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PI(3,4,5)P3 [plasma membrane]
Stable Identifier
R-ALL-179838
Type
Chemical Compound [SimpleEntity]
Compartment
plasma membrane
Synonyms
PIP3, 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate, Phosphatidylinositol-3,4,5-trisphosphate
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
GPVI-mediated activation cascade (Bos taurus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
VAV1 is a GEF for Rho/Rac family GTPases (Bos taurus)
PIP3:VAV1,2,3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Costimulation by the CD28 family (Bos taurus)
CD28 co-stimulation (Bos taurus)
CD28 dependent PI3K/Akt signaling (Bos taurus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
CD28 dependent Vav1 pathway (Bos taurus)
Activation of Cdc42 by pVav1 (Bos taurus)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Activation of Rac1 by pVav1 (Bos taurus)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Activation of Vav1 (Bos taurus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Translocation of Vav1 to CD28 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Bos taurus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Bos taurus)
BLNK (SLP-65) Signalosome [plasma membrane] (Bos taurus)
p-Y223,551-BTK:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y753,Y759,Y1217-PLCG2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
BTK binds BTK inhibitors (Bos taurus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Bos taurus)
BTK:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
BTK:BTK inhibitors [plasma membrane] (Bos taurus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Bos taurus)
BTK:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Bos taurus)
BTK:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-DAPP1 (p-BAM32) binds PLCG2 (Bos taurus)
p-Y139-DAPP1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] (Bos taurus)
p-Y139-DAPP1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
Activation of IKK complex (Bos taurus)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Bos taurus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Bos taurus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Bos taurus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Activation of TAK1-TAB2 complex (Bos taurus)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Bos taurus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Bos taurus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Bos taurus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Bos taurus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Bos taurus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Hydrolysis of PIP3 to PI(3,4)P2 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Interaction and oligomerization of MALT1 to Bcl10 (Bos taurus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Bos taurus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Interaction of Bcl10 to CARMA1 (Bos taurus)
Bcl10 bound to CARMA1 [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Oligomerization of Bcl10 (Bos taurus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Oligomerization of CARMA1 (Bos taurus)
Activated CARMA1 [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of Bcl10 (Bos taurus)
Bcl10 bound to CARMA1 [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of CARMA1 (Bos taurus)
Activated CARMA1 [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 bound to PDK1 [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PKC theta (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of CARMA1 to Plasma membrane (Bos taurus)
CARMA1 bound to PDK1 [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of TRAF6 to CBM complex (Bos taurus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Bos taurus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
TRAF6 trimer bound to CBM complex [plasma membrane] (Bos taurus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Bos taurus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Bos taurus)
CARMA1 trimer [plasma membrane] (Bos taurus)
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-1 processing (Bos taurus)
Interleukin-1 family are secreted (Bos taurus)
GSDMD pore complex [plasma membrane] (Bos taurus)
GSDMD oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Bos taurus)
DAP12 interactions (Bos taurus)
DAP12 signaling (Bos taurus)
Activation of RAC1 by VAV2/3 (Bos taurus)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV and BTK to p-SLP-76 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Release of p-PLCG1 (Bos taurus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated Ca+2 mobilization (Bos taurus)
Autophosphorylation of BTK/ITK (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Hydrolysis of PIP2 by PLCG (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of TEC kinases by p-SYK (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
FCERI mediated MAPK activation (Bos taurus)
Activation of RAC1 by VAV (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Autophosphorylation of PAK (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Recruitment of PAK to the membrane by binding active RAC1 (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Bos taurus)
PI3K associates with phosphorylated GAB2 (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Bos taurus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Bos taurus)
Mother filament:branching complex [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Bos taurus)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Bos taurus)
Mother filament:branching complex [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of VAV (Bos taurus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV1 to p-6Y-SYK (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Bos taurus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Role of phospholipids in phagocytosis (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of PLCG (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Release of PLCG from FCGR (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Toll-like Receptor Cascades (Bos taurus)
Regulation of TLR by endogenous ligand (Bos taurus)
HMGB1 release from cells (Bos taurus)
GSDMD pore complex [plasma membrane] (Bos taurus)
GSDMD oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Metabolism (Bos taurus)
Metabolism of lipids (Bos taurus)
Phospholipid metabolism (Bos taurus)
PI Metabolism (Bos taurus)
Synthesis of PIPs at the plasma membrane (Bos taurus)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Bos taurus)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Programmed Cell Death (Bos taurus)
Regulated Necrosis (Bos taurus)
Pyroptosis (Bos taurus)
GSDMD (1-275) binds PIPs (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD (1-275):PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD forms ring‐shaped oligomers (Bos taurus)
GSDMD oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD pore complex [plasma membrane] (Bos taurus)
GSDMD oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD oligomerizes into arc-, slit-shaped structures (Bos taurus)
GSDMD (1-275):PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME (1-270) binds PIPs (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME (1-270):PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomerizes (Bos taurus)
GSDME (1-270):PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
HMGB1 release from cells (Bos taurus)
GSDMD pore complex [plasma membrane] (Bos taurus)
GSDMD oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Interleukin-1 family are secreted (Bos taurus)
GSDMD pore complex [plasma membrane] (Bos taurus)
GSDMD oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
RIPK1-mediated regulated necrosis (Bos taurus)
MLKL binds PIPs (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Bos taurus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Activator:PI3K [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Activator:PI3K [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
MTOR signalling (Bos taurus)
Inhibition of TSC complex formation by PKB (Bos taurus)
Phosphorylation of TSC2 by PKB (Bos taurus)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of complexed TSC2 by PKB (Bos taurus)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Erythropoietin (Bos taurus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Bos taurus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G-protein beta:gamma signalling (Bos taurus)
G beta:gamma signalling through BTK (Bos taurus)
BTK in PIP3:BTK:G beta-gamma complex is activated (Bos taurus)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
G beta-gamma complex and PIP3 recruit BTK to membrane (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
G beta:gamma signalling through PI3Kgamma (Bos taurus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Extra-nuclear estrogen signaling (Bos taurus)
Estrogen-stimulated signaling through PRKCZ (Bos taurus)
ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Bos taurus)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Bos taurus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Bos taurus)
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PRKCZ autophosphorylates downstream of estrogen stimulation (Bos taurus)
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Bos taurus)
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Bos taurus)
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PRKCZ recruits RAS in response to estrogen stimulation (Bos taurus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Bos taurus)
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Bos taurus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Bos taurus)
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Bos taurus)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Bos taurus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Bos taurus)
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Bos taurus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Bos taurus)
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ALK (Bos taurus)
Active ALK binds PLCG1 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Active ALK:PLCG1 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Active ALK phosphorylates PLCG1 (Bos taurus)
Active ALK:PLCG1 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Active ALK:p-4Y PLCG1 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI3K synthesizes PIP3 downstream of ALK (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by EGFR (Bos taurus)
GAB1 signalosome (Bos taurus)
Activation of SHP2 through the binding to phospho-Gab1 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Dephosphorylation of Gab1 by SHP2 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Bos taurus)
GRB2:p-Y627,Y659-GAB1,GRB2:p-Y627,Y659-GAB1:PIP3 [plasma membrane] (Bos taurus)
GRB2:p-GAB1(partially dephosphorylated):PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Dephosphorylation of PAG by SHP2 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
GAB1 phosphorylation by EGFR kinase (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Bos taurus)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1 binds to phosphorylated EGFR (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Bos taurus)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI3K binds to EGF:EGFR:GRB2:GAB1 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
SHP2 dephosphorylates Tyr 992 on EGFR (Bos taurus)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Sustained activation of SRC kinase by SHP2 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 (Bos taurus)
PI3K events in ERBB2 signaling (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB4 (Bos taurus)
PI3K events in ERBB4 signaling (Bos taurus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Downstream signaling of activated FGFR1 (Bos taurus)
PI-3K cascade:FGFR1 (Bos taurus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade: FGFR1 (Bos taurus)
Activated FGFR1 binds PLCG1 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
activated FGFR1:PLCG1 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR1 phosphorylates PLCG1 (Bos taurus)
activated FGFR1:PLCG1 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR2 (Bos taurus)
Downstream signaling of activated FGFR2 (Bos taurus)
PI-3K cascade:FGFR2 (Bos taurus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR2 (Bos taurus)
Activated FGFR2 binds PLCG1 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
activated FGFR2:PLCG1 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR2 phosphorylates PLCG1 (Bos taurus)
activated FGFR2:PLCG1 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR3 (Bos taurus)
Downstream signaling of activated FGFR3 (Bos taurus)
PI-3K cascade:FGFR3 (Bos taurus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR3 (Bos taurus)
Activated FGFR3 binds PLCG1 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
activated FGFR3:PLCG1 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR3 phosphorylates PLCG1 (Bos taurus)
activated FGFR3:PLCG1 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR4 (Bos taurus)
Downstream signaling of activated FGFR4 (Bos taurus)
PI-3K cascade:FGFR4 (Bos taurus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR4 (Bos taurus)
Activated FGFR4 binds PLCG1 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
activated FGFR4:PLCG1 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR4 phosphorylates PLCG1 (Bos taurus)
activated FGFR4:PLCG1 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Insulin receptor (Bos taurus)
Insulin receptor signalling cascade (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
Activation of AKT2 (Bos taurus)
AKT2 binds PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
AKT2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Bos taurus)
AKT2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by MET (Bos taurus)
MET activates PI3K/AKT signaling (Bos taurus)
MET bound PI3K generates PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
PI3K/AKT activation (Bos taurus)
PI3K produces PIP3 and other phosphatidyl inositides (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by PDGF (Bos taurus)
Downstream signal transduction (Bos taurus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by SCF-KIT (Bos taurus)
Activation of RAC1 (Bos taurus)
p-VAV1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV1 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-VAV1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Bos taurus)
IGF1R signaling cascade (Bos taurus)
IRS-related events triggered by IGF1R (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
Activation of AKT2 (Bos taurus)
AKT2 binds PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
AKT2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Bos taurus)
AKT2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Src kinases phosphorylate VAV (Bos taurus)
PIP3:VAV1,2,3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
VAV exchanges GTP for GDP on RAC1, activating it (Bos taurus)
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Bos taurus)
p-VAV family:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Bos taurus)
p-VAV family:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
VEGFR2 mediated vascular permeability (Bos taurus)
PAK1-3 autophosphorylates (Bos taurus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Bos taurus)
p-VAV family:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Bos taurus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Bos taurus)
p-VAV family:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PAK1-3 dimer disassociates (Bos taurus)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Bos taurus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Bos taurus)
p-VAV family:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Bos taurus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Bos taurus)
p-VAV family:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
RAC1 binds PAK1-3 (Bos taurus)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Bos taurus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Bos taurus)
p-VAV family:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Bos taurus)
p-VAV family:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3 binds RAC1:GDP (Bos taurus)
p-VAV family:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Bos taurus)
p-VAV family:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases Activate WASPs and WAVEs (Bos taurus)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Bos taurus)
Mother filament:branching complex [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Bos taurus)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Bos taurus)
Mother filament:branching complex [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Bos taurus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Bos taurus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
RHO GTPases activate PKNs (Bos taurus)
PDPK1 phosphorylates PKN1,2,3 (Bos taurus)
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Bos taurus)
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Bos taurus)
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Bos taurus)
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PI(3,4,5)P3 [plasma membrane]
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
Transcriptional Regulation by TP53 (Caenorhabditis elegans)
Regulation of TP53 Activity (Caenorhabditis elegans)
Regulation of TP53 Expression and Degradation (Caenorhabditis elegans)
Regulation of TP53 Degradation (Caenorhabditis elegans)
PDPK1 phosphorylates SGK1 (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
GPVI-mediated activation cascade (Caenorhabditis elegans)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
VAV1 is a GEF for Rho/Rac family GTPases (Caenorhabditis elegans)
PIP3:VAV1,2,3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
Costimulation by the CD28 family (Caenorhabditis elegans)
CD28 co-stimulation (Caenorhabditis elegans)
CD28 dependent PI3K/Akt signaling (Caenorhabditis elegans)
AKT binds PDPK1 (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Caenorhabditis elegans)
AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Caenorhabditis elegans)
AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Caenorhabditis elegans)
Downstream TCR signaling (Caenorhabditis elegans)
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PKC theta (Caenorhabditis elegans)
PDK1:PIP2,PIP3 [plasma membrane] (Caenorhabditis elegans)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Caenorhabditis elegans)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Caenorhabditis elegans)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Caenorhabditis elegans)
Fc epsilon receptor (FCERI) signaling (Caenorhabditis elegans)
Role of LAT2/NTAL/LAB on calcium mobilization (Caenorhabditis elegans)
Translocation of PDK1 to Plasma membrane (Caenorhabditis elegans)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Caenorhabditis elegans)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Caenorhabditis elegans)
Regulation of actin dynamics for phagocytic cup formation (Caenorhabditis elegans)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Caenorhabditis elegans)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Caenorhabditis elegans)
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Caenorhabditis elegans)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Metabolism (Caenorhabditis elegans)
Metabolism of lipids (Caenorhabditis elegans)
Phospholipid metabolism (Caenorhabditis elegans)
PI Metabolism (Caenorhabditis elegans)
Synthesis of PIPs at the plasma membrane (Caenorhabditis elegans)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Caenorhabditis elegans)
Intracellular signaling by second messengers (Caenorhabditis elegans)
PIP3 activates AKT signaling (Caenorhabditis elegans)
AKT binds PDPK1 (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Caenorhabditis elegans)
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Caenorhabditis elegans)
AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Caenorhabditis elegans)
AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates SGK1 (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Caenorhabditis elegans)
AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Caenorhabditis elegans)
AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G-protein beta:gamma signalling (Caenorhabditis elegans)
G beta:gamma signalling through PI3Kgamma (Caenorhabditis elegans)
PIP3 binds to RhoA and activates it (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDK1 and AKT to the membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDK1:AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by Nuclear Receptors (Caenorhabditis elegans)
ESR-mediated signaling (Caenorhabditis elegans)
Extra-nuclear estrogen signaling (Caenorhabditis elegans)
Estrogen-stimulated signaling through PRKCZ (Caenorhabditis elegans)
ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Caenorhabditis elegans)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PRKCZ autophosphorylates downstream of estrogen stimulation (Caenorhabditis elegans)
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PRKCZ recruits RAS in response to estrogen stimulation (Caenorhabditis elegans)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Caenorhabditis elegans)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by ALK (Caenorhabditis elegans)
PI3K synthesizes PIP3 downstream of ALK (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by EGFR (Caenorhabditis elegans)
GAB1 signalosome (Caenorhabditis elegans)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 (Caenorhabditis elegans)
PI3K events in ERBB2 signaling (Caenorhabditis elegans)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB4 (Caenorhabditis elegans)
PI3K events in ERBB4 signaling (Caenorhabditis elegans)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR (Caenorhabditis elegans)
Signaling by FGFR1 (Caenorhabditis elegans)
Downstream signaling of activated FGFR1 (Caenorhabditis elegans)
PI-3K cascade:FGFR1 (Caenorhabditis elegans)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade: FGFR1 (Caenorhabditis elegans)
Activated FGFR1 phosphorylates PLCG1 (Caenorhabditis elegans)
activated FGFR1:PLCG1 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR4 (Caenorhabditis elegans)
Downstream signaling of activated FGFR4 (Caenorhabditis elegans)
PI-3K cascade:FGFR4 (Caenorhabditis elegans)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR4 (Caenorhabditis elegans)
Activated FGFR4 phosphorylates PLCG1 (Caenorhabditis elegans)
activated FGFR4:PLCG1 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by Insulin receptor (Caenorhabditis elegans)
Insulin receptor signalling cascade (Caenorhabditis elegans)
IRS-mediated signalling (Caenorhabditis elegans)
PI3K Cascade (Caenorhabditis elegans)
Activation of AKT2 (Caenorhabditis elegans)
AKT2 binds PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
AKT2:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Caenorhabditis elegans)
AKT2:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by MET (Caenorhabditis elegans)
MET activates PI3K/AKT signaling (Caenorhabditis elegans)
MET bound PI3K generates PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRKs (Caenorhabditis elegans)
Signaling by NTRK1 (TRKA) (Caenorhabditis elegans)
PI3K/AKT activation (Caenorhabditis elegans)
PIP3 binds to RhoA and activates it (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by PDGF (Caenorhabditis elegans)
Downstream signal transduction (Caenorhabditis elegans)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by SCF-KIT (Caenorhabditis elegans)
Activation of RAC1 (Caenorhabditis elegans)
p-VAV1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Synthesis of PIP3 from PIP2 by PI3K (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Caenorhabditis elegans)
IGF1R signaling cascade (Caenorhabditis elegans)
IRS-related events triggered by IGF1R (Caenorhabditis elegans)
IRS-mediated signalling (Caenorhabditis elegans)
PI3K Cascade (Caenorhabditis elegans)
Activation of AKT2 (Caenorhabditis elegans)
AKT2 binds PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
AKT2:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Caenorhabditis elegans)
AKT2:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
VAV exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
VEGFR2 mediated vascular permeability (Caenorhabditis elegans)
AKT binds PDPK1 (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PAK1-3 autophosphorylates (Caenorhabditis elegans)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PAK1-3 dimer disassociates (Caenorhabditis elegans)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
RAC1 binds PAK1-3 (Caenorhabditis elegans)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Caenorhabditis elegans)
AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Caenorhabditis elegans)
AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3 binds RAC1:GDP (Caenorhabditis elegans)
p-VAV family:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Caenorhabditis elegans)
Signaling by Rho GTPases (Caenorhabditis elegans)
RHO GTPase Effectors (Caenorhabditis elegans)
RHO GTPases Activate WASPs and WAVEs (Caenorhabditis elegans)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Caenorhabditis elegans)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Caenorhabditis elegans)
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Caenorhabditis elegans)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
RHO GTPases activate PKNs (Caenorhabditis elegans)
PDPK1 phosphorylates PKN1,2,3 (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PI(3,4,5)P3 [plasma membrane]
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by TP53 (Canis familiaris)
Regulation of TP53 Activity (Canis familiaris)
Regulation of TP53 Expression and Degradation (Canis familiaris)
Regulation of TP53 Degradation (Canis familiaris)
PDPK1 phosphorylates SGK1 (Canis familiaris)
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
GPVI-mediated activation cascade (Canis familiaris)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
VAV1 is a GEF for Rho/Rac family GTPases (Canis familiaris)
PIP3:VAV1,2,3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Costimulation by the CD28 family (Canis familiaris)
CD28 co-stimulation (Canis familiaris)
CD28 dependent PI3K/Akt signaling (Canis familiaris)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
CD28 dependent Vav1 pathway (Canis familiaris)
Activation of Cdc42 by pVav1 (Canis familiaris)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Activation of Rac1 by pVav1 (Canis familiaris)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Activation of Vav1 (Canis familiaris)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Translocation of Vav1 to CD28 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Canis familiaris)
BLNK (SLP-65) Signalosome [plasma membrane] (Canis familiaris)
p-Y223,551-BTK:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y753,Y759,Y1217-PLCG2:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
BTK binds BTK inhibitors (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
BTK:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
BTK:BTK inhibitors [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
BTK:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
BTK:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-DAPP1 (p-BAM32) binds PLCG2 (Canis familiaris)
p-Y139-DAPP1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] (Canis familiaris)
p-Y139-DAPP1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
Activation of IKK complex (Canis familiaris)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Canis familiaris)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Canis familiaris)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Activation of TAK1-TAB2 complex (Canis familiaris)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Canis familiaris)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Canis familiaris)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Canis familiaris)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Auto-ubiquitination of TRAF6 (Canis familiaris)
TRAF6 trimer bound to CBM complex [plasma membrane] (Canis familiaris)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Canis familiaris)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Hydrolysis of PIP3 to PI(3,4)P2 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Interaction and oligomerization of MALT1 to Bcl10 (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Interaction of Bcl10 to CARMA1 (Canis familiaris)
Bcl10 bound to CARMA1 [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Oligomerization of Bcl10 (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Oligomerization of CARMA1 (Canis familiaris)
Activated CARMA1 [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of Bcl10 (Canis familiaris)
Bcl10 bound to CARMA1 [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of CARMA1 (Canis familiaris)
Activated CARMA1 [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 bound to PDK1 [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PKC theta (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of CARMA1 to Plasma membrane (Canis familiaris)
CARMA1 bound to PDK1 [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of TRAF6 to CBM complex (Canis familiaris)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
TRAF6 trimer bound to CBM complex [plasma membrane] (Canis familiaris)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Ubiquitination of NEMO by TRAF6 (Canis familiaris)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Canis familiaris)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 processing (Canis familiaris)
Interleukin-1 family are secreted (Canis familiaris)
GSDMD pore complex [plasma membrane] (Canis familiaris)
GSDMD oligomer:PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
Ubiquitination of NEMO by TRAF6 (Canis familiaris)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Canis familiaris)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
DAP12 interactions (Canis familiaris)
DAP12 signaling (Canis familiaris)
Activation of RAC1 by VAV2/3 (Canis familiaris)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV2/VAV3 by SYK (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of BTK by p-SYK (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-SYK/p-BTK [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV and BTK to p-SLP-76 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Release of p-PLCG1 (Canis familiaris)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Autophosphorylation of BTK/ITK (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Hydrolysis of PIP2 by PLCG (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of TEC kinases by p-SYK (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
FCERI mediated MAPK activation (Canis familiaris)
Activation of RAC1 by VAV (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Autophosphorylation of PAK (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Recruitment of PAK to the membrane by binding active RAC1 (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
FCERI mediated NF-kB activation (Canis familiaris)
Ubiquitination of NEMO by TRAF6 (Canis familiaris)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Canis familiaris)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Canis familiaris)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Canis familiaris)
CARMA1 trimer [plasma membrane] (Canis familiaris)
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Canis familiaris)
PI3K associates with phosphorylated GAB2 (Canis familiaris)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Canis familiaris)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PIP2 to PIP3 by PI3K (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Canis familiaris)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Canis familiaris)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)
