Polo-like kinase mediated events

Stable Identifier
R-HSA-156711
Type
Pathway
Species
Homo sapiens
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Summation

At mitotic entry, Plk1 phosphorylates and activates Cdc25C phosphatase, whereas it phosphorylates and down-regulates Wee1A (Watanabe et al. 2004). Plk1 also phosphorylates and inhibits Myt1 activity (Sagata 2005). Cyclin B1-bound Cdc2, which is the target of Cdc25C, Wee1A, and Myt1, functions in a feedback loop and phosphorylates the latter components (Cdc25C, Wee1A, Myt1). The Cdc2- dependent phosphorylation provides docking sites for the polo-box domain of Plk1, thus promoting the Plk1-dependent regulation of these components and, as a result, activation of Cdc2-Cyclin B1.

PLK1 phosphorylates and activates the transcription factor FOXM1 which stimulates the expression of a number of genes needed for G2/M transition, including PLK1, thereby creating a positive feedback loop (Laoukili et al. 2005, Fu et al. 2008, Sadasivam et al. 2012, Chen et al. 2013).

Literature References
PubMed ID Title Journal Year
22391450 The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expression

Sadasivam, S, Duan, S, DeCaprio, JA

Genes Dev. 2012
15654331 FoxM1 is required for execution of the mitotic programme and chromosome stability

Laoukili, J, Kooistra, MR, Brás, A, Kauw, J, Kerkhoven, RM, Morrison, A, Clevers, HC, Medema, RH

Nat. Cell Biol. 2005
15692562 The Polo-like kinase Plx1 interacts with and inhibits Myt1 after fertilization of Xenopus eggs

Sagata, N

EMBO J 2005
15070733 M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP

Watanabe, N, Arai, H, Nishihara, Y, Taniguchi, M, Watanabe, N, Hunter, T, Osada, H

Proc Natl Acad Sci U S A 2004
23109430 The forkhead transcription factor FOXM1 controls cell cycle-dependent gene expression through an atypical chromatin binding mechanism

Chen, X, Müller, GA, Quaas, M, Fischer, M, Han, N, Stutchbury, B, Sharrocks, AD, Engeland, K

Mol. Cell. Biol. 2013
19160488 Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression

Fu, Z, Malureanu, L, Huang, J, Wang, W, Li, H, van Deursen, JM, Tindall, DJ, Chen, J

Nat. Cell Biol. 2008
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