosol]
Fe2+ [cytosol]
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Xenopus tropicalis)
Fe2+ [cytosol]
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Xenopus tropicalis)
Fe2+ [cytosol]
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Xenopus tropicalis)
Fe2+ [cytosol]
External Reference Information
External Reference
iron(2+) [ChEBI:29033]
Participates
as a component of
ALKBH8:Fe2+ [cytosol] (Homo sapiens)
ALOX12B:Fe2+ [cytosol] (Gallus gallus)
ALOX12B:Fe2+ [cytosol] (Xenopus tropicalis)
ALOX12B:Fe2+ [cytosol] (Rattus norvegicus)
ALOX12B:Fe2+ [cytosol] (Danio rerio)
ALOX12B:Fe2+ [cytosol] (Sus scrofa)
ALOX12B:Fe2+ [cytosol] (Bos taurus)
ALOX12B:Fe2+ [cytosol] (Mus musculus)
ALOX12B:Fe2+ [cytosol] (Canis familiaris)
ALOX12B:Fe2+ [cytosol] (Dictyostelium discoideum)
ALOX12B:Fe2+ [cytosol] (Homo sapiens)
MIOX:2xFe2+ [cytosol] (Rattus norvegicus)
MIOX:2xFe2+ [cytosol] (Gallus gallus)
MIOX:2xFe2+ [cytosol] (Canis familiaris)
MIOX:2xFe2+ [cytosol] (Dictyostelium discoideum)
MIOX:2xFe2+ [cytosol] (Danio rerio)
MIOX:2xFe2+ [cytosol] (Bos taurus)
MIOX:2xFe2+ [cytosol] (Sus scrofa)
MIOX:2xFe2+ [cytosol] (Caenorhabditis elegans)
MIOX:2xFe2+ [cytosol] (Drosophila melanogaster)
MIOX:2xFe2+ [cytosol] (Mus musculus)
MIOX:2xFe2+ [cytosol] (Homo sapiens)
BCMO1:Fe2+ [cytosol] (Xenopus tropicalis)
BCMO1:Fe2+ [cytosol] (Canis familiaris)
BCMO1:Fe2+ [cytosol] (Caenorhabditis elegans)
BCMO1:Fe2+ [cytosol] (Rattus norvegicus)
BCMO1:Fe2+ [cytosol] (Gallus gallus)
BCMO1:Fe2+ [cytosol] (Sus scrofa)
BCMO1:Fe2+ [cytosol] (Drosophila melanogaster)
BCMO1:Fe2+ [cytosol] (Bos taurus)
BCMO1:Fe2+ [cytosol] (Mus musculus)
BCMO1:Fe2+ [cytosol] (Danio rerio)
BCMO1:Fe2+ [cytosol] (Homo sapiens)
PAH S40L:Fe2+ tetramer [cytosol] (Homo sapiens)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Gallus gallus)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Mus musculus)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Danio rerio)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Rattus norvegicus)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Xenopus tropicalis)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Sus scrofa)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Caenorhabditis elegans)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Dictyostelium discoideum)
CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane] (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Rattus norvegicus)
ALOX12:Fe2+ [cytosol] (Danio rerio)
ALOX12:Fe2+ [cytosol] (Dictyostelium discoideum)
ALOX12:Fe2+ [cytosol] (Sus scrofa)
ALOX12:Fe2+ [cytosol] (Canis familiaris)
ALOX12:Fe2+ [cytosol] (Mus musculus)
ALOX12:Fe2+ [cytosol] (Bos taurus)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
p-S272-ALOX5:Ca2+:Fe2+ [cytosol] (Dictyostelium discoideum)
p-S272-ALOX5:Ca2+:Fe2+ [cytosol] (Canis familiaris)
p-S272-ALOX5:Ca2+:Fe2+ [cytosol] (Bos taurus)
p-S272-ALOX5:Ca2+:Fe2+ [cytosol] (Danio rerio)
p-S272-ALOX5:Ca2+:Fe2+ [cytosol] (Rattus norvegicus)
p-S272-ALOX5:Ca2+:Fe2+ [cytosol] (Xenopus tropicalis)
p-S272-ALOX5:Ca2+:Fe2+ [cytosol] (Mus musculus)
p-S272-ALOX5:Ca2+:Fe2+ [cytosol] (Gallus gallus)
p-S272-ALOX5:Ca2+:Fe2+ [cytosol] (Sus scrofa)