Mother filament:branching complex [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Canis familiaris)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Canis familiaris)
Mother filament:branching complex [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of VAV (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV1 to p-6Y-SYK (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Role of phospholipids in phagocytosis (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of PLCG (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Release of PLCG from FCGR (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Toll-like Receptor Cascades (Canis familiaris)
Regulation of TLR by endogenous ligand (Canis familiaris)
HMGB1 release from cells (Canis familiaris)
GSDMD pore complex [plasma membrane] (Canis familiaris)
GSDMD oligomer:PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Metabolism (Canis familiaris)
Metabolism of lipids (Canis familiaris)
Phospholipid metabolism (Canis familiaris)
PI Metabolism (Canis familiaris)
Synthesis of PIPs at the plasma membrane (Canis familiaris)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Canis familiaris)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Programmed Cell Death (Canis familiaris)
Regulated Necrosis (Canis familiaris)
Pyroptosis (Canis familiaris)
GSDMD (1-275) binds PIPs (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD (1-275):PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD forms ring‐shaped oligomers (Canis familiaris)
GSDMD oligomer:PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD pore complex [plasma membrane] (Canis familiaris)
GSDMD oligomer:PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD oligomerizes into arc-, slit-shaped structures (Canis familiaris)
GSDMD (1-275):PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD oligomer:PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME (1-270) binds PIPs (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME (1-270):PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomerizes (Canis familiaris)
GSDME (1-270):PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
HMGB1 release from cells (Canis familiaris)
GSDMD pore complex [plasma membrane] (Canis familiaris)
GSDMD oligomer:PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Interleukin-1 family are secreted (Canis familiaris)
GSDMD pore complex [plasma membrane] (Canis familiaris)
GSDMD oligomer:PIPs [plasma membrane] (Canis familiaris)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Activator:PI3K [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates SGK1 (Canis familiaris)
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Activator:PI3K [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by Erythropoietin (Canis familiaris)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Canis familiaris)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G-protein beta:gamma signalling (Canis familiaris)
G beta:gamma signalling through BTK (Canis familiaris)
BTK in PIP3:BTK:G beta-gamma complex is activated (Canis familiaris)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
G beta-gamma complex and PIP3 recruit BTK to membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
G beta:gamma signalling through PI3Kgamma (Canis familiaris)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by Nuclear Receptors (Canis familiaris)
ESR-mediated signaling (Canis familiaris)
Extra-nuclear estrogen signaling (Canis familiaris)
Estrogen-stimulated signaling through PRKCZ (Canis familiaris)
ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Canis familiaris)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Canis familiaris)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Canis familiaris)
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PRKCZ autophosphorylates downstream of estrogen stimulation (Canis familiaris)
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Canis familiaris)
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Canis familiaris)
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PRKCZ recruits RAS in response to estrogen stimulation (Canis familiaris)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Canis familiaris)
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Canis familiaris)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Canis familiaris)
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Canis familiaris)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Canis familiaris)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Canis familiaris)
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Canis familiaris)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Canis familiaris)
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ALK (Canis familiaris)
Active ALK binds PLCG1 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Active ALK:PLCG1 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Active ALK phosphorylates PLCG1 (Canis familiaris)
Active ALK:PLCG1 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Active ALK:p-4Y PLCG1 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI3K synthesizes PIP3 downstream of ALK (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by EGFR (Canis familiaris)
GAB1 signalosome (Canis familiaris)
Activation of SHP2 through the binding to phospho-Gab1 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Dephosphorylation of Gab1 by SHP2 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Canis familiaris)
GRB2:p-Y627,Y659-GAB1,GRB2:p-Y627,Y659-GAB1:PIP3 [plasma membrane] (Canis familiaris)
GRB2:p-GAB1(partially dephosphorylated):PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Dephosphorylation of PAG by SHP2 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
GAB1 phosphorylation by EGFR kinase (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Canis familiaris)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Canis familiaris)
GRB2:GAB1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1 binds to phosphorylated EGFR (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Canis familiaris)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Canis familiaris)
GRB2:GAB1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Canis familiaris)
GRB2:GAB1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI3K binds to EGF:EGFR:GRB2:GAB1 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
SHP2 dephosphorylates Tyr 992 on EGFR (Canis familiaris)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Sustained activation of SRC kinase by SHP2 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 (Canis familiaris)
PI3K events in ERBB2 signaling (Canis familiaris)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB4 (Canis familiaris)
PI3K events in ERBB4 signaling (Canis familiaris)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR (Canis familiaris)
Signaling by FGFR1 (Canis familiaris)
Downstream signaling of activated FGFR1 (Canis familiaris)
PI-3K cascade:FGFR1 (Canis familiaris)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade: FGFR1 (Canis familiaris)
Activated FGFR1 binds PLCG1 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
activated FGFR1:PLCG1 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR1 phosphorylates PLCG1 (Canis familiaris)
activated FGFR1:PLCG1 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR2 (Canis familiaris)
Downstream signaling of activated FGFR2 (Canis familiaris)
PI-3K cascade:FGFR2 (Canis familiaris)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR2 (Canis familiaris)
Activated FGFR2 binds PLCG1 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
activated FGFR2:PLCG1 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR2 phosphorylates PLCG1 (Canis familiaris)
activated FGFR2:PLCG1 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR3 (Canis familiaris)
Downstream signaling of activated FGFR3 (Canis familiaris)
PI-3K cascade:FGFR3 (Canis familiaris)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR3 (Canis familiaris)
Activated FGFR3 binds PLCG1 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
activated FGFR3:PLCG1 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR3 phosphorylates PLCG1 (Canis familiaris)
activated FGFR3:PLCG1 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR4 (Canis familiaris)
Downstream signaling of activated FGFR4 (Canis familiaris)
PI-3K cascade:FGFR4 (Canis familiaris)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR4 (Canis familiaris)
Activated FGFR4 binds PLCG1 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
activated FGFR4:PLCG1 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR4 phosphorylates PLCG1 (Canis familiaris)
activated FGFR4:PLCG1 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by Insulin receptor (Canis familiaris)
Insulin receptor signalling cascade (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
Activation of AKT2 (Canis familiaris)
PDPK1 binds PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by MET (Canis familiaris)
MET activates PI3K/AKT signaling (Canis familiaris)
MET bound PI3K generates PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRKs (Canis familiaris)
Signaling by NTRK1 (TRKA) (Canis familiaris)
PI3K/AKT activation (Canis familiaris)
PI3K produces PIP3 and other phosphatidyl inositides (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by PDGF (Canis familiaris)
Downstream signal transduction (Canis familiaris)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by SCF-KIT (Canis familiaris)
Activation of RAC1 (Canis familiaris)
p-VAV1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV1 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-VAV1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Synthesis of PIP3 from PIP2 by PI3K (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Canis familiaris)
IGF1R signaling cascade (Canis familiaris)
IRS-related events triggered by IGF1R (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
Activation of AKT2 (Canis familiaris)
PDPK1 binds PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Src kinases phosphorylate VAV (Canis familiaris)
PIP3:VAV1,2,3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
VAV exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Canis familiaris)
p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Canis familiaris)
p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
VEGFR2 mediated vascular permeability (Canis familiaris)
PAK1-3 autophosphorylates (Canis familiaris)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Canis familiaris)
p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Canis familiaris)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Canis familiaris)
p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PAK1-3 dimer disassociates (Canis familiaris)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Canis familiaris)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Canis familiaris)
p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Canis familiaris)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Canis familiaris)
p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
RAC1 binds PAK1-3 (Canis familiaris)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Canis familiaris)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Canis familiaris)
p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Canis familiaris)
p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3 binds RAC1:GDP (Canis familiaris)
p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Canis familiaris)
p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases Activate WASPs and WAVEs (Canis familiaris)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)
Mother filament:branching complex [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Canis familiaris)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Canis familiaris)
Mother filament:branching complex [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
RHO GTPases activate PKNs (Canis familiaris)
PDPK1 phosphorylates PKN1,2,3 (Canis familiaris)
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Canis familiaris)
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PI(3,4,5)P3 [plasma membrane]
Gene expression (Transcription) (Danio rerio)
RNA Polymerase II Transcription (Danio rerio)
Generic Transcription Pathway (Danio rerio)
Transcriptional Regulation by TP53 (Danio rerio)
Regulation of TP53 Activity (Danio rerio)
Regulation of TP53 Expression and Degradation (Danio rerio)
Regulation of TP53 Degradation (Danio rerio)
PDPK1 phosphorylates SGK1 (Danio rerio)
PDPK1:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
GPVI-mediated activation cascade (Danio rerio)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Immune System (Danio rerio)
Adaptive Immune System (Danio rerio)
Costimulation by the CD28 family (Danio rerio)
CD28 co-stimulation (Danio rerio)
CD28 dependent PI3K/Akt signaling (Danio rerio)
AKT binds PDPK1 (Danio rerio)
PDPK1:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Danio rerio)
PDPK1:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Danio rerio)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Danio rerio)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Danio rerio)
Downstream TCR signaling (Danio rerio)
PTEN dephosphorylates PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Danio rerio)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Danio rerio)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Danio rerio)
Fc epsilon receptor (FCERI) signaling (Danio rerio)
Role of LAT2/NTAL/LAB on calcium mobilization (Danio rerio)
Translocation of PDK1 to Plasma membrane (Danio rerio)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Danio rerio)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Toll-like Receptor Cascades (Danio rerio)
Regulation of TLR by endogenous ligand (Danio rerio)
HMGB1 release from cells (Danio rerio)
GSDME oligomer:PIP [plasma membrane] (Danio rerio)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Metabolism (Danio rerio)
Metabolism of lipids (Danio rerio)
Phospholipid metabolism (Danio rerio)
PI Metabolism (Danio rerio)
Synthesis of PIPs at the plasma membrane (Danio rerio)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Danio rerio)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Programmed Cell Death (Danio rerio)
Regulated Necrosis (Danio rerio)
Pyroptosis (Danio rerio)
GSDME (1-270) binds PIPs (Danio rerio)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME (1-270):PIPs [plasma membrane] (Danio rerio)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomerizes (Danio rerio)
GSDME (1-270):PIPs [plasma membrane] (Danio rerio)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Danio rerio)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
HMGB1 release from cells (Danio rerio)
GSDME oligomer:PIP [plasma membrane] (Danio rerio)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Danio rerio)
Intracellular signaling by second messengers (Danio rerio)
PIP3 activates AKT signaling (Danio rerio)
AKT binds PDPK1 (Danio rerio)
PDPK1:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Danio rerio)
PDPK1:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Negative regulation of the PI3K/AKT network (Danio rerio)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Danio rerio)
AKT:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Danio rerio)
AKT:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates SGK1 (Danio rerio)
PDPK1:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G-protein beta:gamma signalling (Danio rerio)
G beta:gamma signalling through PI3Kgamma (Danio rerio)
PIP3 binds to RhoA and activates it (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDK1 and AKT to the membrane (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PDK1:AKT:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by ALK (Danio rerio)
Active ALK binds PLCG1 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Active ALK:PLCG1 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Active ALK phosphorylates PLCG1 (Danio rerio)
Active ALK:PLCG1 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Active ALK:p-4Y PLCG1 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PI3K synthesizes PIP3 downstream of ALK (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by EGFR (Danio rerio)
GAB1 signalosome (Danio rerio)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 (Danio rerio)
PI3K events in ERBB2 signaling (Danio rerio)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB4 (Danio rerio)
PI3K events in ERBB4 signaling (Danio rerio)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR (Danio rerio)
Signaling by FGFR1 (Danio rerio)
Downstream signaling of activated FGFR1 (Danio rerio)
PI-3K cascade:FGFR1 (Danio rerio)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade: FGFR1 (Danio rerio)
Activated FGFR1 binds PLCG1 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
activated FGFR1:PLCG1 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR1 phosphorylates PLCG1 (Danio rerio)
activated FGFR1:PLCG1 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR2 (Danio rerio)
Downstream signaling of activated FGFR2 (Danio rerio)
Phospholipase C-mediated cascade; FGFR2 (Danio rerio)
Activated FGFR2 binds PLCG1 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
activated FGFR2:PLCG1 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR2 phosphorylates PLCG1 (Danio rerio)
activated FGFR2:PLCG1 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR3 (Danio rerio)
Downstream signaling of activated FGFR3 (Danio rerio)
Phospholipase C-mediated cascade; FGFR3 (Danio rerio)
Activated FGFR3 binds PLCG1 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
activated FGFR3:PLCG1 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR3 phosphorylates PLCG1 (Danio rerio)
activated FGFR3:PLCG1 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR4 (Danio rerio)
Downstream signaling of activated FGFR4 (Danio rerio)
Phospholipase C-mediated cascade; FGFR4 (Danio rerio)
Activated FGFR4 binds PLCG1 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
activated FGFR4:PLCG1 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR4 phosphorylates PLCG1 (Danio rerio)
activated FGFR4:PLCG1 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by Insulin receptor (Danio rerio)
Insulin receptor signalling cascade (Danio rerio)
IRS-mediated signalling (Danio rerio)
PI3K Cascade (Danio rerio)
Activation of AKT2 (Danio rerio)
AKT2 binds PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
AKT2:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Danio rerio)
AKT2:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRKs (Danio rerio)
Signaling by NTRK1 (TRKA) (Danio rerio)
PI3K/AKT activation (Danio rerio)
PIP3 binds to RhoA and activates it (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by PDGF (Danio rerio)
Downstream signal transduction (Danio rerio)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by SCF-KIT (Danio rerio)
Synthesis of PIP3 from PIP2 by PI3K (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Danio rerio)
IGF1R signaling cascade (Danio rerio)
IRS-related events triggered by IGF1R (Danio rerio)
IRS-mediated signalling (Danio rerio)
PI3K Cascade (Danio rerio)
Activation of AKT2 (Danio rerio)
AKT2 binds PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
AKT2:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Danio rerio)
AKT2:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Danio rerio)
VEGFA-VEGFR2 Pathway (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
VEGFR2 mediated vascular permeability (Danio rerio)
AKT binds PDPK1 (Danio rerio)
PDPK1:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Danio rerio)
PDPK1:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
Signaling by Rho GTPases (Danio rerio)
RHO GTPase Effectors (Danio rerio)
RHO GTPases activate PKNs (Danio rerio)
PDPK1 phosphorylates PKN1,2,3 (Danio rerio)
PDPK1:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Danio rerio)
PDPK1:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Danio rerio)
PDPK1:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Danio rerio)
PDPK1:PIP3 [plasma membrane] (Danio rerio)
PI(3,4,5)P3 [plasma membrane]
Gene expression (Transcription) (Dictyostelium discoideum)
RNA Polymerase II Transcription (Dictyostelium discoideum)
Generic Transcription Pathway (Dictyostelium discoideum)
Transcriptional Regulation by TP53 (Dictyostelium discoideum)
Regulation of TP53 Activity (Dictyostelium discoideum)
Regulation of TP53 Expression and Degradation (Dictyostelium discoideum)
Regulation of TP53 Degradation (Dictyostelium discoideum)
PDPK1 phosphorylates SGK1 (Dictyostelium discoideum)
PDPK1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Dictyostelium discoideum)
Platelet activation, signaling and aggregation (Dictyostelium discoideum)
GPVI-mediated activation cascade (Dictyostelium discoideum)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Immune System (Dictyostelium discoideum)
Adaptive Immune System (Dictyostelium discoideum)
Costimulation by the CD28 family (Dictyostelium discoideum)
CD28 co-stimulation (Dictyostelium discoideum)
CD28 dependent PI3K/Akt signaling (Dictyostelium discoideum)
AKT binds PDPK1 (Dictyostelium discoideum)
PDPK1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PDPK1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Dictyostelium discoideum)
AKT:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Dictyostelium discoideum)
AKT:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Dictyostelium discoideum)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Dictyostelium discoideum)
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-DAPP1 (p-BAM32) binds PLCG2 (Dictyostelium discoideum)
p-Y139-DAPP1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] (Dictyostelium discoideum)
p-Y139-DAPP1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Dictyostelium discoideum)
Downstream TCR signaling (Dictyostelium discoideum)
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PKC theta (Dictyostelium discoideum)
PDK1:PIP2,PIP3 [plasma membrane] (Dictyostelium discoideum)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Dictyostelium discoideum)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Dictyostelium discoideum)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Dictyostelium discoideum)
Fc epsilon receptor (FCERI) signaling (Dictyostelium discoideum)
Role of LAT2/NTAL/LAB on calcium mobilization (Dictyostelium discoideum)
Translocation of PDK1 to Plasma membrane (Dictyostelium discoideum)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Dictyostelium discoideum)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Dictyostelium discoideum)
Regulation of actin dynamics for phagocytic cup formation (Dictyostelium discoideum)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Dictyostelium discoideum)
Mother filament:branching complex [cytosol] (Dictyostelium discoideum)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Dictyostelium discoideum)
Mother filament:branching complex [cytosol] (Dictyostelium discoideum)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Dictyostelium discoideum)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Metabolism (Dictyostelium discoideum)
Metabolism of lipids (Dictyostelium discoideum)
Phospholipid metabolism (Dictyostelium discoideum)
PI Metabolism (Dictyostelium discoideum)
Synthesis of PIPs at the plasma membrane (Dictyostelium discoideum)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Dictyostelium discoideum)
Intracellular signaling by second messengers (Dictyostelium discoideum)
PIP3 activates AKT signaling (Dictyostelium discoideum)
AKT binds PDPK1 (Dictyostelium discoideum)
PDPK1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PDPK1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Negative regulation of the PI3K/AKT network (Dictyostelium discoideum)
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Dictyostelium discoideum)
AKT:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Dictyostelium discoideum)
AKT:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates SGK1 (Dictyostelium discoideum)
PDPK1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Dictyostelium discoideum)
AKT:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Dictyostelium discoideum)
AKT:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
MTOR signalling (Dictyostelium discoideum)
Inhibition of TSC complex formation by PKB (Dictyostelium discoideum)
Phosphorylation of TSC2 by PKB (Dictyostelium discoideum)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Dictyostelium discoideum)
GPCR downstream signalling (Dictyostelium discoideum)
G-protein beta:gamma signalling (Dictyostelium discoideum)
G beta:gamma signalling through PI3Kgamma (Dictyostelium discoideum)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDK1 and AKT to the membrane (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PDK1:AKT:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Signaling by Nuclear Receptors (Dictyostelium discoideum)
ESR-mediated signaling (Dictyostelium discoideum)
Extra-nuclear estrogen signaling (Dictyostelium discoideum)
Estrogen-stimulated signaling through PRKCZ (Dictyostelium discoideum)
PRKCZ autophosphorylates downstream of estrogen stimulation (Dictyostelium discoideum)
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Dictyostelium discoideum)
PDPK1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Dictyostelium discoideum)
PDPK1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Dictyostelium discoideum)
Signaling by Insulin receptor (Dictyostelium discoideum)
Insulin receptor signalling cascade (Dictyostelium discoideum)
IRS-mediated signalling (Dictyostelium discoideum)
PI3K Cascade (Dictyostelium discoideum)
Activation of AKT2 (Dictyostelium discoideum)
AKT2 binds PIP3 (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
AKT2:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Dictyostelium discoideum)
AKT2:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Dictyostelium discoideum)
IGF1R signaling cascade (Dictyostelium discoideum)
IRS-related events triggered by IGF1R (Dictyostelium discoideum)
IRS-mediated signalling (Dictyostelium discoideum)
PI3K Cascade (Dictyostelium discoideum)
Activation of AKT2 (Dictyostelium discoideum)
AKT2 binds PIP3 (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
AKT2:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Dictyostelium discoideum)
AKT2:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Dictyostelium discoideum)
VEGFA-VEGFR2 Pathway (Dictyostelium discoideum)
VEGFR2 mediated vascular permeability (Dictyostelium discoideum)
AKT binds PDPK1 (Dictyostelium discoideum)
PDPK1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PDPK1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Dictyostelium discoideum)
AKT:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Dictyostelium discoideum)
AKT:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Dictyostelium discoideum)
Signaling by Rho GTPases (Dictyostelium discoideum)
RHO GTPase Effectors (Dictyostelium discoideum)
RHO GTPases Activate WASPs and WAVEs (Dictyostelium discoideum)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Dictyostelium discoideum)
Mother filament:branching complex [cytosol] (Dictyostelium discoideum)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Dictyostelium discoideum)
Mother filament:branching complex [cytosol] (Dictyostelium discoideum)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Dictyostelium discoideum)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Dictyostelium discoideum)
PI(3,4,5)P3 [plasma membrane]
Drosophila signaling pathways (Drosophila melanogaster)
Insulin receptor mediated signaling (Drosophila melanogaster)
Insulin signaling pathway (Drosophila melanogaster)
Activation of DAkt1 by DPDK1 (Drosophila melanogaster)
DAkt1:PIP3 complex [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Increased PIP3 levels recruit DAkt1 to the membrane (Drosophila melanogaster)
DAkt1:PIP3 complex [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
GPVI-mediated activation cascade (Drosophila melanogaster)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
VAV1 is a GEF for Rho/Rac family GTPases (Drosophila melanogaster)
PIP3:VAV1,2,3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Costimulation by the CD28 family (Drosophila melanogaster)
CD28 co-stimulation (Drosophila melanogaster)
CD28 dependent PI3K/Akt signaling (Drosophila melanogaster)
AKT binds PDPK1 (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Drosophila melanogaster)
AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Drosophila melanogaster)
AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Drosophila melanogaster)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Drosophila melanogaster)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Drosophila melanogaster)
Downstream TCR signaling (Drosophila melanogaster)
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PKC theta (Drosophila melanogaster)
PDK1:PIP2,PIP3 [plasma membrane] (Drosophila melanogaster)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Drosophila melanogaster)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Drosophila melanogaster)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Drosophila melanogaster)
DAP12 interactions (Drosophila melanogaster)
DAP12 signaling (Drosophila melanogaster)
Activation of RAC1 by VAV2/3 (Drosophila melanogaster)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV and BTK to p-SLP-76 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Release of p-PLCG1 (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated Ca+2 mobilization (Drosophila melanogaster)
Autophosphorylation of BTK/ITK (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Hydrolysis of PIP2 by PLCG (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
FCERI mediated MAPK activation (Drosophila melanogaster)
Activation of RAC1 by VAV (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Autophosphorylation of PAK (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Recruitment of PAK to the membrane by binding active RAC1 (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Drosophila melanogaster)
PI3K associates with phosphorylated GAB2 (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PIP2 to PIP3 by PI3K (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Drosophila melanogaster)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Drosophila melanogaster)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Drosophila melanogaster)
Regulation of actin dynamics for phagocytic cup formation (Drosophila melanogaster)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Drosophila melanogaster)
Mother filament:branching complex [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Drosophila melanogaster)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Drosophila melanogaster)
Mother filament:branching complex [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Drosophila melanogaster)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Metabolism (Drosophila melanogaster)
Metabolism of lipids (Drosophila melanogaster)
Phospholipid metabolism (Drosophila melanogaster)
PI Metabolism (Drosophila melanogaster)
Synthesis of PIPs at the plasma membrane (Drosophila melanogaster)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Drosophila melanogaster)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
AKT binds PDPK1 (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Drosophila melanogaster)
AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Drosophila melanogaster)
AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Drosophila melanogaster)
AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Drosophila melanogaster)
AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
MTOR signalling (Drosophila melanogaster)
Inhibition of TSC complex formation by PKB (Drosophila melanogaster)
