Reactome: A Curated Pathway Database

Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)

Stable Identifier
R-HSA-2404192
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Binding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS-RAS-RAF-MAPK (ERK) pathway and the PI3K-PKB (AKT) pathway (recently reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parella et al. 2010, Annunziata et al. 2011, Siddle et al. 2012, Holzenberger 2012).

Literature References
Participants
Participant Of
Orthologous Events