p-S272-ALOX5:Ca2+:Fe2+ [cytosol] (Homo sapiens)
ALOX5:Ca2+:Fe2+ [cytosol] (Xenopus tropicalis)
ALOX5:Ca2+:Fe2+ [cytosol] (Bos taurus)
ALOX5:Ca2+:Fe2+ [cytosol] (Gallus gallus)
ALOX5:Ca2+:Fe2+ [cytosol] (Canis familiaris)
ALOX5:Ca2+:Fe2+ [cytosol] (Mus musculus)
ALOX5:Ca2+:Fe2+ [cytosol] (Sus scrofa)
ALOX5:Ca2+:Fe2+ [cytosol] (Dictyostelium discoideum)
ALOX5:Ca2+:Fe2+ [cytosol] (Danio rerio)
ALOX5:Ca2+:Fe2+ [cytosol] (Rattus norvegicus)
ALOX5:Ca2+:Fe2+ [cytosol] (Homo sapiens)
JMJD4:Fe2+ [cytosol] (Danio rerio)
JMJD4:Fe2+ [cytosol] (Drosophila melanogaster)
JMJD4:Fe2+ [cytosol] (Rattus norvegicus)
JMJD4:Fe2+ [cytosol] (Bos taurus)
JMJD4:Fe2+ [cytosol] (Gallus gallus)
JMJD4:Fe2+ [cytosol] (Schizosaccharomyces pombe)
JMJD4:Fe2+ [cytosol] (Caenorhabditis elegans)
JMJD4:Fe2+ [cytosol] (Sus scrofa)
JMJD4:Fe2+ [cytosol] (Canis familiaris)
JMJD4:Fe2+ [cytosol] (Mus musculus)
JMJD4:Fe2+ [cytosol] (Homo sapiens)
JMJD7:Fe2+ [cytosol] (Xenopus tropicalis)
JMJD7:Fe2+ [cytosol] (Mus musculus)
JMJD7:Fe2+ [cytosol] (Drosophila melanogaster)
JMJD7:Fe2+ [cytosol] (Danio rerio)
JMJD7:Fe2+ [cytosol] (Bos taurus)
JMJD7:Fe2+ [cytosol] (Dictyostelium discoideum)
JMJD7:Fe2+ [cytosol] (Sus scrofa)
JMJD7:Fe2+ [cytosol] (Canis familiaris)
JMJD7:Fe2+ [cytosol] (Rattus norvegicus)
JMJD7:Fe2+ [cytosol] (Gallus gallus)
JMJD7:Fe2+ [cytosol] (Homo sapiens)
KDM8:Fe2+ [cytosol] (Danio rerio)
KDM8:Fe2+ [cytosol] (Caenorhabditis elegans)
KDM8:Fe2+ [cytosol] (Dictyostelium discoideum)
KDM8:Fe2+ [cytosol] (Xenopus tropicalis)
KDM8:Fe2+ [cytosol] (Sus scrofa)
KDM8:Fe2+ [cytosol] (Canis familiaris)
KDM8:Fe2+ [cytosol] (Gallus gallus)
KDM8:Fe2+ [cytosol] (Mus musculus)
KDM8:Fe2+ [cytosol] (Bos taurus)
KDM8:Fe2+ [cytosol] (Rattus norvegicus)
KDM8:Fe2+ [cytosol] (Drosophila melanogaster)
KDM8:Fe2+ [cytosol] (Homo sapiens)
DOHH:Fe++ [cytosol] (Gallus gallus)
DOHH:Fe++ [cytosol] (Sus scrofa)
DOHH:Fe++ [cytosol] (Bos taurus)
DOHH:Fe++ [cytosol] (Saccharomyces cerevisiae)
DOHH:Fe++ [cytosol] (Danio rerio)
DOHH:Fe++ [cytosol] (Xenopus tropicalis)
DOHH:Fe++ [cytosol] (Plasmodium falciparum)
DOHH:Fe++ [cytosol] (Dictyostelium discoideum)
DOHH:Fe++ [cytosol] (Canis familiaris)
DOHH:Fe++ [cytosol] (Mus musculus)
DOHH:Fe++ [cytosol] (Drosophila melanogaster)
DOHH:Fe++ [cytosol] (Caenorhabditis elegans)
DOHH:Fe++ [cytosol] (Schizosaccharomyces pombe)
DOHH:Fe++ [cytosol] (Rattus norvegicus)
DOHH:Fe++ [cytosol] (Homo sapiens)
SodB tetramer [cytosol] (Mycobacterium tuberculosis)
PP1A(Fe and Mn cofactors) [cytosol] (Canis familiaris)
PP1A(Fe and Mn cofactors) [cytosol] (Mus musculus)
PP1A(Fe and Mn cofactors) [cytosol] (Rattus norvegicus)
PP1A(Fe and Mn cofactors) [cytosol] (Bos taurus)
PP1A(Fe and Mn cofactors) [cytosol] (Sus scrofa)
PP1A(Fe and Mn cofactors) [cytosol] (Homo sapiens)
BBOX1:AscH-:Fe2+ [cytosol] (Gallus gallus)
BBOX1:AscH-:Fe2+ [cytosol] (Canis familiaris)
BBOX1:AscH-:Fe2+ [cytosol] (Saccharomyces cerevisiae)
BBOX1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
BBOX1:AscH-:Fe2+ [cytosol] (Danio rerio)
BBOX1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
BBOX1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
BBOX1:AscH-:Fe2+ [cytosol] (Sus scrofa)