Phosphorylation of TSC2 by PKB (Drosophila melanogaster)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of complexed TSC2 by PKB (Drosophila melanogaster)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by Erythropoietin (Drosophila melanogaster)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Drosophila melanogaster)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Drosophila melanogaster)
GPCR downstream signalling (Drosophila melanogaster)
G-protein beta:gamma signalling (Drosophila melanogaster)
G beta:gamma signalling through BTK (Drosophila melanogaster)
BTK in PIP3:BTK:G beta-gamma complex is activated (Drosophila melanogaster)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
G beta-gamma complex and PIP3 recruit BTK to membrane (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
G beta:gamma signalling through PI3Kgamma (Drosophila melanogaster)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDK1 and AKT to the membrane (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PDK1:AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by Nuclear Receptors (Drosophila melanogaster)
ESR-mediated signaling (Drosophila melanogaster)
Extra-nuclear estrogen signaling (Drosophila melanogaster)
Estrogen-stimulated signaling through PRKCZ (Drosophila melanogaster)
ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Drosophila melanogaster)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PRKCZ autophosphorylates downstream of estrogen stimulation (Drosophila melanogaster)
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PRKCZ recruits RAS in response to estrogen stimulation (Drosophila melanogaster)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Drosophila melanogaster)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by ALK (Drosophila melanogaster)
PI3K synthesizes PIP3 downstream of ALK (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by EGFR (Drosophila melanogaster)
GAB1 signalosome (Drosophila melanogaster)
Dephosphorylation of Gab1 by SHP2 (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Drosophila melanogaster)
GRB2:p-Y627,Y659-GAB1,GRB2:p-Y627,Y659-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:p-GAB1(partially dephosphorylated):PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
GAB1 phosphorylation by EGFR kinase (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1 binds to phosphorylated EGFR (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
SHP2 dephosphorylates Tyr 992 on EGFR (Drosophila melanogaster)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Sustained activation of SRC kinase by SHP2 (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 (Drosophila melanogaster)
PI3K events in ERBB2 signaling (Drosophila melanogaster)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB4 (Drosophila melanogaster)
PI3K events in ERBB4 signaling (Drosophila melanogaster)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR (Drosophila melanogaster)
Signaling by FGFR1 (Drosophila melanogaster)
Downstream signaling of activated FGFR1 (Drosophila melanogaster)
PI-3K cascade:FGFR1 (Drosophila melanogaster)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade: FGFR1 (Drosophila melanogaster)
Activated FGFR1 binds PLCG1 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
activated FGFR1:PLCG1 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR1 phosphorylates PLCG1 (Drosophila melanogaster)
activated FGFR1:PLCG1 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR2 (Drosophila melanogaster)
Downstream signaling of activated FGFR2 (Drosophila melanogaster)
PI-3K cascade:FGFR2 (Drosophila melanogaster)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR2 (Drosophila melanogaster)
Activated FGFR2 binds PLCG1 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
activated FGFR2:PLCG1 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR2 phosphorylates PLCG1 (Drosophila melanogaster)
activated FGFR2:PLCG1 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR3 (Drosophila melanogaster)
Downstream signaling of activated FGFR3 (Drosophila melanogaster)
PI-3K cascade:FGFR3 (Drosophila melanogaster)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR3 (Drosophila melanogaster)
Activated FGFR3 binds PLCG1 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
activated FGFR3:PLCG1 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR3 phosphorylates PLCG1 (Drosophila melanogaster)
activated FGFR3:PLCG1 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR4 (Drosophila melanogaster)
Downstream signaling of activated FGFR4 (Drosophila melanogaster)
PI-3K cascade:FGFR4 (Drosophila melanogaster)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR4 (Drosophila melanogaster)
Activated FGFR4 binds PLCG1 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
activated FGFR4:PLCG1 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR4 phosphorylates PLCG1 (Drosophila melanogaster)
activated FGFR4:PLCG1 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by Insulin receptor (Drosophila melanogaster)
Insulin receptor signalling cascade (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
Activation of AKT2 (Drosophila melanogaster)
AKT2 binds PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
AKT2:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Drosophila melanogaster)
AKT2:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRKs (Drosophila melanogaster)
Signaling by NTRK1 (TRKA) (Drosophila melanogaster)
PI3K/AKT activation (Drosophila melanogaster)
PI3K produces PIP3 and other phosphatidyl inositides (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by PDGF (Drosophila melanogaster)
Downstream signal transduction (Drosophila melanogaster)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by SCF-KIT (Drosophila melanogaster)
Activation of RAC1 (Drosophila melanogaster)
p-VAV1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Drosophila melanogaster)
IGF1R signaling cascade (Drosophila melanogaster)
IRS-related events triggered by IGF1R (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
Activation of AKT2 (Drosophila melanogaster)
AKT2 binds PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
AKT2:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Drosophila melanogaster)
AKT2:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Drosophila melanogaster)
VEGFA-VEGFR2 Pathway (Drosophila melanogaster)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
VAV exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Drosophila melanogaster)
p-VAV family:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Drosophila melanogaster)
p-VAV family:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
VEGFR2 mediated vascular permeability (Drosophila melanogaster)
AKT binds PDPK1 (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PAK1-3 autophosphorylates (Drosophila melanogaster)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Drosophila melanogaster)
p-VAV family:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Drosophila melanogaster)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Drosophila melanogaster)
p-VAV family:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PAK1-3 dimer disassociates (Drosophila melanogaster)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Drosophila melanogaster)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Drosophila melanogaster)
p-VAV family:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Drosophila melanogaster)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Drosophila melanogaster)
p-VAV family:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
RAC1 binds PAK1-3 (Drosophila melanogaster)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Drosophila melanogaster)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Drosophila melanogaster)
p-VAV family:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Drosophila melanogaster)
p-VAV family:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Drosophila melanogaster)
AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Drosophila melanogaster)
AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3 binds RAC1:GDP (Drosophila melanogaster)
p-VAV family:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Drosophila melanogaster)
p-VAV family:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Drosophila melanogaster)
Signaling by Rho GTPases (Drosophila melanogaster)
RHO GTPase Effectors (Drosophila melanogaster)
RHO GTPases Activate WASPs and WAVEs (Drosophila melanogaster)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Drosophila melanogaster)
Mother filament:branching complex [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Drosophila melanogaster)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Drosophila melanogaster)
Mother filament:branching complex [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Drosophila melanogaster)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
RHO GTPases activate PKNs (Drosophila melanogaster)
PDPK1 phosphorylates PKN1,2,3 (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PI(3,4,5)P3 [plasma membrane]
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
Transcriptional Regulation by TP53 (Gallus gallus)
Regulation of TP53 Activity (Gallus gallus)
Regulation of TP53 Expression and Degradation (Gallus gallus)
Regulation of TP53 Degradation (Gallus gallus)
PDPK1 phosphorylates SGK1 (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
GPVI-mediated activation cascade (Gallus gallus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Costimulation by the CD28 family (Gallus gallus)
CD28 co-stimulation (Gallus gallus)
CD28 dependent PI3K/Akt signaling (Gallus gallus)
AKT binds PDPK1 (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Gallus gallus)
AKT:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Gallus gallus)
AKT:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
CD28 dependent Vav1 pathway (Gallus gallus)
Activation of Cdc42 by pVav1 (Gallus gallus)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Activation of Rac1 by pVav1 (Gallus gallus)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Activation of Vav1 (Gallus gallus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Gallus gallus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Gallus gallus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Gallus gallus)
BLNK (SLP-65) Signalosome [plasma membrane] (Gallus gallus)
p-Y223,551-BTK:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-Y753,Y759,Y1217-PLCG2:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
BTK binds BTK inhibitors (Gallus gallus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Gallus gallus)
BTK:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
BTK:BTK inhibitors [plasma membrane] (Gallus gallus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Gallus gallus)
BTK:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-DAPP1 (p-BAM32) binds PLCG2 (Gallus gallus)
p-Y139-DAPP1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] (Gallus gallus)
p-Y139-DAPP1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Gallus gallus)
Downstream TCR signaling (Gallus gallus)
Activation of TAK1-TAB2 complex (Gallus gallus)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Gallus gallus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Gallus gallus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Gallus gallus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Gallus gallus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Gallus gallus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Hydrolysis of PIP3 to PI(3,4)P2 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Interaction and oligomerization of MALT1 to Bcl10 (Gallus gallus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Gallus gallus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Interaction of Bcl10 to CARMA1 (Gallus gallus)
Bcl10 bound to CARMA1 [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Oligomerization of Bcl10 (Gallus gallus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Oligomerization of CARMA1 (Gallus gallus)
Activated CARMA1 [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of Bcl10 (Gallus gallus)
Bcl10 bound to CARMA1 [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of CARMA1 to Plasma membrane (Gallus gallus)
CARMA1 bound to PDK1 [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Gallus gallus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of TRAF6 to CBM complex (Gallus gallus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Gallus gallus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
TRAF6 trimer bound to CBM complex [plasma membrane] (Gallus gallus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Gallus gallus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-1 family signaling (Gallus gallus)
Interleukin-1 processing (Gallus gallus)
Interleukin-1 family are secreted (Gallus gallus)
GSDMD pore complex [plasma membrane] (Gallus gallus)
GSDMD oligomer:PIPs [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Gallus gallus)
DAP12 interactions (Gallus gallus)
DAP12 signaling (Gallus gallus)
Activation of RAC1 by VAV2/3 (Gallus gallus)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV2/VAV3 by SYK (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of BTK by p-SYK (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-SYK/p-BTK [plasma membrane] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV and BTK to p-SLP-76 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Release of p-PLCG1 (Gallus gallus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Gallus gallus)
FCERI mediated Ca+2 mobilization (Gallus gallus)
Autophosphorylation of BTK/ITK (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Hydrolysis of PIP2 by PLCG (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
FCERI mediated MAPK activation (Gallus gallus)
Activation of RAC1 by VAV (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Autophosphorylation of PAK (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Recruitment of PAK to the membrane by binding active RAC1 (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Gallus gallus)
PI3K associates with phosphorylated GAB2 (Gallus gallus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Gallus gallus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PIP2 to PIP3 by PI3K (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Gallus gallus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Gallus gallus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Gallus gallus)
Regulation of actin dynamics for phagocytic cup formation (Gallus gallus)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Gallus gallus)
Mother filament:branching complex [cytosol] (Gallus gallus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Gallus gallus)
WAVE2, WASP, N-WASP [plasma membrane] (Gallus gallus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Gallus gallus)
WAVE2, WASP, N-WASP [plasma membrane] (Gallus gallus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Gallus gallus)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Gallus gallus)
Mother filament:branching complex [cytosol] (Gallus gallus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Gallus gallus)
WAVE2, WASP, N-WASP [plasma membrane] (Gallus gallus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Gallus gallus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of VAV (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV1 to p-6Y-SYK (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Gallus gallus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Role of phospholipids in phagocytosis (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of PLCG (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Release of PLCG from FCGR (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Toll-like Receptor Cascades (Gallus gallus)
Regulation of TLR by endogenous ligand (Gallus gallus)
HMGB1 release from cells (Gallus gallus)
GSDMD pore complex [plasma membrane] (Gallus gallus)
GSDMD oligomer:PIPs [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Metabolism (Gallus gallus)
Metabolism of lipids (Gallus gallus)
Phospholipid metabolism (Gallus gallus)
PI Metabolism (Gallus gallus)
Synthesis of PIPs at the plasma membrane (Gallus gallus)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Gallus gallus)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Programmed Cell Death (Gallus gallus)
Regulated Necrosis (Gallus gallus)
Pyroptosis (Gallus gallus)
GSDMD (1-275) binds PIPs (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD (1-275):PIPs [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD forms ring‐shaped oligomers (Gallus gallus)
GSDMD oligomer:PIPs [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD pore complex [plasma membrane] (Gallus gallus)
GSDMD oligomer:PIPs [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD oligomerizes into arc-, slit-shaped structures (Gallus gallus)
GSDMD (1-275):PIPs [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD oligomer:PIPs [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME (1-270) binds PIPs (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME (1-270):PIPs [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomerizes (Gallus gallus)
GSDME (1-270):PIPs [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
HMGB1 release from cells (Gallus gallus)
GSDMD pore complex [plasma membrane] (Gallus gallus)
GSDMD oligomer:PIPs [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Interleukin-1 family are secreted (Gallus gallus)
GSDMD pore complex [plasma membrane] (Gallus gallus)
GSDMD oligomer:PIPs [plasma membrane] (Gallus gallus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
AKT binds PDPK1 (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Negative regulation of the PI3K/AKT network (Gallus gallus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Activator:PI3K [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Gallus gallus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Gallus gallus)
AKT:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Gallus gallus)
AKT:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates SGK1 (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Activator:PI3K [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Gallus gallus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Gallus gallus)
AKT:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Gallus gallus)
AKT:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Gallus gallus)
GPCR downstream signalling (Gallus gallus)
G-protein beta:gamma signalling (Gallus gallus)
G beta:gamma signalling through BTK (Gallus gallus)
BTK in PIP3:BTK:G beta-gamma complex is activated (Gallus gallus)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
G beta-gamma complex and PIP3 recruit BTK to membrane (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
G beta:gamma signalling through PI3Kgamma (Gallus gallus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDK1 and AKT to the membrane (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PDK1:AKT:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Nuclear Receptors (Gallus gallus)
ESR-mediated signaling (Gallus gallus)
Extra-nuclear estrogen signaling (Gallus gallus)
Estrogen-stimulated signaling through PRKCZ (Gallus gallus)
ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Gallus gallus)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Gallus gallus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PRKCZ autophosphorylates downstream of estrogen stimulation (Gallus gallus)
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PRKCZ recruits RAS in response to estrogen stimulation (Gallus gallus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Gallus gallus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Gallus gallus)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Gallus gallus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Gallus gallus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ALK (Gallus gallus)
Active ALK binds PLCG1 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Active ALK:PLCG1 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Active ALK phosphorylates PLCG1 (Gallus gallus)
Active ALK:PLCG1 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Active ALK:p-4Y PLCG1 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PI3K synthesizes PIP3 downstream of ALK (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by EGFR (Gallus gallus)
GAB1 signalosome (Gallus gallus)
Activation of SHP2 through the binding to phospho-Gab1 (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Gallus gallus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Gallus gallus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Dephosphorylation of Gab1 by SHP2 (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Gallus gallus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Gallus gallus)
GRB2:p-Y627,Y659-GAB1,GRB2:p-Y627,Y659-GAB1:PIP3 [plasma membrane] (Gallus gallus)
GRB2:p-GAB1(partially dephosphorylated):PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Dephosphorylation of PAG by SHP2 (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Gallus gallus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
GAB1 phosphorylation by EGFR kinase (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Gallus gallus)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Gallus gallus)
GRB2:GAB1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Gallus gallus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1 binds to phosphorylated EGFR (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Gallus gallus)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Gallus gallus)
GRB2:GAB1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Gallus gallus)
GRB2:GAB1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PI3K binds to EGF:EGFR:GRB2:GAB1 (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Gallus gallus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Gallus gallus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Gallus gallus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
SHP2 dephosphorylates Tyr 992 on EGFR (Gallus gallus)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Gallus gallus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Gallus gallus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Sustained activation of SRC kinase by SHP2 (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Gallus gallus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 (Gallus gallus)
PI3K events in ERBB2 signaling (Gallus gallus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB4 (Gallus gallus)
PI3K events in ERBB4 signaling (Gallus gallus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR (Gallus gallus)
Signaling by FGFR1 (Gallus gallus)
Downstream signaling of activated FGFR1 (Gallus gallus)
PI-3K cascade:FGFR1 (Gallus gallus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade: FGFR1 (Gallus gallus)
Activated FGFR1 binds PLCG1 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
activated FGFR1:PLCG1 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR1 phosphorylates PLCG1 (Gallus gallus)
activated FGFR1:PLCG1 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR2 (Gallus gallus)
Downstream signaling of activated FGFR2 (Gallus gallus)
PI-3K cascade:FGFR2 (Gallus gallus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR2 (Gallus gallus)
Activated FGFR2 binds PLCG1 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
activated FGFR2:PLCG1 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR2 phosphorylates PLCG1 (Gallus gallus)
activated FGFR2:PLCG1 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR3 (Gallus gallus)
Downstream signaling of activated FGFR3 (Gallus gallus)
PI-3K cascade:FGFR3 (Gallus gallus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR3 (Gallus gallus)
Activated FGFR3 binds PLCG1 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
activated FGFR3:PLCG1 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR3 phosphorylates PLCG1 (Gallus gallus)
activated FGFR3:PLCG1 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR4 (Gallus gallus)
Downstream signaling of activated FGFR4 (Gallus gallus)
PI-3K cascade:FGFR4 (Gallus gallus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR4 (Gallus gallus)
Activated FGFR4 binds PLCG1 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
activated FGFR4:PLCG1 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR4 phosphorylates PLCG1 (Gallus gallus)
activated FGFR4:PLCG1 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Insulin receptor (Gallus gallus)
Insulin receptor signalling cascade (Gallus gallus)
IRS-mediated signalling (Gallus gallus)
PI3K Cascade (Gallus gallus)
Activation of AKT2 (Gallus gallus)
PDPK1 binds PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by MET (Gallus gallus)
MET activates PI3K/AKT signaling (Gallus gallus)
MET bound PI3K generates PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRKs (Gallus gallus)
Signaling by NTRK1 (TRKA) (Gallus gallus)
PI3K/AKT activation (Gallus gallus)
PI3K produces PIP3 and other phosphatidyl inositides (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by PDGF (Gallus gallus)
Downstream signal transduction (Gallus gallus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by SCF-KIT (Gallus gallus)
Synthesis of PIP3 from PIP2 by PI3K (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Gallus gallus)
IGF1R signaling cascade (Gallus gallus)
IRS-related events triggered by IGF1R (Gallus gallus)
IRS-mediated signalling (Gallus gallus)
PI3K Cascade (Gallus gallus)
Activation of AKT2 (Gallus gallus)
PDPK1 binds PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Src kinases phosphorylate VAV (Gallus gallus)
PIP3:VAV1,2,3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
VAV exchanges GTP for GDP on RAC1, activating it (Gallus gallus)
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Gallus gallus)
p-VAV family:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Gallus gallus)
p-VAV family:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
VEGFR2 mediated vascular permeability (Gallus gallus)
AKT binds PDPK1 (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PAK1-3 autophosphorylates (Gallus gallus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Gallus gallus)
p-VAV family:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Gallus gallus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Gallus gallus)
p-VAV family:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PAK1-3 dimer disassociates (Gallus gallus)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Gallus gallus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Gallus gallus)
p-VAV family:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Gallus gallus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Gallus gallus)
p-VAV family:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
RAC1 binds PAK1-3 (Gallus gallus)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Gallus gallus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Gallus gallus)
p-VAV family:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Gallus gallus)
p-VAV family:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Gallus gallus)
AKT:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Gallus gallus)
AKT:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3 binds RAC1:GDP (Gallus gallus)
p-VAV family:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Gallus gallus)
p-VAV family:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Gallus gallus)
Signaling by Rho GTPases (Gallus gallus)
RHO GTPase Effectors (Gallus gallus)
RHO GTPases Activate WASPs and WAVEs (Gallus gallus)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Gallus gallus)
Mother filament:branching complex [cytosol] (Gallus gallus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Gallus gallus)
WAVE2, WASP, N-WASP [plasma membrane] (Gallus gallus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Gallus gallus)
WAVE2, WASP, N-WASP [plasma membrane] (Gallus gallus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Gallus gallus)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Gallus gallus)
Mother filament:branching complex [cytosol] (Gallus gallus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Gallus gallus)
WAVE2, WASP, N-WASP [plasma membrane] (Gallus gallus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Gallus gallus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Gallus gallus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
RHO GTPases activate PKNs (Gallus gallus)
PDPK1 phosphorylates PKN1,2,3 (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PI(3,4,5)P3 [plasma membrane]
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective pyroptosis (Homo sapiens)
GSDME variant does not bind PIPs (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K gain of function mutants phosphorylate PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PTEN Loss of Function in Cancer (Homo sapiens)
PTEN cancer mutants do not dephosphorylate PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
ALK fusion proteins bind PLCG1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PLC gamma-binding ALK fusion proteins:PLCG1 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
ALK fusions phosphorylate PLCG1 (Homo sapiens)
ALK fusions:p-4Y PLCG1 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PLC gamma-binding ALK fusion proteins:PLCG1 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI3K synthesizes PIP3 downstream of ALK mutants (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by EGFR in Cancer (Homo sapiens)
Signaling by EGFRvIII in Cancer (Homo sapiens)
Constitutive Signaling by EGFRvIII (Homo sapiens)
Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by Ligand-Responsive EGFR Variants in Cancer (Homo sapiens)
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (Homo sapiens)
Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 in Cancer (Homo sapiens)
Signaling by ERBB2 ECD mutants (Homo sapiens)
PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 KD Mutants (Homo sapiens)
PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR in disease (Homo sapiens)
Signaling by FGFR1 in disease (Homo sapiens)
Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR1 mutants and fusions bind PLCG1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR1 mutants and fusions:PLCG1 [cytosol] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR1 mutants and fusions phosphorylate PLCG1 (Homo sapiens)
Activated FGFR1 mutants and fusions:PLCG1 [cytosol] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
FGFR1 mutant receptor activation (Homo sapiens)
Signaling by cytosolic FGFR1 fusion mutants (Homo sapiens)
BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3. (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR2 in disease (Homo sapiens)
Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR2 mutants bind PLCG1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR2 mutants:PLCG1 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR2 mutants phosphorylate PLCG1 (Homo sapiens)
Activated FGFR2 mutants:PLCG1 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR3 in disease (Homo sapiens)
Activated FGFR3 point and translocation mutants bind PLCG1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR3 point and translocation mutants: PLCG1 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR3 point and translocation mutants phosphorylate PLCG1 (Homo sapiens)
Activated FGFR3 point and translocation mutants: PLCG1 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR4 in disease (Homo sapiens)
Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR4 mutants bind PLCG1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR4 mutants:PLCG1 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR4 mutants phosphorylate PLCG1 (Homo sapiens)
Activated FGFR4 mutants:PLCG1 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by KIT in disease (Homo sapiens)
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants (Homo sapiens)
KIT mutants:PI3K catalyze synthesis of PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by PDGFR in disease (Homo sapiens)
