Reactome: A Curated Pathway Database

Integrin cell surface interactions (R-HSA-216083)

Species Homo sapiens

Summation

The extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength and also influences the behavior and differentiation state of cells in contact with it. The ECM are diverse in composition, but they generally comprise a mixture of fibrillar proteins, polysaccharides synthesized, secreted and organized by neighboring cells. Collagens, fibronectin, and laminins are the principal components involved in cell matrix interactions; other components, such as vitronectin, thrombospondin, and osteopontin, although less abundant, are also important adhesive molecules.
Integrins are the receptors that mediate cell adhesion to ECM. Integrins consists of one alpha and one beta subunit forming a noncovalently bound heterodimer. 18 alpha and 8 beta subunits have been identified in humans that combine to form 24 different receptors.
The integrin dimers can be broadly divided into three families consisting of the beta1, beta2/beta7, and beta3/alphaV integrins. beta1 associates with 12 alpha-subunits and can be further divided into RGD-, collagen-, or laminin binding and the related alpha4/alpha9 integrins that recognise both matrix and vascular ligands. beta2/beta7 integrins are restricted to leukocytes and mediate cell-cell rather than cell-matrix interactions, although some recognize fibrinogen. The beta3/alphaV family members are all RGD receptors and comprise aIIbb3, an important receptor on platelets, and the remaining b-subunits, which all associate with alphaV. It is the collagen receptors and leukocyte-specific integrins that contain alpha A-domains.

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Literature References
pubMedId Title Journal Year
8866399 Inside-out signaling through integrins J Am Soc Nephrol 1996
12231361 Coming to grips with integrin binding to ligands Curr Opin Cell Biol 2002
15147720 The collagen receptor subfamily of the integrins Int J Biochem Cell Biol 2004
10215583 Extracellular matrix and integrin signalling: the shape of things to come Biochem. J. 1999
19273203 Integrins and proximal signaling mechanisms in cardiovascular disease Front. Biosci. 2009