BBOX1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
BBOX1:AscH-:Fe2+ [cytosol] (Mus musculus)
BBOX1:AscH-:Fe2+ [cytosol] (Bos taurus)
BBOX1:AscH-:Fe2+ [cytosol] (Homo sapiens)
ARD:Fe++ [cytosol] (Gallus gallus)
ARD:Fe++ [cytosol] (Caenorhabditis elegans)
ARD:Fe++ [cytosol] (Mus musculus)
ARD:Fe++ [cytosol] (Schizosaccharomyces pombe)
ARD:Fe++ [cytosol] (Canis familiaris)
ARD:Fe++ [cytosol] (Rattus norvegicus)
ARD:Fe++ [cytosol] (Saccharomyces cerevisiae)
ARD:Fe++ [cytosol] (Bos taurus)
ARD:Fe++ [cytosol] (Drosophila melanogaster)
ARD:Fe++ [cytosol] (Danio rerio)
ARD:Fe++ [cytosol] (Xenopus tropicalis)
ARD:Fe++ [cytosol] (Sus scrofa)
ARD:Fe++ [cytosol] (Dictyostelium discoideum)
ARD:Fe++ [cytosol] (Homo sapiens)
ADO:Fe2+ [cytosol] (Dictyostelium discoideum)
ADO:Fe2+ [cytosol] (Xenopus tropicalis)
ADO:Fe2+ [cytosol] (Sus scrofa)
ADO:Fe2+ [cytosol] (Bos taurus)
ADO:Fe2+ [cytosol] (Drosophila melanogaster)
ADO:Fe2+ [cytosol] (Mus musculus)
ADO:Fe2+ [cytosol] (Caenorhabditis elegans)
ADO:Fe2+ [cytosol] (Canis familiaris)
ADO:Fe2+ [cytosol] (Rattus norvegicus)
ADO:Fe2+ [cytosol] (Danio rerio)
ADO:Fe2+ [cytosol] (Homo sapiens)
CDO1:Fe2+ [cytosol] (Dictyostelium discoideum)
CDO1:Fe2+ [cytosol] (Rattus norvegicus)
CDO1:Fe2+ [cytosol] (Canis familiaris)
CDO1:Fe2+ [cytosol] (Caenorhabditis elegans)
CDO1:Fe2+ [cytosol] (Drosophila melanogaster)
CDO1:Fe2+ [cytosol] (Sus scrofa)
CDO1:Fe2+ [cytosol] (Xenopus tropicalis)
CDO1:Fe2+ [cytosol] (Gallus gallus)
CDO1:Fe2+ [cytosol] (Danio rerio)
CDO1:Fe2+ [cytosol] (Mus musculus)
CDO1:Fe2+ [cytosol] (Bos taurus)
CDO1:Fe2+ [cytosol] (Homo sapiens)
HAAO [cytosol] (Bos taurus)
HAAO [cytosol] (Dictyostelium discoideum)
HAAO [cytosol] (Xenopus tropicalis)
HAAO [cytosol] (Gallus gallus)
HAAO [cytosol] (Rattus norvegicus)
HAAO [cytosol] (Caenorhabditis elegans)
HAAO [cytosol] (Sus scrofa)
HAAO [cytosol] (Mus musculus)
HAAO [cytosol] (Canis familiaris)
HAAO [cytosol] (Saccharomyces cerevisiae)
HAAO [cytosol] (Danio rerio)
HAAO [cytosol] (Homo sapiens)
HGD hexamer [cytosol] (Sus scrofa)
HGD hexamer [cytosol] (Rattus norvegicus)
HGD hexamer [cytosol] (Mus musculus)
HGD hexamer [cytosol] (Dictyostelium discoideum)
HGD hexamer [cytosol] (Drosophila melanogaster)
HGD hexamer [cytosol] (Bos taurus)
HGD hexamer [cytosol] (Caenorhabditis elegans)
HGD hexamer [cytosol] (Gallus gallus)
HGD hexamer [cytosol] (Danio rerio)
HGD hexamer [cytosol] (Homo sapiens)
HPD:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
HPD:AscH-:Fe2+ [cytosol] (Dictyostelium discoideum)
HPD:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
HPD:AscH-:Fe2+ [cytosol] (Bos taurus)
HPD:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
HPD:AscH-:Fe2+ [cytosol] (Mus musculus)
HPD:AscH-:Fe2+ [cytosol] (Sus scrofa)
HPD:AscH-:Fe2+ [cytosol] (Gallus gallus)
HPD:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
HPD:AscH-:Fe2+ [cytosol] (Danio rerio)
HPD:AscH-:Fe2+ [cytosol] (Homo sapiens)
PAH:Fe2+ tetramer [cytosol] (Sus scrofa)
PAH:Fe2+ tetramer [cytosol] (Rattus norvegicus)
PAH:Fe2+ tetramer [cytosol] (Mus musculus)
PAH:Fe2+ tetramer [cytosol] (Bos taurus)
PAH:Fe2+ tetramer [cytosol] (Xenopus tropicalis)