Signaling by PDGFRA extracellular domain mutants (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
Interleukin-1 family are secreted (Homo sapiens)
GSDMD pore complex [plasma membrane] (Homo sapiens)
GSDMD oligomer:PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
FCGR3A-mediated IL10 synthesis (Homo sapiens)
Phosphorylation and activation of PLCG due to FCGR3A effect (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Release of PLCG from FCGR3A (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 binds VAV1,2,3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
VAV1,2,3:PI(3,4,5)P3 binds p-6Y-SYK (Homo sapiens)
IgG:Leishmania surface:FCGR3Ap-CD3 dimers:p-6Y-SYK:VAV1,2,3:PI(3,4,5)P3 [plasma membrane] (Homo sapiens)
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-6Y-SYK phosphorylates VAV1,2,3 (Homo sapiens)
IgG:Leishmania surface:FCGR3Ap-CD3 dimers:p-6Y-SYK:VAV1,2,3:PI(3,4,5)P3 [plasma membrane] (Homo sapiens)
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:p-VAV1,2,3:PI(3,4,5)P3 [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP (Homo sapiens)
IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:p-VAV1,2,3:PI(3,4,5)P3 [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
BTK binds BTK inhibitors (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
BTK:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
BTK:BTK inhibitors [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
BTK:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 targets host intracellular signalling and regulatory pathways (Homo sapiens)
PDPK1 phosphorylates AKT at T308 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Expression and Degradation (Homo sapiens)
Regulation of TP53 Degradation (Homo sapiens)
PDPK1 phosphorylates SGK1 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
PDPK1 activates PRKCZ (Homo sapiens)
PDPK1:PIP3:PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PRKCZ (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 binds VAV1,2,3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
VAV1 is a GEF for Rho/Rac family GTPases (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
CD28 co-stimulation (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
AKT binds PDPK1 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT at T308 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Homo sapiens)
AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
CD28 dependent Vav1 pathway (Homo sapiens)
Activation of Cdc42 by pVav1 (Homo sapiens)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activation of Rac1 by pVav1 (Homo sapiens)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activation of Vav1 (Homo sapiens)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Translocation of Vav1 to CD28 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Homo sapiens)
BLNK (SLP-65) Signalosome [plasma membrane] (Homo sapiens)
p-Y223,551-BTK:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y753,Y759,Y1217-PLCG2:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
BTK autophosphorylates (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y223,Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
PLCG2:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y223,551-BTK:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
PLCG2:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y551-BTK:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
BTK binds BTK inhibitors (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
BTK:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
BTK:BTK inhibitors [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
BTK:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
BTK:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phosphorylated BTK phosphorylates PLCG2 (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y223,Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
PLCG2:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y223,551-BTK:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
BLNK (SLP-65) Signalosome [plasma membrane] (Homo sapiens)
p-Y223,551-BTK:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y753,Y759,Y1217-PLCG2:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-DAPP1 (p-BAM32) binds PLCG2 (Homo sapiens)
p-Y139-DAPP1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] (Homo sapiens)
p-Y139-DAPP1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-SYK and LYN phosphorylate BTK (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
BTK:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
PLCG2:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y551-BTK:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
LYN, p-SYK [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
BTK:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
Activation of IKK complex (Homo sapiens)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Homo sapiens)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
CARMA1 trimer [plasma membrane] (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Activation of TAK1-TAB2 complex (Homo sapiens)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Homo sapiens)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
CARMA1 trimer [plasma membrane] (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
CARMA1 trimer [plasma membrane] (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Auto-ubiquitination of TRAF6 (Homo sapiens)
TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
CARMA1 trimer [plasma membrane] (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
CARMA1 trimer [plasma membrane] (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Hydrolysis of PIP3 to PI(3,4)P2 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Interaction and oligomerization of MALT1 to Bcl10 (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
CARMA1 trimer [plasma membrane] (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
CARMA1 trimer [plasma membrane] (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Interaction of Bcl10 to CARMA1 (Homo sapiens)
Bcl10 bound to CARMA1 [plasma membrane] (Homo sapiens)
CARMA1 trimer [plasma membrane] (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 trimer [plasma membrane] (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Oligomerization of Bcl10 (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
CARMA1 trimer [plasma membrane] (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Homo sapiens)
CARMA1 trimer [plasma membrane] (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Oligomerization of CARMA1 (Homo sapiens)
Activated CARMA1 [plasma membrane] (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 trimer [plasma membrane] (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of Bcl10 (Homo sapiens)
Bcl10 bound to CARMA1 [plasma membrane] (Homo sapiens)
CARMA1 trimer [plasma membrane] (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Homo sapiens)
CARMA1 trimer [plasma membrane] (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of CARMA1 (Homo sapiens)
Activated CARMA1 [plasma membrane] (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 bound to PDK1 [plasma membrane] (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PKC theta (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of CARMA1 to Plasma membrane (Homo sapiens)
CARMA1 bound to PDK1 [plasma membrane] (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of TRAF6 to CBM complex (Homo sapiens)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
CARMA1 trimer [plasma membrane] (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
CARMA1 trimer [plasma membrane] (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Ubiquitination of NEMO by TRAF6 (Homo sapiens)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
CARMA1 trimer [plasma membrane] (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by CSF1 (M-CSF) in myeloid cells (Homo sapiens)
CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 processing (Homo sapiens)
Interleukin-1 family are secreted (Homo sapiens)
GSDMD pore complex [plasma membrane] (Homo sapiens)
GSDMD oligomer:PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
Ubiquitination of NEMO by TRAF6 (Homo sapiens)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
CARMA1 trimer [plasma membrane] (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
DAP12 interactions (Homo sapiens)
DAP12 signaling (Homo sapiens)
Activation of RAC1 by VAV2/3 (Homo sapiens)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV2/VAV3 by SYK (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of BTK by p-SYK (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-SYK/p-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV and BTK to p-SLP-76 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Release of p-PLCG1 (Homo sapiens)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Autophosphorylation of BTK/ITK (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Hydrolysis of PIP2 by PLCG (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PLC-gamma (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-SYK/p-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of TEC kinases by p-SYK (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Recruitment of TEC kinases to p-SLP-76 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
FCERI mediated MAPK activation (Homo sapiens)
Activation of RAC1 by VAV (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Autophosphorylation of PAK (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Recruitment of PAK to the membrane by binding active RAC1 (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
FCERI mediated NF-kB activation (Homo sapiens)
Ubiquitination of NEMO by TRAF6 (Homo sapiens)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
CARMA1 trimer [plasma membrane] (Homo sapiens)
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Homo sapiens)
PI3K associates with phosphorylated GAB2 (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of GAB2 by SYK/FYN (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:GAB2 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PIP2 to PIP3 by PI3K (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Recruitment of GAB2 to PM and FCERI by binding to GRB2 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:GAB2 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Homo sapiens)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of VAV (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV1 to p-6Y-SYK (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Role of phospholipids in phagocytosis (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of PLCG (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Release of PLCG from FCGR (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Toll-like Receptor Cascades (Homo sapiens)
Regulation of TLR by endogenous ligand (Homo sapiens)
HMGB1 release from cells (Homo sapiens)
GSDMD pore complex [plasma membrane] (Homo sapiens)
GSDMD oligomer:PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Homo sapiens)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
RSK activation (Homo sapiens)
PDPK1 phosphorylates RSKs (Homo sapiens)
PDPK1:PIP3,PDPK1:PIP2 [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
Pyroptosis (Homo sapiens)
GSDMD (1-275) binds PIPs (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD (1-275):PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD forms ring‐shaped oligomers (Homo sapiens)
GSDMD oligomer:PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD pore complex [plasma membrane] (Homo sapiens)
GSDMD oligomer:PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD oligomerizes into arc-, slit-shaped structures (Homo sapiens)
GSDMD (1-275):PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD oligomer:PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME (1-270) binds PIPs (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME (1-270):PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomerizes (Homo sapiens)
GSDME (1-270):PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
HMGB1 release from cells (Homo sapiens)
GSDMD pore complex [plasma membrane] (Homo sapiens)
GSDMD oligomer:PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Interleukin-1 family are secreted (Homo sapiens)
GSDMD pore complex [plasma membrane] (Homo sapiens)
GSDMD oligomer:PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
RIPK1-mediated regulated necrosis (Homo sapiens)
MLKL binds PIPs (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Homo sapiens)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
AKT binds PDPK1 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Homo sapiens)
AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Homo sapiens)
AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT at T308 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates SGK1 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Homo sapiens)
AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
MTOR signalling (Homo sapiens)
Inhibition of TSC complex formation by PKB (Homo sapiens)
Phosphorylation of TSC2 by PKB (Homo sapiens)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of complexed TSC2 by PKB (Homo sapiens)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by Erythropoietin (Homo sapiens)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Homo sapiens)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G-protein beta:gamma signalling (Homo sapiens)
G beta:gamma signalling through BTK (Homo sapiens)
BTK in PIP3:BTK:G beta-gamma complex is activated (Homo sapiens)
PIP3:Active BTK:G-protein beta-gamma complex [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
G beta-gamma complex and PIP3 recruit BTK to membrane (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3:Active BTK:G-protein beta-gamma complex [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
G beta:gamma signalling through PI3Kgamma (Homo sapiens)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDK1 and AKT to the membrane (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDK1:AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
Estrogen-stimulated signaling through PRKCZ (Homo sapiens)
ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1 activates PRKCZ (Homo sapiens)
PDPK1:PIP3:PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PRKCZ (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PRKCZ autophosphorylates downstream of estrogen stimulation (Homo sapiens)
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PRKCZ recruits RAS in response to estrogen stimulation (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
Active ALK binds PLCG1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Active ALK:PLCG1 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Active ALK phosphorylates PLCG1 (Homo sapiens)
Active ALK:PLCG1 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Active ALK:p-4Y PLCG1 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI3K synthesizes PIP3 downstream of ALK (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by EGFR (Homo sapiens)
GAB1 signalosome (Homo sapiens)
Activation of SHP2 through the binding to phospho-Gab1 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Dephosphorylation of Gab1 by SHP2 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Homo sapiens)
GRB2:p-Y627,Y659-GAB1,GRB2:p-Y627,Y659-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:p-GAB1(partially dephosphorylated):PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Dephosphorylation of PAG by SHP2 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
GAB1 phosphorylation by EGFR kinase (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Homo sapiens)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:GAB1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1 binds to phosphorylated EGFR (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Homo sapiens)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:GAB1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:GAB1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI3K binds to EGF:EGFR:GRB2:GAB1 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
SHP2 dephosphorylates Tyr 992 on EGFR (Homo sapiens)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Sustained activation of SRC kinase by SHP2 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 (Homo sapiens)
PI3K events in ERBB2 signaling (Homo sapiens)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB4 (Homo sapiens)
PI3K events in ERBB4 signaling (Homo sapiens)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR (Homo sapiens)
Signaling by FGFR1 (Homo sapiens)
Downstream signaling of activated FGFR1 (Homo sapiens)
PI-3K cascade:FGFR1 (Homo sapiens)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade: FGFR1 (Homo sapiens)
Activated FGFR1 binds PLCG1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
activated FGFR1:PLCG1 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR1 phosphorylates PLCG1 (Homo sapiens)
activated FGFR1:PLCG1 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR2 (Homo sapiens)
Downstream signaling of activated FGFR2 (Homo sapiens)
PI-3K cascade:FGFR2 (Homo sapiens)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR2 (Homo sapiens)
Activated FGFR2 binds PLCG1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
activated FGFR2:PLCG1 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR2 phosphorylates PLCG1 (Homo sapiens)
activated FGFR2:PLCG1 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR3 (Homo sapiens)
Downstream signaling of activated FGFR3 (Homo sapiens)
PI-3K cascade:FGFR3 (Homo sapiens)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR3 (Homo sapiens)
Activated FGFR3 binds PLCG1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
activated FGFR3:PLCG1 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR3 phosphorylates PLCG1 (Homo sapiens)
activated FGFR3:PLCG1 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR4 (Homo sapiens)
Downstream signaling of activated FGFR4 (Homo sapiens)
PI-3K cascade:FGFR4 (Homo sapiens)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR4 (Homo sapiens)
Activated FGFR4 binds PLCG1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
activated FGFR4:PLCG1 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR4 phosphorylates PLCG1 (Homo sapiens)
activated FGFR4:PLCG1 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
Activation of AKT2 (Homo sapiens)
AKT2 binds PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
AKT2:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Homo sapiens)
AKT2:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PKB-mediated events (Homo sapiens)
PDE3B signalling (Homo sapiens)
p-T309,S474-AKT2:PIP3 phosphorylates PDE3B (Homo sapiens)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by MET (Homo sapiens)
MET activates PI3K/AKT signaling (Homo sapiens)
MET bound PI3K generates PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
PI3K/AKT activation (Homo sapiens)
PI3K produces PIP3 and other phosphatidyl inositides (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRK2 (TRKB) (Homo sapiens)
Activated NTRK2 signals through PI3K (Homo sapiens)
NTRK2-activated PI3K generates PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRK3 (TRKC) (Homo sapiens)
Activated NTRK3 signals through PI3K (Homo sapiens)
Activated NTRK3 stimulates PI3K activity (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by PDGF (Homo sapiens)
Downstream signal transduction (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by SCF-KIT (Homo sapiens)
Activation of RAC1 (Homo sapiens)
p-VAV1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV1 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-VAV1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Synthesis of PIP3 from PIP2 by PI3K (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
Activation of AKT2 (Homo sapiens)
AKT2 binds PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
AKT2:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Homo sapiens)
AKT2:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PKB-mediated events (Homo sapiens)
PDE3B signalling (Homo sapiens)
p-T309,S474-AKT2:PIP3 phosphorylates PDE3B (Homo sapiens)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
PI(3,4,5)P3 binds VAV1,2,3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Src kinases phosphorylate VAV (Homo sapiens)
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
VEGFR2 mediated vascular permeability (Homo sapiens)
AKT binds PDPK1 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PAK1-3 autophosphorylates (Homo sapiens)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Homo sapiens)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PAK1-3 dimer disassociates (Homo sapiens)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Homo sapiens)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Homo sapiens)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT at T308 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
RAC1 binds PAK1-3 (Homo sapiens)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Homo sapiens)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Homo sapiens)
AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3 binds RAC1:GDP (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
RHO GTPases activate PKNs (Homo sapiens)
PDPK1 phosphorylates PKN1,2,3 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional Regulation by TP53 (Mus musculus)
Regulation of TP53 Activity (Mus musculus)
Regulation of TP53 Expression and Degradation (Mus musculus)
Regulation of TP53 Degradation (Mus musculus)
PDPK1 phosphorylates SGK1 (Mus musculus)
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
GPVI-mediated activation cascade (Mus musculus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
VAV1 is a GEF for Rho/Rac family GTPases (Mus musculus)
PIP3:VAV1,2,3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Costimulation by the CD28 family (Mus musculus)
CD28 co-stimulation (Mus musculus)
CD28 dependent PI3K/Akt signaling (Mus musculus)
AKT binds PDPK1 (Mus musculus)
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Mus musculus)
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Mus musculus)
AKT:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Mus musculus)
AKT:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
CD28 dependent Vav1 pathway (Mus musculus)
Activation of Cdc42 by pVav1 (Mus musculus)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Activation of Rac1 by pVav1 (Mus musculus)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Activation of Vav1 (Mus musculus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Translocation of Vav1 to CD28 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Mus musculus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Mus musculus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Mus musculus)
BLNK (SLP-65) Signalosome [plasma membrane] (Mus musculus)
p-Y223,551-BTK:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-Y753,Y759,Y1217-PLCG2:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
BTK binds BTK inhibitors (Mus musculus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Mus musculus)
BTK:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
BTK:BTK inhibitors [plasma membrane] (Mus musculus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Mus musculus)
BTK:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Mus musculus)
BTK:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-DAPP1 (p-BAM32) binds PLCG2 (Mus musculus)
p-Y139-DAPP1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] (Mus musculus)
p-Y139-DAPP1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Mus musculus)
Downstream TCR signaling (Mus musculus)
Activation of IKK complex (Mus musculus)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Mus musculus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Mus musculus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Mus musculus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Mus musculus)
CARMA1 trimer [plasma membrane] (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Activation of TAK1-TAB2 complex (Mus musculus)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Mus musculus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Mus musculus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Mus musculus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Mus musculus)
CARMA1 trimer [plasma membrane] (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Mus musculus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Mus musculus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Mus musculus)
CARMA1 trimer [plasma membrane] (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Auto-ubiquitination of TRAF6 (Mus musculus)
TRAF6 trimer bound to CBM complex [plasma membrane] (Mus musculus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Mus musculus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Mus musculus)
CARMA1 trimer [plasma membrane] (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Mus musculus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Mus musculus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Mus musculus)
CARMA1 trimer [plasma membrane] (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Hydrolysis of PIP3 to PI(3,4)P2 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Interaction and oligomerization of MALT1 to Bcl10 (Mus musculus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Mus musculus)
CARMA1 trimer [plasma membrane] (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Mus musculus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Mus musculus)
CARMA1 trimer [plasma membrane] (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Interaction of Bcl10 to CARMA1 (Mus musculus)
Bcl10 bound to CARMA1 [plasma membrane] (Mus musculus)
CARMA1 trimer [plasma membrane] (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 trimer [plasma membrane] (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Oligomerization of Bcl10 (Mus musculus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Mus musculus)
CARMA1 trimer [plasma membrane] (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Mus musculus)
CARMA1 trimer [plasma membrane] (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Oligomerization of CARMA1 (Mus musculus)
Activated CARMA1 [plasma membrane] (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 trimer [plasma membrane] (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of Bcl10 (Mus musculus)
Bcl10 bound to CARMA1 [plasma membrane] (Mus musculus)
CARMA1 trimer [plasma membrane] (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Mus musculus)
CARMA1 trimer [plasma membrane] (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of CARMA1 (Mus musculus)
Activated CARMA1 [plasma membrane] (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 bound to PDK1 [plasma membrane] (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PKC theta (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of CARMA1 to Plasma membrane (Mus musculus)
CARMA1 bound to PDK1 [plasma membrane] (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of TRAF6 to CBM complex (Mus musculus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Mus musculus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Mus musculus)
CARMA1 trimer [plasma membrane] (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
TRAF6 trimer bound to CBM complex [plasma membrane] (Mus musculus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Mus musculus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Mus musculus)
CARMA1 trimer [plasma membrane] (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Ubiquitination of NEMO by TRAF6 (Mus musculus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Mus musculus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Mus musculus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Mus musculus)
CARMA1 trimer [plasma membrane] (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-1 processing (Mus musculus)
Interleukin-1 family are secreted (Mus musculus)
GSDMD pore complex [plasma membrane] (Mus musculus)
GSDMD oligomer:PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Mus musculus)
C-type lectin receptors (CLRs) (Mus musculus)
CLEC7A (Dectin-1) signaling (Mus musculus)
Ubiquitination of NEMO by TRAF6 (Mus musculus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Mus musculus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Mus musculus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Mus musculus)
CARMA1 trimer [plasma membrane] (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
DAP12 interactions (Mus musculus)
DAP12 signaling (Mus musculus)
Activation of RAC1 by VAV2/3 (Mus musculus)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV2/VAV3 by SYK (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of BTK by p-SYK (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-SYK/p-BTK [plasma membrane] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV and BTK to p-SLP-76 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Release of p-PLCG1 (Mus musculus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated Ca+2 mobilization (Mus musculus)
Autophosphorylation of BTK/ITK (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Hydrolysis of PIP2 by PLCG (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of TEC kinases by p-SYK (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
FCERI mediated MAPK activation (Mus musculus)
Activation of RAC1 by VAV (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Autophosphorylation of PAK (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Recruitment of PAK to the membrane by binding active RAC1 (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
FCERI mediated NF-kB activation (Mus musculus)
Ubiquitination of NEMO by TRAF6 (Mus musculus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Mus musculus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Mus musculus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Mus musculus)
CARMA1 trimer [plasma membrane] (Mus musculus)
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Mus musculus)
PI3K associates with phosphorylated GAB2 (Mus musculus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Mus musculus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PIP2 to PIP3 by PI3K (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Mus musculus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Mus musculus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
Regulation of actin dynamics for phagocytic cup formation (Mus musculus)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Mus musculus)
Mother filament:branching complex [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Mus musculus)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Mus musculus)
Mother filament:branching complex [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of VAV (Mus musculus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV1 to p-6Y-SYK (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Mus musculus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Role of phospholipids in phagocytosis (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of PLCG (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Release of PLCG from FCGR (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Toll-like Receptor Cascades (Mus musculus)
Regulation of TLR by endogenous ligand (Mus musculus)
HMGB1 release from cells (Mus musculus)
GSDMD pore complex [plasma membrane] (Mus musculus)
GSDMD oligomer:PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Metabolism (Mus musculus)
Metabolism of lipids (Mus musculus)
Phospholipid metabolism (Mus musculus)
PI Metabolism (Mus musculus)
Synthesis of PIPs at the plasma membrane (Mus musculus)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Mus musculus)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Programmed Cell Death (Mus musculus)
Regulated Necrosis (Mus musculus)
Pyroptosis (Mus musculus)
GSDMD (1-275) binds PIPs (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD (1-275):PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD forms ring‐shaped oligomers (Mus musculus)
GSDMD oligomer:PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD pore complex [plasma membrane] (Mus musculus)
GSDMD oligomer:PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD oligomerizes into arc-, slit-shaped structures (Mus musculus)
GSDMD (1-275):PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD oligomer:PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME (1-270) binds PIPs (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME (1-270):PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomerizes (Mus musculus)
GSDME (1-270):PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
HMGB1 release from cells (Mus musculus)
GSDMD pore complex [plasma membrane] (Mus musculus)
GSDMD oligomer:PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Interleukin-1 family are secreted (Mus musculus)
GSDMD pore complex [plasma membrane] (Mus musculus)
GSDMD oligomer:PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
RIPK1-mediated regulated necrosis (Mus musculus)
MLKL binds PIPs (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Mus musculus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
AKT binds PDPK1 (Mus musculus)
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Mus musculus)
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Negative regulation of the PI3K/AKT network (Mus musculus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Activator:PI3K [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Mus musculus)
AKT:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Mus musculus)
AKT:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates SGK1 (Mus musculus)
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Activator:PI3K [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Mus musculus)
AKT:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Mus musculus)
AKT:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
MTOR signalling (Mus musculus)
Inhibition of TSC complex formation by PKB (Mus musculus)
Phosphorylation of TSC2 by PKB (Mus musculus)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of complexed TSC2 by PKB (Mus musculus)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Erythropoietin (Mus musculus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Mus musculus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G-protein beta:gamma signalling (Mus musculus)
G beta:gamma signalling through BTK (Mus musculus)
BTK in PIP3:BTK:G beta-gamma complex is activated (Mus musculus)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
G beta-gamma complex and PIP3 recruit BTK to membrane (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
G beta:gamma signalling through PI3Kgamma (Mus musculus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDK1 and AKT to the membrane (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PDK1:AKT:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Nuclear Receptors (Mus musculus)
ESR-mediated signaling (Mus musculus)
Extra-nuclear estrogen signaling (Mus musculus)
Estrogen-stimulated signaling through PRKCZ (Mus musculus)
ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Mus musculus)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Mus musculus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Mus musculus)
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PRKCZ autophosphorylates downstream of estrogen stimulation (Mus musculus)
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Mus musculus)
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Mus musculus)
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PRKCZ recruits RAS in response to estrogen stimulation (Mus musculus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Mus musculus)
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Mus musculus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Mus musculus)
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Mus musculus)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Mus musculus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Mus musculus)
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Mus musculus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Mus musculus)
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by ALK (Mus musculus)
Active ALK binds PLCG1 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Active ALK:PLCG1 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Active ALK phosphorylates PLCG1 (Mus musculus)
Active ALK:PLCG1 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Active ALK:p-4Y PLCG1 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PI3K synthesizes PIP3 downstream of ALK (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by EGFR (Mus musculus)
GAB1 signalosome (Mus musculus)
Activation of SHP2 through the binding to phospho-Gab1 (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Dephosphorylation of Gab1 by SHP2 (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Mus musculus)
GRB2:p-Y627,Y659-GAB1,GRB2:p-Y627,Y659-GAB1:PIP3 [plasma membrane] (Mus musculus)
GRB2:p-GAB1(partially dephosphorylated):PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Dephosphorylation of PAG by SHP2 (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
GAB1 phosphorylation by EGFR kinase (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Mus musculus)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Mus musculus)
GRB2:GAB1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1 binds to phosphorylated EGFR (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Mus musculus)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Mus musculus)
GRB2:GAB1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Mus musculus)
GRB2:GAB1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PI3K binds to EGF:EGFR:GRB2:GAB1 (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
SHP2 dephosphorylates Tyr 992 on EGFR (Mus musculus)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Mus musculus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Sustained activation of SRC kinase by SHP2 (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 (Mus musculus)
PI3K events in ERBB2 signaling (Mus musculus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB4 (Mus musculus)
PI3K events in ERBB4 signaling (Mus musculus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR (Mus musculus)
Signaling by FGFR1 (Mus musculus)
Downstream signaling of activated FGFR1 (Mus musculus)
PI-3K cascade:FGFR1 (Mus musculus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade: FGFR1 (Mus musculus)
Activated FGFR1 binds PLCG1 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
activated FGFR1:PLCG1 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR1 phosphorylates PLCG1 (Mus musculus)
activated FGFR1:PLCG1 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR2 (Mus musculus)
Downstream signaling of activated FGFR2 (Mus musculus)
PI-3K cascade:FGFR2 (Mus musculus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR2 (Mus musculus)
Activated FGFR2 binds PLCG1 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
activated FGFR2:PLCG1 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR2 phosphorylates PLCG1 (Mus musculus)
activated FGFR2:PLCG1 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR3 (Mus musculus)
Downstream signaling of activated FGFR3 (Mus musculus)
PI-3K cascade:FGFR3 (Mus musculus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR3 (Mus musculus)
Activated FGFR3 binds PLCG1 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
activated FGFR3:PLCG1 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR3 phosphorylates PLCG1 (Mus musculus)
activated FGFR3:PLCG1 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR4 (Mus musculus)
Downstream signaling of activated FGFR4 (Mus musculus)
PI-3K cascade:FGFR4 (Mus musculus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR4 (Mus musculus)
Activated FGFR4 binds PLCG1 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
activated FGFR4:PLCG1 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR4 phosphorylates PLCG1 (Mus musculus)
activated FGFR4:PLCG1 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Insulin receptor (Mus musculus)
Insulin receptor signalling cascade (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
Activation of AKT2 (Mus musculus)
AKT2 binds PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
AKT2:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Mus musculus)
AKT2:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by MET (Mus musculus)
MET activates PI3K/AKT signaling (Mus musculus)
MET bound PI3K generates PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRKs (Mus musculus)
Signaling by NTRK1 (TRKA) (Mus musculus)
PI3K/AKT activation (Mus musculus)
PI3K produces PIP3 and other phosphatidyl inositides (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by PDGF (Mus musculus)
Downstream signal transduction (Mus musculus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by SCF-KIT (Mus musculus)
Activation of RAC1 (Mus musculus)
p-VAV1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV1 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-VAV1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Synthesis of PIP3 from PIP2 by PI3K (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Mus musculus)
IGF1R signaling cascade (Mus musculus)
IRS-related events triggered by IGF1R (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
Activation of AKT2 (Mus musculus)
AKT2 binds PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
AKT2:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Mus musculus)
AKT2:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Src kinases phosphorylate VAV (Mus musculus)
PIP3:VAV1,2,3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
VAV exchanges GTP for GDP on RAC1, activating it (Mus musculus)
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Mus musculus)
p-VAV family:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Mus musculus)
p-VAV family:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
VEGFR2 mediated vascular permeability (Mus musculus)
AKT binds PDPK1 (Mus musculus)
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Mus musculus)
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PAK1-3 autophosphorylates (Mus musculus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Mus musculus)
p-VAV family:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Mus musculus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Mus musculus)
p-VAV family:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PAK1-3 dimer disassociates (Mus musculus)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Mus musculus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Mus musculus)
p-VAV family:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Mus musculus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Mus musculus)
p-VAV family:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
RAC1 binds PAK1-3 (Mus musculus)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Mus musculus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Mus musculus)
p-VAV family:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Mus musculus)
p-VAV family:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Mus musculus)
AKT:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Mus musculus)
AKT:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3 binds RAC1:GDP (Mus musculus)
p-VAV family:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Mus musculus)
p-VAV family:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase Effectors (Mus musculus)
RHO GTPases Activate WASPs and WAVEs (Mus musculus)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Mus musculus)
Mother filament:branching complex [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Mus musculus)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Mus musculus)
Mother filament:branching complex [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Mus musculus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
RHO GTPases activate PKNs (Mus musculus)
PDPK1 phosphorylates PKN1,2,3 (Mus musculus)
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Mus musculus)
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Mus musculus)
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Mus musculus)
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Plasmodium falciparum)
Platelet activation, signaling and aggregation (Plasmodium falciparum)
GPVI-mediated activation cascade (Plasmodium falciparum)
PIP3 recruits PDPK1 to the membrane (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
Immune System (Plasmodium falciparum)
Adaptive Immune System (Plasmodium falciparum)
Costimulation by the CD28 family (Plasmodium falciparum)
CD28 co-stimulation (Plasmodium falciparum)
CD28 dependent PI3K/Akt signaling (Plasmodium falciparum)
PIP3 recruits PDPK1 to the membrane (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Plasmodium falciparum)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Plasmodium falciparum)
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PIP3 [plasma membrane] (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
p-DAPP1 (p-BAM32) binds PLCG2 (Plasmodium falciparum)
p-Y139-DAPP1:PIP3 [plasma membrane] (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] (Plasmodium falciparum)
p-Y139-DAPP1:PIP3 [plasma membrane] (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Plasmodium falciparum)
Downstream TCR signaling (Plasmodium falciparum)
Translocation of PDK1 to Plasma membrane (Plasmodium falciparum)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Plasmodium falciparum)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Plasmodium falciparum)
Fc epsilon receptor (FCERI) signaling (Plasmodium falciparum)
Role of LAT2/NTAL/LAB on calcium mobilization (Plasmodium falciparum)
Translocation of PDK1 to Plasma membrane (Plasmodium falciparum)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Plasmodium falciparum)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Metabolism (Plasmodium falciparum)
Metabolism of lipids (Plasmodium falciparum)
Phospholipid metabolism (Plasmodium falciparum)
PI Metabolism (Plasmodium falciparum)
Synthesis of PIPs at the plasma membrane (Plasmodium falciparum)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Plasmodium falciparum)
Intracellular signaling by second messengers (Plasmodium falciparum)
PIP3 activates AKT signaling (Plasmodium falciparum)
PIP3 recruits PDPK1 to the membrane (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Plasmodium falciparum)
Signaling by Insulin receptor (Plasmodium falciparum)
Insulin receptor signalling cascade (Plasmodium falciparum)
IRS-mediated signalling (Plasmodium falciparum)
PI3K Cascade (Plasmodium falciparum)
Activation of AKT2 (Plasmodium falciparum)
PDPK1 binds PIP3 (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Plasmodium falciparum)
IGF1R signaling cascade (Plasmodium falciparum)
IRS-related events triggered by IGF1R (Plasmodium falciparum)
IRS-mediated signalling (Plasmodium falciparum)
PI3K Cascade (Plasmodium falciparum)
Activation of AKT2 (Plasmodium falciparum)
PDPK1 binds PIP3 (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Plasmodium falciparum)
VEGFA-VEGFR2 Pathway (Plasmodium falciparum)
VEGFR2 mediated vascular permeability (Plasmodium falciparum)
PIP3 recruits PDPK1 to the membrane (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Plasmodium falciparum)
PI(3,4,5)P3 [plasma membrane]
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional Regulation by TP53 (Rattus norvegicus)
Regulation of TP53 Activity (Rattus norvegicus)
Regulation of TP53 Expression and Degradation (Rattus norvegicus)
Regulation of TP53 Degradation (Rattus norvegicus)
PDPK1 phosphorylates SGK1 (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
GPVI-mediated activation cascade (Rattus norvegicus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
VAV1 is a GEF for Rho/Rac family GTPases (Rattus norvegicus)
PIP3:VAV1,2,3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Costimulation by the CD28 family (Rattus norvegicus)
CD28 co-stimulation (Rattus norvegicus)
CD28 dependent PI3K/Akt signaling (Rattus norvegicus)
AKT binds PDPK1 (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Rattus norvegicus)
AKT:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Rattus norvegicus)
AKT:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
CD28 dependent Vav1 pathway (Rattus norvegicus)
Activation of Cdc42 by pVav1 (Rattus norvegicus)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Activation of Rac1 by pVav1 (Rattus norvegicus)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Activation of Vav1 (Rattus norvegicus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Translocation of Vav1 to CD28 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Rattus norvegicus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Rattus norvegicus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Rattus norvegicus)
BLNK (SLP-65) Signalosome [plasma membrane] (Rattus norvegicus)
p-Y223,551-BTK:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-Y753,Y759,Y1217-PLCG2:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
BTK binds BTK inhibitors (Rattus norvegicus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Rattus norvegicus)
BTK:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
BTK:BTK inhibitors [plasma membrane] (Rattus norvegicus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Rattus norvegicus)
BTK:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Rattus norvegicus)
BTK:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-DAPP1 (p-BAM32) binds PLCG2 (Rattus norvegicus)
p-Y139-DAPP1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] (Rattus norvegicus)
p-Y139-DAPP1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Rattus norvegicus)
Downstream TCR signaling (Rattus norvegicus)
Activation of IKK complex (Rattus norvegicus)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Rattus norvegicus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Rattus norvegicus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Rattus norvegicus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Activation of TAK1-TAB2 complex (Rattus norvegicus)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Rattus norvegicus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Rattus norvegicus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Rattus norvegicus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Rattus norvegicus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Rattus norvegicus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Hydrolysis of PIP3 to PI(3,4)P2 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Interaction and oligomerization of MALT1 to Bcl10 (Rattus norvegicus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Rattus norvegicus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Interaction of Bcl10 to CARMA1 (Rattus norvegicus)
Bcl10 bound to CARMA1 [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Oligomerization of Bcl10 (Rattus norvegicus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Oligomerization of CARMA1 (Rattus norvegicus)
Activated CARMA1 [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of Bcl10 (Rattus norvegicus)
Bcl10 bound to CARMA1 [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of CARMA1 (Rattus norvegicus)
Activated CARMA1 [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 bound to PDK1 [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PKC theta (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of CARMA1 to Plasma membrane (Rattus norvegicus)
CARMA1 bound to PDK1 [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of TRAF6 to CBM complex (Rattus norvegicus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Rattus norvegicus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
TRAF6 trimer bound to CBM complex [plasma membrane] (Rattus norvegicus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Rattus norvegicus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-1 family signaling (Rattus norvegicus)
Interleukin-1 processing (Rattus norvegicus)
Interleukin-1 family are secreted (Rattus norvegicus)
GSDMD pore complex [plasma membrane] (Rattus norvegicus)
GSDMD oligomer:PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Rattus norvegicus)
DAP12 interactions (Rattus norvegicus)
DAP12 signaling (Rattus norvegicus)
Activation of RAC1 by VAV2/3 (Rattus norvegicus)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV2/VAV3 by SYK (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of BTK by p-SYK (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-SYK/p-BTK [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV and BTK to p-SLP-76 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Release of p-PLCG1 (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
FCERI mediated Ca+2 mobilization (Rattus norvegicus)
Autophosphorylation of BTK/ITK (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Hydrolysis of PIP2 by PLCG (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of TEC kinases by p-SYK (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
FCERI mediated MAPK activation (Rattus norvegicus)
Activation of RAC1 by VAV (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Autophosphorylation of PAK (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Recruitment of PAK to the membrane by binding active RAC1 (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Rattus norvegicus)
PI3K associates with phosphorylated GAB2 (Rattus norvegicus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Rattus norvegicus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PIP2 to PIP3 by PI3K (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Rattus norvegicus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
Regulation of actin dynamics for phagocytic cup formation (Rattus norvegicus)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Rattus norvegicus)
Mother filament:branching complex [cytosol] (Rattus norvegicus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Rattus norvegicus)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Rattus norvegicus)
Mother filament:branching complex [cytosol] (Rattus norvegicus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of VAV (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV1 to p-6Y-SYK (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Rattus norvegicus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Role of phospholipids in phagocytosis (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of PLCG (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Release of PLCG from FCGR (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Toll-like Receptor Cascades (Rattus norvegicus)
Regulation of TLR by endogenous ligand (Rattus norvegicus)
HMGB1 release from cells (Rattus norvegicus)
GSDMD pore complex [plasma membrane] (Rattus norvegicus)
GSDMD oligomer:PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Metabolism (Rattus norvegicus)
Metabolism of lipids (Rattus norvegicus)
Phospholipid metabolism (Rattus norvegicus)
PI Metabolism (Rattus norvegicus)
Synthesis of PIPs at the plasma membrane (Rattus norvegicus)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Rattus norvegicus)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Programmed Cell Death (Rattus norvegicus)
Regulated Necrosis (Rattus norvegicus)
Pyroptosis (Rattus norvegicus)
GSDMD (1-275) binds PIPs (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD (1-275):PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD forms ring‐shaped oligomers (Rattus norvegicus)
GSDMD oligomer:PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD pore complex [plasma membrane] (Rattus norvegicus)
GSDMD oligomer:PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD oligomerizes into arc-, slit-shaped structures (Rattus norvegicus)
GSDMD (1-275):PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD oligomer:PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME (1-270) binds PIPs (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME (1-270):PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomerizes (Rattus norvegicus)
GSDME (1-270):PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
HMGB1 release from cells (Rattus norvegicus)
GSDMD pore complex [plasma membrane] (Rattus norvegicus)
GSDMD oligomer:PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Interleukin-1 family are secreted (Rattus norvegicus)
GSDMD pore complex [plasma membrane] (Rattus norvegicus)
GSDMD oligomer:PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
RIPK1-mediated regulated necrosis (Rattus norvegicus)
MLKL binds PIPs (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Rattus norvegicus)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
AKT binds PDPK1 (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Negative regulation of the PI3K/AKT network (Rattus norvegicus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Activator:PI3K [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Rattus norvegicus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Rattus norvegicus)
AKT:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Rattus norvegicus)
AKT:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates SGK1 (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Activator:PI3K [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Rattus norvegicus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Rattus norvegicus)
AKT:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Rattus norvegicus)
AKT:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
MTOR signalling (Rattus norvegicus)
Inhibition of TSC complex formation by PKB (Rattus norvegicus)
Phosphorylation of TSC2 by PKB (Rattus norvegicus)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of complexed TSC2 by PKB (Rattus norvegicus)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Erythropoietin (Rattus norvegicus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Rattus norvegicus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G-protein beta:gamma signalling (Rattus norvegicus)
G beta:gamma signalling through PI3Kgamma (Rattus norvegicus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDK1 and AKT to the membrane (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PDK1:AKT:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Nuclear Receptors (Rattus norvegicus)
ESR-mediated signaling (Rattus norvegicus)
Extra-nuclear estrogen signaling (Rattus norvegicus)
Estrogen-stimulated signaling through PRKCZ (Rattus norvegicus)
ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Rattus norvegicus)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PRKCZ autophosphorylates downstream of estrogen stimulation (Rattus norvegicus)
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PRKCZ recruits RAS in response to estrogen stimulation (Rattus norvegicus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Rattus norvegicus)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by ALK (Rattus norvegicus)
Active ALK binds PLCG1 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Active ALK:PLCG1 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Active ALK phosphorylates PLCG1 (Rattus norvegicus)
Active ALK:PLCG1 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Active ALK:p-4Y PLCG1 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PI3K synthesizes PIP3 downstream of ALK (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Signaling by EGFR (Rattus norvegicus)
GAB1 signalosome (Rattus norvegicus)
Activation of SHP2 through the binding to phospho-Gab1 (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Rattus norvegicus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Rattus norvegicus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Dephosphorylation of Gab1 by SHP2 (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Rattus norvegicus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Rattus norvegicus)
GRB2:p-Y627,Y659-GAB1,GRB2:p-Y627,Y659-GAB1:PIP3 [plasma membrane] (Rattus norvegicus)
GRB2:p-GAB1(partially dephosphorylated):PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Dephosphorylation of PAG by SHP2 (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Rattus norvegicus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
GAB1 phosphorylation by EGFR kinase (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Rattus norvegicus)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Rattus norvegicus)
GRB2:GAB1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Rattus norvegicus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1 binds to phosphorylated EGFR (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Rattus norvegicus)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Rattus norvegicus)
GRB2:GAB1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Rattus norvegicus)
GRB2:GAB1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PI3K binds to EGF:EGFR:GRB2:GAB1 (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Rattus norvegicus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Rattus norvegicus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Rattus norvegicus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
SHP2 dephosphorylates Tyr 992 on EGFR (Rattus norvegicus)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Rattus norvegicus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Rattus norvegicus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Rattus norvegicus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Sustained activation of SRC kinase by SHP2 (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Rattus norvegicus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 (Rattus norvegicus)
PI3K events in ERBB2 signaling (Rattus norvegicus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB4 (Rattus norvegicus)
PI3K events in ERBB4 signaling (Rattus norvegicus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR (Rattus norvegicus)
Signaling by FGFR1 (Rattus norvegicus)
Downstream signaling of activated FGFR1 (Rattus norvegicus)
PI-3K cascade:FGFR1 (Rattus norvegicus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade: FGFR1 (Rattus norvegicus)
Activated FGFR1 binds PLCG1 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
activated FGFR1:PLCG1 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR1 phosphorylates PLCG1 (Rattus norvegicus)
activated FGFR1:PLCG1 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR2 (Rattus norvegicus)
Downstream signaling of activated FGFR2 (Rattus norvegicus)
PI-3K cascade:FGFR2 (Rattus norvegicus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR2 (Rattus norvegicus)
Activated FGFR2 binds PLCG1 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
activated FGFR2:PLCG1 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR2 phosphorylates PLCG1 (Rattus norvegicus)
activated FGFR2:PLCG1 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR3 (Rattus norvegicus)
Downstream signaling of activated FGFR3 (Rattus norvegicus)
PI-3K cascade:FGFR3 (Rattus norvegicus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR3 (Rattus norvegicus)
Activated FGFR3 binds PLCG1 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
activated FGFR3:PLCG1 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR3 phosphorylates PLCG1 (Rattus norvegicus)
activated FGFR3:PLCG1 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR4 (Rattus norvegicus)
Downstream signaling of activated FGFR4 (Rattus norvegicus)
PI-3K cascade:FGFR4 (Rattus norvegicus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR4 (Rattus norvegicus)
Activated FGFR4 binds PLCG1 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
activated FGFR4:PLCG1 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR4 phosphorylates PLCG1 (Rattus norvegicus)
activated FGFR4:PLCG1 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Insulin receptor (Rattus norvegicus)