PAH:Fe2+ tetramer [cytosol] (Danio rerio)
PAH:Fe2+ tetramer [cytosol] (Dictyostelium discoideum)
PAH:Fe2+ tetramer [cytosol] (Caenorhabditis elegans)
PAH:Fe2+ tetramer [cytosol] (Gallus gallus)
PAH:Fe2+ tetramer [cytosol] (Drosophila melanogaster)
PAH:Fe2+ tetramer [cytosol] (Homo sapiens)
PAH:Fe2+ tetramer [cytosol] (Canis familiaris)
HPD:AscH-:Fe2+ [cytosol] (Canis familiaris)
HGD hexamer [cytosol] (Canis familiaris)
PPAT dimer [cytosol] (Mus musculus)
PPAT dimer [cytosol] (Drosophila melanogaster)
PPAT dimer [cytosol] (Caenorhabditis elegans)
PPAT dimer [cytosol] (Danio rerio)
PPAT dimer [cytosol] (Bos taurus)
PPAT dimer [cytosol] (Xenopus tropicalis)
PPAT dimer [cytosol] (Sus scrofa)
PPAT dimer [cytosol] (Canis familiaris)
PPAT dimer [cytosol] (Gallus gallus)
PPAT dimer [cytosol] (Homo sapiens)
PPAT dimer [cytosol] (Rattus norvegicus)
TH:Fe2+ [cytosol] (Canis familiaris)
TH:Fe2+ [cytosol] (Mus musculus)
TH:Fe2+ [cytosol] (Danio rerio)
TH:Fe2+ [cytosol] (Rattus norvegicus)
TH:Fe2+ [cytosol] (Dictyostelium discoideum)
TH:Fe2+ [cytosol] (Caenorhabditis elegans)
TH:Fe2+ [cytosol] (Gallus gallus)
TH:Fe2+ [cytosol] (Sus scrofa)
TH:Fe2+ [cytosol] (Bos taurus)
TH:Fe2+ [cytosol] (Drosophila melanogaster)
TH:Fe2+ [cytosol] (Xenopus tropicalis)
TH:Fe2+ [cytosol] (Homo sapiens)
FIH1:AscH-:Fe2+ [cytosol] (Gallus gallus)
FIH1:AscH-:Fe2+ [cytosol] (Danio rerio)
FIH1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
FIH1:AscH-:Fe2+ [cytosol] (Mus musculus)
FIH1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
FIH1:AscH-:Fe2+ [cytosol] (Canis familiaris)
FIH1:AscH-:Fe2+ [cytosol] (Sus scrofa)
FIH1:AscH-:Fe2+ [cytosol] (Bos taurus)
FIH1:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
EGLN3:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
EGLN3:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
EGLN3:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
EGLN1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
EGLN1:AscH-:Fe2+ [cytosol] (Sus scrofa)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Canis familiaris)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN3:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
ALOX15B:Fe2+ [cytosol] (Gallus gallus)
ALOX15B:Fe2+ [cytosol] (Xenopus tropicalis)
ALOX15B:Fe2+ [cytosol] (Danio rerio)
ALOX15B:Fe2+ [cytosol] (Mus musculus)
ALOX15B:Fe2+ [cytosol] (Bos taurus)
ALOX15B:Fe2+ [cytosol] (Canis familiaris)
ALOX15B:Fe2+ [cytosol] (Sus scrofa)
ALOX15B:Fe2+ [cytosol] (Rattus norvegicus)
ALOX15B:Fe2+ [cytosol] (Dictyostelium discoideum)
ALOX15B:Fe2+ [cytosol] (Homo sapiens)
ALOX15:Fe2+ [cytosol] (Dictyostelium discoideum)
ALOX15:Fe2+ [cytosol] (Canis familiaris)
ALOX15:Fe2+ [cytosol] (Rattus norvegicus)
RPEL1:Fe2+ [cytosol] (Homo sapiens)
RPEL1:Fe2+ [cytosol] (Schizosaccharomyces pombe)
RPEL1:Fe2+ [cytosol] (Rattus norvegicus)
RPEL1:Fe2+ [cytosol] (Bos taurus)
RPEL1:Fe2+ [cytosol] (Drosophila melanogaster)
RPEL1:Fe2+ [cytosol] (Xenopus tropicalis)
RPEL1:Fe2+ [cytosol] (Caenorhabditis elegans)
RPEL1:Fe2+ [cytosol] (Danio rerio)
RPEL1:Fe2+ [cytosol] (Dictyostelium discoideum)
RPEL1:Fe2+ [cytosol] (Mus musculus)
RPEL1:Fe2+ [cytosol] (Gallus gallus)
RPEL1:Fe2+ [cytosol] (Plasmodium falciparum)