Insulin receptor signalling cascade (Rattus norvegicus)
IRS-mediated signalling (Rattus norvegicus)
PI3K Cascade (Rattus norvegicus)
Activation of AKT2 (Rattus norvegicus)
AKT2 binds PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
AKT2:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Rattus norvegicus)
AKT2:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Signaling by MET (Rattus norvegicus)
MET activates PI3K/AKT signaling (Rattus norvegicus)
MET bound PI3K generates PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRKs (Rattus norvegicus)
Signaling by NTRK1 (TRKA) (Rattus norvegicus)
PI3K/AKT activation (Rattus norvegicus)
PI3K produces PIP3 and other phosphatidyl inositides (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Signaling by PDGF (Rattus norvegicus)
Downstream signal transduction (Rattus norvegicus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Signaling by SCF-KIT (Rattus norvegicus)
Activation of RAC1 (Rattus norvegicus)
p-VAV1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV1 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-VAV1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Synthesis of PIP3 from PIP2 by PI3K (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Rattus norvegicus)
IGF1R signaling cascade (Rattus norvegicus)
IRS-related events triggered by IGF1R (Rattus norvegicus)
IRS-mediated signalling (Rattus norvegicus)
PI3K Cascade (Rattus norvegicus)
Activation of AKT2 (Rattus norvegicus)
AKT2 binds PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
AKT2:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Rattus norvegicus)
AKT2:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Src kinases phosphorylate VAV (Rattus norvegicus)
PIP3:VAV1,2,3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
VAV exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Rattus norvegicus)
p-VAV family:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Rattus norvegicus)
p-VAV family:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
VEGFR2 mediated vascular permeability (Rattus norvegicus)
AKT binds PDPK1 (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PAK1-3 autophosphorylates (Rattus norvegicus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Rattus norvegicus)
p-VAV family:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Rattus norvegicus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Rattus norvegicus)
p-VAV family:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PAK1-3 dimer disassociates (Rattus norvegicus)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Rattus norvegicus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Rattus norvegicus)
p-VAV family:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Rattus norvegicus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Rattus norvegicus)
p-VAV family:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
RAC1 binds PAK1-3 (Rattus norvegicus)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Rattus norvegicus)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Rattus norvegicus)
p-VAV family:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Rattus norvegicus)
p-VAV family:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Rattus norvegicus)
AKT:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Rattus norvegicus)
AKT:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3 binds RAC1:GDP (Rattus norvegicus)
p-VAV family:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Rattus norvegicus)
p-VAV family:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
Signaling by Rho GTPases (Rattus norvegicus)
RHO GTPase Effectors (Rattus norvegicus)
RHO GTPases Activate WASPs and WAVEs (Rattus norvegicus)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Rattus norvegicus)
Mother filament:branching complex [cytosol] (Rattus norvegicus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Rattus norvegicus)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Rattus norvegicus)
Mother filament:branching complex [cytosol] (Rattus norvegicus)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Rattus norvegicus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
RHO GTPases activate PKNs (Rattus norvegicus)
PDPK1 phosphorylates PKN1,2,3 (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PI(3,4,5)P3 [plasma membrane]
Gene expression (Transcription) (Saccharomyces cerevisiae)
RNA Polymerase II Transcription (Saccharomyces cerevisiae)
Generic Transcription Pathway (Saccharomyces cerevisiae)
Transcriptional Regulation by TP53 (Saccharomyces cerevisiae)
Regulation of TP53 Activity (Saccharomyces cerevisiae)
Regulation of TP53 Expression and Degradation (Saccharomyces cerevisiae)
Regulation of TP53 Degradation (Saccharomyces cerevisiae)
PDPK1 phosphorylates SGK1 (Saccharomyces cerevisiae)
PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Saccharomyces cerevisiae)
Platelet activation, signaling and aggregation (Saccharomyces cerevisiae)
GPVI-mediated activation cascade (Saccharomyces cerevisiae)
PIP3 recruits PDPK1 to the membrane (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
Immune System (Saccharomyces cerevisiae)
Adaptive Immune System (Saccharomyces cerevisiae)
Costimulation by the CD28 family (Saccharomyces cerevisiae)
CD28 co-stimulation (Saccharomyces cerevisiae)
CD28 dependent PI3K/Akt signaling (Saccharomyces cerevisiae)
AKT binds PDPK1 (Saccharomyces cerevisiae)
PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Saccharomyces cerevisiae)
AKT:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Saccharomyces cerevisiae)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Saccharomyces cerevisiae)
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
p-DAPP1 (p-BAM32) binds PLCG2 (Saccharomyces cerevisiae)
p-Y139-DAPP1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
p-Y139-DAPP1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Saccharomyces cerevisiae)
Downstream TCR signaling (Saccharomyces cerevisiae)
PTEN dephosphorylates PIP3 (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PKC theta (Saccharomyces cerevisiae)
PDK1:PIP2,PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Saccharomyces cerevisiae)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Saccharomyces cerevisiae)
Fc epsilon receptor (FCERI) signaling (Saccharomyces cerevisiae)
Role of LAT2/NTAL/LAB on calcium mobilization (Saccharomyces cerevisiae)
Translocation of PDK1 to Plasma membrane (Saccharomyces cerevisiae)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Metabolism (Saccharomyces cerevisiae)
Metabolism of lipids (Saccharomyces cerevisiae)
Phospholipid metabolism (Saccharomyces cerevisiae)
PI Metabolism (Saccharomyces cerevisiae)
Synthesis of PIPs at the plasma membrane (Saccharomyces cerevisiae)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Saccharomyces cerevisiae)
Intracellular signaling by second messengers (Saccharomyces cerevisiae)
PIP3 activates AKT signaling (Saccharomyces cerevisiae)
AKT binds PDPK1 (Saccharomyces cerevisiae)
PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
Negative regulation of the PI3K/AKT network (Saccharomyces cerevisiae)
PTEN dephosphorylates PIP3 (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates SGK1 (Saccharomyces cerevisiae)
PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Saccharomyces cerevisiae)
AKT:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Saccharomyces cerevisiae)
GPCR downstream signalling (Saccharomyces cerevisiae)
G-protein beta:gamma signalling (Saccharomyces cerevisiae)
G beta:gamma signalling through PI3Kgamma (Saccharomyces cerevisiae)
PIP3 binds to RhoA and activates it (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDK1 and AKT to the membrane (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
PDK1:AKT:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
Signaling by Nuclear Receptors (Saccharomyces cerevisiae)
ESR-mediated signaling (Saccharomyces cerevisiae)
Extra-nuclear estrogen signaling (Saccharomyces cerevisiae)
Estrogen-stimulated signaling through PRKCZ (Saccharomyces cerevisiae)
PRKCZ autophosphorylates downstream of estrogen stimulation (Saccharomyces cerevisiae)
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Saccharomyces cerevisiae)
PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Saccharomyces cerevisiae)
PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Saccharomyces cerevisiae)
Signaling by Insulin receptor (Saccharomyces cerevisiae)
Insulin receptor signalling cascade (Saccharomyces cerevisiae)
IRS-mediated signalling (Saccharomyces cerevisiae)
PI3K Cascade (Saccharomyces cerevisiae)
Activation of AKT2 (Saccharomyces cerevisiae)
PDPK1 binds PIP3 (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Saccharomyces cerevisiae)
AKT2:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRKs (Saccharomyces cerevisiae)
Signaling by NTRK1 (TRKA) (Saccharomyces cerevisiae)
PI3K/AKT activation (Saccharomyces cerevisiae)
PIP3 binds to RhoA and activates it (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Saccharomyces cerevisiae)
IGF1R signaling cascade (Saccharomyces cerevisiae)
IRS-related events triggered by IGF1R (Saccharomyces cerevisiae)
IRS-mediated signalling (Saccharomyces cerevisiae)
PI3K Cascade (Saccharomyces cerevisiae)
Activation of AKT2 (Saccharomyces cerevisiae)
PDPK1 binds PIP3 (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Saccharomyces cerevisiae)
AKT2:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Saccharomyces cerevisiae)
VEGFA-VEGFR2 Pathway (Saccharomyces cerevisiae)
VEGFR2 mediated vascular permeability (Saccharomyces cerevisiae)
AKT binds PDPK1 (Saccharomyces cerevisiae)
PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Saccharomyces cerevisiae)
AKT:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Saccharomyces cerevisiae)
Signaling by Rho GTPases (Saccharomyces cerevisiae)
RHO GTPase Effectors (Saccharomyces cerevisiae)
RHO GTPases activate PKNs (Saccharomyces cerevisiae)
PDPK1 phosphorylates PKN1,2,3 (Saccharomyces cerevisiae)
PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Saccharomyces cerevisiae)
PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PI(3,4,5)P3 [plasma membrane]
Gene expression (Transcription) (Schizosaccharomyces pombe)
RNA Polymerase II Transcription (Schizosaccharomyces pombe)
Generic Transcription Pathway (Schizosaccharomyces pombe)
Transcriptional Regulation by TP53 (Schizosaccharomyces pombe)
Regulation of TP53 Activity (Schizosaccharomyces pombe)
Regulation of TP53 Expression and Degradation (Schizosaccharomyces pombe)
Regulation of TP53 Degradation (Schizosaccharomyces pombe)
PDPK1 phosphorylates SGK1 (Schizosaccharomyces pombe)
PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Schizosaccharomyces pombe)
Platelet activation, signaling and aggregation (Schizosaccharomyces pombe)
GPVI-mediated activation cascade (Schizosaccharomyces pombe)
PIP3 recruits PDPK1 to the membrane (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
Immune System (Schizosaccharomyces pombe)
Adaptive Immune System (Schizosaccharomyces pombe)
Costimulation by the CD28 family (Schizosaccharomyces pombe)
CD28 co-stimulation (Schizosaccharomyces pombe)
CD28 dependent PI3K/Akt signaling (Schizosaccharomyces pombe)
AKT binds PDPK1 (Schizosaccharomyces pombe)
PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Schizosaccharomyces pombe)
AKT:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Schizosaccharomyces pombe)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Schizosaccharomyces pombe)
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
p-DAPP1 (p-BAM32) binds PLCG2 (Schizosaccharomyces pombe)
p-Y139-DAPP1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
p-Y139-DAPP1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Schizosaccharomyces pombe)
Downstream TCR signaling (Schizosaccharomyces pombe)
PTEN dephosphorylates PIP3 (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PKC theta (Schizosaccharomyces pombe)
PDK1:PIP2,PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Schizosaccharomyces pombe)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Schizosaccharomyces pombe)
Fc epsilon receptor (FCERI) signaling (Schizosaccharomyces pombe)
Role of LAT2/NTAL/LAB on calcium mobilization (Schizosaccharomyces pombe)
Translocation of PDK1 to Plasma membrane (Schizosaccharomyces pombe)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Metabolism (Schizosaccharomyces pombe)
Metabolism of lipids (Schizosaccharomyces pombe)
Phospholipid metabolism (Schizosaccharomyces pombe)
PI Metabolism (Schizosaccharomyces pombe)
Synthesis of PIPs at the plasma membrane (Schizosaccharomyces pombe)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Schizosaccharomyces pombe)
Intracellular signaling by second messengers (Schizosaccharomyces pombe)
PIP3 activates AKT signaling (Schizosaccharomyces pombe)
AKT binds PDPK1 (Schizosaccharomyces pombe)
PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
Negative regulation of the PI3K/AKT network (Schizosaccharomyces pombe)
PTEN dephosphorylates PIP3 (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates SGK1 (Schizosaccharomyces pombe)
PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits AKT to the membrane (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
AKT:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Schizosaccharomyces pombe)
AKT:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
MTOR signalling (Schizosaccharomyces pombe)
Inhibition of TSC complex formation by PKB (Schizosaccharomyces pombe)
Phosphorylation of TSC2 by PKB (Schizosaccharomyces pombe)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of complexed TSC2 by PKB (Schizosaccharomyces pombe)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Schizosaccharomyces pombe)
GPCR downstream signalling (Schizosaccharomyces pombe)
G-protein beta:gamma signalling (Schizosaccharomyces pombe)
G beta:gamma signalling through PI3Kgamma (Schizosaccharomyces pombe)
PIP3 binds to RhoA and activates it (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDK1 and AKT to the membrane (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
PDK1:AKT:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
Signaling by Nuclear Receptors (Schizosaccharomyces pombe)
ESR-mediated signaling (Schizosaccharomyces pombe)
Extra-nuclear estrogen signaling (Schizosaccharomyces pombe)
Estrogen-stimulated signaling through PRKCZ (Schizosaccharomyces pombe)
PRKCZ autophosphorylates downstream of estrogen stimulation (Schizosaccharomyces pombe)
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Schizosaccharomyces pombe)
PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Schizosaccharomyces pombe)
PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Schizosaccharomyces pombe)
Signaling by Insulin receptor (Schizosaccharomyces pombe)
Insulin receptor signalling cascade (Schizosaccharomyces pombe)
IRS-mediated signalling (Schizosaccharomyces pombe)
PI3K Cascade (Schizosaccharomyces pombe)
Activation of AKT2 (Schizosaccharomyces pombe)
PDPK1 binds PIP3 (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Schizosaccharomyces pombe)
AKT2:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRKs (Schizosaccharomyces pombe)
Signaling by NTRK1 (TRKA) (Schizosaccharomyces pombe)
PI3K/AKT activation (Schizosaccharomyces pombe)
PIP3 binds to RhoA and activates it (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Schizosaccharomyces pombe)
IGF1R signaling cascade (Schizosaccharomyces pombe)
IRS-related events triggered by IGF1R (Schizosaccharomyces pombe)
IRS-mediated signalling (Schizosaccharomyces pombe)
PI3K Cascade (Schizosaccharomyces pombe)
Activation of AKT2 (Schizosaccharomyces pombe)
PDPK1 binds PIP3 (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Schizosaccharomyces pombe)
AKT2:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Schizosaccharomyces pombe)
VEGFA-VEGFR2 Pathway (Schizosaccharomyces pombe)
VEGFR2 mediated vascular permeability (Schizosaccharomyces pombe)
AKT binds PDPK1 (Schizosaccharomyces pombe)
PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
TORC2 (mTOR) phosphorylates AKT at S473 (Schizosaccharomyces pombe)
AKT:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
p-S-AKT:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Schizosaccharomyces pombe)
Signaling by Rho GTPases (Schizosaccharomyces pombe)
RHO GTPase Effectors (Schizosaccharomyces pombe)
RHO GTPases activate PKNs (Schizosaccharomyces pombe)
PDPK1 phosphorylates PKN1,2,3 (Schizosaccharomyces pombe)
PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Schizosaccharomyces pombe)
PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PI(3,4,5)P3 [plasma membrane]
Gene expression (Transcription) (Sus scrofa)
RNA Polymerase II Transcription (Sus scrofa)
Generic Transcription Pathway (Sus scrofa)
Transcriptional Regulation by TP53 (Sus scrofa)
Regulation of TP53 Activity (Sus scrofa)
Regulation of TP53 Expression and Degradation (Sus scrofa)
Regulation of TP53 Degradation (Sus scrofa)
PDPK1 phosphorylates SGK1 (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Sus scrofa)
Platelet activation, signaling and aggregation (Sus scrofa)
GPVI-mediated activation cascade (Sus scrofa)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
VAV1 is a GEF for Rho/Rac family GTPases (Sus scrofa)
PIP3:VAV1,2,3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Costimulation by the CD28 family (Sus scrofa)
CD28 co-stimulation (Sus scrofa)
CD28 dependent PI3K/Akt signaling (Sus scrofa)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
CD28 dependent Vav1 pathway (Sus scrofa)
Activation of Cdc42 by pVav1 (Sus scrofa)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Activation of Rac1 by pVav1 (Sus scrofa)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Activation of Vav1 (Sus scrofa)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Translocation of Vav1 to CD28 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Sus scrofa)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Sus scrofa)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Sus scrofa)
BLNK (SLP-65) Signalosome [plasma membrane] (Sus scrofa)
p-Y223,551-BTK:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-Y753,Y759,Y1217-PLCG2:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
BTK binds BTK inhibitors (Sus scrofa)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Sus scrofa)
BTK:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
BTK:BTK inhibitors [plasma membrane] (Sus scrofa)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Sus scrofa)
BTK:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Sus scrofa)
BTK:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PLCG2:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-DAPP1 (p-BAM32) binds PLCG2 (Sus scrofa)
p-Y139-DAPP1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] (Sus scrofa)
p-Y139-DAPP1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Sus scrofa)
Downstream TCR signaling (Sus scrofa)
Activation of IKK complex (Sus scrofa)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Sus scrofa)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Sus scrofa)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Activation of TAK1-TAB2 complex (Sus scrofa)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Sus scrofa)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Sus scrofa)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Sus scrofa)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Auto-ubiquitination of TRAF6 (Sus scrofa)
TRAF6 trimer bound to CBM complex [plasma membrane] (Sus scrofa)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Sus scrofa)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Hydrolysis of PIP3 to PI(3,4)P2 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Interaction and oligomerization of MALT1 to Bcl10 (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Interaction of Bcl10 to CARMA1 (Sus scrofa)
Bcl10 bound to CARMA1 [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Oligomerization of Bcl10 (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Oligomerization of CARMA1 (Sus scrofa)
Activated CARMA1 [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of Bcl10 (Sus scrofa)
Bcl10 bound to CARMA1 [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of CARMA1 (Sus scrofa)
Activated CARMA1 [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 bound to PDK1 [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PKC theta (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of CARMA1 to Plasma membrane (Sus scrofa)
CARMA1 bound to PDK1 [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of TRAF6 to CBM complex (Sus scrofa)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
TRAF6 trimer bound to CBM complex [plasma membrane] (Sus scrofa)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Ubiquitination of NEMO by TRAF6 (Sus scrofa)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Sus scrofa)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Cytokine Signaling in Immune system (Sus scrofa)
Signaling by Interleukins (Sus scrofa)
Interleukin-1 family signaling (Sus scrofa)
Interleukin-1 processing (Sus scrofa)
Interleukin-1 family are secreted (Sus scrofa)
GSDMD pore complex [plasma membrane] (Sus scrofa)
GSDMD oligomer:PIPs [plasma membrane] (Sus scrofa)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Sus scrofa)
C-type lectin receptors (CLRs) (Sus scrofa)
CLEC7A (Dectin-1) signaling (Sus scrofa)
Ubiquitination of NEMO by TRAF6 (Sus scrofa)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Sus scrofa)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
DAP12 interactions (Sus scrofa)
DAP12 signaling (Sus scrofa)
Activation of RAC1 by VAV2/3 (Sus scrofa)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV2/VAV3 by SYK (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of BTK by p-SYK (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-SYK/p-BTK [plasma membrane] (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV and BTK to p-SLP-76 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Release of p-PLCG1 (Sus scrofa)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Sus scrofa)
FCERI mediated Ca+2 mobilization (Sus scrofa)
Autophosphorylation of BTK/ITK (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Hydrolysis of PIP2 by PLCG (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of TEC kinases by p-SYK (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
FCERI mediated MAPK activation (Sus scrofa)
Activation of RAC1 by VAV (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Autophosphorylation of PAK (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Recruitment of PAK to the membrane by binding active RAC1 (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
FCERI mediated NF-kB activation (Sus scrofa)
Ubiquitination of NEMO by TRAF6 (Sus scrofa)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Sus scrofa)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Sus scrofa)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Sus scrofa)
CARMA1 trimer [plasma membrane] (Sus scrofa)
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Sus scrofa)
PI3K associates with phosphorylated GAB2 (Sus scrofa)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Sus scrofa)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PIP2 to PIP3 by PI3K (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Sus scrofa)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Sus scrofa)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Sus scrofa)
Regulation of actin dynamics for phagocytic cup formation (Sus scrofa)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Sus scrofa)
Mother filament:branching complex [cytosol] (Sus scrofa)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Sus scrofa)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Sus scrofa)
Mother filament:branching complex [cytosol] (Sus scrofa)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of VAV (Sus scrofa)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV1 to p-6Y-SYK (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Sus scrofa)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Role of phospholipids in phagocytosis (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of PLCG (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Release of PLCG from FCGR (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Metabolism (Sus scrofa)
Metabolism of lipids (Sus scrofa)
Phospholipid metabolism (Sus scrofa)
PI Metabolism (Sus scrofa)
Synthesis of PIPs at the plasma membrane (Sus scrofa)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Sus scrofa)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Programmed Cell Death (Sus scrofa)
Regulated Necrosis (Sus scrofa)
Pyroptosis (Sus scrofa)
GSDMD (1-275) binds PIPs (Sus scrofa)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD (1-275):PIPs [plasma membrane] (Sus scrofa)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD forms ring‐shaped oligomers (Sus scrofa)
GSDMD oligomer:PIPs [plasma membrane] (Sus scrofa)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD pore complex [plasma membrane] (Sus scrofa)
GSDMD oligomer:PIPs [plasma membrane] (Sus scrofa)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD oligomerizes into arc-, slit-shaped structures (Sus scrofa)
GSDMD (1-275):PIPs [plasma membrane] (Sus scrofa)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDMD oligomer:PIPs [plasma membrane] (Sus scrofa)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME (1-270) binds PIPs (Sus scrofa)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME (1-270):PIPs [plasma membrane] (Sus scrofa)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomerizes (Sus scrofa)
GSDME (1-270):PIPs [plasma membrane] (Sus scrofa)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Sus scrofa)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Interleukin-1 family are secreted (Sus scrofa)
GSDMD pore complex [plasma membrane] (Sus scrofa)
GSDMD oligomer:PIPs [plasma membrane] (Sus scrofa)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
RIPK1-mediated regulated necrosis (Sus scrofa)
MLKL binds PIPs (Sus scrofa)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Sus scrofa)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Sus scrofa)
Intracellular signaling by second messengers (Sus scrofa)
PIP3 activates AKT signaling (Sus scrofa)
Negative regulation of the PI3K/AKT network (Sus scrofa)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Activator:PI3K [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates SGK1 (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Activator:PI3K [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
MTOR signalling (Sus scrofa)
Inhibition of TSC complex formation by PKB (Sus scrofa)
Phosphorylation of TSC2 by PKB (Sus scrofa)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of complexed TSC2 by PKB (Sus scrofa)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Signaling by Erythropoietin (Sus scrofa)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Sus scrofa)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Sus scrofa)
GPCR downstream signalling (Sus scrofa)
G-protein beta:gamma signalling (Sus scrofa)
G beta:gamma signalling through BTK (Sus scrofa)
BTK in PIP3:BTK:G beta-gamma complex is activated (Sus scrofa)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
G beta-gamma complex and PIP3 recruit BTK to membrane (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
G beta:gamma signalling through PI3Kgamma (Sus scrofa)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Signaling by Nuclear Receptors (Sus scrofa)
ESR-mediated signaling (Sus scrofa)
Extra-nuclear estrogen signaling (Sus scrofa)
Estrogen-stimulated signaling through PRKCZ (Sus scrofa)
ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Sus scrofa)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Sus scrofa)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PRKCZ autophosphorylates downstream of estrogen stimulation (Sus scrofa)
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PRKCZ recruits RAS in response to estrogen stimulation (Sus scrofa)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Sus scrofa)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Sus scrofa)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Sus scrofa)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Sus scrofa)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by ALK (Sus scrofa)
Active ALK binds PLCG1 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Active ALK:PLCG1 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Active ALK phosphorylates PLCG1 (Sus scrofa)
Active ALK:PLCG1 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Active ALK:p-4Y PLCG1 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PI3K synthesizes PIP3 downstream of ALK (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Signaling by EGFR (Sus scrofa)
GAB1 signalosome (Sus scrofa)
Activation of SHP2 through the binding to phospho-Gab1 (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Dephosphorylation of Gab1 by SHP2 (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Sus scrofa)
GRB2:p-Y627,Y659-GAB1,GRB2:p-Y627,Y659-GAB1:PIP3 [plasma membrane] (Sus scrofa)
GRB2:p-GAB1(partially dephosphorylated):PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Dephosphorylation of PAG by SHP2 (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
GAB1 phosphorylation by EGFR kinase (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Sus scrofa)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Sus scrofa)
GRB2:GAB1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1 binds to phosphorylated EGFR (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Sus scrofa)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Sus scrofa)
GRB2:GAB1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Sus scrofa)
GRB2:GAB1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PI3K binds to EGF:EGFR:GRB2:GAB1 (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
SHP2 dephosphorylates Tyr 992 on EGFR (Sus scrofa)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Sus scrofa)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Sustained activation of SRC kinase by SHP2 (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 (Sus scrofa)
PI3K events in ERBB2 signaling (Sus scrofa)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB4 (Sus scrofa)
PI3K events in ERBB4 signaling (Sus scrofa)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR (Sus scrofa)
Signaling by FGFR1 (Sus scrofa)
Downstream signaling of activated FGFR1 (Sus scrofa)
PI-3K cascade:FGFR1 (Sus scrofa)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade: FGFR1 (Sus scrofa)
Activated FGFR1 binds PLCG1 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
activated FGFR1:PLCG1 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR1 phosphorylates PLCG1 (Sus scrofa)
activated FGFR1:PLCG1 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR2 (Sus scrofa)
Downstream signaling of activated FGFR2 (Sus scrofa)
PI-3K cascade:FGFR2 (Sus scrofa)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR3 (Sus scrofa)
Downstream signaling of activated FGFR3 (Sus scrofa)
PI-3K cascade:FGFR3 (Sus scrofa)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR4 (Sus scrofa)
Downstream signaling of activated FGFR4 (Sus scrofa)
PI-3K cascade:FGFR4 (Sus scrofa)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR4 (Sus scrofa)
Activated FGFR4 binds PLCG1 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
activated FGFR4:PLCG1 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR4 phosphorylates PLCG1 (Sus scrofa)
activated FGFR4:PLCG1 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Signaling by Insulin receptor (Sus scrofa)
Insulin receptor signalling cascade (Sus scrofa)
IRS-mediated signalling (Sus scrofa)
PI3K Cascade (Sus scrofa)
Activation of AKT2 (Sus scrofa)
AKT2 binds PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
AKT2:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Sus scrofa)
AKT2:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Signaling by MET (Sus scrofa)
MET activates PI3K/AKT signaling (Sus scrofa)
MET bound PI3K generates PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRKs (Sus scrofa)
Signaling by NTRK1 (TRKA) (Sus scrofa)
PI3K/AKT activation (Sus scrofa)
PI3K produces PIP3 and other phosphatidyl inositides (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Signaling by PDGF (Sus scrofa)
Downstream signal transduction (Sus scrofa)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Signaling by SCF-KIT (Sus scrofa)
Activation of RAC1 (Sus scrofa)
p-VAV1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV1 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-VAV1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Synthesis of PIP3 from PIP2 by PI3K (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Sus scrofa)
IGF1R signaling cascade (Sus scrofa)
IRS-related events triggered by IGF1R (Sus scrofa)
IRS-mediated signalling (Sus scrofa)
PI3K Cascade (Sus scrofa)
Activation of AKT2 (Sus scrofa)
AKT2 binds PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
AKT2:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PDPK1 binds PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PDPK1 phosphorylates AKT2 (Sus scrofa)
AKT2:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-T309,S474-AKT2:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Sus scrofa)
VEGFA-VEGFR2 Pathway (Sus scrofa)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Src kinases phosphorylate VAV (Sus scrofa)
PIP3:VAV1,2,3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
VAV exchanges GTP for GDP on RAC1, activating it (Sus scrofa)
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Sus scrofa)
p-VAV family:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Sus scrofa)
p-VAV family:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
VEGFR2 mediated vascular permeability (Sus scrofa)
PAK1-3 autophosphorylates (Sus scrofa)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Sus scrofa)
p-VAV family:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Sus scrofa)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Sus scrofa)
p-VAV family:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PAK1-3 dimer disassociates (Sus scrofa)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Sus scrofa)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Sus scrofa)
p-VAV family:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Sus scrofa)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Sus scrofa)
p-VAV family:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
RAC1 binds PAK1-3 (Sus scrofa)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Sus scrofa)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Sus scrofa)
p-VAV family:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Sus scrofa)
p-VAV family:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3 binds RAC1:GDP (Sus scrofa)
p-VAV family:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Sus scrofa)
p-VAV family:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Sus scrofa)
Signaling by Rho GTPases (Sus scrofa)
RHO GTPase Effectors (Sus scrofa)
RHO GTPases Activate WASPs and WAVEs (Sus scrofa)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Sus scrofa)
Mother filament:branching complex [cytosol] (Sus scrofa)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Sus scrofa)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Sus scrofa)
Mother filament:branching complex [cytosol] (Sus scrofa)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Sus scrofa)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
RHO GTPases activate PKNs (Sus scrofa)
PDPK1 phosphorylates PKN1,2,3 (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PI(3,4,5)P3 [plasma membrane]
Hemostasis (Xenopus tropicalis)
Platelet activation, signaling and aggregation (Xenopus tropicalis)
GPVI-mediated activation cascade (Xenopus tropicalis)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
VAV1 is a GEF for Rho/Rac family GTPases (Xenopus tropicalis)
PIP3:VAV1,2,3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Immune System (Xenopus tropicalis)
Adaptive Immune System (Xenopus tropicalis)
Costimulation by the CD28 family (Xenopus tropicalis)
CD28 co-stimulation (Xenopus tropicalis)
CD28 dependent PI3K/Akt signaling (Xenopus tropicalis)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
CD28 dependent Vav1 pathway (Xenopus tropicalis)
Activation of Cdc42 by pVav1 (Xenopus tropicalis)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Activation of Rac1 by pVav1 (Xenopus tropicalis)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Activation of Vav1 (Xenopus tropicalis)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Translocation of Vav1 to CD28 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Signaling by the B Cell Receptor (BCR) (Xenopus tropicalis)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Xenopus tropicalis)
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-DAPP1 (p-BAM32) binds PLCG2 (Xenopus tropicalis)
p-Y139-DAPP1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] (Xenopus tropicalis)
p-Y139-DAPP1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
TCR signaling (Xenopus tropicalis)
Downstream TCR signaling (Xenopus tropicalis)
Hydrolysis of PIP3 to PI(3,4)P2 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Oligomerization of CARMA1 (Xenopus tropicalis)
Activated CARMA1 [plasma membrane] (Xenopus tropicalis)
PDK1:PIP2,PIP3 [plasma membrane] (Xenopus tropicalis)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
CARMA1 trimer [plasma membrane] (Xenopus tropicalis)
PDK1:PIP2,PIP3 [plasma membrane] (Xenopus tropicalis)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Translocation of CARMA1 to Plasma membrane (Xenopus tropicalis)
CARMA1 bound to PDK1 [plasma membrane] (Xenopus tropicalis)
PDK1:PIP2,PIP3 [plasma membrane] (Xenopus tropicalis)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Xenopus tropicalis)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Xenopus tropicalis)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Xenopus tropicalis)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Innate Immune System (Xenopus tropicalis)
DAP12 interactions (Xenopus tropicalis)
DAP12 signaling (Xenopus tropicalis)
Activation of RAC1 by VAV2/3 (Xenopus tropicalis)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Xenopus tropicalis)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Recruitment of VAV and BTK to p-SLP-76 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Release of p-PLCG1 (Xenopus tropicalis)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Fc epsilon receptor (FCERI) signaling (Xenopus tropicalis)
FCERI mediated Ca+2 mobilization (Xenopus tropicalis)
Autophosphorylation of BTK/ITK (Xenopus tropicalis)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Hydrolysis of PIP2 by PLCG (Xenopus tropicalis)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
FCERI mediated MAPK activation (Xenopus tropicalis)
Activation of RAC1 by VAV (Xenopus tropicalis)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Autophosphorylation of PAK (Xenopus tropicalis)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Xenopus tropicalis)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Recruitment of PAK to the membrane by binding active RAC1 (Xenopus tropicalis)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Xenopus tropicalis)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Role of LAT2/NTAL/LAB on calcium mobilization (Xenopus tropicalis)
PI3K associates with phosphorylated GAB2 (Xenopus tropicalis)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Xenopus tropicalis)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation of PIP2 to PIP3 by PI3K (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Xenopus tropicalis)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Translocation of PDK1 to Plasma membrane (Xenopus tropicalis)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PDK1:PIP2,PIP3 [plasma membrane] (Xenopus tropicalis)
PIP3, PI(3,4)P2 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Fcgamma receptor (FCGR) dependent phagocytosis (Xenopus tropicalis)
Regulation of actin dynamics for phagocytic cup formation (Xenopus tropicalis)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Xenopus tropicalis)
Mother filament:branching complex [cytosol] (Xenopus tropicalis)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Xenopus tropicalis)
WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Xenopus tropicalis)
WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Xenopus tropicalis)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Xenopus tropicalis)
Mother filament:branching complex [cytosol] (Xenopus tropicalis)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Xenopus tropicalis)
WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Xenopus tropicalis)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Toll-like Receptor Cascades (Xenopus tropicalis)
Regulation of TLR by endogenous ligand (Xenopus tropicalis)
HMGB1 release from cells (Xenopus tropicalis)
GSDME oligomer:PIP [plasma membrane] (Xenopus tropicalis)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Metabolism (Xenopus tropicalis)
Metabolism of lipids (Xenopus tropicalis)
Phospholipid metabolism (Xenopus tropicalis)
PI Metabolism (Xenopus tropicalis)
Synthesis of PIPs at the plasma membrane (Xenopus tropicalis)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Xenopus tropicalis)
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Programmed Cell Death (Xenopus tropicalis)
Regulated Necrosis (Xenopus tropicalis)
Pyroptosis (Xenopus tropicalis)
GSDME (1-270) binds PIPs (Xenopus tropicalis)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME (1-270):PIPs [plasma membrane] (Xenopus tropicalis)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomerizes (Xenopus tropicalis)
GSDME (1-270):PIPs [plasma membrane] (Xenopus tropicalis)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
GSDME oligomer:PIP [plasma membrane] (Xenopus tropicalis)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
HMGB1 release from cells (Xenopus tropicalis)
GSDME oligomer:PIP [plasma membrane] (Xenopus tropicalis)
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Signal Transduction (Xenopus tropicalis)
Intracellular signaling by second messengers (Xenopus tropicalis)
PIP3 activates AKT signaling (Xenopus tropicalis)
Negative regulation of the PI3K/AKT network (Xenopus tropicalis)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Xenopus tropicalis)
PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Activator:PI3K [plasma membrane] (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Xenopus tropicalis)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Xenopus tropicalis)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PTEN dephosphorylates PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Activator:PI3K [plasma membrane] (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Xenopus tropicalis)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Xenopus tropicalis)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Signaling by Erythropoietin (Xenopus tropicalis)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Xenopus tropicalis)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Signaling by GPCR (Xenopus tropicalis)
GPCR downstream signalling (Xenopus tropicalis)
G-protein beta:gamma signalling (Xenopus tropicalis)
G beta:gamma signalling through BTK (Xenopus tropicalis)
BTK in PIP3:BTK:G beta-gamma complex is activated (Xenopus tropicalis)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
G beta-gamma complex and PIP3 recruit BTK to membrane (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
G beta:gamma signalling through PI3Kgamma (Xenopus tropicalis)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by ALK (Xenopus tropicalis)
PI3K synthesizes PIP3 downstream of ALK (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Signaling by EGFR (Xenopus tropicalis)
GAB1 signalosome (Xenopus tropicalis)
Activation of SHP2 through the binding to phospho-Gab1 (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Xenopus tropicalis)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Xenopus tropicalis)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Xenopus tropicalis)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Xenopus tropicalis)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Dephosphorylation of Gab1 by SHP2 (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Xenopus tropicalis)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Xenopus tropicalis)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
GRB2:p-Y627,Y659-GAB1,GRB2:p-Y627,Y659-GAB1:PIP3 [plasma membrane] (Xenopus tropicalis)
GRB2:p-GAB1(partially dephosphorylated):PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Dephosphorylation of PAG by SHP2 (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Xenopus tropicalis)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Xenopus tropicalis)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
GAB1 phosphorylation by EGFR kinase (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Xenopus tropicalis)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Xenopus tropicalis)
GRB2:GAB1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Xenopus tropicalis)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Xenopus tropicalis)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1 binds to phosphorylated EGFR (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Xenopus tropicalis)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Xenopus tropicalis)
GRB2:GAB1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Xenopus tropicalis)
GRB2:GAB1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PI3K binds to EGF:EGFR:GRB2:GAB1 (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Xenopus tropicalis)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Xenopus tropicalis)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Xenopus tropicalis)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Xenopus tropicalis)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Xenopus tropicalis)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Xenopus tropicalis)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
SHP2 dephosphorylates Tyr 992 on EGFR (Xenopus tropicalis)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Xenopus tropicalis)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Xenopus tropicalis)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Xenopus tropicalis)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB2 (Xenopus tropicalis)
PI3K events in ERBB2 signaling (Xenopus tropicalis)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Signaling by ERBB4 (Xenopus tropicalis)
PI3K events in ERBB4 signaling (Xenopus tropicalis)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR (Xenopus tropicalis)
Signaling by FGFR1 (Xenopus tropicalis)
Downstream signaling of activated FGFR1 (Xenopus tropicalis)
PI-3K cascade:FGFR1 (Xenopus tropicalis)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade: FGFR1 (Xenopus tropicalis)
Activated FGFR1 binds PLCG1 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
activated FGFR1:PLCG1 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR1 phosphorylates PLCG1 (Xenopus tropicalis)
activated FGFR1:PLCG1 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR2 (Xenopus tropicalis)
Downstream signaling of activated FGFR2 (Xenopus tropicalis)
PI-3K cascade:FGFR2 (Xenopus tropicalis)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR3 (Xenopus tropicalis)
Downstream signaling of activated FGFR3 (Xenopus tropicalis)
PI-3K cascade:FGFR3 (Xenopus tropicalis)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Signaling by FGFR4 (Xenopus tropicalis)
Downstream signaling of activated FGFR4 (Xenopus tropicalis)
PI-3K cascade:FGFR4 (Xenopus tropicalis)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Phospholipase C-mediated cascade; FGFR4 (Xenopus tropicalis)
Activated FGFR4 binds PLCG1 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
activated FGFR4:PLCG1 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Activated FGFR4 phosphorylates PLCG1 (Xenopus tropicalis)
activated FGFR4:PLCG1 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Signaling by Insulin receptor (Xenopus tropicalis)
Insulin receptor signalling cascade (Xenopus tropicalis)
IRS-mediated signalling (Xenopus tropicalis)
PI3K Cascade (Xenopus tropicalis)
Activation of AKT2 (Xenopus tropicalis)
PDPK1 binds PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Signaling by MET (Xenopus tropicalis)
MET activates PI3K/AKT signaling (Xenopus tropicalis)
MET bound PI3K generates PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Signaling by NTRKs (Xenopus tropicalis)
Signaling by NTRK1 (TRKA) (Xenopus tropicalis)
PI3K/AKT activation (Xenopus tropicalis)
PI3K produces PIP3 and other phosphatidyl inositides (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PIP3 binds to RhoA and activates it (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PIP3:RhoA [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Signaling by PDGF (Xenopus tropicalis)
Downstream signal transduction (Xenopus tropicalis)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Signaling by SCF-KIT (Xenopus tropicalis)
Activation of RAC1 (Xenopus tropicalis)
p-VAV1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Phosphorylation and activation of VAV1 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-VAV1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Synthesis of PIP3 from PIP2 by PI3K (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Xenopus tropicalis)
IGF1R signaling cascade (Xenopus tropicalis)
IRS-related events triggered by IGF1R (Xenopus tropicalis)
IRS-mediated signalling (Xenopus tropicalis)
PI3K Cascade (Xenopus tropicalis)
Activation of AKT2 (Xenopus tropicalis)
PDPK1 binds PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Signaling by VEGF (Xenopus tropicalis)
VEGFA-VEGFR2 Pathway (Xenopus tropicalis)
VAV exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Xenopus tropicalis)
p-VAV family:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Xenopus tropicalis)
p-VAV family:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
VEGFR2 mediated vascular permeability (Xenopus tropicalis)
PAK1-3 autophosphorylates (Xenopus tropicalis)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Xenopus tropicalis)
p-VAV family:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Xenopus tropicalis)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Xenopus tropicalis)
p-VAV family:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PAK1-3 dimer disassociates (Xenopus tropicalis)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Xenopus tropicalis)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Xenopus tropicalis)
p-VAV family:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Xenopus tropicalis)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Xenopus tropicalis)
p-VAV family:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PIP3 recruits PDPK1 to the membrane (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
PDPK1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
RAC1 binds PAK1-3 (Xenopus tropicalis)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Xenopus tropicalis)
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Xenopus tropicalis)
p-VAV family:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Xenopus tropicalis)
p-VAV family:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3 binds RAC1:GDP (Xenopus tropicalis)
p-VAV family:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Xenopus tropicalis)
p-VAV family:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Xenopus tropicalis)
Signaling by Rho GTPases (Xenopus tropicalis)
RHO GTPase Effectors (Xenopus tropicalis)
RHO GTPases Activate WASPs and WAVEs (Xenopus tropicalis)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Xenopus tropicalis)
Mother filament:branching complex [cytosol] (Xenopus tropicalis)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Xenopus tropicalis)
WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Xenopus tropicalis)
WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
ABL phosphorylates WAVEs (Xenopus tropicalis)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
Detachment of WASP/WAVE (Xenopus tropicalis)
Mother filament:branching complex [cytosol] (Xenopus tropicalis)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Xenopus tropicalis)
WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-ERK phosphorylates WAVEs and ABI (Xenopus tropicalis)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
RHO GTPases activate PKNs (Xenopus tropicalis)
PDPK1 phosphorylates PKN1,2,3 (Xenopus tropicalis)
PDPK1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Xenopus tropicalis)
PDPK1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Xenopus tropicalis)
PDPK1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Xenopus tropicalis)
PDPK1:PIP3 [plasma membrane] (Xenopus tropicalis)
PI(3,4,5)P3 [plasma membrane]
External Reference Information
External Reference
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-) [ChEBI:57836]
Participates
as a component of
DAkt1:PIP3 complex [plasma membrane] (Drosophila melanogaster)
ALK fusions:p-4Y PLCG1 [plasma membrane] (Homo sapiens)
PLC gamma-binding ALK fusion proteins:PLCG1 [plasma membrane] (Homo sapiens)
Active ALK:p-4Y PLCG1 [plasma membrane] (Gallus gallus)
Active ALK:p-4Y PLCG1 [plasma membrane] (Canis familiaris)
Active ALK:p-4Y PLCG1 [plasma membrane] (Rattus norvegicus)
Active ALK:p-4Y PLCG1 [plasma membrane] (Bos taurus)
Active ALK:p-4Y PLCG1 [plasma membrane] (Mus musculus)
Active ALK:p-4Y PLCG1 [plasma membrane] (Danio rerio)
Active ALK:p-4Y PLCG1 [plasma membrane] (Sus scrofa)
Active ALK:p-4Y PLCG1 [plasma membrane] (Homo sapiens)
Active ALK:PLCG1 [plasma membrane] (Bos taurus)
Active ALK:PLCG1 [plasma membrane] (Gallus gallus)
Active ALK:PLCG1 [plasma membrane] (Danio rerio)
Active ALK:PLCG1 [plasma membrane] (Rattus norvegicus)
Active ALK:PLCG1 [plasma membrane] (Sus scrofa)
Active ALK:PLCG1 [plasma membrane] (Mus musculus)
Active ALK:PLCG1 [plasma membrane] (Canis familiaris)
Active ALK:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR2 mutants:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR3 point and translocation mutants: PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants and fusions:PLCG1 [cytosol] (Homo sapiens)
PDK1:AKT:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PDK1:AKT:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PDK1:AKT:PIP3 [plasma membrane] (Rattus norvegicus)
PDK1:AKT:PIP3 [plasma membrane] (Gallus gallus)
PDK1:AKT:PIP3 [plasma membrane] (Danio rerio)
PDK1:AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
PDK1:AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PDK1:AKT:PIP3 [plasma membrane] (Dictyostelium discoideum)
PDK1:AKT:PIP3 [plasma membrane] (Mus musculus)
PDK1:AKT:PIP3 [plasma membrane] (Homo sapiens)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Homo sapiens)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Xenopus tropicalis)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Canis familiaris)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Gallus gallus)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Bos taurus)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Mus musculus)
PIP3:Active BTK:G-protein beta-gamma complex [plasma membrane] (Homo sapiens)
p-Y139-DAPP1:PIP3 [plasma membrane] (Gallus gallus)
p-Y139-DAPP1:PIP3 [plasma membrane] (Bos taurus)
p-Y139-DAPP1:PIP3 [plasma membrane] (Canis familiaris)
p-Y139-DAPP1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
p-Y139-DAPP1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
p-Y139-DAPP1:PIP3 [plasma membrane] (Dictyostelium discoideum)
p-Y139-DAPP1:PIP3 [plasma membrane] (Danio rerio)
p-Y139-DAPP1:PIP3 [plasma membrane] (Mus musculus)
p-Y139-DAPP1:PIP3 [plasma membrane] (Sus scrofa)
p-Y139-DAPP1:PIP3 [plasma membrane] (Xenopus tropicalis)
p-Y139-DAPP1:PIP3 [plasma membrane] (Rattus norvegicus)
p-Y139-DAPP1:PIP3 [plasma membrane] (Homo sapiens)
p-Y139-DAPP1:PIP3 [plasma membrane] (Plasmodium falciparum)
Btk:PIP3 [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Xenopus tropicalis)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Xenopus tropicalis)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Xenopus tropicalis)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
PIP3:PDK1:AKT [plasma membrane] (Rattus norvegicus)
PIP3:RhoA [plasma membrane] (Schizosaccharomyces pombe)
PIP3:RhoA [plasma membrane] (Rattus norvegicus)
PIP3:RhoA [plasma membrane] (Gallus gallus)
PIP3:RhoA [plasma membrane] (Canis familiaris)
PIP3:RhoA [plasma membrane] (Bos taurus)
PIP3:RhoA [plasma membrane] (Caenorhabditis elegans)
PIP3:RhoA [plasma membrane] (Xenopus tropicalis)
PIP3:RhoA [plasma membrane] (Drosophila melanogaster)
PIP3:RhoA [plasma membrane] (Sus scrofa)
PIP3:RhoA [plasma membrane] (Saccharomyces cerevisiae)
PIP3:RhoA [plasma membrane] (Danio rerio)
PIP3:RhoA [plasma membrane] (Homo sapiens)
PIP3:RhoA [plasma membrane] (Mus musculus)
p-VAV1:PIP3 [plasma membrane] (Bos taurus)
p-VAV1:PIP3 [plasma membrane] (Xenopus tropicalis)
p-VAV1:PIP3 [plasma membrane] (Drosophila melanogaster)
p-VAV1:PIP3 [plasma membrane] (Canis familiaris)
p-VAV1:PIP3 [plasma membrane] (Mus musculus)
p-VAV1:PIP3 [plasma membrane] (Sus scrofa)
p-VAV1:PIP3 [plasma membrane] (Rattus norvegicus)
p-VAV1:PIP3 [plasma membrane] (Caenorhabditis elegans)
p-VAV1:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Gallus gallus)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Canis familiaris)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Mus musculus)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Sus scrofa)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Bos taurus)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Xenopus tropicalis)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Gallus gallus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Xenopus tropicalis)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Mus musculus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Bos taurus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Sus scrofa)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Gallus gallus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Xenopus tropicalis)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Sus scrofa)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Xenopus tropicalis)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Xenopus tropicalis)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Rattus norvegicus)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Danio rerio)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Drosophila melanogaster)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Bos taurus)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Rattus norvegicus)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Dictyostelium discoideum)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Sus scrofa)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Caenorhabditis elegans)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Homo sapiens)
AKT2:PIP3 [plasma membrane] (Rattus norvegicus)
AKT2:PIP3 [plasma membrane] (Danio rerio)
AKT2:PIP3 [plasma membrane] (Drosophila melanogaster)
AKT2:PIP3 [plasma membrane] (Bos taurus)
AKT2:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
AKT2:PIP3 [plasma membrane] (Caenorhabditis elegans)
AKT2:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
AKT2:PIP3 [plasma membrane] (Sus scrofa)
AKT2:PIP3 [plasma membrane] (Dictyostelium discoideum)
AKT2:PIP3 [plasma membrane] (Homo sapiens)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Mus musculus)
AKT2:PIP3 [plasma membrane] (Mus musculus)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:p-GAB1(partially dephosphorylated):PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:p-GAB1(partially dephosphorylated):PIP3 [plasma membrane] (Bos taurus)
GRB2:p-GAB1(partially dephosphorylated):PIP3 [plasma membrane] (Canis familiaris)
GRB2:p-GAB1(partially dephosphorylated):PIP3 [plasma membrane] (Gallus gallus)
GRB2:p-GAB1(partially dephosphorylated):PIP3 [plasma membrane] (Rattus norvegicus)
GRB2:p-GAB1(partially dephosphorylated):PIP3 [plasma membrane] (Mus musculus)
GRB2:p-GAB1(partially dephosphorylated):PIP3 [plasma membrane] (Xenopus tropicalis)
GRB2:p-GAB1(partially dephosphorylated):PIP3 [plasma membrane] (Sus scrofa)
GRB2:p-GAB1(partially dephosphorylated):PIP3 [plasma membrane] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Mus musculus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Bos taurus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Sus scrofa)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Homo sapiens)
PIP3:Vav1 [cytosol] (Mus musculus)
PIP3:VAV1,2,3 [plasma membrane] (Rattus norvegicus)
PIP3:VAV1,2,3 [plasma membrane] (Caenorhabditis elegans)
PIP3:VAV1,2,3 [plasma membrane] (Sus scrofa)
PIP3:VAV1,2,3 [plasma membrane] (Gallus gallus)
PIP3:VAV1,2,3 [plasma membrane] (Mus musculus)
PIP3:VAV1,2,3 [plasma membrane] (Drosophila melanogaster)
PIP3:VAV1,2,3 [plasma membrane] (Xenopus tropicalis)
PIP3:VAV1,2,3 [plasma membrane] (Bos taurus)
PIP3:VAV1,2,3 [plasma membrane] (Canis familiaris)
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 [plasma membrane] (Caenorhabditis elegans)
p-VAV family:PIP3 [plasma membrane] (Gallus gallus)
p-VAV family:PIP3 [plasma membrane] (Sus scrofa)
p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
p-VAV family:PIP3 [plasma membrane] (Xenopus tropicalis)
p-VAV family:PIP3 [plasma membrane] (Rattus norvegicus)
p-VAV family:PIP3 [plasma membrane] (Drosophila melanogaster)
p-VAV family:PIP3 [plasma membrane] (Bos taurus)
p-VAV family:PIP3 [plasma membrane] (Mus musculus)
p-VAV family:PIP3 [plasma membrane] (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Gallus gallus)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Dictyostelium discoideum)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Xenopus tropicalis)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Bos taurus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Drosophila melanogaster)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Dictyostelium discoideum)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Gallus gallus)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Gallus gallus)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Dictyostelium discoideum)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Bos taurus)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Xenopus tropicalis)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Gallus gallus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Sus scrofa)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Bos taurus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Mus musculus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Rattus norvegicus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Gallus gallus)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Rattus norvegicus)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Sus scrofa)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Bos taurus)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Mus musculus)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Xenopus tropicalis)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:GAB2 [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Mus musculus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Gallus gallus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Rattus norvegicus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Canis familiaris)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Sus scrofa)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Xenopus tropicalis)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Xenopus tropicalis)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
BTK:PIP3 [plasma membrane] (Gallus gallus)
BTK:PIP3 [plasma membrane] (Bos taurus)
BTK:PIP3 [plasma membrane] (Canis familiaris)