RPEL1:Fe2+ [cytosol] (Canis familiaris)
RPEL1:Fe2+ [cytosol] (Saccharomyces cerevisiae)
RPEL1:Fe2+ [cytosol] (Sus scrofa)
RPE:Fe2+ [cytosol] (Homo sapiens)
RPE:Fe2+ [cytosol] (Canis familiaris)
RPE:Fe2+ [cytosol] (Xenopus tropicalis)
RPE:Fe2+ [cytosol] (Sus scrofa)
RPE:Fe2+ [cytosol] (Caenorhabditis elegans)
RPE:Fe2+ [cytosol] (Dictyostelium discoideum)
RPE:Fe2+ [cytosol] (Gallus gallus)
RPE:Fe2+ [cytosol] (Bos taurus)
RPE:Fe2+ [cytosol] (Rattus norvegicus)
RPE:Fe2+ [cytosol] (Danio rerio)
RPE:Fe2+ [cytosol] (Plasmodium falciparum)
RPE:Fe2+ [cytosol] (Saccharomyces cerevisiae)
RPE:Fe2+ [cytosol] (Mus musculus)
RPE:Fe2+ [cytosol] (Schizosaccharomyces pombe)
RPE:Fe2+ [cytosol] (Drosophila melanogaster)
TPH:Fe++ [cytosol] (Homo sapiens)
TPH:Fe++ [cytosol] (Caenorhabditis elegans)
TPH:Fe++ [cytosol] (Bos taurus)
TPH:Fe++ [cytosol] (Drosophila melanogaster)
TPH:Fe++ [cytosol] (Sus scrofa)
TPH:Fe++ [cytosol] (Danio rerio)
TPH:Fe++ [cytosol] (Gallus gallus)
TPH:Fe++ [cytosol] (Dictyostelium discoideum)
TPH:Fe++ [cytosol] (Rattus norvegicus)
TPH:Fe++ [cytosol] (Mus musculus)
TPH:Fe++ [cytosol] (Canis familiaris)
ALOX15:Fe2+ [cytosol] (Homo sapiens)
ALOX15:Fe2+ [cytosol] (Sus scrofa)
ALOX15:Fe2+ [cytosol] (Danio rerio)
ALOX15:Fe2+ [cytosol] (Bos taurus)
ALOX15:Fe2+ [cytosol] (Mus musculus)
as an input of
Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region (Homo sapiens)
BfrB stores iron (Homo sapiens)
BfrA stores iron (Homo sapiens)
Hydrogen peroxide and Fe2+ react to hydroxyl, hydroxide and Fe3+ (Homo sapiens)
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Xenopus tropicalis)
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Danio rerio)
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Mus musculus)
SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Caenorhabditis elegans)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Gallus gallus)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Xenopus tropicalis)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Danio rerio)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Sus scrofa)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Bos taurus)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Canis familiaris)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Rattus norvegicus)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Mus musculus)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Homo sapiens)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Drosophila melanogaster)
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Xenopus tropicalis)
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)
SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Mus musculus)
Ferrous iron reduces the BH3 radical back to BH4 (Homo sapiens)
as an output of
Iron is reduced and separates from enterobactin (Escherichia coli)
Iron is reduced and separates from mycobactin (Homo sapiens)
Superoxide anion reacts with Fe-S cluster (Homo sapiens)
HMOX1 dimer, HMOX2 cleave heme (Gallus gallus)
HMOX1 dimer, HMOX2 cleave heme (Xenopus tropicalis)
HMOX1 dimer, HMOX2 cleave heme (Danio rerio)
HMOX1 dimer, HMOX2 cleave heme (Sus scrofa)
HMOX1 dimer, HMOX2 cleave heme (Bos taurus)
HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)
HMOX1 dimer, HMOX2 cleave heme (Rattus norvegicus)
HMOX1 dimer, HMOX2 cleave heme (Mus musculus)
HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)
HMOX1 dimer, HMOX2 cleave heme (Drosophila melanogaster)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Dictyostelium discoideum)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Caenorhabditis elegans)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Gallus gallus)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Xenopus tropicalis)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Danio rerio)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Sus scrofa)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Bos taurus)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Canis familiaris)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Rattus norvegicus)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Mus musculus)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Homo sapiens)
MCOLN1 transports Fe2+ from endosome lumen to cytosol (Drosophila melanogaster)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Plasmodium falciparum)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Dictyostelium discoideum)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Gallus gallus)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Xenopus tropicalis)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Danio rerio)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Sus scrofa)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Bos taurus)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Canis familiaris)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Rattus norvegicus)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Mus musculus)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Homo sapiens)
SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Drosophila melanogaster)
as a member of
Divalent metals transported by NRAMP1 [cytosol]
This entity regulates
Negatively
ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs
(Homo sapiens)
Positively
ACO1 binds 4Fe-4S
(Plasmodium falciparum)
ACO1 binds 4Fe-4S
(Dictyostelium discoideum)
ACO1 binds 4Fe-4S
(Caenorhabditis elegans)
ACO1 binds 4Fe-4S
(Gallus gallus)
ACO1 binds 4Fe-4S
(Xenopus tropicalis)
ACO1 binds 4Fe-4S
(Danio rerio)
ACO1 binds 4Fe-4S
(Sus scrofa)
ACO1 binds 4Fe-4S
(Bos taurus)
ACO1 binds 4Fe-4S
(Canis familiaris)
ACO1 binds 4Fe-4S
(Rattus norvegicus)
ACO1 binds 4Fe-4S
(Mus musculus)
ACO1 binds 4Fe-4S
(Homo sapiens)
ACO1 binds 4Fe-4S
(Drosophila melanogaster)
Other forms of this molecule
Fe2+ [cytoplasm]
Fe2+ [endoplasmic reticulum lumen]
Fe2+ [endoplasmic reticulum membrane]
Fe2+ [peroxisomal matrix]
Fe2+ [phagocytic vesicle lumen]
Fe2+ [endosome lumen]
Fe2+ [extracellular region]
Fe2+ [mitochondrial inner membrane]
Fe2+ [nucleoplasm]
Fe2+ [nuclear envelope]
Fe2+ [mitochondrial intermembrane space]
Fe2+ [mitochondrial matrix]
Cross References
AraCyc
FE+2
ChEBI
29033
COMPOUND
C14818
,
C00023
PubChem Compound
27284
HMDB Metabolite
HMDB0000692
KEGG Gene
C14818
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