BTK:PIP3 [plasma membrane] (Mus musculus)
BTK:PIP3 [plasma membrane] (Rattus norvegicus)
BTK:PIP3 [plasma membrane] (Sus scrofa)
BTK:PIP3 [plasma membrane] (Homo sapiens)
p-Y551-BTK:PIP3 [plasma membrane] (Homo sapiens)
PLCG2:PIP3 [plasma membrane] (Sus scrofa)
PLCG2:PIP3 [plasma membrane] (Bos taurus)
PLCG2:PIP3 [plasma membrane] (Canis familiaris)
PLCG2:PIP3 [plasma membrane] (Mus musculus)
PLCG2:PIP3 [plasma membrane] (Rattus norvegicus)
PLCG2:PIP3 [plasma membrane] (Gallus gallus)
PLCG2:PIP3 [plasma membrane] (Homo sapiens)
p-Y223,551-BTK:PIP3 [plasma membrane] (Canis familiaris)
p-Y223,551-BTK:PIP3 [plasma membrane] (Sus scrofa)
p-Y223,551-BTK:PIP3 [plasma membrane] (Bos taurus)
p-Y223,551-BTK:PIP3 [plasma membrane] (Mus musculus)
p-Y223,551-BTK:PIP3 [plasma membrane] (Gallus gallus)
p-Y223,551-BTK:PIP3 [plasma membrane] (Rattus norvegicus)
p-Y223,551-BTK:PIP3 [plasma membrane] (Homo sapiens)
p-Y753,Y759,Y1217-PLCG2:PIP3 [plasma membrane] (Gallus gallus)
p-Y753,Y759,Y1217-PLCG2:PIP3 [plasma membrane] (Sus scrofa)
p-Y753,Y759,Y1217-PLCG2:PIP3 [plasma membrane] (Mus musculus)
p-Y753,Y759,Y1217-PLCG2:PIP3 [plasma membrane] (Rattus norvegicus)
p-Y753,Y759,Y1217-PLCG2:PIP3 [plasma membrane] (Bos taurus)
p-Y753,Y759,Y1217-PLCG2:PIP3 [plasma membrane] (Canis familiaris)
p-Y753,Y759,Y1217-PLCG2:PIP3 [plasma membrane] (Homo sapiens)
IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Homo sapiens)
activated FGFR4:PLCG1 [plasma membrane] (Caenorhabditis elegans)
activated FGFR4:PLCG1 [plasma membrane] (Danio rerio)
activated FGFR4:PLCG1 [plasma membrane] (Rattus norvegicus)
activated FGFR4:PLCG1 [plasma membrane] (Gallus gallus)
activated FGFR4:PLCG1 [plasma membrane] (Bos taurus)
activated FGFR4:PLCG1 [plasma membrane] (Mus musculus)
activated FGFR4:PLCG1 [plasma membrane] (Drosophila melanogaster)
activated FGFR4:PLCG1 [plasma membrane] (Xenopus tropicalis)
activated FGFR4:PLCG1 [plasma membrane] (Sus scrofa)
activated FGFR4:PLCG1 [plasma membrane] (Canis familiaris)
activated FGFR4:PLCG1 [plasma membrane] (Homo sapiens)
activated FGFR2:PLCG1 [plasma membrane] (Rattus norvegicus)
activated FGFR2:PLCG1 [plasma membrane] (Bos taurus)
activated FGFR2:PLCG1 [plasma membrane] (Mus musculus)
activated FGFR2:PLCG1 [plasma membrane] (Drosophila melanogaster)
activated FGFR2:PLCG1 [plasma membrane] (Gallus gallus)
activated FGFR2:PLCG1 [plasma membrane] (Danio rerio)
activated FGFR2:PLCG1 [plasma membrane] (Canis familiaris)
activated FGFR2:PLCG1 [plasma membrane] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Mus musculus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Bos taurus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Sus scrofa)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Homo sapiens)
activated FGFR1:PLCG1 [plasma membrane] (Mus musculus)
activated FGFR1:PLCG1 [plasma membrane] (Drosophila melanogaster)
activated FGFR1:PLCG1 [plasma membrane] (Bos taurus)
activated FGFR1:PLCG1 [plasma membrane] (Xenopus tropicalis)
activated FGFR1:PLCG1 [plasma membrane] (Canis familiaris)
activated FGFR1:PLCG1 [plasma membrane] (Danio rerio)
activated FGFR1:PLCG1 [plasma membrane] (Sus scrofa)
activated FGFR1:PLCG1 [plasma membrane] (Rattus norvegicus)
activated FGFR1:PLCG1 [plasma membrane] (Caenorhabditis elegans)
activated FGFR1:PLCG1 [plasma membrane] (Gallus gallus)
activated FGFR1:PLCG1 [plasma membrane] (Homo sapiens)
activated FGFR3:PLCG1 [plasma membrane] (Gallus gallus)
activated FGFR3:PLCG1 [plasma membrane] (Rattus norvegicus)
activated FGFR3:PLCG1 [plasma membrane] (Danio rerio)
activated FGFR3:PLCG1 [plasma membrane] (Drosophila melanogaster)
activated FGFR3:PLCG1 [plasma membrane] (Bos taurus)
activated FGFR3:PLCG1 [plasma membrane] (Canis familiaris)
activated FGFR3:PLCG1 [plasma membrane] (Mus musculus)
activated FGFR3:PLCG1 [plasma membrane] (Homo sapiens)
GRB2:GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIP3 [plasma membrane] (Xenopus tropicalis)
GRB2:GAB1:PIP3 [plasma membrane] (Rattus norvegicus)
GRB2:GAB1:PIP3 [plasma membrane] (Sus scrofa)
GRB2:GAB1:PIP3 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIP3 [plasma membrane] (Gallus gallus)
GRB2:GAB1:PIP3 [plasma membrane] (Bos taurus)
GRB2:GAB1:PIP3 [plasma membrane] (Mus musculus)
GRB2:GAB1:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT:PIP3 [plasma membrane] (Mus musculus)
p-S-AKT:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
p-S-AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
p-S-AKT:PIP3 [plasma membrane] (Danio rerio)
p-S-AKT:PIP3 [plasma membrane] (Gallus gallus)
p-S-AKT:PIP3 [plasma membrane] (Rattus norvegicus)
p-S-AKT:PIP3 [plasma membrane] (Dictyostelium discoideum)
p-S-AKT:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
p-S-AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Sus scrofa)
PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Canis familiaris)
PDPK1:PIP3 [plasma membrane] (Danio rerio)
PDPK1:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
PDPK1:PIP3 [plasma membrane] (Dictyostelium discoideum)
PDPK1:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Mus musculus)
PDPK1:PIP3 [plasma membrane] (Bos taurus)
PDPK1:PIP3 [plasma membrane] (Plasmodium falciparum)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Xenopus tropicalis)
AKT:PIP3 [plasma membrane] (Homo sapiens)
AKT:PIP3 [plasma membrane] (Rattus norvegicus)
AKT:PIP3 [plasma membrane] (Danio rerio)
AKT:PIP3 [plasma membrane] (Gallus gallus)
AKT:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
AKT:PIP3 [plasma membrane] (Mus musculus)
AKT:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
AKT:PIP3 [plasma membrane] (Caenorhabditis elegans)
AKT:PIP3 [plasma membrane] (Dictyostelium discoideum)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Bos taurus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Gallus gallus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Rattus norvegicus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Xenopus tropicalis)
as an input of
ALK fusion proteins bind PLCG1 (Homo sapiens)
Active ALK binds PLCG1 (Gallus gallus)
Active ALK binds PLCG1 (Danio rerio)
Active ALK binds PLCG1 (Sus scrofa)
Active ALK binds PLCG1 (Bos taurus)
Active ALK binds PLCG1 (Canis familiaris)
Active ALK binds PLCG1 (Rattus norvegicus)
Active ALK binds PLCG1 (Mus musculus)
Active ALK binds PLCG1 (Homo sapiens)
PTEN cancer mutants do not dephosphorylate PIP3 (Homo sapiens)
Activated FGFR4 mutants bind PLCG1 (Homo sapiens)
Activated FGFR2 mutants bind PLCG1 (Homo sapiens)
Activated FGFR3 point and translocation mutants bind PLCG1 (Homo sapiens)
Activated FGFR1 mutants and fusions bind PLCG1 (Homo sapiens)
PIP3 recruits PDK1 and AKT to the membrane (Saccharomyces cerevisiae)
PIP3 recruits PDK1 and AKT to the membrane (Schizosaccharomyces pombe)
PIP3 recruits PDK1 and AKT to the membrane (Dictyostelium discoideum)
PIP3 recruits PDK1 and AKT to the membrane (Caenorhabditis elegans)
PIP3 recruits PDK1 and AKT to the membrane (Drosophila melanogaster)
PIP3 recruits PDK1 and AKT to the membrane (Gallus gallus)
PIP3 recruits PDK1 and AKT to the membrane (Danio rerio)
PIP3 recruits PDK1 and AKT to the membrane (Rattus norvegicus)
PIP3 recruits PDK1 and AKT to the membrane (Mus musculus)
PIP3 recruits PDK1 and AKT to the membrane (Homo sapiens)
G beta-gamma complex and PIP3 recruit BTK to membrane (Drosophila melanogaster)
G beta-gamma complex and PIP3 recruit BTK to membrane (Gallus gallus)
G beta-gamma complex and PIP3 recruit BTK to membrane (Xenopus tropicalis)
G beta-gamma complex and PIP3 recruit BTK to membrane (Sus scrofa)
G beta-gamma complex and PIP3 recruit BTK to membrane (Bos taurus)
G beta-gamma complex and PIP3 recruit BTK to membrane (Canis familiaris)
G beta-gamma complex and PIP3 recruit BTK to membrane (Mus musculus)
G beta-gamma complex and PIP3 recruit BTK to membrane (Homo sapiens)
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Saccharomyces cerevisiae)
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Schizosaccharomyces pombe)
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Dictyostelium discoideum)
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Gallus gallus)
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Xenopus tropicalis)
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Danio rerio)
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Sus scrofa)
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Bos taurus)
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Canis familiaris)
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Rattus norvegicus)
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Mus musculus)
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Homo sapiens)
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Plasmodium falciparum)
Recruitment of Tec kinases to p-Slp-76 (Mus musculus)
Recruitment of TEC kinases to p-SLP-76 (Homo sapiens)
PIP3 binds to RhoA and activates it (Saccharomyces cerevisiae)
PIP3 binds to RhoA and activates it (Schizosaccharomyces pombe)
PIP3 binds to RhoA and activates it (Caenorhabditis elegans)
PIP3 binds to RhoA and activates it (Drosophila melanogaster)
PIP3 binds to RhoA and activates it (Gallus gallus)
PIP3 binds to RhoA and activates it (Xenopus tropicalis)
PIP3 binds to RhoA and activates it (Danio rerio)
PIP3 binds to RhoA and activates it (Sus scrofa)
PIP3 binds to RhoA and activates it (Bos taurus)
PIP3 binds to RhoA and activates it (Canis familiaris)
PIP3 binds to RhoA and activates it (Rattus norvegicus)
PIP3 binds to RhoA and activates it (Homo sapiens)
PIP3 binds to RhoA and activates it (Mus musculus)
Phosphorylation and activation of VAV1 (Xenopus tropicalis)
Phosphorylation and activation of VAV1 (Sus scrofa)
Phosphorylation and activation of VAV1 (Bos taurus)
Phosphorylation and activation of VAV1 (Canis familiaris)
Phosphorylation and activation of VAV1 (Rattus norvegicus)
Phosphorylation and activation of VAV1 (Mus musculus)
Phosphorylation and activation of VAV1 (Homo sapiens)
Recruitment of VAV and BTK to p-SLP-76 (Drosophila melanogaster)
Recruitment of VAV and BTK to p-SLP-76 (Gallus gallus)
Recruitment of VAV and BTK to p-SLP-76 (Xenopus tropicalis)
Recruitment of VAV and BTK to p-SLP-76 (Sus scrofa)
Recruitment of VAV and BTK to p-SLP-76 (Bos taurus)
Recruitment of VAV and BTK to p-SLP-76 (Canis familiaris)
Recruitment of VAV and BTK to p-SLP-76 (Mus musculus)
Recruitment of VAV and BTK to p-SLP-76 (Homo sapiens)
Recruitment of VAV and BTK to p-SLP-76 (Rattus norvegicus)
AKT2 binds PIP3 (Dictyostelium discoideum)
AKT2 binds PIP3 (Caenorhabditis elegans)
AKT2 binds PIP3 (Drosophila melanogaster)
AKT2 binds PIP3 (Danio rerio)
AKT2 binds PIP3 (Sus scrofa)
AKT2 binds PIP3 (Bos taurus)
AKT2 binds PIP3 (Rattus norvegicus)
AKT2 binds PIP3 (Homo sapiens)
AKT2 binds PIP3 (Mus musculus)
PDPK1 binds PIP3 (Plasmodium falciparum)
PDPK1 binds PIP3 (Saccharomyces cerevisiae)
PDPK1 binds PIP3 (Schizosaccharomyces pombe)
PDPK1 binds PIP3 (Dictyostelium discoideum)
PDPK1 binds PIP3 (Caenorhabditis elegans)
PDPK1 binds PIP3 (Drosophila melanogaster)
PDPK1 binds PIP3 (Gallus gallus)
PDPK1 binds PIP3 (Xenopus tropicalis)
PDPK1 binds PIP3 (Danio rerio)
PDPK1 binds PIP3 (Sus scrofa)
PDPK1 binds PIP3 (Bos taurus)
PDPK1 binds PIP3 (Canis familiaris)
PDPK1 binds PIP3 (Rattus norvegicus)
PDPK1 binds PIP3 (Homo sapiens)
PDPK1 binds PIP3 (Mus musculus)
Recruitment of VAV1 to p-6Y-SYK (Gallus gallus)
Recruitment of VAV1 to p-6Y-SYK (Sus scrofa)
Recruitment of VAV1 to p-6Y-SYK (Bos taurus)
Recruitment of VAV1 to p-6Y-SYK (Canis familiaris)
Recruitment of VAV1 to p-6Y-SYK (Rattus norvegicus)
Recruitment of VAV1 to p-6Y-SYK (Mus musculus)
Recruitment of VAV1 to p-6Y-SYK (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Drosophila melanogaster)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Gallus gallus)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Sus scrofa)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Bos taurus)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Canis familiaris)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Rattus norvegicus)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Mus musculus)
PIP3 stimulates Vav1 (Mus musculus)
PI(3,4,5)P3 binds VAV1,2,3 (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
Translocation of Vav1 to CD28 (Xenopus tropicalis)
Translocation of Vav1 to CD28 (Sus scrofa)
Translocation of Vav1 to CD28 (Bos taurus)
Translocation of Vav1 to CD28 (Canis familiaris)
Translocation of Vav1 to CD28 (Rattus norvegicus)
Translocation of Vav1 to CD28 (Mus musculus)
Translocation of Vav1 to CD28 (Homo sapiens)
Recruitment of GAB2 to PM and FCERI by binding to GRB2 (Homo sapiens)
Hydrolysis of PIP3 to PI(3,4)P2 (Gallus gallus)
Hydrolysis of PIP3 to PI(3,4)P2 (Xenopus tropicalis)
Hydrolysis of PIP3 to PI(3,4)P2 (Sus scrofa)
Hydrolysis of PIP3 to PI(3,4)P2 (Bos taurus)
Hydrolysis of PIP3 to PI(3,4)P2 (Canis familiaris)
Hydrolysis of PIP3 to PI(3,4)P2 (Rattus norvegicus)
Hydrolysis of PIP3 to PI(3,4)P2 (Mus musculus)
Hydrolysis of PIP3 to PI(3,4)P2 (Homo sapiens)
PIP3 recruits PDPK1 to the membrane (Plasmodium falciparum)
PIP3 recruits PDPK1 to the membrane (Saccharomyces cerevisiae)
PIP3 recruits PDPK1 to the membrane (Schizosaccharomyces pombe)
PIP3 recruits PDPK1 to the membrane (Dictyostelium discoideum)
PIP3 recruits PDPK1 to the membrane (Caenorhabditis elegans)
PIP3 recruits PDPK1 to the membrane (Drosophila melanogaster)
PIP3 recruits PDPK1 to the membrane (Gallus gallus)
PIP3 recruits PDPK1 to the membrane (Xenopus tropicalis)
PIP3 recruits PDPK1 to the membrane (Danio rerio)
PIP3 recruits PDPK1 to the membrane (Sus scrofa)
PIP3 recruits PDPK1 to the membrane (Bos taurus)
PIP3 recruits PDPK1 to the membrane (Canis familiaris)
PIP3 recruits PDPK1 to the membrane (Rattus norvegicus)
PIP3 recruits PDPK1 to the membrane (Mus musculus)
PIP3 recruits PDPK1 to the membrane (Homo sapiens)
PIP3 recruits AKT to the membrane (Saccharomyces cerevisiae)
PIP3 recruits AKT to the membrane (Schizosaccharomyces pombe)
PIP3 recruits AKT to the membrane (Dictyostelium discoideum)
PIP3 recruits AKT to the membrane (Caenorhabditis elegans)
PIP3 recruits AKT to the membrane (Drosophila melanogaster)
PIP3 recruits AKT to the membrane (Gallus gallus)
PIP3 recruits AKT to the membrane (Danio rerio)
PIP3 recruits AKT to the membrane (Rattus norvegicus)
PIP3 recruits AKT to the membrane (Mus musculus)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Sus scrofa)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Bos taurus)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Canis familiaris)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Rattus norvegicus)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Mus musculus)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Homo sapiens)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Plasmodium falciparum)
PTEN dephosphorylates PIP3 (Saccharomyces cerevisiae)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Saccharomyces cerevisiae)
PTEN dephosphorylates PIP3 (Schizosaccharomyces pombe)
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Dictyostelium discoideum)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Caenorhabditis elegans)
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Drosophila melanogaster)
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Gallus gallus)
PTEN dephosphorylates PIP3 (Gallus gallus)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Xenopus tropicalis)
PTEN dephosphorylates PIP3 (Xenopus tropicalis)
PTEN dephosphorylates PIP3 (Danio rerio)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Danio rerio)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Sus scrofa)
PTEN dephosphorylates PIP3 (Sus scrofa)
PTEN dephosphorylates PIP3 (Bos taurus)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Bos taurus)
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Canis familiaris)
PTEN dephosphorylates PIP3 (Mus musculus)
PTEN dephosphorylates PIP3 (Rattus norvegicus)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Rattus norvegicus)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Homo sapiens)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Mus musculus)
Phosphorylation and activation of PLCG due to FCGR3A effect (Homo sapiens)
Activated FGFR4 binds PLCG1 (Drosophila melanogaster)
Activated FGFR4 binds PLCG1 (Gallus gallus)
Activated FGFR4 binds PLCG1 (Xenopus tropicalis)
Activated FGFR4 binds PLCG1 (Danio rerio)
Activated FGFR4 binds PLCG1 (Sus scrofa)
Activated FGFR4 binds PLCG1 (Bos taurus)
Activated FGFR4 binds PLCG1 (Canis familiaris)
Activated FGFR4 binds PLCG1 (Rattus norvegicus)
Activated FGFR4 binds PLCG1 (Mus musculus)
Activated FGFR4 binds PLCG1 (Homo sapiens)
Activated FGFR2 binds PLCG1 (Drosophila melanogaster)
Activated FGFR2 binds PLCG1 (Gallus gallus)
Activated FGFR2 binds PLCG1 (Danio rerio)
Activated FGFR2 binds PLCG1 (Bos taurus)
Activated FGFR2 binds PLCG1 (Canis familiaris)
Activated FGFR2 binds PLCG1 (Rattus norvegicus)
Activated FGFR2 binds PLCG1 (Mus musculus)
Activated FGFR2 binds PLCG1 (Homo sapiens)
Phosphorylation and activation of PLCG (Gallus gallus)
Phosphorylation and activation of PLCG (Sus scrofa)
Phosphorylation and activation of PLCG (Bos taurus)
Phosphorylation and activation of PLCG (Canis familiaris)
Phosphorylation and activation of PLCG (Rattus norvegicus)
Phosphorylation and activation of PLCG (Mus musculus)
Phosphorylation and activation of PLCG (Homo sapiens)
Activated FGFR1 binds PLCG1 (Drosophila melanogaster)
Activated FGFR1 binds PLCG1 (Gallus gallus)
Activated FGFR1 binds PLCG1 (Xenopus tropicalis)
Activated FGFR1 binds PLCG1 (Danio rerio)
Activated FGFR1 binds PLCG1 (Sus scrofa)
Activated FGFR1 binds PLCG1 (Bos taurus)
Activated FGFR1 binds PLCG1 (Canis familiaris)
Activated FGFR1 binds PLCG1 (Rattus norvegicus)
Activated FGFR1 binds PLCG1 (Mus musculus)
Activated FGFR1 binds PLCG1 (Homo sapiens)
Activated FGFR3 binds PLCG1 (Drosophila melanogaster)
Activated FGFR3 binds PLCG1 (Gallus gallus)
Activated FGFR3 binds PLCG1 (Danio rerio)
Activated FGFR3 binds PLCG1 (Bos taurus)
Activated FGFR3 binds PLCG1 (Canis familiaris)
Activated FGFR3 binds PLCG1 (Rattus norvegicus)
Activated FGFR3 binds PLCG1 (Mus musculus)
Activated FGFR3 binds PLCG1 (Homo sapiens)
PTEN dephosphorylates PIP3 (Homo sapiens)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Drosophila melanogaster)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Gallus gallus)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Xenopus tropicalis)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Sus scrofa)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Bos taurus)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Canis familiaris)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Rattus norvegicus)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Mus musculus)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Homo sapiens)
PIP3 recruits AKT to the membrane (Homo sapiens)
as an output of
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate (Mus musculus)
CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2 (Homo sapiens)
PI3K synthesizes PIP3 downstream of ALK mutants (Homo sapiens)
PI3K synthesizes PIP3 downstream of ALK (Caenorhabditis elegans)
PI3K synthesizes PIP3 downstream of ALK (Drosophila melanogaster)
PI3K synthesizes PIP3 downstream of ALK (Gallus gallus)
PI3K synthesizes PIP3 downstream of ALK (Xenopus tropicalis)
PI3K synthesizes PIP3 downstream of ALK (Danio rerio)
PI3K synthesizes PIP3 downstream of ALK (Sus scrofa)
PI3K synthesizes PIP3 downstream of ALK (Bos taurus)
PI3K synthesizes PIP3 downstream of ALK (Canis familiaris)
PI3K synthesizes PIP3 downstream of ALK (Rattus norvegicus)
PI3K synthesizes PIP3 downstream of ALK (Mus musculus)
PI3K synthesizes PIP3 downstream of ALK (Homo sapiens)
Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII (Homo sapiens)
Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR (Homo sapiens)
PI3K gain of function mutants phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)
PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)
PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3 (Homo sapiens)
KIT mutants:PI3K catalyze synthesis of PIP3 (Homo sapiens)
Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3. (Homo sapiens)
Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Drosophila melanogaster)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Gallus gallus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Xenopus tropicalis)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Danio rerio)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Sus scrofa)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Bos taurus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Canis familiaris)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Rattus norvegicus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Mus musculus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Homo sapiens)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Caenorhabditis elegans)
Activated Ntrk2 activates PI3K signaling (Mus musculus)
NTRK2-activated PI3K generates PIP3 (Homo sapiens)
Activated Ntrk3 stimulates PI3K activity (Mus musculus)
Activated NTRK3 stimulates PI3K activity (Homo sapiens)
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Drosophila melanogaster)
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Gallus gallus)
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Xenopus tropicalis)
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Sus scrofa)
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Bos taurus)
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Canis familiaris)
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Mus musculus)
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Drosophila melanogaster)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Gallus gallus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Xenopus tropicalis)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Danio rerio)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Sus scrofa)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Bos taurus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Canis familiaris)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Rattus norvegicus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Mus musculus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Caenorhabditis elegans)
MET bound PI3K generates PIP3 (Caenorhabditis elegans)
MET bound PI3K generates PIP3 (Xenopus tropicalis)
MET bound PI3K generates PIP3 (Sus scrofa)
MET bound PI3K generates PIP3 (Bos taurus)
MET bound PI3K generates PIP3 (Canis familiaris)
MET bound PI3K generates PIP3 (Rattus norvegicus)
MET bound PI3K generates PIP3 (Mus musculus)
MET bound PI3K generates PIP3 (Homo sapiens)
MET bound PI3K generates PIP3 (Gallus gallus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Synthesis of PIP3 from PIP2 by PI3K (Caenorhabditis elegans)
Synthesis of PIP3 from PIP2 by PI3K (Gallus gallus)
Synthesis of PIP3 from PIP2 by PI3K (Xenopus tropicalis)
Synthesis of PIP3 from PIP2 by PI3K (Sus scrofa)
Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)
Synthesis of PIP3 from PIP2 by PI3K (Canis familiaris)
Synthesis of PIP3 from PIP2 by PI3K (Rattus norvegicus)
Synthesis of PIP3 from PIP2 by PI3K (Mus musculus)
Synthesis of PIP3 from PIP2 by PI3K (Homo sapiens)
Synthesis of PIP3 from PIP2 by PI3K (Danio rerio)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Xenopus tropicalis)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Drosophila melanogaster)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Gallus gallus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Xenopus tropicalis)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Sus scrofa)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Canis familiaris)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Rattus norvegicus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Mus musculus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Homo sapiens)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Caenorhabditis elegans)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Drosophila melanogaster)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Gallus gallus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Danio rerio)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Sus scrofa)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Canis familiaris)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Rattus norvegicus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Homo sapiens)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Caenorhabditis elegans)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Drosophila melanogaster)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Gallus gallus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Xenopus tropicalis)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Danio rerio)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Sus scrofa)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Canis familiaris)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Rattus norvegicus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Mus musculus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Homo sapiens)
Phosphorylation of PIP2 to PIP3 by PI3K (Drosophila melanogaster)
Phosphorylation of PIP2 to PIP3 by PI3K (Gallus gallus)
Phosphorylation of PIP2 to PIP3 by PI3K (Xenopus tropicalis)
Phosphorylation of PIP2 to PIP3 by PI3K (Sus scrofa)
Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)
Phosphorylation of PIP2 to PIP3 by PI3K (Canis familiaris)
Phosphorylation of PIP2 to PIP3 by PI3K (Rattus norvegicus)
Phosphorylation of PIP2 to PIP3 by PI3K (Mus musculus)
Phosphorylation of PIP2 to PIP3 by PI3K (Homo sapiens)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Gallus gallus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Sus scrofa)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Bos taurus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Canis familiaris)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Mus musculus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Homo sapiens)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Dictyostelium discoideum)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Caenorhabditis elegans)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Drosophila melanogaster)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Gallus gallus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Xenopus tropicalis)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Danio rerio)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Sus scrofa)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Bos taurus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Canis familiaris)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Rattus norvegicus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Mus musculus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Homo sapiens)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Dictyostelium discoideum)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Drosophila melanogaster)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Gallus gallus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Xenopus tropicalis)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Sus scrofa)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Bos taurus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Canis familiaris)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Rattus norvegicus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Mus musculus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Homo sapiens)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Gallus gallus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Danio rerio)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Sus scrofa)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Sus scrofa)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Plasmodium falciparum)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Rattus norvegicus)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Canis familiaris)
PI3K produces PIP3 and other phosphatidyl inositides (Canis familiaris)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Saccharomyces cerevisiae)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Schizosaccharomyces pombe)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Dictyostelium discoideum)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Caenorhabditis elegans)
PI3K produces PIP3 and other phosphatidyl inositides (Drosophila melanogaster)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Drosophila melanogaster)
PI3K produces PIP3 and other phosphatidyl inositides (Gallus gallus)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Gallus gallus)
PI3K produces PIP3 and other phosphatidyl inositides (Xenopus tropicalis)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Xenopus tropicalis)
PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Xenopus tropicalis)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Danio rerio)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Danio rerio)
PI3K produces PIP3 and other phosphatidyl inositides (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Sus scrofa)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Sus scrofa)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Mus musculus)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Homo sapiens)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI3K produces PIP3 and other phosphatidyl inositides (Bos taurus)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI3K produces PIP3 and other phosphatidyl inositides (Mus musculus)
PI3K produces PIP3 and other phosphatidyl inositides (Homo sapiens)
PI3K produces PIP3 and other phosphatidyl inositides (Rattus norvegicus)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Rattus norvegicus)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Homo sapiens)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Mus musculus)
Release of PLCG from FCGR3A (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Release of PLCG from FCGR (Gallus gallus)
Release of PLCG from FCGR (Sus scrofa)
Release of PLCG from FCGR (Bos taurus)
Release of PLCG from FCGR (Canis familiaris)
Release of PLCG from FCGR (Rattus norvegicus)
Release of PLCG from FCGR (Mus musculus)
Release of PLCG from FCGR (Homo sapiens)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Caenorhabditis elegans)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Drosophila melanogaster)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Gallus gallus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Xenopus tropicalis)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Danio rerio)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Sus scrofa)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Bos taurus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Canis familiaris)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Rattus norvegicus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Mus musculus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
as a member of
PI(4,5)P2, PI(3,4,5)P3 [plasma membrane]
PIP3, PI(3,4)P2 [plasma membrane]
PI4P,PI(4,5)P2,PIP3 [plasma membrane]
This entity regulates
Positively
Phosphorylation and activation of VAV
(Drosophila melanogaster)
Phosphorylation and activation of VAV
(Gallus gallus)
Phosphorylation and activation of VAV
(Xenopus tropicalis)
Phosphorylation and activation of VAV
(Sus scrofa)
Phosphorylation and activation of VAV
(Bos taurus)
Phosphorylation and activation of VAV
(Canis familiaris)
Phosphorylation and activation of VAV
(Rattus norvegicus)
Phosphorylation and activation of VAV
(Mus musculus)
Phosphorylation and activation of VAV
(Homo sapiens)
Other forms of this molecule
PIP3 [plasma membrane]
PI(3,4,5)P3 [endocytic vesicle membrane]
PI(3,4,5)P3 [endosome membrane]
PI(3,4,5)P3 [early endosome membrane]
PI(3,4,5)P3 [cytoplasmic vesicle membrane]
Cross References
COMPOUND
C05981
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